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Genetic analysis of transcription factors in dopaminergic neuronal development in Parkinson’s disease

Chinese Medical Journal 2024年第4期137卷 450-456页

作者： Yuwen Zhao Lixia Qin Hongxu Pan Tingwei Song Yige Wang Xiaoxia Zhou Yaqin Xiang Jinchen Li Zhenhua Liu Qiying Sun Jifeng Guo xinxiang Yan Beisha Tang Qian Xu Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Bioinformatics Center National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Geriatrics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangshaHunan 410008China

Background:Genetic variants of dopaminergic transcription factor-encoding genes are suggested to be Parkinson’s disease(PD)risk factors;however,no comprehensive analyses of these genes in patients with PD have been undertaken.Therefore,we aimed to genetically analyze 16 dopaminergic transcription factor genes in Chinese patients with PD.Methods:Whole-exome sequencing(WES)was performed using a Chinese cohort comprising 1917 unrelated patients with familial or sporadic early-onset PD and 1652 controls.Additionally,whole-genome sequencing(WGS)was performed using another Chinese cohort comprising 1962 unrelated patients with sporadic late-onset PD and 1279 controls.Results:We detected 308 rare and 208 rare protein-altering variants in the WES and WGS cohorts,respectively.Gene-based association analyses of rare variants suggested that MSX1 is enriched in sporadic late-onset PD.However,the significance did not pass the Bonferroni correction.Meanwhile,72 and 1730 common variants were found in the WES and WGS cohorts,respectively.Unfortunately,single-variant logistic association analyses did not identify significant associations between common variants and PD.Conclusions:Variants of 16 typical dopaminergic transcription factors might not be major genetic risk factors for PD in Chinese patients.However,we highlight the complexity of PD and the need for extensive research elucidating its etiology.

关键词： Parkinson’s disease Transcription factors Dopaminergic neurons Genetic Variants

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Potassium alleviated high nitrogen-induced apple growth inhibition by regulating photosynthetic nitrogen allocation and enhancing nitrogen utilization capacity

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Horticultural Plant Journal 2024年第1期10卷 1-14页

作者： xinxiang Xu Guangyuan Liu Jingquan Liu Mengxue Lyu Fen Wang Yue Xing Hao Meng Min Li Yu Jiang Ge Tian Zhanling Zhu Yuanmao Jiang Shunfeng Ge State Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai'anShandong 271018China Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong College of Biological and Agricultural EngineeringWeifang UniversityWeifangShandong 261061China

There is a close relationship between potassium(K)and nitrogen(N).However,the roles of K under high N conditions remain unclear.Using a hydroponics approach,we monitored the morphological,physiological,and molecular changes in M9T337 apple(Malus domestica)rootstocks under different nitrate(10 and 30 mmol·L^(-1)NO_(3)^(-))and K supply(0.5,6,10,and 20 mmol·L_(-1)K^(+))conditions.Results revealed that high nitrate inhibited the root growth of M9T337 rootstocks,downregulated the expressions of K transporter genes(MdPT5,MdHKT1,and MdATK1),and reduced the net NO3-and K+influx at the surface of roots,thereby resulting in an N/K imbalance in rootstocks.Further investigation showed that 10 mmol·L^(-1)K increased the activity of N metabolic enzymes(NR,GS,NiR,and GOGAT),upregulated the expressions of genes related to nitrate uptake and transport(MdNRT1.1,MdNRT1.2,MdNRT1.5,and MdNRT2.4),promoted15N transport from the roots to the shoots,optimized leaf N distribution,and improved photosynthetic N utilization efficiency under high nitrate conditions.These results suggest that the negative effects of high nitrate may be related to the N/K imbalance and that reducing N/K in plants by increasing K supply level can effectively alleviate the inhibition of N assimilation by high nitrate stress.

