检索结果-南通市图书馆

World Journal of Gastroenterology 2011年第26期17卷 3145-3150页

作者： Fei Gao yang-kui gu Wei-Jun Fan Liang Zhang Jin-Hua Huang State Key Laboratory of Oncology in South China Cancer Center Sun Yat-Sen University Guangzhou 510060Guangdong Province China Department of Medical Imaging and InterventionalRadiology Cancer Center Sun Yat-Sen University Guangzhou510060 Guangdong Province China

AIM： To assess the effects of combined transcatheter arterial chemoembolization （TACE） and percutaneous ethanol ablation （PEA） in patients with large hepatocellular carcinoma （HCC）.METHODS： A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimension of the tumors ranged from 5.3 cm to 17.8 cm. The survival rates, acute effects, toxicity and prognostic factors were analyzed.RESULTS： The cumulative survival rates at 1, 3 and 5 years were 59.4%, 28.4% and 15.8%, respectively （a median survival of 27.7 too）. Tumor area was reduced by more than 50% in 30 （47.6%） cases. In 56 cases with increased α-fetoprotein （AFP） values, AFP level was declined by more than 75%. The combined thera- py was generally well tolerated. Only two patients died from variceal bleeding associated with the therapy. The Cox proportional hazards model showed that the num- ber of tumors, the tumor margin and the ethanol dose were independent prognostic factors. CONCLUSION： The combined TACE and PEA therapy is a promising approach for unresectable large HCC.

关键词： Hepatocellular carcinoma Chemoembolizaion Ethanol ablation Combination therapy

Combined treatment of hepatocellular carcinoma with partial splenic embolization and transcatheter hepatic arterial chemoembolization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第48期13卷 6593-6597页

作者： Jin-Hua Huang Fei Gao yang-kui gu Wen-Quan Li Lian-Wei Lu Department of Imaging and Interventional Radiology Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM: To prospectively evaluate the effi cacy and safety of partial splenic embolization (PSE) combined with transcatheter hepatic arterial chemoembolization (TACE) in treatment of hepatocellular carcinoma (HCC). METHODS: Fifty patients suffering from primary HCC associated with hypersplenism caused by cirrhosis were randomly assigned to 2 groups: group A receiving PSE combined with TACE (n = 26) and group B receiving TACE alone (n = 24). Follow-up examinations included calculation of peripheral blood cells (leukcytes, platelets and red blood cells) and treatment-associated complications. RESULTS: Prior to treatment, there was no signifi cant difference in sex, age, Child-Pugh grade, tumor diameter, mass pathology type and peripheral blood cell counts between the 2 groups. After treatment, leukocyte and platelet counts were significantly higher in group A during the 3-mo follow-up period (P 0.05). CONCLUSION: PSE combined with TACE is more effective and safe than TACE alone for patients with HCC associated with hypersplenism caused by cirrhosis.

关键词： Hepatocellular carcinoma Hypersplenism Cirrhosis Partial splenic embolization Transcatheter hepatic arterial chemoembolization

Hydrochloric acid-enhanced radiofrequency ablation for treating a large hepatocellular carcinoma with spontaneous rapture:a case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第1期36卷 44-49页

作者： Ru-Hai Zou yang-kui gu Fei Gao Tian-Qi Zhang Wang Yao Xiong-Ying Jiang Yan-yang Zhang Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Oncologic Interventional Therapy The First Affiliated Hospital Sun Yat-sen University Department of Radiology Intervention Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Intervention The Third Affiliated Hospital Sun Yat-sen University

Background:A ruptured hepatocellular carcinoma(HCC)is often *** addition to surgery and transarterial embo?lization,radiofrequency ablation(RFA)might be another option for treating a ruptured ***,conven?tional RFA has a limited ablation zone;as such,it is rarely used to treat ruptured *** presentation:This case was a 60?year?old man who had a large,ruptured HCC in which hydrochloric acid(HCl)?enhanced RFA successfully controlled the bleeding and made the tumor completely ***:Considering the effectiveness of HCl?enhanced RFA in achieving hemostasis and tumor ablation,it might be a new option for treating large,ruptured HCCs.

