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Successful treatment of Purpureocillium lilacinum pulmonary infection with isavuconazole: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1772-1777页

作者： Xue-Lin yang Jun-Yu Zhang jian-min Ren Department of Emergency Medicine Lishui Central HospitalLishui 323000Zhejiang ProvinceChina Department of Hematology Lishui Central HospitalLishui 323000Zhejiang ProvinceChina Department of Clinical Laboratory The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Purpureocillium lilacinum(***)is a saprophytic fungus widespread in soil and *** a causative agent,it is very rarely detected in humans,most commonly in the *** SUMMARY In this article,we reported the case of a 72-year-old patient with chronic lymphocytic leukemia who was admitted with cough and *** tomography revealed an infection in the right lower *** lavage fluid culture and metagenomic next-generation sequencing were ultimately confirmed to have a pulmonary infection with *** was eventually discharged with good outcomes after treatment with *** Pulmonary infection with *** was exceedingly *** currently there are no definitive therapeutic agents,there are reports of high resistance to amphotericin B and fluconazole and good sensitivity to second-generation *** present report is the first known use of isavuconazole for pulmonary *** *** provides new evidence for the characterization and treatment of clinical *** lung infections.

关键词： Purpureocillium lilacinum Pulmonary infection Isavuconazole Case report

Relationship between hs-CRP, proMMP-1, TIMP-1 and coronary plaque morphology: intravascular ultrasound study

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Chinese Medical Journal 2006年第20期119卷 1689-1694页

作者： ZHANG Xing-wei GE Jun-bo yang jian-min GE Lei WANG Ning-fu GAO Yan LI Pei-zhang PAN Hao TONG Guo-xin ZHOU Liang YE Xian-hua XU jian Department of Cardiology Hangzhou First Municipal Hospital ＆ Hangzhou Hospital Affiliated to Nanjing Medical University Hangzhou 310006 China Department of Cardiology Zhongshan Hospital Medical College of Fudan University Shanghai 200032 China

Background Rupture of unstable plaque with subsequent thrombus formation is the common pathophysiological substrate of the acute coronary syndrome （ACS）. It is of potential significance to explore the blood indexes predicting plaque characteristics. Little studies have focused on this field. Therefore we investigated the relationship between hypersensitive C-reactive protein （hs-CRP）, pro-matrix metalloproteinase-1 （proMMP-1）, tissue inhibitors of matrix metalloproteinase-1 （TIMP-1） and coronary plaque morphology. Methods Intravascular ultrasound （IVUS） examination was done in 152 patients with confirmed coronary heart disease before percutaneous coronary intervention from February 2003 to July 2005. Plasma samples of arterial blood were collected prior to the procedure. The level of hs-CRP, proMMP-1 and TIMP-1 were respectively measured by enzyme-linked immunosorbent assay （ELISA）. Results Unstable and ruptured plaque were found more frequently in patients with acute myocardial infarction and unstable angina. External elastic membrane cross-sectional area （EEM CSA）, plaque area, lipid pool area and plaque burden were significantly larger in ruptured and unstable plaque group. Positive remolding, thinner fabric-cap, smaller minimal lumen cross-sectional area （MLA）, dissection and thrombus were significantly more frequent in ruptured and unstable plaque group. The levels of plasma hs-CRP, proMMP-1 and TIMP-1 were higher in ruptured plaque group, hs-CRP〉8.94 mg/L was used to predict ruptured plaque with a ROC curve area of 0.76 [95% confidence interval （CI）, 67.0%-85.8%], sensitivity of 71.8%, specificity of 77.0% and accuracy of 69.2% （P〈0.01）, similarly for proMMP-1〉0.12 ng/ml with a ROC curve area of 0.69 [95% CI, 58.2%- 80.2%], sensitivity of 69.2%, specificity of 75.2% and accuracy of 66.2% （P〈0.01）, and TIMP-1〉83.45 ng/ml with a ROC curve area of 0.67 [95% CI, 56.2%-78.3%], sensitivity of 66.7%, specificity of 61.9% and accuracy of 66.2% （P〈0.01）. Conclusion

关键词： ultrasonography, interventional C-reactive protein matrix metalloproteinase

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基于非线性破坏准则的主动土压力上限计算

岩土力学 2009年第2期30卷 503-508页

作者：杨建民湖南城市学院土木工程学院湖南益阳413000

主要叙述了一种基于非线性破坏准则下的主动土压力计算分析方法。引入Power-Law非线性破坏准则,并根据切线法引入了变量ct、?0,建立了一个统一的容许速度场,通过上限分析得出了主动土压力的计算表达式。由于主动土压力计算表达式中自变... 详细信息