关键词： Apple rootstock K level High nitrate stress N metabolism ^(15)N

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Partition airflow varying features of chaos-theory-based coalmine ventilation system and related safety forecasting and forewarning system

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International Journal of Mining Science and Technology 2017年第2期27卷 269-275页

作者： Zhang Xiaoqiang Cheng Weimin Zhang Qin yang xinxiang Du Wenzhou Key Laboratory of Ministry of Education for Mine Disaster Prevention and Control Shandong University of Sdence and TechnologyQingdao 266590China College of Mining and Safety Engineering Shandong University of Science and Technology Qingdao 266590China

To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems(CVS), in this paper, we first established a joint surface and underground CVS safety management system consisting of main ventilation fan, safety-partition linked passageways, and air-required locations. We then applied chaos theory to identify the air quantity and gas concentration of underground partition boundaries, and adopted a fixed data quantity, multi-step progressive, weighted first-order local-domain method to setup a chaos prediction model and a CVS safety forecasting and forewarning system formed by the normal change level, orange forewarning level, and red alarm level. We next conduct the on-field application of the system in a coalmine in Jining, Shandong, China. The results showed that (1) in the statistical scale of 5 min, the changes in both air quantity and gas concentration along CVS partition airflow boundaries were characteristic of chaos and could be used for short-term chaos prediction, and the latter was more chaotic than the former;(2) the setup chaos prediction model had a higher prediction precision and the established safety prediction system could not only predict the variation in CVS stability but also reflect the rationality of underground mining intensity. Thus, this CVS safety forecasting and forewarning system is of better application value.

关键词：安全预警系统矿井通风系统混沌理论安全预测气流变化安全分区加权一阶局域法特征

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加快塑造深港金融合作新格局

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中国金融 2024年第4期 49-51页

作者：温信祥中国人民银行深圳市分行党委

习近平总书记在广东考察时强调,广东省要坚定不移全面深化改革扩大高水平对外开放,在推进中国式现代化建设中走在前列。稳步扩大金融高水平双向开放,是深圳金融在新时代的历史使命。人民银行深圳市分行(以下简称深圳市分行)、外汇局深... 详细信息

习近平总书记在广东考察时强调,广东省要坚定不移全面深化改革扩大高水平对外开放,在推进中国式现代化建设中走在前列。稳步扩大金融高水平双向开放,是深圳金融在新时代的历史使命。人民银行深圳市分行(以下简称深圳市分行)、外汇局深圳市分局学习贯彻中央金融工作会议精神。

关键词：人民银行深圳金融中国式现代化外汇局双向开放新格局深港金融合作全面深化改革

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早发性结直肠癌的诊治进展

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中华胃肠外科杂志 2024年第5期27卷 441-446页

作者：李雅琪李心翔复旦大学附属肿瘤医院大肠外二科、复旦大学上海医学院肿瘤学系上海200032

近年来,早发性结直肠癌(EOCRC)的发病率持续上升,但其发病机制尚不清楚。EOCRC的临床特征和分子病理学特征不同于晚发性结直肠癌,但目前两者治疗并无差别,尚缺乏关于EOCRC针对性的筛查及诊治指南。本文总结了EOCRC患者的流行病学特点、... 详细信息

近年来,早发性结直肠癌(EOCRC)的发病率持续上升,但其发病机制尚不清楚。EOCRC的临床特征和分子病理学特征不同于晚发性结直肠癌,但目前两者治疗并无差别,尚缺乏关于EOCRC针对性的筛查及诊治指南。本文总结了EOCRC患者的流行病学特点、危险因素、临床特征、分子病理特征、发生发展机制及预防筛查策略的研究进展,以期为EOCRC的诊治提供理论依据。

关键词：结直肠肿瘤,早发性流行病学危险因素临床特征分子特征

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社会学的二重性与中国特色社会学

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浙江社会科学 2024年第3期 4-18,155页

作者：陈心想中央民族大学民族学与社会学学院北京100081

本文从社会学的二重性,即科学性与人文性角度出发,尝试分析如何构建“中国特色社会学”。首先,通过回顾美国社会学学科发展历程中科学性与人文性的张力,总结出一些经验和特征。接着,对由于范式挑战而引起的对社会学“科学性”的质疑进... 详细信息

