检索结果-南通市图书馆

Enhancing the Performance of Perovskite Light-Emitting Diodes via Synergistic Effect of Defect Passivation and Dielectric Screening

引用

Nano-Micro Letters 2024年第10期16卷 244-256页

作者： Xuanchi Yu Jia Guo Yulin Mao Chengwei Shan Fengshou Tian Bingheng Meng Zhaojin Wang Tianqi Zhang Aung ko.ko kyaw Shuming Chen Xiaowei sun kai Wang Rui Chen Guichuan Xing Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao 999078People's Republic of China Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055People's Republic of China

Metal halide perovskites,particularly the quasi-two-dimensional perovskite subclass,have exhibited considerable potential for next-generation electroluminescent materials for lighting and ***,the presence of defects within these perovskites has a substantial influence on the emission efficiency and durability of the *** this study,we revealed a synergistic passivation mechanism on perovskite films by using a dual-functional compound of potassium *** dual functional potassium bromide on the one hand can passivate the defects of halide vacancies with bromine anions and,on the other hand,can screen the charged defects at the grain boundaries with potassium *** approach effectively reduces the probability of carriers quenching resulting from charged defects capture and consequently enhances the radiative recombination efficiency of perovskite thin films,leading to a significant enhancement of photoluminescence quantum yield to near-unity values(95%).Meanwhile,the potassium bromide treatment promoted the growth of homogeneous and smooth film,facilitating the charge carrier injection in the ***,the perovskite light-emitting diodes based on this strategy achieve a maximum external quantum efficiency of~21%and maximum luminance of~60,000 cd m^(-2).This work provides a deeper insight into the passivation mechanism of ionic compound additives in perovskite with the solution method.

关键词： Synergistic passivation strategy Defects passivation Dielectric screening Perovskite light-emitting diodes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Programmable directional color dynamics using plasmonics

引用

Microsystems & Nanoengineering 2024年第1期10卷 325-334页

作者： Gyurin kim Doeun kim Soeun ko Jang-Hwan Han Juhwan kim Joo Hwan ko Young Min Song Hyeon-Ho Jeong School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Semiconductor Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Artificial Intelligence(AI)Graduate School Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

Adaptive multicolor filters have emerged as key components for ensuring color accuracy and resolution in outdoor visual ***,the current state of this technology is still in its infancy and largely reliant on liquid crystal devices that require high voltage and bulky structural ***,we present a multicolor nanofilter consisting of multilayered‘active’plasmonic nanocomposites,wherein metallic nanoparticles are embedded within a conductive polymer *** nanocomposites are fabricated with a total thickness below 100 nm using a‘lithography-free’method at the wafer level,and they inherently exhibit three prominent optical modes,accompanying scattering phenomena that produce distinct dichroic reflection and transmission ***,a pivotal achievement is that all these colors are electrically manipulated with an applied external voltage of less than 1 V with 3.5 s of switching speed,encompassing the entire visible ***,this electrically programmable multicolor function enables the effective and dynamic modulation of the color temperature of white light across the warm-to-cool spectrum(3250 k-6250 k).This transformative capability is exceptionally valuable for enhancing the performance of outdoor optical devices that are independent of factors such as the sun’s elevation and prevailing weather conditions.

关键词： directional prevailing exceptional

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

p53 exerts anticancer effects by regulating enhancer formation and activity

引用

Journal of Biomedical Research 2024年第4期38卷 334-347页

作者： Shuhan Chen Xuchun Wang Nan yang Yuechi Song He Cheng Yujie sun key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Department of Cell Biology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