关键词： Hydrochloric acid Radiofrequency ablation Spontaneous rupture Hepatocellular carcinoma

Experimental study of destruction to porcine spleen in vivo by microwave ablation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第45期17卷 5014-5020页

作者： Fei Gao yang-kui gu Jing-Xian Shen Chang-Lun Li Xiong-Ying Jiang Jin-Hua Huang State Key Laboratory of Oncology in South China Guangzhou 510060 Guangdong Province China Medical Imaging and Interventional Center Cancer Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM: To discuss the safety, feasibility and regularity of destruction to porcine spleen in vivo with congestion and tumescence by microwave ablation (MWA). METHODS: Ligation of the splenic vein was used to induce congestion and tumescence in vivo in five porcine spleens, and microwave ablation was performed 2-4 h later. A total of 56 ablation points were ablated and the ablation powers were 30-100 W. The ablation time (1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 min) was performed at a power of 60 W. After ablation, the ablation size was measured in pigs A, C, D and E and spleen resection. In pig B, the ablation size was measuredand 2 ablation points were sent for pathology analysis and all tissues were sutured following ablation. Pig B was killed 1 wk later and the ablation points were sent for pathology analysis. Bleeding, tissue carbonization surrounding electrodes, and pathological changes were observed, and the effect on destruction volume relative to different ablation powers, times and positions was analyzed. RESULTS: The incidence of bleeding (only small amounts, < 20 mL) in the course of ablation was 5.4% (3/56) and was attributed to tissue carbonization surrounding electrodes, which also exhibited an incidence of 5.4% (3/56). The destruction volume was influenced by different ablation powers, times and points. It showed that the ablation lesion size increased with increased ablation time, from 1 to 10 min, when the ablation power was 60 W. Also, the ablation lesion size increased with the increase of ablation power, ranging from 30 to 100 W when the ablation time was set to 3 min. A direct correlation was seen between the destruction volume and ablation time by the power of 60 W (r = 0.97542, P < 0.0001, and also between the destruction volume and ablation powers at an ablation time of 3 min (r = 0.98258, P < 0.0001). The destruction volume of zone Ⅱ (the extra-2/3 part of the spleen, relative to the fi rst or second class vascular branches), which was near the hilum

关键词： Experimental study Microwave ablation Porcine spleen In vivo Water-cooled antenna

Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase Ⅱ study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第11期8卷 5556-5562页

作者： Tian-Qi Zhang Zhi-Jun Geng Meng-Xuan Zuo Ji-Bin Li Jin-Hua Huang Zi-Lin Huang Pei-Hong Wu yang-kui gu Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhouP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhouP.R.China Department of Radiology Sun Yat-sen University Cancer CenterGuangzhouP.R.China Department of Clinical Research Sun Yat-sen University Cancer CenterGuangzhouP.R.China

Hepatic arterial infusion chemotherapy(HAIC)using a combination of oxaliplatin,fluorouracil,and leucovorin(FOLFOX)has shown promise for hepatocellular carcinoma(HCC)patients classified under Barcelona Clinic Liver Cancer(BCLC)stage *** China,the combined therapy of camrelizumab and apatinib is now an approved first-line approach for inoperable *** study(NCT04191889)evaluated the benefit of combining camrelizumab and apatinib with HAIC-FOLFOX for HCC patients in BCLC stage *** patients were given a maximum of six cycles of HAIC-FOLFOX,along with camrelizumab and apatinib,until either disease progression or intolerable toxicities *** primary outcome measured was the objective response rate(ORR)based on the Response Evaluation Criteria in Solid Tumors(RECIST)***-five patients were *** on RECIST v1.1 criteria,the confirmed ORR stood at 77.1%(95%CI:59.9%to 89.6%),with a disease control rate of 97.1%(95%CI:85.1%to 99.9%).The median progression-free survival was 10.38 months(95%CI:7.79 to 12.45).Patient quality of life had a transient deterioration within four cycles of treatment,and generally recovered *** most frequent grade≥3 or above treatment-related adverse events included reduced lymphocyte count(37.1%)and diminished neutrophil count(34.3%).The combination of camrelizumab,apatinib,and HAIC demonstrated encouraging results and manageable safety concerns for HCC at BCLC stage C.

关键词： infusion transient Barcelona

Radiofrequency ablation as a treatment for hilar cholangiocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第28期14卷 4540-4545页

作者： Wei-Jun Fan Pei-Hong Wu Liang Zhang Jin-Hua Huang Fu-Jun Zhang yang-kui gu Ming Zhao Xiang-Long Huang Chang-Yu guo Cancer Center of Sun Yat-Sen University 651# Dong Feng Dong Road Guangzhou 510060 Guangdong Province China Radiology Department Centro Hospitalar Conde de Sao Januario (CHCSJ) Macao SAR CP3002 China

AIM: To explore the role of radio-frequency ablation (RFA) as a treatment for hilar cholangiocarcinoma. METHODS: Eleven patients with obstructive cholestasis underwent Computed Tomography (CT) examination, occupying lesions were observed in the hepatic hilar region in each patient. All lesions were confirmed as cholangioadenocarcinoma by biopsy and were classified as type or by percutaneous transhepatic cholangiography. Patients were treated with multiple electrodes RFA combined with other adjuvant therapy. The survival rate, change of CT attenuation coefficient of the tumor and tumor size were studied in these patients after RFA. RESULTS: In a follow-up CT scan one month after RFA, a size reduction of about 30% was observed in six masses, and two masses were reduced by about 20% in size, three of the eleven masses remained unchanged. In a follow-up CT scan 6 mo after RFA, all the masses were reduced in size (overall 35%), in which the most significant size reduction was 60%. The survival follow-up among these eleven cases was 18 mo in average. Ongoing follow-up showed that the longest survival case was 30 mo and the shortest case was 10 mo. CONCLUSION: RFA is a microinvasive and effective treatment for hilar cholangiocarcinoma.

