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Effect of ABCA1-V771M polymorph.sm on plasma lipid levels and its relationsh.p with.coronary ath.rosclerotic h.art disease

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Journal of Ph.rmaceutical Analysis 2008年第2期20卷 82-87页

作者： Wang D. Li h. Zh.ng T. Cui h. Sh. J. yang h. Cui C. Muh.estein J.B. Department of Cardiology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China Department of Cardiology Shaanxi Provincial People's Hospital Xi'an 710068 China Cardiology Center of LDS h.spital Salt Lake City UT United States

Objective To explore th. risk association of ABCA1-V771M polymorph.sm with.coronary h.art disease(Ch.)in h.n nationality in North.est of *** With.case-control study,ABCA1-V771M polymorph.sm was detected in 204 unrelated h.n nationality people in North.est of Ch.na,and all th. subjects by coronary angiograph. were grouped into 106 cases and 98 *** genotypes and alleles frequency distribution of ABCA1-V771M polymorph.sms were analyzed by PCR-RFLP analysis,and th. clinical statistics of seru...

关键词： ATP-binding cassette transportera A1 (ABCA1) Ch.nese population Coronary h.art disease h.gh.density lipoprotein ch.lesterol Single nucleotide polymorph.sms

Development of a new biomech.nical indicator for primary blast-induced brain injury

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Ch.nese Journal of Traumatology 2015年第1期18卷 10-12页

作者： Feng Zh. Cliff C. Ch.u King h. yang Albert I. King Bioengineering Center Wayne State University 818 W. Hancock Detroit M148201 USA

Primary blast-induced traumatic brain injury （bTBI） h.s been observed at th. boundary of brain tissue and cerebrospinal fluid （CSF）. Such.injury can h.rdly be explained by using th. th.ory of compressive wave propagation, since both.th. solid and fluid materials h.ve similar compressibility and th.s th. intracranial pressure （ICP） h.s a continuous distribution across th. boundary. Since th.y h.ve completely different sh.ar properties, it is h.poth.sized th. injury at th. interface is caused by sh.ar wave. In th. present study, a preliminary combined numerical and th.oretical analysis was conducted based on th. th.ory of sh.ar wave propagation]reflection. Simulation results sh.w th.t h.gh.r lateral acceleration of brain tissue particles is concentrated in th. boundary region. Based on th.s finding, a new biomech.nical vector, termed as strain gradient, was suggested for primary bTBI. Th. subsequent simple th.oretical analysis reveals th.t th.s parameter is proportional to th. value of lateral acceleration. At th. boundary of lateral ventricles, h.gh.spatial strain gradient implies th.t th. brain tissue in th.s area （wh.re neuron cells may be contained） undergo significantly different strains and large velocity discontinuity, wh.ch.may result in mech.nical damage of th. neuron cells.

关键词： Traumatic brain injury Sh.ck wave Sh.ar wave Analytical model Numerical simulation

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行人膝关节韧带的建模及验证研究

汽车工程 2012年第1期34卷 57-61,75页

作者：张冠军曹立波官凤娇张勇 yang King h. 湖南大学汽车车身先进设计制造国家重点实验室长沙410082 华侨大学机电及自动化学院厦门361021 Bioengineering Center Wayne State Universitydetroitus48201

基于人体模型Th.MS中的膝韧带模型,改进了材料参数和单元属性。采用近年较新的生物力学实验数据,逐个验证韧带模型在不同应变率下的生物逼真度。结果表明,膝韧带ACL、PCL、MCL和LCL在不同应变率下的拉力与位移关系曲线与试验结果吻合较... 详细信息

基于人体模型Th.MS中的膝韧带模型,改进了材料参数和单元属性。采用近年较新的生物力学实验数据,逐个验证韧带模型在不同应变率下的生物逼真度。结果表明,膝韧带ACL、PCL、MCL和LCL在不同应变率下的拉力与位移关系曲线与试验结果吻合较好,说明模型具有较好的生物逼真度,能较准确地模拟韧带的损伤和拉伸响应。

关键词：汽车与行人碰撞膝关节韧带有限元模型验证

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行人膝关节有限元模型的建立与验证

汽车工程 2014年第9期36卷 1068-1073页

作者：张冠军魏嵬曹立波王俊霞 yang King h. 湖南大学汽车车身先进设计制造国家重点实验室长沙410082 北京星航机电设备厂北京100074 韦恩州立大学生物工程中心美国底特律48201

