检索结果-南通市图书馆

Development and Validation of a Carbohydrate Metabolism-related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

在线全文

学校读者我要写书评

暂无评论

当代医学科学（英文） 2024年第4期44卷 771-788页

作者： Hong-xiang HUANG Pei-yuan ZHONG Ping LI Su-juan PENG Xin-jing DING Xiang-lian CAI Jin-hong CHEN Xie ZHU Zhi-hui LU Xing-yu TAO yang-yang liu Li CHEN Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Oncology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Objective:The activities and products of carbohydrate metabolism are involved in key processes of ***,its relationship with hepatocellular carcinoma(HCC)is ***:The cancer genome atlas(TCGA)-HCC and ICGC-LIRI-JP datasets were acquired via public *** expressed genes(DEGs)between HCC and control samples in the TCGA-HCC dataset were identified and overlapped with 355 carbohydrate metabolism-related genes(CRGs)to obtain differentially expressed CRGs(DE-CRGs).Then,univariate Cox and least absolute shrinkage and selection operator(LASSO)analyses were applied to identify risk model genes,and HCC samples were divided into high/low-risk groups according to the median risk ***,gene set enrichment analysis(GSEA)was performed on the risk model *** sensitivity of the risk model to immunotherapy and chemotherapy was also ***:A total of 8 risk model genes,namely,G6PD,PFKFB4,ACAT1,ALDH2,ACYP1,OGDHL,ACADS,and TKTL1,were ***,the risk score,cancer status,age,and pathologic T stage were strongly associated with the prognosis of HCC *** the stromal score and immune score had significant negative/positive correlations with the risk score,reflecting the important role of the risk model in immunotherapy ***,the stromal and immune scores had significant negative/positive correlations with risk scores,reflecting the important role of the risk model in immunotherapy ***,we found that high-/low-risk patients were more sensitive to 102 drugs,suggesting that the risk model exhibited sensitivity to chemotherapy *** results of the experiments in HCC tissue samples validated the expression of the risk model ***:Through bioinformatic analysis,we constructed a carbohydrate metabolism-related risk model for HCC,contributing to the prognosis prediction and treatment of HCC patients.

关键词： bioinformatics carbohydrate metabolism hepatocellular carcinoma the cancer genome atlas

Nuclear decay database in fission product mass region

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第7期48卷 176-180页

作者：黄小龙杨东葛智刚王香涵刘洋阳金永利李剑 China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China College of Physics Jilin UniversityChangchun 130012China

Accurate and reliable nuclear decay databases are essential for fundamental and applied nuclear research ***,decay data are not usually as accurate as expected and need ***,a new Chinese nuclear decay database in the fission product mass region(A=66−172)based on several major national evaluated data libraries has been developed under joint efforts in the CNDC working group.A total of 2358 nuclides have been included in this decay *** main data formats,namely ENSDF and ENDF,have been *** the total meanβandγenergies,available data from total absorption gamma ray spectroscopy measurements have been *** some nuclides without experimental measurements,theoretically calculated values have been added.

关键词： nuclear decay data evaluation database fission product mass region

Phase transformation behavior of Ti_(49)Ni_(49.5)Fe_1V_(0.5) and Ti_(48)Ni_(48.5)Fe_1V_(2.5) alloys after different heat treatments

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2014年第1期33卷 16-20页

作者： yang-yang liu Fu-Shun liu School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics

The effects of heat treatments on the phase transformation behavior of Ti49Ni49.5Fe1V0.5and Ti48Ni48.5Fe1V2.5 alloys were investigated. The results indicate that the alloys subjected to different heat treatments have B2 structure at room temperature. All the specimens exhibit a twostage B2 → R → B19r martensitic transformation on cooling, but a B19’ → B2 one-stage reverse martensitic transformation on heating except aged A1 alloy, which undergoes an abnormal two-stage transformation upon heating. The phase transformation temperatures are affected by heat treatments and V content, which can be attributed to the variation of the second-phase particles content in the matrix.

