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H_(2)O_(2)-sensitive nanoscale coordination polymers for photoacoustic tumors imaging via in vivo chromogenic assay

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Journal of Innovative Optical Health Sciences 2022年第5期15卷 1-12页

作者： Jiayue Zhao Fei Gong Nailin yang Huali Lei Zhihui Han yuqi yang Liang Cheng Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of FunctionalNano&Soft Materials(FUNSOM)Soochow University Suzhou 215123 JiangsuP.R.China Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 P.R.China

Photoacoustic(PA)imaging with much deeper tissue penetration and better spatial resolution had been widely employed for the prevention and diagnosis of many *** this study,a new type of hydrogen peroxide(H_(2)O_(2)T-activated photoacoustic nanoprobe[Mn-AH nanoscale coordination polymer nanodots(NCPs)]was successfully synthesized by a simple one-step method in water phase containing 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS),horse radish peroxidase(HRP),and manganese ion(Mn^(2+).After modification by polyethylene glycol(PEG),Mn-AH NCPs exhibited excellent stability and biocompatibility for in vivo H_(2)O_(2)-responsive chromogenic assay with great speci¯city and *** the presence of H_(2)O_(2),colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared(NIR)absorbance,enabling photoacoustic detection of endogenous H_(2)O_(2).Using H_(2)O_(2)-activated Mn-AH NCPs,we have successfully performed PA imaging and H_(2)O_(2)detection of subcutaneous murine colon CT26 tumor and deep-seated orthotopic bladder *** to the inherent Mn element existence inside the Mn-AH,this nanoprobe also serves as a good T1-weighted magnetic resonance imaging(MRI)contrast agent ***,after accomplishing its imaging functions,the Mn-AH NCPs could be cleared out from the body without any long-term toxicity,providing a new opportunity for cancer diagnosis and treatment.

关键词： Nanoscale coordination polymers(NCPs) PA imaging MRI H2O2 detection metabolic nanoprobes

Effects of cobalt carbide on Fischer–Tropsch synthesis with MnO supported Co-based catalysts

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Journal of Energy Chemistry 2020年第3期29卷 227-232页

作者： Fanfei Sun Ruoou yang Zhaoming Xia yuqi yang Ziang Zhao Songqi Gu Dongshuang Wu Yunjie Ding Zheng Jiang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China Shanghai Synchrotron Radiation Facility Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100100China Center for Applied Chemical Research Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049ShaanxiChina Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Graduate school of science Kyoto UniversityKitashirakawaOiwake-choSakyo-kuKyoto-shiKyoto-fu606-8502Japan

Cobalt carbide(Co2C)was considered as potential catalysts available for large-scale industrialization of transforming syngas(H2 and CO)to clean ***,we successfully synthesized Co-based catalysts with MnO supported,to comprehend the effects of Co2C for Fischer–Tropsch synthesis(FTS)under ambient *** huge variety of product selectivity which was contained by different active sites(Co and Co2C)has been ***,density functional theory(DFT)shows that Co2C is efficacious of CO adsorption,whereas is weaker for H adsorption than *** the advantages of Co and Co2C,the catalyst herein can not only obtain more C5+products but also suppress methane *** can be a commendable guide for the design of industrial application products in FTS.

关键词： Cobalt carbide Fischer–Tropsch synthesis X-ray absorption fine spectroscopy nanomaterials Density functional theory

The decisive role of adsorbed OH^(*)in low‐potential CO electro‐oxidation on single‐atom catalytic sites

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Carbon Energy 2023年第9期5卷 63-73页

作者： yang Li Xian Wang Ying Wang Zhaoping Shi yuqi yang Tuo Zhao Zheng Jiang Changpeng Liu Wei Xing Junjie Ge State Key Laboratory of Electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiChina State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghaiChina Shanghai Synchrotron Radiation Facility Zhangjiang National LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Dalian National Laboratory for Clean Energy DalianChina

CO impurity-induced catalyst deactivation has long been one of the biggest challenges in proton-exchange membrane fuel cells,with the poisoning phenomenon mainly attributed to the overly strong adsorption on the catalytic ***,we present a mechanistic study that overturns this understanding by using Rh-based single-atom catalysis centers as model *** precisely modulated the chelation structure of the Rh catalyst by coordinating Rh with C or N atoms,and probed the reaction mechanism by surface-enhanced Raman *** spectroscopic evidence for intermediates indicates that the reactivity of adsorbed OH^(*),rather than the adsorption strength of CO^(*),dictates the CO electrocatalytic oxidation *** RhN_(4)sites,which adsorb the OH^(*)intermediate more weakly than RhC4 sites,showed prominent CO oxidation activity that not only far exceeded the traditional Pt/C but also the RhC4 sites with similar CO adsorption *** this study,it is clear that a paradigm shift in future research should be considered to rationally design high-performance CO electro-oxidation reaction catalysts by sufficiently considering the water-related reaction intermediate during catalysis.

