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Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science China Life Sciences 2025年

作者： Lu Gan yi yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend <0.005). In contrast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend <0.005). Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao yang Ronghao Wang yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian yang chun-Hao yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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多阵列数据融合的声定位研究

声学技术 2007年第5期26卷 1064-1065页

作者：滕鹏晓杨亦春李晓东田静中国科学院声学研究所北京100080

传声器阵列在视频会议系统，人机交互．车载电话等领域得到广泛的应用．其中声源定位是一项重要研究内容。通常在复杂环境下，使用单一传声器阵列对声源进行定位时不能够得到较好的精度．尤其是定距方面：而空间分布的多个传感器阵列的... 详细信息

传声器阵列在视频会议系统，人机交互．车载电话等领域得到广泛的应用．其中声源定位是一项重要研究内容。通常在复杂环境下，使用单一传声器阵列对声源进行定位时不能够得到较好的精度．尤其是定距方面：而空间分布的多个传感器阵列的联合处理则提供了一种精确定位的解决方案。多阵列联合处理的算法一直是研究的热点．分数据级（datafusion：DAF）、特征级（featurefusion：FEF）、决策级（decisionfusion：DEF）三级融合处理。

关键词：传声器阵列声定位数据融合视频会议系统声源定位联合处理传感器阵列车载电话

Malicious Document Detection Based on GGE Visualization

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Computers, Materials & Continua 2025年第1期82卷 1233-1254页

作者： Youhe Wang yi Sun Yujie Li Chuanqi Zhou Henan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

With the development of anti-virus technology,malicious documents have gradually become the main pathway of Advanced Persistent Threat(APT)attacks,therefore,the development of effective malicious document classifiers has become particularly ***,detection methods based on document structure and behavioral features encounter challenges in feature engineering,these methods not only have limited accuracy,but also consume large resources,and usually can only detect documents in specific formats,which lacks versatility and *** address such problems,this paper proposes a novel malicious document detection method-visualizing documents as GGE images(Grayscale,Grayscale matrix,Entropy).The GGE method visualizes the original byte sequence of the malicious document as a grayscale image,the information entropy sequence of the document as an entropy image,and at the same time,the grayscale level co-occurrence matrix and the texture and spatial information stored in it are converted into grayscale matrix image,and fuses the three types of images to get the GGE color *** Convolutional Block Attention Module-EfficientNet-B0(CBAM-EfficientNet-B0)model is then used for classification,combining transfer learning and applying the pre-trained model on the ImageNet dataset to the feature extraction process of GGE *** shown in the experimental results,the GGE method has superior performance compared with other methods,which is suitable for detecting malicious documents in different formats,and achieves an accuracy of 99.44%and 97.39%on Portable Document Format(PDF)and office datasets,respectively,and consumes less time during the detection process,which can be effectively applied to the task of detecting malicious documents in real-time.

关键词： Malicious document visualization EfficientNet-B0 convolutional block attention module GGE image

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复合材料在中型公务机结构中的应用研究

飞机设计 2017年第2期37卷 28-30,43页

作者：杨懿春何景武马骏北京航空航天大学航空科学与工程学院北京100191 北京航空航天大学北京100191

复合材料越来越广泛的应用于通用航空领域,很多小飞机都是全复合材料结构。本文针对中型公务机复合材料应用情况进行分析研究,包括应用的材料和应用的位置及现航空应用复合材料的情况,以及公务机应用复合材料的真正优势所在。

关键词：复合材料通用航空中型公务机应用优势

如何在中医住院医师规培中改善“临床超声”教学

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教育教学论坛 2022年第46期 145-148页

作者：刘柯兵赵萍杨义春广州中医药大学第一附属医院超声科广东广州510405

超声是目前最常用、最简便的影像学检查之一,是临床医生需要了解和掌握的技能。中医院规培医师的知识体系和培训目标不尽相同,而且在超声科学习周期较短,因而在规范化培训过程中提高“临床超声”教学质量是非常必要的。通过在超声科轮... 详细信息

超声是目前最常用、最简便的影像学检查之一,是临床医生需要了解和掌握的技能。中医院规培医师的知识体系和培训目标不尽相同,而且在超声科学习周期较短,因而在规范化培训过程中提高“临床超声”教学质量是非常必要的。通过在超声科轮科学习中总结分析中医规培医师存在的问题,提出一对一导师教学制、定期讨论疑难病例、建立典型病例图库、鼓励多样化学习方式、培养为人秉性的医者情怀等教学策略,以更好地帮助临床医师掌握超声知识,形成临床诊断思维并积累超声实践经验。

关键词：超声诊断学临床教学临床教学现状带教策略

Forecasting the Atmospheric Visibility in Taipei Metropolitan Area by Means of Fuzzy Time Series

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Forecasting the Atmospheric Visibility in Taipei Metropolita...

第七届海峡两岸气胶技术研讨会暨第二届空气污染技术研讨会

作者： Wang-Kun Chen,Hong-Yu yang,yi-chun Wang Department of Environment and Property Management,Jinwen University of Science and Technology,New Taipei City,Taiwan.Department of Civil Engineering,chunghwa University of Science and Technology,Taipei,Taiwan.

＜正＞This study employs a fuzzy time series system for the development of an atmospheric visibility forecasting method in order to simulate and forecast the atmospheric visibility in Taipei Metropolitan District and ... 详细信息

关键词： visibility fuzzy time series episode day.

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利用双线性聚集签名实现公平的签名交换方案

通信学报 2004年第12期25卷 59-64页

作者：李梦东杨义先马春光蔡满春北京电子科技学院电子信息工程系北京100070 北京邮电大学信息安全中心北京100876

公平的签名交换方案是实现数字合同签署、电子支付等电子商务活动的一项重要技术,它的有效实现一直是人们追求的目标。利用最近Boneh提出的基于双线性聚集签名的签名可验证加密方案,设计了一种公平的签名交换方案。该方案基于双线性群... 详细信息

公平的签名交换方案是实现数字合同签署、电子支付等电子商务活动的一项重要技术,它的有效实现一直是人们追求的目标。利用最近Boneh提出的基于双线性聚集签名的签名可验证加密方案,设计了一种公平的签名交换方案。该方案基于双线性群对上计算co-Diffie-Hellman假设,借助双线性映射实现加密可验证性,具有签名长度短、计算简便等优点,可有效提高公平签名交换的实现效率。

关键词：密码学公平的签名交换可验证加密聚集签名双线性映射