关键词： Keywords Heat treatments Phase transformationbehavior Ti-Ni-Fe-V alloy Second-phase particles

Complete Space-like λ-surfaces in the Minkowski Space R1^3 with the Second Fundamental Form of Constant Length

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2020年第5期36卷 559-577页

作者： Xing Xiao LI yang yang liu Rui Na QIAO School of Mathematics and Information Sciences Henan Normal UniversityXinxiang 453007P.R.China

In this paper we study the complete space-like λ-surfaces in the three dimensional Minkowski space R1^*** the result,we obtain a complete classification theorem for all the complete space-like λ-surfaces x:M^2→R1^3 with the second fundamental form of constant *** is a natural extension to the λ-surfaces in R1^3 of a recent interesting classification theorem by Cheng and Wei forλ-surfaces in the Euclidean space R^3.

关键词： Mean curvature second fundamental form space-likeλ-surfaces classification

Effects of polar cortical cytoskeleton and unbalanced cortical surface tension on intercellular bridge thinning during cytokinesis

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2011年第6期27卷 1081-1090页

作者： Li Wang Mei-Wen An Xiao-Na Li Fang yang yang liu Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology 030024 Taiyuan China

To probe the contributions of polar cortical cytoskeleton and the surface tension of daughter cells to intercellular bridge thinning dynamics during cytokinesis,we applied cytochalasin D（CD） or colchicine（COLC） in a highly localized manner to polar regions of dividing normal rat kidney（NRK） *** observed cellular morphological changes and analyzed the intercellular bridge thinning trajectories of dividing cells with different polar cortical *** blebbistatin（BS） application was used to obtain cells losing active contractile force *** results show that locally released CD or colchicine at the polar region caused inhibition of cytokinesis before *** treatment at phases after ingression allowed completion of cytokinesis but dramatically influenced the trajectories of intercellular bridge *** single polar cortical actin induced transformation of the intercellular bridge thinning process,and polar cortical tension controlled deformation time of intercellular *** study provides a feasible framework to induce and analyze the effects of local changes in mechanical properties of cellular components on single cellular cytokinesis.

关键词： Cytokinesis Normal rat kidney epithelial cells Intercellular bridge Polar cortical cytoskeleton - Cortical surface tension

Preparation of Negative Thermal Expansion ZrW_2O_8 Powders and Its Application in Polyimide/ZrW_2O_8 Composites

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2010年第7期26卷 665-668页

作者： Juan yang Vongsen yang Qinqin liu Cuifang Xu Xiaonong Cheng School of Materials Science and Engineering Jiangsu University Zhenjiang 212013 China

Negative thermal expansion （NTE） ZrW2O8 powders were prepared by step-by-step solid-state reaction with ZrO2 and WO3 powders. The coefficient of thermal expansion （CTE） of the as-prepared ZrW208 was around -5.08×10^-6 K^-1 at 20-700℃. Different amounts of ZrW208 powders were added in BTDA-ODA polyamic acid to form polyimide/ZrW2O8 composites （PI/ZrW2O8）. With the increment of ZrW2O8, experimental results show that ZrW2O8 powders can significantly enhance the thermal stability of the composites, and reduce the thermal expansion. A 50 wt pct ZrW2O8 addition can give rise to a 31% reduction of CTE. It is suggested that the PI/ZrW2O8 composites have potential applications in high performance microelectronic devices.

