Evaluation of transarterial chemoembolization combined with percutaneous ethanol ablation for large hepatocellular carcinoma

作     者：Fei Gao Yang-Kui Gu Wei-Jun Fan Liang Zhang Jin-Hua Huang 

作者机构：State Key Laboratory of Oncology in South ChinaCancer Center Sun Yat-Sen University Guangzhou 510060Guangdong Province China Department of Medical Imaging and InterventionalRadiology Cancer Center Sun Yat-Sen University Guangzhou510060 Guangdong Province China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第26期

页      面：3145-3150页

核心收录：

学科分类：0710[理学-生物学] 0907[农学-林学] 07[理学] 08[工学] 0829[工学-林业工程] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：Supported by Guangdong Provincial Science and Technology Project China No.2008B030301127 

主　　题：Hepatocellular carcinoma Chemoembolizaion Ethanol ablation Combination therapy 

摘      要：AIM： To assess the effects of combined transcatheter arterial chemoembolization （TACE） and percutaneous ethanol ablation （PEA） in patients with large hepatocellular carcinoma （HCC）. METHODS： A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimension of the tumors ranged from 5.3 cm to 17.8 cm. The survival rates, acute effects, toxicity and prognostic factors were analyzed. RESULTS： The cumulative survival rates at 1, 3 and 5 years were 59.4%, 28.4% and 15.8%, respectively （a median survival of 27.7 too）. Tumor area was reduced by more than 50% in 30 （47.6%） cases. In 56 cases with increased α-fetoprotein （AFP） values, AFP level was declined by more than 75%. The combined thera- py was generally well tolerated. Only two patients died from variceal bleeding associated with the therapy. The Cox proportional hazards model showed that the num- ber of tumors, the tumor margin and the ethanol dose were independent prognostic factors. CONCLUSION： The combined TACE and PEA therapy is a promising approach for unresectable large HCC.