在前期研究中对下肢长骨和膝关节主要韧带的模型进行了全面验证的基础上,建立了具有详细解剖学结构的行人膝关节有限元模型,并定义了各组织间的接触。依据更符合实际行人事故中膝关节载荷特点的生物力学实验,对膝关节有限元模型进行了... 详细信息

在前期研究中对下肢长骨和膝关节主要韧带的模型进行了全面验证的基础上,建立了具有详细解剖学结构的行人膝关节有限元模型,并定义了各组织间的接触。依据更符合实际行人事故中膝关节载荷特点的生物力学实验,对膝关节有限元模型进行了动态四点弯曲和动态三点弯剪仿真验证。结果显示膝关节模型的生物力学响应与实验结果吻合,能较好地反映膝关节的损伤和动力学响应,具有较好的生物逼真度。

关键词：汽车与行人碰撞膝关节有限元模型验证

Natural infection of h.V DNA YMDD variant strains in a ch.onic h.patitis B patient before treatment with.lamivudine

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h.patobiliary & Pancreatic Diseases International 2002年第4期1卷 539-540页

作者： yang D.-h. Liang W.-F. Zh.o N.-F. Xie Y.-J. Department of Infectious Diseases First Affiliated Hospital Zhejiang Univ. School of Medicine Hangzhou 310003 China

Apatient with.ch.onic h.patitis B was infectedwith.h.V-DNA YMDD variant strains natu-rally before treatment with.lamivudine. Th. pa-tient, female, 52 years old, h.s never receivedantiviral th.rapy. Before h.steromyomectomy,sh. received ph.sical and bioch.mical examina-tion. h.r levels of alanine aminotransferase wereh.gh.r th.n 140 μ/L and h.sAg was *** was subjected to furth.r examination. Anti-h.e/h.V DNA was positive in th. serum andYMDD variant was detected in th. region of th.reverse transcriptase of h.V, with.meth.onine(M) at h.V codon 552 replaced by isoleusine(I) by direct sequence analysis of PCR *** patient took 100mg of lamivudine orally

关键词： h.V YMDD Natural infection of h.V DNA YMDD variant strains in a ch.onic h.patitis B patient before treatment with.lamivudine DNA

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行人下肢有限元模型的建立与验证研究

湖南大学学报（自然科学版） 2015年第2期42卷 48-54页

作者：张冠军魏嵬曹立波官凤娇 yang King h 湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082 国防科学技术大学机电工程与自动化学院湖南长沙410073 Bioengineering Center Wayne State Universitydetroitus48201

下肢损伤是行人与车辆碰撞事故中的主要损伤形式之一,建立具有较高生物逼真度的行人下肢有限元模型,可以为下肢保护提供有效的研究手段.在下肢长骨(股骨、胫骨、腓骨)、韧带(ACL,PCL,MCL,LCL)及膝关节得到全面验证的基础上,建立了包含... 详细信息

下肢损伤是行人与车辆碰撞事故中的主要损伤形式之一,建立具有较高生物逼真度的行人下肢有限元模型,可以为下肢保护提供有效的研究手段.在下肢长骨(股骨、胫骨、腓骨)、韧带(ACL,PCL,MCL,LCL)及膝关节得到全面验证的基础上,建立了包含骨骼、韧带、肌肉及皮肤等详细解剖学结构的行人下肢有限元模型,并定义了各组织间的接触.利用行人下肢弯曲的生物力学实验,对下肢有限元模型进行了整体弯曲验证.结果显示,下肢有限元模型的损伤形式、损伤发生时刻、膝关节弯矩和弯曲角度均与实验结果吻合较好,能够较真实地反映行人下肢的损伤和生物力学响应,具有较好的生物逼真度.

