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Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson＇s disease in the northern Han Chinese population

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Chinese Medical Journal 2012年第4期000卷 588-592页

作者： Zhu Lan-hui Luo Xiao-guang Zhou yi-shu Li Feng-rui yang yi-chun Ren Yan Pang Hao China Med Univ Sch Forens Med Shenyang 110001 Liaoning Peoples R China China Med Univ Hosp 1 Dept Neurol Shenyang 110001 Liaoning Peoples R China Baotou Med Coll Dept Forens Med Baotou 014060 Inner Mongolia Peoples R China Dalian Univ Affiliated Xinhua Hosp Dept Neurosurg Dalian 116021 Liaoning Peoples R China

Background Parkinson＇s disease （PD） is an autosomally inherited neurodegenerative disease in elderly *** etiology of PD has long been thought to be associated with both genetic and environmental *** explore potential genetic risk factors for PD in the northern Han Chinese population,we investigated three single nucleotide polymorphisms （SNPs）（rs4538475,rs11107 and rs12564040） in the BST1,PARK15 and PARK9 *** Genomic DNA from 215 PD patients and 212 matched controls was amplified in two independent PCR systems and subsequently genotyped by digestion with the endonuclease *** parameter and association studies were carried out with SPSS 13.0 and PLINK 1.07 *** We could accurately detect all genotypes in the three loci with the PCR-RFLP or mismatched PCR-RFLP *** observed heterozygosities of the rs4538475 and rs11107 loci in PD and control groups ranged from 0.460-0.481 and 0.410-0.441,in BST1,PARK15 respectively,while we detected no heterozygosity at the rs12564040 locus in *** similar distributions of genotypic frequency between both groups suggest that the three SNPs investigated in this study are unlikely to play roles as common risk factors or pathogenic mutations for PD in northern Han *** The SNPs investigated in the BST1,PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population.

关键词： Parkinson disease PARK9 PARK15 BST1 genetic association studies

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang yi yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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GCr15钢冲模失效原因的分析

材料保护 2005年第8期38卷 64-66页

作者：张勃杨怡春上海造币厂上海200061

冲模在短期使用后表面出现微裂缝,导致产品表面呈现许多“闪光点”,影响产品外观质量。采用宏、微观检测方法,对模具失效原因进行了分析。结果表明,镀铬层表面存在网状裂纹是导致模具表面出现微裂缝的主要原因。

关键词：失效分析冲模 GCr15

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu Wang chun Cheng yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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大地震前出现的异常次声波观测研究

物理学报 2014年第13期63卷 216-229页

作者：杨亦春郭泉吕君滕鹏晓中国科学院声学研究所北京100190

研究了一种在大地震前出现的异常次声波,揭示其与地震发生的空间、时间、强度的对应关系.利用CASI-ICM-2011型次声测量传感器在一系列Ms6.0级以上大地震发生前2周以内检测到的一种频率范围0.001 Hz至0.01 Hz的次声波,其特征有:幅值范围5... 详细信息

研究了一种在大地震前出现的异常次声波,揭示其与地震发生的空间、时间、强度的对应关系.利用CASI-ICM-2011型次声测量传感器在一系列Ms6.0级以上大地震发生前2周以内检测到的一种频率范围0.001 Hz至0.01 Hz的次声波,其特征有:幅值范围50 Pa至200 Pa,持续时间0.5 h至4 h,传播速度10 m/s至30 m/s,震级越高信号越强.通过建立广域次声传感器网络,成功定位了芦山地震前4天出现的异常次声波,以及巴基斯担地震前12天出现的异常次声波.通过对8年时间连续监测数据的分析,研究了这类次声波的出现规律.同时,对其产生机理提出了大地起伏激发次声波的假设,进行了理论论证,并用智利地震测量信号和玉树地震测量信号证明S波可以激发出本地同振的次声波.文中所列举的数个震前异常次声信号的观测结果对于地震预测的信息获取具有参考价值.

关键词：地震前异常次声波次声观测

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma yang Qu Jiaxin Ren yingying Sun Zhen-Ni Guo yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han yi-yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

地形对贺兰山步甲群落物种多样性分布格局的影响

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昆虫学报 2017年第9期60卷 1060-1073页

作者：杨益春杨贵军王杰宁夏大学生命科学学院银川750021

【目的】步甲是主要栖息于地表的种类最丰富的昆虫类群之一,它们对生境的变化更为敏感。分析地形因子对贺兰山步甲昆虫群落物种多样性分布格局的影响,以期揭示步甲昆虫物种多样性分布格局形成和稳定的机制。【方法】2015年7-8月选取贺... 详细信息

【目的】步甲是主要栖息于地表的种类最丰富的昆虫类群之一,它们对生境的变化更为敏感。分析地形因子对贺兰山步甲昆虫群落物种多样性分布格局的影响,以期揭示步甲昆虫物种多样性分布格局形成和稳定的机制。【方法】2015年7-8月选取贺兰山山地针叶林、山地疏林、山地灌丛、山地草原和浅山荒漠5种生境98个样地,用杯诱法对步甲群落物种组成和多样性进行调查,并采用典范对应分析(CCA)分析物种多样性指数和物种分布与地形因子之间的关系,运用广义可加模型(GAM)拟合不同生境步甲群落多样性指数对海拔梯度的响应曲线,探讨贺兰山步甲群落物种多样性的垂直分布格局。【结果】共采集步甲昆虫21属65种10 989头,其中,直角通缘步甲Pterostichus gebleri和径婪步甲Harpalus salinus为优势种,其个体数量分别占总捕获个体数的44.93%和11.33%。山地疏林生境步甲物种丰富度最高,山地针叶林的步甲Shannon-Wiener多样性指数最高,浅山荒漠的步甲均匀度最高。海拔、坡向、坡度、剖面曲率和地形湿度指数的综合作用对步甲物种多样性分布格局有显著影响。其中,海拔对5种生境的步甲分布影响均显著,且解释力度最高;坡向对山地针叶林和浅山荒漠步甲分布影响显著。步甲总体丰富度和个体数量与海拔呈不对称的单峰曲线关系,Shannon-Wiener多样性指数随海拔呈先递增后保持稳定的变化,均匀度指数与海拔呈"V"型变化趋势。【结论】贺兰山山地步甲物种多样性的分布格局受海拔为主的多种地形因子综合作用的影响。

关键词：步甲物种多样性分布格局地形山地贺兰山

二级Kalman滤波的被动声定位后置处理方法

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应用声学 2008年第1期27卷 11-16页

作者：马驰州杨亦春中国科学院声学研究所北京100080

阵列定位的计算结果中往往存在大量的野值,需要用后置处理方法从结果中选取真实目标信息。本文提出了一种基于Kalman滤波的二级后置处理方法,建立了相应的滤波模型,并对主要参数进行讨论选取,同时给出了外场实验结果。结果表明此方法后... 详细信息

阵列定位的计算结果中往往存在大量的野值,需要用后置处理方法从结果中选取真实目标信息。本文提出了一种基于Kalman滤波的二级后置处理方法,建立了相应的滤波模型,并对主要参数进行讨论选取,同时给出了外场实验结果。结果表明此方法后置处理效果明显,并可以满足系统实时性的要求。

关键词：被动声定位后置处理卡尔曼滤波滤波模型阵列定位