本文从社会学的二重性,即科学性与人文性角度出发,尝试分析如何构建“中国特色社会学”。首先,通过回顾美国社会学学科发展历程中科学性与人文性的张力,总结出一些经验和特征。接着,对由于范式挑战而引起的对社会学“科学性”的质疑进行梳理,进而从逻辑、实证与有限理性方面对社会学的科学性进行定义。最后,通过对中国社会学可能的“特色”来源与“特色”自觉意识进行分析,提出构建中国特色社会学要扎根在自己的社会历史土壤,在实现中国式现代化的过程中,坚持实事求是的“科学性”和人类命运共同体的价值观下的“人文性”共同发挥作用,发展出中国的“科学性”与“人文性”俱强且和谐一体的社会学。

关键词：社会学的二重性科学性人文性中国特色社会学

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Optimizing 3d spin polarization of CoOOH by in situ Mo doping for efficient oxygen evolution reaction

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Carbon Energy 2024年第1期6卷 236-244页

作者： Zhichao Jia yang Yuan Yanxing Zhang Xiang Lyu Chenhong Liu Xiaoli yang Zhengyu Bai Haijiang Wang Lin yang Key Laboratory of Green Chemical Media and Reactions School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsMinistry of EducationHenan Normal UniversityXinxiangHenanChina School of Physics Henan Normal UniversityXinxiangHenanChina Oak Ridge National Laboratory Electrification and Energy Infrastructures DivisionOak RidgeTennesseeUSA Department of Mechanical and Energy Engineering Key Laboratory of Energy Conversion and Storage TechnologiesSouthern University of Science and TechnologyShenzhenGuangdongChina

Transition-metal oxyhydroxides are attractive catalysts for oxygen evolution reactions(OERs).Further studies for developing transition-metal oxyhydroxide catalysts and understanding their catalytic mechanisms will benefit their quick transition to the next catalysts.Herein,Mo-doped CoOOH was designed as a high-performance model electrocatalyst with durability for 20 h at 10 mAcm−2.Additionally,it had an overpotential of 260 mV(glassy carbon)or 215 mV(nickel foam),which was 78 mV lower than that of IrO_(2)(338 mV).In situ,Raman spectroscopy revealed the transformation process of CoOOH.Calculations using the density functional theory showed that during OER,doped Mo increased the spin-up density of states and shrank the spin-down bandgap of the 3d orbits in the reconstructed CoOOH under the electrochemical activation process,which simultaneously optimized the adsorption and electron conduction of oxygen-related intermediates on Co sites and lowered the OER overpotentials.Our research provides new insights into the methodical planning of the creation of transition-metal oxyhydroxide OER catalysts.

关键词： electrocatalyst in situ Raman Mo-doped CoOOH oxygen evolution reaction

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Targeting ferroptosis and ferritinophagy:new targets for cardiovascular diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 1-22页

作者： Yi LUAN yang yang Ying LUAN Hui LIU Han XING Jinyan PEI Hengdao LIU Bo QIN Kaidi REN Clinical Systems Biology Research Laboratories Translational Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of PhysicsPeking UniversityBeijing100871China School of Laboratory Medicine Xinxiang Medical UniversityXinxiang453003China Quality Management Department Henan No.3 Provincial People’s HospitalZhengzhou450052China Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Center for Translational Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China Henan Engineering Research Center for Application&Translation of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China

Cardiovascular diseases(CVDs)are a leading factor driving mortality worldwide.Iron,an essential trace mineral,is important in numerous biological processes,and its role in CVDs has raised broad discussion for decades.Iron-mediated cell death,namely ferroptosis,has attracted much attention due to its critical role in cardiomyocyte damage and CVDs.Furthermore,ferritinophagy is the upstream mechanism that induces ferroptosis,and is closely related to CVDs.This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy,and the regulatory pathways and molecular targets involved in ferritinophagy,and to determine their roles in CVDs.Furthermore,we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs.Collectively,this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