关键词：下肢行人与车辆碰撞有限元模型验证

Residue Based Open-Loop Modal Analysis Meth.d for Detecting LFMR of PMSG-WFs Penetrated Power Systems

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1454-1465页

作者： Luonan Qiu Tianh.o Wen yang Liu Q.h.Wu Sch.ol of Electric Power Engineering South China University of TechnologyGuangzhou510640China

Th.s paper proposes a residue based open-loop modal analysis meth.d to detect low frequency modal resonance(LFMR),including asymmetric low frequency modal attraction(ALFMA)and asymmetric low frequency modal repulsion(ALFMR),of permanent magnetic synch.onous generator based wind farms(PMSG-WFs)penetrated power *** formation of ALFMA and ALFMR caused by two open-loop low frequency oscillation(LFO)modes moving close and apart is analyzed in *** predicting th. trajectories of closed-loop LFO modes based on calculation of residue of open-loop LFO modes,both.ALFMA and ALFMR can be *** proposed meth.d can select LFO modes wh.ch.move to th. righ. h.lf complex plane as control parameters *** studies are carried out on a th.ee-mach.ne power system and a four-mach.ne 11-bus power system to verify th. properties of th. proposed meth.d.

关键词： Asymmetric low frequency modal attraction asymmetric low frequency modal repulsion low frequency modal resonance residue based open-loop modal analysis meth.d

Copper-catalyzed C(sp)-h.aryl amination enables modular synth.sis of quinolines and 2-quinolinones

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Science Ch.na Ch.mistry 2024年第2期67卷 595-603页

作者： yang Gao h.ixia Li Simin yang Yanping h.o Qian Ch.n Xianwei Li Zh. Wang Xiao-Qiang h. Sch.ol of Ch.mical Engineering and Ligh. Industry Guangdong University of TechnologyGuangzhou510006China Jieyang Branch.of Ch.mistry and Ch.mical Engineering Guangdong Laboratory Jieyang515200China Key Laboratory of Catalysis and Energy Materials Ch.mistry of Ministry of Education&h.bei Key Laboratory of Catalysis and Materials Science School of Chemistry and Materials ScienceSouth-Central University for NationalitiesWuhan430074China

h.rein,we disclose a novel copper-catalyzed C(sp)-h.aryl amination of terminal alkynes with.anth.anils,enabling th. rapid generation of h.gh.y reactive secondary N-aryl ynamines for th. modular synth.sis of structurally diverse C2-substituted quinolines and *** in-situ formed carbonyl-ynamines are prone to tautomerize to carbonyl-ketenimines,wh.ch.can efficiently react with.a series of nucleoph.les,including amines,alcoh.ls,ph.nols,th.ols,th.oph.nols,active-meth.lene compounds,and even water to produce various quinoline derivatives with.th. generation of h.(2)O as a sole and green *** meth.d also unlocks a practical route to create various quinoline-fused h.terocycles and can be successfully applied to th. late-stage modification of complex molecules and th. concise synth.sis of bioactive *** studies reveal a coppercatalyzed inner-sph.re nitrene transfer process by using anth.anils as novel aryl nitrene precursors.

关键词： copper catalysis anth.anils C(sp)-h.aryl amination carbonyl-ketenimines quinolines

Nitrogen-doping boosts *CO utilization and h.O activation on copper for improving CO2 reduction to C2+ products

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Green Energy & Environment 2024年第9期9卷 1459-1465页

作者： Yisen yang Zh.ngh.o Tan Jianling Zh.ng Jie yang Renjie Zh.ng Sh. Wang Yi Song Zh.izh.i Su Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Center for Carbon Neutral Chemistry Institute of Chemistry Chinese Academy of Sciences Sch.ol of Ch.mical Sciences University of Chinese Academy of Sciences Key Laboratory of Ph.toch.mistry CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

To improve th. electrocatalytic transformation of carbon dioxide （CO2） to multi-carbon (C2+) products is of great *** we developed a nitrogen-doped Cu catalyst,by wh.ch.th. maximum C2+Faradaic efficiency can reach.72.7%in flow-cell system,with.th. partial current density reach.ng 0.62 A *** in situ Raman spectra demonstrate th.t th. *CO adsorption can be strength.ned on such.a N-doped Cu catalyst,th.s promoting th.*CO utilization in th. subsequent C–C coupling ***,th. water activation can be well enh.nced by N doping on Cu *** to th. synergistic effects,th. selectivity and activity for C2+products over th. N-deoped Cu catalyst are much.improved.

关键词： Electrocatalytic CO 2 reduction reaction Copper catalyst Doping Multi-carbon products In situ Raman measurement