Architecture design and advanced manufacturing of heart-on-a-chip:scaffolds,stimulation and sensors
作者机构：Pen-Tung Sah Institute of Micro-Nano Science and TechnologyXiamen UniversityXiamen 361102China Guangdong Provincial People’s HospitalGuangzhou 510080China School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2024年第10卷第4期
页 面：1-21页
核心收录：
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by the National Natural Science Foundation of China(No.U2005214) the National Key Research and Development Program of China(2022YFB4600600)
主 题：stimulation summarized maturity
摘 要：Heart-on-a-chip(HoC)has emerged as a highly efficient,cost-effective device for the development of engineered cardiac tissue,facilitating high-throughput testing in drug development and clinical *** is primarily used to create a biomimetic microphysiological environment conducive to fostering the maturation of cardiac tissue and to gather information regarding the real-time condition of cardiac *** development of architectural design and advanced manufacturing for these“3Scomponents,scaffolds,stimulation,and sensors is essential for improving the maturity of cardiac tissue cultivated on-chip,as well as the precision and accuracy of tissue *** this review,the typical structures and manufacturing technologies of the“3Scomponents are *** design and manufacturing suggestions for each component are ***,key challenges and future perspectives of HoC platforms with integrated“3Scomponents are discussed.
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