The abnormality of the p53 tumor suppressor is crucial in lung cancer development,because p53 regulates target gene promoters to combat *** studies have shown extensive p53 binding to enhancer ***,whether p53 exerts a tumor suppressor role by shaping the enhancer landscape remains poorly *** the current study,we employed several functional genomics approaches to assess the enhancer activity at p53 binding sites throughout the genome based on our established TP53 knockout(ko)human bronchial epithelial cells(BEAS-2B).A total of 943 active regular enhancers and 370 super-enhancers(SEs)disappeared upon the deletion of p53,indicating that p53 modulates the activity of hundreds of enhancer *** found that one p53-dependent SE,located on chromosome 9 and designated as kLF4-SE,regulated the expression of the krüppel-like factor 4(kLF4)***,the deletion of p53 significantly decreased the kLF4-SE enhancer activity and the kLF4 expression,but increased colony formation ability in the nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced cell transformation ***,in TP53 ko cells,the overexpression of kLF4 partially reversed the increased clonogenic capacity caused by p53 ***,kLF4 expression also decreased in lung cancer tissues and cell *** appeared that overexpression of kLF4 significantly suppressed the proliferation and migration of lung cancer ***,our results suggest that the regulation of enhancer formation and activity by p53 is an integral component of the p53 tumor suppressor ***,our findings offer some novel insights into the regulation mechanism of p53 in lung oncogenesis and introduce a new strategy for screening therapeutic targets.

关键词： p53 enhancer tumor malignant transformation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

引用

Journal of Molecular Cell Biology 2024年第1期16卷 29-42页

作者： Qiyao Liu Manyun Li Minli sun Ruyue Xin Yushu Wang Qin Chen Xiang Gao Zhaoyu Lin MOE key Laboratory of Model Animals for Disease Study State Key Laboratory of Pharmaceutical BiotechnologyJiangsu Key Laboratory of Molecular MedicineModel Animal Research CenterNational Resource Center for Mutant Mice of ChinaNanjing Drum Tower HospitalSchool of MedicineNanjing UniversityNanjing 210061China Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China

Homeostasis of the skin barrier is essential for maintaining normal skin *** A(GSDMA)is highly expressed in the skin and associated with many skin diseases,such as melanoma and *** mice,GSDMA is encoded by three gene homologues,namely Gsdma1,Gsdma2,and *** Gsdma3 gain-of-function mutations cause hair loss and skin inflammation,Gsdma3-deficient mice do not show any visible phenotypes in skin and hair *** explore the physiological function of GSDMA,we generated conventional Gsdma1/2/3 knockout(ko)*** mice showed significantly alleviated epidermal hyperplasia and inflammation induced by phorbol 12-myristate 13-acetate(PMA).Furthermore,the alleviation of epidermal hyperplasia depended on the expression of Gsdma1/2/3 specifically in ***,Gsdma1/2/3 depletion downregulated epidermal growth factor receptor(EGFR)ligands,leading to the decreased EGFR–Stat3/Akt *** results demonstrate that depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia partially by inhibiting the EGFR–Stat3/Akt pathway.

关键词： GSDMA epidermal hyperplasia PMA Hb-egf EGFR Stat3 Akt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice

引用

Journal of Genetics and Genomics 2024年第4期51卷 407-418页

作者： Yaling Wang Xueying Huang Guoying sun Jingwen Chen Bangguo Wu Jiahui Luo Shuyan Tang Peng Dai Feng Zhang Jinsong Li Lingbo Wang Shanghai key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai key Laboratory of Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful *** deformities in flagella cause a male infertility syndrome,multiple morphological abnormalities of the flagella(MMAF),while acrosomal hypoplasia in some cases leads to sub-optimal embryonic developmental ***,evidence regarding the occurrence of acrosomal hypoplasia in MMAF is ***,we report the generation of base-edited mice knocked out for coiled-coil domain-containing 38(Ccdc38)via inducing a nonsense mutation and find that the males are *** Ccdc38-ko sperm display acrosomal hypoplasia and typical MMAF *** find that the acrosomal membrane is loosely anchored to the nucleus and fibrous sheaths are disorganized in Ccdc38-ko *** analyses reveal that Ccdc38 knockout causes a decreased level of TEkT3,a protein associated with acrosome biogenesis,in testes and an aberrant distribution of TEkT3 in *** finally show that intracytoplasmic sperm injection overcomes Ccdc38-related *** study thus reveals a previously unknown role for CCDC38 in acrosome biogenesis and provides additional evidence for the occurrence of acrosomal hypoplasia in MMAF.

关键词： Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) Infertility Sperm motility Asthenoteratozoospermia Disease modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

引用

Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi sun Lin Huang Liwei Lu Chengping Wen key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer Institute(key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International Institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to *** dysregulation of double-negative(DN)T cells is considered as a crucial commander during ***,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune ***,the function of neddylation in SLE is still ***,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus *** investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus *** double knockout(ko)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus *** findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus ***,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was ***,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation ***,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE ***,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Handover Mechanism Based on Underwater Hybrid Software-Defined Modem in Advanced Diver Networks

引用

Computers, Materials & Continua 2022年第3期70卷 5721-5743页

作者： k.M.Delphin Raj sun-Ho Yum Jinyoung Lee Eunbi ko Soo-Yong Shin Soo-Hyun Park Department of Financial Information Security Kookmin UniversitySeoul02707Korea Special Communication&Convergence Service Research Center Kookmin UniversitySeoul02707Korea Department of Computer Science Kookmin UniversitySeoul02707Korea

For the past few decades,the internet of underwater things(IoUT)otained a lot of attention in mobile aquatic applications such as oceanography,diver network monitoring,unmanned underwater exploration,underwater surveillance,location tracking system,*** of the IoUT applications rely on acoustic *** current IoUT applications face difficulty in delivering a reliable communication system due to the various technical limitations of IoUT environment such as low data rate,attenuation,limited bandwidth,limited battery,limited memory,connectivity problem,*** of the significant applications of IoUT include monitoring underwater diver *** order to perform a reliable and energy-efficient communication system in the underwater diver networks,a smart underwater hybrid softwaredefined modem(UHSDM)for the mobile ad-hoc network was developed that is used for selecting the best channel/medium among acoustic,visible light communication(VLC),and infrared(IR)based on the criteria established within the ***,due to the mobility of underwater divers,the developed UHSDMmeets the challenges such as connectivity errors,frequent link failure,transmission delay caused by re-routing,*** emergency,the divers are most at the risk of *** deal with diver mobility,connectivity,energy efficiency,and reducing the latency in ADN,a handover mechanism based on pre-built UHSDM is proposed in this *** paper focuses on(1)design of UHSDM for ADN(2)propose the channel selection mechanism in UHSDM for selecting the best medium for handover and(3)propose handover protocol *** implementation result shows that the proposed mechanism can be used to find the new route for divers in advance and the latency can be reduced ***,this paper shows the real field experiment of air tests and underwater tests with various *** research will contribute much to the profit of researchers in underwater diver networks and underwater net

关键词： Internet of underwater things(IoUT) underwater hybrid software-defined modem(UHSDM) advanced diver networks(ADN) channel selection mechanism(CSM) handover mechanism acoustic visible light communication(VLC) infrared(IR)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms

引用

World Journal of Stem Cells 2020年第9期12卷 1032-1049页

作者： Yunejin Song Jung-Yeon Lim Taekyu Lim keon-Il Im Nayoun kim Young-sun Nam Young-Woo Jeon Jong Chul Shin Hyun sun ko In yang Park Seok-Goo Cho Institute for Translational Research and Molecular Imaging College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Laboratory of Immune Regulation Convergent Research Consortium for Immunologic DiseaseCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Biomedicine and Health Sciences College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Hematology Oncology Department of Internal MedicineVeterans Health Service Medical CenterSeoul 05368South Korea Department of Hematology Catholic Blood and Marrow Transplantation CenterSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Obstetrics and Gynecology CHA Bundang Medical CenterCHA UniversitySeongnam 13496South Korea Department of Obstetrics and Gynecology College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Division of Hematology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACkGROUND Mesenchymal stem cells(MSCs)are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory *** human bone marrow-derived MSCs(BM-MSCs)were the most widely used MSCs in cell therapy until recently,MSCs derived from human umbilical cords(UC-MSCs)have gained popularity as cell therapy material for their ethical and noninvasive *** To investigate the difference in mechanisms of the immunosuppressive effects of UC-MSCs and *** To analyze soluble factors expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prostaglandin E2 and interleukin(IL)-6,inflammatory environments in vitro were reconstituted with combinations of interferon-gamma(IFN-γ),tumor necrosis factor alpha and IL-1βor with IFN-γ*** T cells were cocultured with MSCs treated with indomethacin and/or *** assess the ability of MSCs to inhibit T helper 17 cells and induce regulatory T cells,induced T helper 17 cells were cocultured with MSCs treated with indomethacin or *** graft-versus-host disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were treated as cell *** Our data demonstrated that BM-MSCs and UC-MSCs shared similar phenotypic characteristics and immunomodulation ***-MSCs expressed more indolamine 2,3-dioxygenase after cytokine stimulation with different combinations of IFN-γ,tumor necrosis factor alpha-αand IL-1βor IFN-γ***-MSCs expressed more prostaglandin E2,IL-6,programmed death-ligand 1 and 2 in the in vitro inflammatory ***-2 and IL-10 were key factors in the immunomodulatory mechanisms of both *** addition,UC-MSCs inhibited more T helper 17 cells and induced more regulatory T cells than ***-MSCs and BM-MSCs exhibited similar effects on attenuating graft-versus-host *** UC-MSCs and BM-MSCs exert similar immunosuppressive effects with different mechanisms