关键词： Radio-frequency ablation Cholangiocarcinoma Computed tomography

Evaluation of combined therapy of transarterial chemoembolization and percutaneous ethanol ablation for large hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of combined therapy of transarterial chemoemboliz...

Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture

中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Fei Gao,yang-kui gu,Wei-Jun Fan,Liang Zhang,Jin-Hua Huang Fei Gao,yang-kui gu,Wei-Jun Fan,Liang Zhang,Jin-Hua Huang,State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-Sen University, guangzhou 510060,China Fei Gao,yang-kui gu,Wei-Jun Fan,Liang Zhang,Jin-Hua Huang,Department of Medical Imaging and Interventional Radiology,Cancer Center,Sun Yat-Sen University,guangzhou 510060,China

AIM:To assess the effects of combined transcatheter arterial chemoembolization(TACE) and percutaneous ethanol ablation(PEA) in patients with large hepato-cellular carcinoma(HCC). METHODS:A total of 63 patients with unresectable large HCC were treated with TACE followed by *** largest dimension of the tumors ranged from 5.3 cm to *** survival rates,acute effects,toxicity and prognostic factors were analyzed. RESULTS:The cumulative survival rates at 1,3 and 5 years were 59.4%,28.4%and 15.8%,respectively(a median survival of 27.7 mo).Tumor area was reduced by more than 50%in 30(47.6%) *** 56 cases with increased a-fetoprotein(AFP) values,AFP level was declined by more than 75%.The combined thera-py was generally well *** two patients died from variceal bleeding associated with the *** Cox proportional hazards model showed that the num-ber of tumors,the tumor margin and the ethanol dose were independent prognostic factors. CONCLUSION:The combined TACE and PEA therapy is a promising approach for unresectable large HCC.

关键词： Hepatocellular carcinoma Chemoemboliza-tion Ethanol ablation Combination therapy

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第45期16卷 5766-5772页

作者： yang-kui gu, Rong-guang Luo, Jin-Hua Huang, Qi-Jiao Si Tu, Xiao-Xia Li, Fei Gao,State Key Laboratory of Oncology in Southern China,Department of Medical Imaging and Interventional Radiology,Cancer Center,Sun Yat-sen University,guangzhou510060,guangdong Province,China Department of Medical Imaging and Interventional Radiology, the First Affiliated Hospital of Nan-Chang University, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China State Key Laboratory of Oncology in Southern China Department of Medical Imaging and Interventional Radiology Cancer Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China.

AIM: To determine the safety and effectiveness of transarterial embolization ablation (TEA) of hepatocellular carcinoma (HCC) with a lipiodol-ethanol mixture. METHODS: Between January 1 and December 31, 2009, 15 patients with HCC (13 men/two women, aged 38-75 years) accepted TEA treatment and were enrolled in this study, including five newly diagnosed patients and 10 with refractory disease. Two months after TEA, angiography and contrast computed tomography (CT) were performed, and responses were assessed using a modified version of Response Evaluation Criteria in Solid Tumors (RECIST version 1.1). The follow-up period was to June 30, 2010. RESULTS: Every new case was treated once. Angiography was performed immediately after TEA, and showed that the tumor-feeding vessels were completely embolized and that lipiodol was densely deposited inside tumors. Two months after treatment, contrast CT showed no enhanced lesions. Alpha fetoprotein levels returned to normal in four patients and markedly decreased in another. mean ± SD survival after treatment was 10.8 ± 4.5 mo. All five patients survived during the follow-up period. Ten patients with refractory disease were treated a total of 14 times. Angiography immediately after TEA showed that blood flow to the tumors was obviously decreased in all cases, and contrast CT showed obvious depositions of lipiodol. Two months after treatment, the tumors had shrunk (6/10) or were stable (3/10). One had progressed after 2 mo and died of tumor rupture 3 mo after TEA. mean ± SD survival after treatment was 8.6 ± 4.3 mo; two patients survived during the follow-up period. Adverse effects included reversible hepatic decompensation, upper abdominal pain, and fever. CONCLUSION: TEA is an effective therapy for patients with HCC and might be more effective than transcather arterial chemoembolization for treating refractory disease.

关键词： Transarterial embolization ablation Lipiodolethanol mixture Hepatocellular carcinoma

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian gu Haoyu Li Mengyao Li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction