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Interseismic slip distribution and locking characteristics of the mid-southern segment of the Tanlu fault zone

Earthquake Research Advances 2024年第3期4卷 16-26页

作者： Shuyuan Yu Layue Li Jiaji Luo yuanyuan yang Anhui Earthquake Agency Hefei230031China Anhui Mengcheng National Geophysical Observatory MengCheng200527China China University of Mining and Technology Xuzhou221116China The First Monitoring and Application Center Tianjin300180China

We employ the block negative dislocation model to invert the distribution of fault coupling and slip rate deficit on the different segments of the Tanlu(Tancheng-Lujiang) fault zone, according to the GPS horizontal velocity field from 1991 to 2007(the first phase) and 2013 to 2018(the second phase). By comparing the deformation characteristics results, we discuss the relationship between the deformation characteristics with the M earthquake in Japan. The results showed that the fault coupling rate of the northern section of Tancheng in the second phase reduced compared with that in the first phase. However, the results of the two phases showed that the northern section of Juxian still has a high coupling rate, a deep blocking depth, and a dextral compressive deficit, which is the enrapture section of the 1668 Tancheng earthquake. At the same time, the area strain results show that the strain rate of the central and eastern regions of the second phase is obviously enhanced compared with that of the first phase. The occurrence of the great earthquake in Japan has played a specific role in alleviating the strain accumulation in the middle and south sections of the Tanlu fault zone. The results of the maximum shear strain show that the shear strain in the middle section of the Tanlu fault zone in the second phase is weaker than that in the first phase, and the maximum shear strain in the southern section is stronger than that in the first phase. The fault coupling coefficient of the south Sihong to Jiashan section is high, and it is also the unruptured section of historical earthquakes. At the same time, small earthquakes in this area are not active and accumulate stress easily, so the future earthquake risk deserves attention.

关键词： Tanlu fault Middle-southern segment GPS velocity field Inter-seismic slip Fault couping Steepest descent method

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Absorbable 3D-printed pancreaticojejunostomy device with a dual-layer drug coating for the prevention of postoperative local recurrence of pancreatic cancer

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Journal of Materials Science & Technology 2023年第23期154卷 178-188页

作者： Maoen Pan Tingting Huang Zeya Xu Wei Luo yuanyuan yang Tianhong Teng Heguang Huang Department of General Surgery Fujian Medical University Union Hospital Fuzhou China Key Laboratory of Optoelectronic Materials Chemical and Physics Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter Fuzhou China

The high local recurrence rate of pancreatic cancer after surgery is one of the important risk factors affecting patient *** traditionally used silicone tube stent is not only complicated to operate but also lacks antitumor *** purpose of this study was to develop a dual-layer drug-coated pancreaticojejunostomy *** coating consisted of two layers,an outer basic fibroblast growth factor(bFGF)coating layer and an inner nanoparticle albumin-bound paclitaxel(nab-PTX)coating layer with chitosan as the drug-carrying *** to the diffusion barrier from the outer coating,the release of nab-PTX from the inner layer was delayed and slowed *** studied the degradation rates,mechanical properties,surface morphologies,drug release kinetics,promoting the growth of fibroblasts and antitumor properties of the coated *** was found that 100 ng of bFGF and 50µg of nab-PTX were suitable drug concentrations that can effectively promote the growth of fibroblasts and inhibit pancreatic cancer *** results also confirmed that the dual-layer drug-coated pancreaticojejunostomy device showed good antitumor activity both in vitro and in vivo without obvious systemic *** addition,the device has a suitable degradation *** conclusion,this biodegradable dual-layer drug-coated pancreaticojejunostomy device can potentially inhibit the local recurrence of pancreatic cancer after surgery and promote the healing of pancreaticointestinal *** device has great potential to treat pancreatic cancer in the future.

关键词： Pancreaticojejunostomy device 3D printing Drug coating Anti-tumor effect Pancreatic cancer

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Experimental study on the effect of water absorption level on rockburst occurrence of sandstone

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 136-152页

作者： Dongqiao Liu Jie Sun Pengfei He Manchao He Binghao Cao yuanyuan yang State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing100083China Institute for Deep Underground Science and Engineering China University of Mining and Technology(Beijing)Beijing100083China

To investigate the mechanism of rockburst prevention by spraying water onto the surrounding rocks,15 experiments are performed considering different water absorption levels on a single ***-speed photography and acoustic emission(AE)system are used to monitor the rockburst *** effect of water on sandstone rockburst and the prevention mechanism of water on sandstone rockburst are analyzed from the perspective of energy and failure *** results show that the higher the ab-sorption degree,the lower the intensity of the rockburst after absorbing water on single side of *** is reflected in the fact that with the increase in the water absorption level,the ejection velocity of rockburst fragments is smaller,the depth of the rockburst pit is shallower,and the AE energy is *** the water absorption level of 100%,the magnitude of rockburst intensity changes from medium to *** prevention mechanism of water on sandstone rockburst is that water reduces the capacity of sandstone to store strain energy and accelerates the expansion of shear cracks,which is not conducive to the occurrence of plate cracking before rockburst,and destroys the conditions for rockburst incubation.

关键词： Rockburst Water Prevention effect Crack evolution

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A ResNet-based approach for accurate radiographic diagnosis of knee osteoarthritis

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 512-521页

作者： Yu Wang Shibo Li Baoliang Zhao Jianwei Zhang yuanyuan yang Bing Li School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhenChina Shenzhen Key Laboratory of Minimally Invasive Surgical Robotics and System Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina TAMS Department of InformaticsUniversity of HamburgHamburgGermany

Currently X-ray images are clinically graded by experienced clinicians using the Kellgren and Lawrence(KL)scoring ***,individual scoring is subjective and error *** study proposes an approach for automated knee osteoarthritis classification based on deep neural *** knee X-ray images are first preprocessed with frequency-domain filtering and histogram normalisation,making the trabecular bone texture more obvious and benefiting the subsequent classification ***,a two-step classification strategy is proposed by extracting the joint centre based on the VGG network and classifying osteoarthritis grades based on the ResNet-50 *** addition,a rebalance operation is proposed to deal with the dataset unbalance problem,and a quick search technique is proposed to improve the iterative search efficiency for the joint *** all of these techniques,a classification accuracy of 81.41%is obtained,which is higher compared to the state-of-the-art approaches.

关键词： AMSGrad knee osteoarthritis recognition ResNet VGG

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Robust H_(∞)path tracking control of autonomous vehicles with delay and actuator saturation

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Journal of Control and Decision 2022年第1期9卷 45-57页

作者： Changfang Chen Minglei Shu yuanyuan yang Tianlei Gao Lipan Bian Shandong Artificial Intelligence Institute Qilu University of Technology(Shandong Academy of Sciences)JinanPeople’s Republic of China Shandong Computer Science Center(National Supercomputer Center in Jinan) Qilu University of Technology(Shandong Academy of Sciences)JinanPeople’s Republic of China

The path tracking control problem is investigated in this paper for autonomous vehicles(AVs)with time-varying input delay and actuator *** on the Lyapunov-Krasovskii function and the characteristic of the saturation nonlinearity,a robust H_(∞)state-feedback path tracking controller is presented,and the corresponding control gain can be obtained by solving the linear matrix inequalities(LMIs).The asymptotic stability and prescribed H_(∞)performance conditions are studied for the closed-loop control *** reduce the cost of control system,a static robust H_(∞)output-feedback controller is also *** addition,the uncertainty effects of the cornering stiffness and external disturbances are included to improve the robustness of the control *** results are given to verify the effectiveness of the proposed theoretical results.

关键词： Path tracking robust H_(∞)control time delay actuator saturation uncertainties

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The Hydraulic Fracturing Optimization for Stacked Tight Gas Reservoirs Using Multilayers and Multiwells Fracturing Strategies

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Energy Engineering 2024年第12期121卷 3667-3688页

作者： yuanyuan yang Xian Shi Cheng Ji Yujie Yan Na An Teng Zhang School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580China State Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580China Research Institute of Petroleum Engineering Technology Sinopec Northwest Oilfield Company Urumqi830011China Reservoir Engineering Unit Yuanwang Jingsheng Technology(Beijing)Co.Ltd.Beijing100083China

Based on a geology-engineering sweet spot evaluation,the high-quality reservoir zones and horizontal well landing points were ***,fracture propagation and production were simulated with a multilayer fracturing *** optimal hydraulic fracturing strategy for themultilayer fracturing networkwas determined by introducing a vertical asymmetry *** strategy aimed to minimize stress shadowing effects in the vertical direction while maximizing the stimulated reservoir volume(SRV).The study found that the small vertical layer spacing of high-quality reservoirs and the presence of stress-masking layers(with a stress difference of approximately 3∼8 MPa)indicate that interlayer stress interference from multilayers and multiwells fracturing between neighboring developed formations could affect the longitudinal propagation of the *** addition,this study investigated well spacing optimization by comparing uniformly spaced wells(100–300 m)with asymmetric spaced wells(200 m upper layer,250 m lower layer).Numerical results indicated that asymmetric spaced well placement yielded the largest stimulated reservoir volume(SRV)of 73,082 m^(3),representing a 65.42%increase compared to 100 m spaced ***,four different hydraulic fracturing sequences(interlayer,up-down,down-up,and center-edge)were compared for multilayer and multiwell *** center-edge sequence exhibited the lowest vertical asymmetry factor(0.71)and the least stress shadowing effects compared to the other sequences(0.78 for interlayer,0.75 for up-down,and 0.76 for down-up).This sequence also achieved the largest SRV(486,194m^(3)),representing an 11.87%increase compared to the down-up ***,the center-edge fracturing sequence is recommended formultilayer development in this *** results offer valuable insights for optimizing well placement and fracturing sequence design in multilayer well networks,ultimately advancing the development of multila

关键词： Multilayers and multiwells network interlayer stress interference hydraulic fracturing sequence numerical simulation

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Highly luminescence manganese doped carbon dots

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Chinese Chemical Letters 2019年第5期30卷 1051-1054页

作者： Shuangjiao Sun Qingwen Guan Yao Liu Bin Wei yuanyuan yang Zhiqiang Yu School of Pharmaceutical Sciences Shaoyang UniversityShaoyang 422000China State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Research Institute for New Materials Technology Chongqing University of Arts and SciencesChongqing 402160China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510515China

Heteroatom doped carbon dots(CDs)with distinct merits are of great attractions in various fields such as solar cells,catalysis,trace element detection and photothermal *** this work,we successfully synthesized blue-fluorescence and photostability manganese-doped carbon dots(Mn-CDs)with a quantum yield up to 7.5%,which was prepared by a facile one-step hydrothermal method with sodium citrate and manganese *** Mn-CDs is the high mono-dispersity,uniform spherical *** Mn element plays a critical role in achieving a high quantum yield in synthesis of carbon dots,which was confirmed by the structure analysis using XPS and *** investigations proved that the decent PLQY and luminescence properties of Mn-CDs are due to the heteroatom doped,oxidized carbon-based surface *** addition,the Mn-CDs are demonstrated as promising fluorescent sensors for iron ions with a linear range of 0–500 μmol/L and a detection limit of2.1 nmol/L(turn-off),indicating their great potential as a fluorescent probe for chemical sensing.

关键词： Manganese-doped carbon dots Manganese Fluorescent sensors Quantum yield

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SeqCor:correct the effect of guide RNA sequences in clustered regularly interspaced short palindromic repeats/Cas9 screening by machine learning algorithm

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Journal of Genetics and Genomics 2020年第11期47卷 672-680页

作者： Xiaojian Liu yuanyuan yang Yan Qiu Md Reyad-ul-ferdous Qiurong Ding Yi Wang CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Human Phenome Institute Fudan UniversityShanghai 200438China

Clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-based screening using various guide RNA(g RNA)libraries has been executed to identify functional components for a wide range of phenotypes with regard to numerous cell types and *** data from public CRISPR/Cas9-based screening experiments,we found that the sequences of g RNAs in the library influence CRISPR/Cas9-based *** building a standard strategy for correcting results of all g RNA libraries is impractical,we developed Seq Cor,an open-source programming bundle that enables researchers to address the result bias potentially triggered by the composition of g RNA sequences via the organization of g RNA in the library used in CRISPR/Cas9-based ***,Seq Cor completely computerizes the extraction of sequence features that may influence single-guide RNA knockout efficiency using a machine learning *** together,we have developed a software program bundle that ought to be beneficial to the CRISPR/Cas9-based screening platform.

关键词： SeqCor CRISPR/Cas9-based screening Machine learning

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Graphene quantum dots as sulfiphilic and lithiophilic mediator toward high stability and durable life lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第10期85卷 254-266,I0008页

作者： Chaojiang Fan Rong yang Yong Huang Lei Mao yuanyuan yang Le Gong Xin Dong Yinglin Yan Yiming Zou Lisheng Zhong Yunhua Xu International Research Center for Composite and Intelligent Manufacturing Technology Institute of Chemical Power SourcesXi'an University of TechnologyXi'an 710048ShaanxiChina School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048ShaanxiChina School of Chemistry&Chemical Engineering Yulin UniversityYulin 719000ShaanxiChina

The development of lithium-sulfur(Li-S) battery as one of the most attractive energy storage systems among lithium metal batteries is seriously hindered by low sulfur utilization, poor cycle stability and uneven redeposition of Li anode. It is necessary to propose strategies to address the problems as well as improve the electrochemical performance. One of the effective solutions is to improve the sulfiphilicity of sulfur cathode and the lithiophilicity of the Li anode. Herein, we reported that a synergistic functional separator(graphene quantum dots(GQDs)-polyacrylonitrile(PAN) @polypropylene(PP) separator)improved the electrochemical activity of sulfur cathode as well as the stability of Li anode. GQDs induced uniform Li^(+)nucleation and deposition, which slowed down the passivation of Li anode and avoided shortcircuit. Further, three-dimensional network constructed by electrospinning nanofibers and the polar functional groups of GQDs could both effectively inhibit the shuttle of LiPSs and improve the sulfur utilization. The stability of Li-S battery was improved by the synergistic effect. In addition, GQDs and electrospinning nanofibers protector increased lifetime of separators. Benefiting from the unique design strategy, Li//Li symmetric battery with GQDs-PAN@PP separators exhibited stably cycling for over 600 h. More importantly, the Li-S full batteries based GQDs-PAN@PP separators enabled high stability and desirable sulfur electrochemistry, including high reversibility of 558.09 mA h g^(-1)for 200 cycles and durable life with a low fading rate of 0.075% per cycle after 500 cycles at 0.5 C. Moreover, an impressive areal capacity of 3.23 mA h cm^(-2)was maintained under high sulfur loading of 5.10 mg cm^(-2). This work provides a new insight for modification separator to improve the electrochemical performance of Li-S/Li metal batteries.

关键词： Lithium-sulfur batteries Separator Graphene quantum dots Cycle stability Durable life

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Architecture design and advanced manufacturing of heart-on-a-chip:scaffolds,stimulation and sensors

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Microsystems & Nanoengineering 2024年第4期10卷 1-21页

作者： Feng Xu Hang Jin Lingling Liu yuanyuan yang Jianzheng Cen Yaobin Wu Songyue Chen Daoheng Sun Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Guangdong Provincial People’s Hospital Guangzhou 510080China School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515China

Heart-on-a-chip(HoC)has emerged as a highly efficient,cost-effective device for the development of engineered cardiac tissue,facilitating high-throughput testing in drug development and clinical *** is primarily used to create a biomimetic microphysiological environment conducive to fostering the maturation of cardiac tissue and to gather information regarding the real-time condition of cardiac *** development of architectural design and advanced manufacturing for these“3S”components,scaffolds,stimulation,and sensors is essential for improving the maturity of cardiac tissue cultivated on-chip,as well as the precision and accuracy of tissue *** this review,the typical structures and manufacturing technologies of the“3S”components are *** design and manufacturing suggestions for each component are ***,key challenges and future perspectives of HoC platforms with integrated“3S”components are discussed.

关键词： stimulation summarized maturity

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