关键词： Mesenchymal stem cells Graft-versus-host disease Umbilical cord Cell therapy Xenogeneic mouse model Immunomodulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder

引用

Journal of Molecular Cell Biology 2021年第5期13卷 361-373页

作者： Minsoo kang sun kyoung Han Suhyun kim sungyeon Park Yerin Jo Hyeryung kang Jesang ko Division of Life Sciences Korea UniversitySeoul 02841South Korea

Hepatic gluconeogenesis is the central pathway for glucose generation in the *** imbalance between glucose synthesis and uptake leads to metabolic diseases such as obesity,diabetes,and cardiovascular *** leucine zipper protein(sLZIP)is an isoform of LZIP and it mainly functions as a transcription *** sLZIP is known to regulate the transcription of genes involved in various cellular processes,the role of sLZIP in hepatic glucose metabolism is not *** this study,we investigated the regulatory role of sLZIP in hepatic gluconeogenesis and its involvement in metabolic *** found that sLZIP expression was elevated during glucose starvation,leading to the promotion of phosphoenolpyruvate carboxylase and glucose-6-phosphatase expression in ***,sLZIP knockdown suppressed the expression of the gluconeogenic enzymes under low glucose *** also enhanced glucose production in the human liver cells and mouse primary hepatic ***-induced cyclic adenosine monophosphate impeded sLZIP *** of glucose and pyruvate tolerance tests showed that sLZIP transgenic mice exhibited abnormal blood glucose *** findings suggest that sLZIP is a novel regulator of gluconeogenic enzyme expression and plays a role in blood glucose homeostasis during starvation.

关键词： gluconeogenic enzymes hepatic gluconeogenesis hyperglycemia transcription factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mutagenesis of odorant coreceptor Orco reveals the distinct role of olfaction between sexes in Spodoptera frugiperda

引用

Journal of Integrative Agriculture 2023年第7期22卷 2162-2172页

作者： CAO Song sun Dong-dong LIU yang yang Qing WANG Gui-rong Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China State key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Odorant receptor(OR)is crucial for insects to detect and recognize external chemical cues closely related to their *** insect OR forms a heteromeric complex composed of a ligand-specific receptor and a ubiquitously odorant receptor coreceptor(Orco).This study used the CRISPR/Cas9 technique to knock out(ko)Orco and reveal its essential role in acting on OR-meditated olfactory behavior in a critical invasive agricultural pest,the fall armyworm(FAW),Spodoptera ***(EAG)results suggested that the Orco mutants of both male and female moths severely reduced their electrophysiological responses to the eight tested plant volatiles and two sex ***,the Orco gene played distinct roles in mating behavior between sexes:the mating behavior was fully disrupted in mutated males but not in mutated *** oviposition result indicated that the Orco ko females displayed reduced egg laying by 24.1%compared with the mated wild type(WT)***,these results strongly suggest that Orco is an excellent target for disrupting FAW’s normal behavior and provides a feasible pest control approach.

关键词： Spodoptera frugiperda Orco CRISPR/Cas9 EAG olfactory behavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：