主要叙述了一种基于非线性破坏准则下的主动土压力计算分析方法。引入Power-Law非线性破坏准则,并根据切线法引入了变量ct、?0,建立了一个统一的容许速度场,通过上限分析得出了主动土压力的计算表达式。由于主动土压力计算表达式中自变量个数繁多,为实现对上限解的最优化,应用了大型的数学规划软件,采用了目前广泛使用的SQP算法,得出了最优的上限解。通过与同样引入Power-Law非线性破坏准则后的朗肯土压力理论解的比较,发现所述的方法切实有效,并且适用范围更加广泛。

关键词：主动土压力 Power-Law非线性破坏准则上限分析大型数学规划非线性朗肯土压力

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深层软基加固处理方案试验研究

岩土力学 2008年第7期29卷 1981-1986页

作者：杨建民湖南城市学院土木工程学院益阳413000

在软土地区既有铁路线旁修建复线时,为控制施工期沉降与工后沉降,保证既有线路与新建线路的稳定性,对新建复线的深层软基加固区,通过现场试验采用6种方法分7个观察项目进行了对比研究。试验结果表明:无论是沉降分析、稳定分析或是对既... 详细信息

在软土地区既有铁路线旁修建复线时,为控制施工期沉降与工后沉降,保证既有线路与新建线路的稳定性,对新建复线的深层软基加固区,通过现场试验采用6种方法分7个观察项目进行了对比研究。试验结果表明:无论是沉降分析、稳定分析或是对既有线的影响分析,用粉喷桩加固地基比用砂井、插塑板及土工布加固地基均有着显而易见的优越性,相对来说短而密的粉喷桩较长而疏的粉喷桩加固效果更好。

关键词：软基加固方法现场试验对比研究

Time-Domain Simulation for Coupled Motions of Three Barges Moored Side-by-Side in Floatover Operation

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China Ocean Engineering 2015年第2期29卷 155-168页

作者：许鑫杨建民李欣徐亮瑜 State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University

Simulating the coupled motions of multiple bodies in the time domain is a complex problem because of the strong hydrodynamic interactions and coupled effect of various mechanical connectors. In this study, we investigate the hydrodynamic responses of three barges moored side-by-side in a floatover operation in the frequency and time domains. In the frequency domain, the damping lid method is adopted to improve the overestimated hydrodynamic coefficients calculated from conventional potential flow theory. A time-domain computing program based on potential flow theory and impulse theory is compiled for analyses that consider multibody hydrodynamic interactions and mechanical effects from lines and fenders. Correspondingly, an experiment is carried out for comparison with the numerical results. All statistics, time series, and power density spectra from decay and irregular wave tests are in a fairly good agreement.

关键词： coupled motion time-domain simulation side-by-side floatover

Study on Supercooling Point and Freezing Point in Floral Organs of Apricot

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Agricultural Sciences in China 2007年第11期6卷 1330-1335页

作者： MENG Qing-rui LIANG Yin-quan WANG Wen-feng DU Shao-hua LI Yan-hui yang jian-min Agricultural University of Hebei Baoding 071001 P.R.China

Under the environment of an artificial climate chamber, supercooling point （SCP） and freezing point （FP） in flower and young fruit at different development stages and freezing injuries of floral organs were studied. The apricot cultivars tested were Kety, Golden Sun and Honghebao. With the development of flower buds, SCP and FP increased, which indicated that their cold resistance decreased. SCP and FP varied with different floral organs. For different apricot cultivars, it was found that, the lower SCP or FP in floral organs was, the more resistant capacity the cultivar had, and the larger the temperature interval from SCP to FP was. SCP was not a constant value, but a range. Frequency distribution of SCP in petals was more dispersing than that in stamens and pistils. Floral organs could maintain a supercooling state to avoid ice formation, but they were sensitive to freezing. Once floral organs froze, thev turned brown after thawing.