关键词： adsorbed CO^(*)and OH^(*) carbon‐based Rh single‐atom catalysts CO electro‐oxidation reaction electron interaction MNx moiety

Understanding the synergetic interaction within α-MoC/β-Mo2C heterostructured electrocatalyst

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Journal of Energy Chemistry 2019年第8期28卷 66-70,I0004页

作者： Hao Zhang Haiyan Jin yuqi yang Fanfei Sun yang Liu Xianlong Du Shuo Zhang Fei Song Jianqiang Wang Yong Wang Zheng Jiang Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204 China University of Chinese Academy of Sciences Beijing 100100 China Advanced Materials and Catalysis Group Institute of Catalysis Zhejiang UniversityHangzhou 310028 Zhejiang China

Constructing heterostructure is an important strategy to design efficient electrocatalysts. The synergetic interaction between dissimilar materials has been considered as the origin of the activity enhancement,however, the interfacial interaction is challenging to probe, thus, the underlying mechanism remains obscure. Here, we reported a heterostructured α-MoC/β-Mo2 C electrocatalyst for hydrogen evolution in alkaline media, which shows a significant electrocatalytic activity improvement as compared to the single component. Based on extensive characterizations including high-resolution transmission electron microscopy and X-ray absorption fine structure(XAFS) spectroscopy, together with density functional theory, we unraveled the synergetic interaction between α-MoC and β-Mo2 C, implying that α-Mo C sites are beneficial for water dissociation and hydrogen prefers to release on β-Mo2 C sites.

关键词： Hydrogen evolution reaction Heterostructure Molybdenum carbide Synergetic interaction Water dissociation

A Study of Creative Imagery in Public Service Posters Based on Design Cultural Codes Theory

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Advances in Humanities Research

Advances in Humanities Research 2023年第1期2卷 47-55页

作者： yuqi yang HuBei Univeristy Hubei ProvinceChina430000

This study,grounded in design culture code theory,rigorously explores the multifaceted impact of visual imagery on poster *** theory with practicality,it dissects the strategic,semiotic,and technical aspects of poster creation,illuminating how visual elements are strategically employed,convey nuanced meanings,and adhere to design ***,it scrutinizes the adaptability of these strategies across diverse socio-cultural *** study enriches our comprehension of how visual choices endow posters with significance and emotional ***,it contributes novel insights into the technical intricacies of visual design *** synthesizing theory and practice,with an emphasis on cross-cultural adaptability,this study advances our understanding of how visual imagery influences strategic,meaningful,and technical dimensions in poster *** holds implications for design practitioners and offers inspiration for future research in this *** humility,it contributes to the existing body of knowledge while paving the way for further exploration in the discipline.

关键词： visual imagery design culture code public service posters global warming

The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma

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Bioactive Materials 2023年第7期25卷 73-85页

作者： Jun Ge Nailin yang yuqi yang Hao Yu Xiaoyuan yang Yingjie Wang Tianyi Wang Shuning Cheng Yuanjie Wang Zhihui Han Yun Teng Jun Zou Huilin yang Liang Cheng Department of Orthopedic Surgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhouJiangsuChina Department of Neurosurgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Osteosarcoma(OS)patients have a poor prognosis due to its high degree of heterogeneity and high rate of *** hyperthermia therapy(MHT)combined with immunotherapy is an effective strategy to treat solid and metastatic ***,we combined biodegradable magnesium(Mg)macroscale rods,which acted as an eddy thermo-magnetic agent under a low external alternating magnetic field,and immunotherapy to achieve a radical cure for *** eddy thermal effect(ETE)of the Mg rods(MgR)showed outstanding cytotoxic effects and enhanced the maturation of dendritic cells(DCs),and the mild MHT induced the immunogenic cell death(ICD)in the OS *** with immune checkpoint blockade(ICB)therapy,we obtained an excellent curative effect against OS,and a further evaluation demonstrated that the local MHT induced by the MgR increased T cells infiltration and the polarization of M1 ***,the biodegradable MgR also promoted bone *** work highlighted the uneven ETE mediated by the biodegradable MgR induced a comprehensive immunologic activation in the OS tumor microenvironment(TME),which would inspire the application of MHT for the effective treatment of OS.

关键词： Osteosarcoma Eddy thermal effect Magnesium rods(MgR) Osteosarcoma therapy Tumor microenvironment(TME) immunotherapy

Role of local coordination in bimetallic sites for oxygen reduction: A theoretical analysis

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Journal of Energy Chemistry 2020年第5期29卷 131-137页

作者： yuqi yang Hao Zhang Zhaofeng Liang Yaru Yin Bingbao Mei Fei Song Fanfei Sun Songqi Gu Zheng Jiang Yuen Wu Zhiyuan Zhu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China Shanghai Synchrotron Radiation Facility Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)University of Science and Technology of ChinaHefei 230026AnhuiChina ShanghaiTech University Shanghai 201210China

Understanding of the oxygen reduction reaction(ORR)mechanism for single atom catalysts is pivotal for the rational design of non-precious metal cathode materials and the commercialization of fuel ***,a series of non-precious metal electrocatalysts based on nitrogen-doped bimetallic(Fe and Co)carbide were modeled by density functional theory calculations to predict the corresponding reaction *** study elucidated prior oxygen adsorption on the Fe atom in the dual site and the modifier role of Co atoms to tune the electronic structures of *** reaction activity was highly correlated with the bimetallic center and the coordination environment of the adjacent ***,the preadsorption of*OH resulted in the apparent change of metal atoms'electronic states with the d-band center shifting toward the Fermi level,thereby boosting reaction *** result should help promote the fundamental understanding of active sites in ORR catalysts and provide an effective approach to the design of highly efficient ORR catalysts on an atomic scale.

关键词： Non-precious metal catalysts Bimetallic-sites Oxygen reduction reaction Density functional theory

Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment

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Bioactive Materials 2023年第3期21卷 381-393页

作者： Qiong Huang yuqi yang Tianjiao Zhao Qiaohui Chen Min Liu Shuting Ji Yan Zhu Yunrong yang Jinping Zhang Haixin Zhao Yayun Nan Kelong Ai Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha410078China Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078China Geriatric Medical Center People’s Hospital of Ningxia Hui Autonomous RegionYinchuan750002China

Acute kidney injury(AKI)can lead to loss of kidney function and a substantial increase in *** burst of reactive oxygen species(ROS)plays a key role in the pathological progression of ***-targeted antioxidant therapy is very promising because mitochondria are the main source of ROS in *** nanodrugs with actively targeted mitochondria have achieved encouraging success in many oxidative stress-induced ***,most strategies to actively target mitochondria make the size of nanodrugs too large to pass through the glomerular system to reach the renal tubules,the main damage site of ***,an ultra-small Tungsten-based nanodots(TWNDs)with strong ROS scavenging can be very effective for treatment of *** can reach the tubular site after crossing the glomerular barrier,and enter the mitochondria of the renal tubule without resorting to complex active targeting *** our knowledge,this is the first time that ultra-small negatively charged nanodots can be used to passively target mitochondrial therapy for *** in-depth study of the therapeutic mechanism,such passive mitochondria-targeted TWNDs are highly effective in protecting mitochondria by reducing mitochondrial ROS and increasing *** addition,TWNDs can also reduce the infiltration of inflammatory *** work provides a new way to passively target mitochondria for AKI,and give inspiration for the treatment of many major diseases closely related to mitochondria,such as myocardial infarction and cerebral infarction.

关键词： ROS-scavenging Anti-inflammatory Acute kidney injury Passively-targeted mitochondrial Tungsten-Based Nanodots

MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter:In vitro and in vivo study

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2609-2618页

作者： Zhuo-Xun Wu Qiu-Xu Teng yuqi yang Nikita Acharekar Jing-Quan Wang Min He Sabesan Yoganathan Jun Lin Jian Wang Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Anesthesiology Stony Brook University Health Sciences CenterStony BrookNY 11794USA Department of Radiotherapy the Afﬁliated Jiangyin People’s Hospital of Nantong UniversityJiangyin 214400China

Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance(MDR), an obstacle to cancer therapy. Our recent study uncovered that the MET inhibitor,tepotinib, is a potent reversal agent for ABCB1-mediated MDR. In the present study, we reported for the first time that the MET inhibitor tepotinib can also reverse ABCG2-mediated MDR in vitro and in vivo by directly binding to the drug-binding site of ABCG2 and reversibly inhibiting ABCG2 drug efflux activity, therefore enhancing the cytotoxicity of substrate drugs in drug-resistant cancer cells. Furthermore, the ABCB1/ABCG2 double-transfected cell model and ABCG2 gene knockout cell model demonstrated that tepotinib specifically inhibits the two MDR transporters. In mice bearing drug-resistant tumors, tepotinib increased the intratumoral accumulation of ABCG2 substrate drug topotecan and enhanced its antitumor effect. Therefore, our study provides a new potential of repositioning tepotinib as an ABCG2 inhibitor and combining tepotinib with substrate drugs to antagonize ABCG2-mediated MDR.

关键词： MET inhibitor Tepotinib Multidrug resistance ABCG2 transporter Reversal agent Combination treatment Chemotherapy In vivo study