关键词： Negative thermal expansion ZrW2O8 Polyimide Composite Coefficient of thermal expansion

Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus

在线全文

学校读者我要写书评

暂无评论

Insect Science 2015年第1期22卷 150-156页

作者： Wei Wang Si-Lu liu yang-yang liu Chuan-Ling Qiao Shao-Liang Chen Feng Cui College of Biological Sciences and Technology Beijing Forestry University Beijing State Key Laboratory of Integrated Managementof Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China

Insecticide resistance is an evolutionary adaptation that develops quite quickly in mosquitoes because of the high selection pressure of chemical insecticides, rapid generation time and large population size. Identification of genes associated with insecticide resistance is fundamental to understand the complex processes responsible for resistance. We compared the gene transcriptional profiles of parathion-resistant and -susceptible Culex pipiens quinquefasciatus using a combination of suppression subtractive hybridization and complementary DNA （cDNA） microarray techniques. A total of 278 colonies were selected from the resistant-susceptible mosquito subtractive library, 38 of which showed more than two fold stronger immunoblotting signals in the resistant strain than in the susceptible strain using cDNA microarray selection. The sequencing results showed that the 38 colonies can be matched to 12 genes of C. p. quinquefasciatus. Eight genes were confirmed to be overexpressed by more than two fold in the resistant strain. These genes encode chymotrypsin-1, theta glutathione S-transferase, lipase 3, larval serum protein 1β chain, cytochrome b, mitochondrial ribosomal large subunit, 28S rRNA, and a protein with unknown function. This study serves as a preliminary attempt to identify new genes associated with organophosphate resistance in this mosquito species and provides insights into the complicated physiological phenomenon of insecticide resistance.

关键词： cDNA microarray chymotrypsin gene up-regulation insecticide resistance suppression subtractive hybridization theta glutathione S-transferase

Single Goss grain growth by isothermal annealing in rolled Fe–Al–Ga–Nb C sheets

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2023年第10期42卷 3537-3544页

作者： yang-yang liu Ji-Heng Li Xiao-Long Li Xing Mu Xiao-Qian Bao Xue-Xu Gao State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing100083China

The(Fe_(82)Al_(13.5)Ga_(4.5))_(99.9)(NbC)_(0.1) sheets with strong Goss texture and large magnetostriction were prepared by rolling and isothermal annealing *** Goss grain growth was observed in sheets undergoing isothermal annealing at 1050 ℃ for 1 h using Ar as protecting *** annealing time increasing to 8 h at1050℃,a largest magnetostriction of 154×10^(-6) is obtained in sheet and a large λ_(//)(the maximum magnetostriction with magnetic field parallel to rolling direction)of 160×10^(-6) along the rolling direction is also *** fact that a λ_(//) of 160×10^(-6) along RD can be achieved with only 4.5 at% Ga in the Fe-18 at%(Al,Ga) sheet is of practical *** with previous studies in Fe-Al and Fe-Ga sheets,this paper provides a more efficient approach to prepare strong Goss textured *** this way,a slow continuous heating process,sulfur-induced surface energy control and high-temperature annealing above 1200 ℃ are no more *** shows a good prospect for industrial production of high-performance magnetostrictive alloy sheets.

关键词： Fe–Al–Ga sheet Isothermal annealing Goss texture Magnetostriction

Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第6期23卷 727-730页

作者： Xing Li Zhang yang yang liu Jian He Wei Yun yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun liu College of Biological Science and Biotechnology Beijing Forestry University Beijing 100083 China Hainan Branch of Institute of Medicinal Plant Development （Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine） Chinese Academy of Medical Sciences Wanning 571533 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 China School of Food ＆ Bioengineering Shandong Polytechnic University Jinan 250353 China

We used whole-tree agarwood-induction technology to produce agarwood from Aquilaria sinensis trees within 20 months, and evaluated the quality of this agarwood. The results showed its characteristics were similar to those of high-grade wild agarwood in terms of texture, chemical constituents, essential oil content, and ethanol-soluble extract content, with the lattermost quality far surpassing the requirement of traditional Chinese medicine agarwood, as indicated in Chinese Pharmacopoeia 2010. To the best of our knowledge, this is first study to show that high-quality agarwood can be produced in whole A. sinensis trees via a chemically induced technology.

关键词： Agarwood Aquilaria sinensis Chemically induced Quality Whole-tree agarwood-induction technology