关键词： Cardiovascular disease Iron Ferroptosis Ferritinophagy Therapeutic target

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Exploring formation mechanism and source attribution of ozone during the 2019 Wuhan Military World Games:Implications for ozone control strategies

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Journal of Environmental Sciences 2024年第2期136卷 400-411页

作者： Lei Zhang Lili Wang Runyu Wang Nan Chen Yuan yang Ke Li Jie Sun Dan Yao Yuesi Wang Minghui Tao yang Sun Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100049China Hubei Ecological Environment Monitoring Center Station Wuhan 430072China Guizhou Research and Designing Institute of Environmental Sciences Guizhou Academy of Environmental Science and DesignGuiyang 550081China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China School of Environment Key Laboratory for Yellow River and Huai River Water Environment and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiang 453007China Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China

A series of emission reduction measures were conducted in Wuhan,Central China,to ensure good air quality during the 7th Military World Games(MWG)in October 2019.To better understand the implications for ozone(O_(3))pollution control strategies,we applied integrated analysis approaches based on the de-weathered statistical model,parameterization methods,chemical box model,and positive matrix factorization model.During the MWG,concentrations of O_(3),NO_x,and volatile organic compound(VOCs),OFP(O_(3)formation potential),L_(OH)(OH radical loss rate)were 83μg/m^(3),43μg/m^(3),26 ppbv,188μg/m^(3),and 3.9 s^(-1),respectively,which were 26%,18%,3%,15%,and 13%lower than pre-MWG values and 6%,39%,30%,33%,and 50%lower than post-MWG values,respectively.After removing meteorological influence,O_(3)and its precursors during the MWG decreased largely compared with post-MWG values,and only O_(3),NO_(2),and oxygenated VOCs(OVOCs)declined compared with pre-MWG values,which revealed the emission reduction measures during the MWG played an important role for O_(3)decline.For six VOCs sources,the mass contributions of biomass burning and solvents usage during the MWG decreased largely compared with pre-MWG values.O_(3)production was sensitive to VOCs and the key species were aromatics,OVOCs,and alkenes,which originated mainly from solvents usage,biomass burning,industrial-related combustion,and vehicle exhaust.Decreasing O_(3)concentration during the strict control was mainly caused by OVOCs reduction due to biomass burning control.Generally,the O_(3)abatement strategies of Wuhan should be focused on the mitigation of high-reactivity VOCs.

关键词： VOCs Ozone Wuhan Military World Games Source apportionment Relative incremental reactivity Random forest

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Reporting quality evaluation of clinical practice guidelines for pulmonary nodules with the RIGHT checklist

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Chinese Medical Journal 2024年第5期137卷 625-627页

作者： Xuan Wu Wenqiang Wang Quncheng Zhang Ya Sun Nan Wei Li yang Yuanjian yang Huizhen yang Haiyang Liu Xiaoju Zhang Department of Respiratory and Critical Care Medicine Zhengzhou University People’s HospitalHenan Provincial People’s HospitalZhengzhouHenan 450003China Department of Internal Medicine Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450001China Department of Internal Medicine Xinxiang Medical UniversityXinxiangHenan 453003China

To the Editor:Pulmonary nodules are defined as localized opacities of up to 30 mm in diameter,surrounded by pulmonary parenchyma or located adjacent to the pleura.^([1])The ideal management for pulmonary nodules is to diagnose and treat malignant nodules as early as possible and minimize radiation exposures,based on the general guidance.Clinical practice guidelines(CPGs)always provide efficient recommendations based on systematic reviews of high-quality evidence and reporting to optimize patient care.^([2])Accumulating evidence shows that adherence to the guidelines improves patient outcomes.^([3])However,the reporting quality of CPGs seems poor.^([4])Several instruments have been generated to evaluate the quality of CPGs.

关键词： pulmonary Clinical clinical

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