关键词： apricot floral organs supercooling point freezing point frost

TESTS AND APPLICATIONS OF A BOUSSINESQ MODEL WITH AMBIENT CURRENT

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Journal of Hydrodynamics 2010年第4期22卷 526-536页

作者： ZHANG Hong-sheng WANG Wei-yuan FENG Wen-jing WANG Ya-ling yang jian-min State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240 China Shanghai Water Planning and Design Research Institute Shanghai 200232 China College of Transport and Communications Shanghai Maritime University Shanghai 200135 China

A new type Boussinesq model is proposed and applied for wave propagation in a wave flume of uniform depth and over a submerged bar with current present or absent,***,for the propagation of monochromatic incident wave with current absent,the Boussinesq model is tested in its complete form,and in a form without the introduction of utility velocity *** is validated that the introduction of utility velocity variables can improve the characteristics of velocity field,dispersion and *** versions of the Boussinesq models are of higher accuracy than the fully-nonlinear fourth-order model,which is one of the best forms among the existing traditional Boussinesq models that do not incorporate breaking mechanism in one ***,the Boussinesq model in its complete form is applied to simulating the propagation of bichromatic incident waves with current present or absent,respectively,and the modeled results are compared to the analytical ones or the experimental *** modeled results are reasonable in the case of inputting bichromatic incident waves with the strong opposing current present.

关键词： Boussinesq model ambient current wave-wave interactions velocity field bichromatic incident waves

Spatial construction of ultrasmall Pt-decorated 3D spinel oxidemodified N-doped graphene nanoarchitectures as high-efficiency methanol oxidation electrocatalysts

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Rare Metals 2024年第1期43卷 186-197页

作者： Qi Zhang min-min Yan Wen-Fa Du Chen-Yu Yin jian Zhang Lu yang Yun-Qing Kang Hai-Yan He Hua-Jie Huang College of Mechanics and Materials Hohai UniversityNanjing 210098China New Energy Technology Engineering Lab of jiangsu Province College of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China International Center for Materials Nanoarchitectonics(WPIMANA) National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan

Direct methanol fuel cell technology recently becomes the focus of both academic and engineering circles,which stimulates the exploitation and utilization of advanced electrode catalysts with high activity and long ***,we demonstrate a robust bottom-up approach to the spatial construction of three-dimensional(3D) spinel manganese-cobalt oxide-modified N-doped graphene nanoarchitectures decorated with ultrasmall Pt nanoparticles(Pt/MnCo_(2)O_(4)-NG) via a controllable selfassembly *** incorporation of MnCo_(2)O_(4)nanocrystals provides abundant hydroxyl sources to promote the oxidative removal of CO-like byproducts on Pt sites,while the existence of 3D porous N-doped graphene networks facilitates the transportation of both ions and electrons in the hybrid system,thus giving rise to remarkable synergetic coupling effects during the methanol oxidation ***,the optimized Pt/MnCo_(2)O_(4)-NG nano architecture expres ses exceptional electrocatalytic properties with a large electrochemically active surface area of 99.5 m^(2)·g^(-1),a high mass activity of1508.3 mA·mg^(-1),strong toxicity resistance and reliable long-term durability,which have obvious competitive advantages over those of conventional Pt/carbon black,Pt/carbon nano tube,Pt/graphene,and Pt/N-doped graphene catalysts with the same Pt usage.

关键词： Platinum MnCo_(2)O_(4) 3D graphene Electrocatalysts Methanol oxidation

平台运动影响下张力腿涡激振动特性研究（英文）

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船舶力学 2015年第6期19卷 677-689页

作者：谷家扬杨建民江苏科技大学船舶与海洋工程学院江苏镇江212003 上海交通大学海洋工程国家重点实验室上海200240

张力腿涡激振动易引起系泊系统的疲劳损伤,危害张力腿平台的安全性和可靠性。该文借鉴细长立管涡激振动的相关研究,同时考虑张力腿与立管在截面尺度、预张力大小以及边界条件存在的巨大差距,采用切片理论结合CFD数值模拟方法,对平台运... 详细信息

张力腿涡激振动易引起系泊系统的疲劳损伤,危害张力腿平台的安全性和可靠性。该文借鉴细长立管涡激振动的相关研究,同时考虑张力腿与立管在截面尺度、预张力大小以及边界条件存在的巨大差距,采用切片理论结合CFD数值模拟方法,对平台运动影响下张力腿涡激振动开展了研究。考虑定常张力与时变张力对涡激振动的影响,采用GAMBIT软件分区建立了多切片计算网格,将编制求解涡激振动的UDF程序嵌入Fluent软件中,采用动网格技术实现流场的更新并计算作用于张力腿上的瞬时升力和拖曳力。文中还比较了仅考虑流和考虑浪、流联合作用张力腿的时变张力影响,研究了两种典型波高共计六种工况,计算结果表明:随着流速的增加,各模态权重比例将发生跳转现象;尽管由于平台运动导致张力腿受力的随机性,但平台运动对张力腿涡激振动影响较小。

关键词：张力腿涡激振动平台运动尾涡结构