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Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy:Network pharmacology analysis and experimental validation

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World Journal of Diabetes 2024年第9期15卷 1942-1961页

作者： Yi-Fan yang Ling Yuan Xiang-yang Li Qian Liu Wen-Jie Jiang Tai-Qiang Jiao Jia-Qing Li Meng-Yi Ye yang niu Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes *** blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is ***,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic *** To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo *** This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular ***,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully *** mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin *** was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core *** Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using *** analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR *** docking prediction indica

关键词： Diabetic retinopathy Network pharmacology Animal models Oxidative stress Inflammatory

Secular trends of asthma mortality in China and the United States from 1990 to 2019

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Chinese Medical Journal 2024年第3期137卷 273-282页

作者： Xiaochen Li Mingzhou Guo yang niu Min Xie Xiansheng Liu Department of Pulmonary and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China NHC Key Laboratory of Respiratory Diseases WuhanHubei 430030China

Background:Asthma imposes a large healthcare burden in China and the United States(US).However,the trends of asthma mortality and the relative risk factors have not been comparatively analyzed between the *** aim of this study was to compare the mortality and risk factors between China and the ***:The deaths,and mortality rates of asthma in China and the US during 1990–2019 were obtained from the Global Burden of Disease Study *** age–period–cohort model was used to estimate these mortality rates based on a log-linear scale with additive age,period,and cohort *** population attributable fractions of risk factors for asthma were ***:In 1990–2019,the asthma mortality rate was higher in China than in the *** crude and age-standardized asthma mortality rates trended downward in both China and the US from 1990 to *** decline in mortality was more obvious in *** gap between the two countries was narrowing.A sex difference in asthma mortality was observed with higher mortality in males in China and females in the *** age effects showed that mortality increased with age in adults older than 20 years,particularly in the *** trends were generally observed in the period and cohort rate ratios in both countries,with China experiencing a more obvious *** and high body mass index(BMI)were the leading risk factors for asthma mortality in China and the US,*** attributable to occupational asthmagens and smoking decreased the most in China and the US,***:In 1990–2019,the asthma mortality rate was higher in China than in the US;however,the mortality gap has *** increased with age in *** improvements in asthma death risk with period and birth cohort were more obvious in China than in the ***,high BMI,and aging are major health problems associated with asthma *** role of occupational asthmagens in asthma mortality under

关键词： Asthma Mortality Global disease burden China the United States Age–period–cohort model

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融合深度学习的贝叶斯滤波综述

自动化学报 2024年第8期50卷 1502-1516页

作者：张文安林安迪杨旭升俞立杨小牛浙江工业大学信息工程学院杭州310023 浙江省嵌入式系统联合重点实验室杭州310023 电磁空间安全全国重点实验室嘉兴314033

当前动态系统呈现大型化、复杂化的趋势,基于贝叶斯滤波的动态系统状态估计遇到一系列新的挑战.随着深度学习在特征提取与模式识别等方面的优势与潜力不断显现,深度学习与传统贝叶斯滤波相结合的研究也随之兴起.为此,梳理了不同领域融... 详细信息

当前动态系统呈现大型化、复杂化的趋势,基于贝叶斯滤波的动态系统状态估计遇到一系列新的挑战.随着深度学习在特征提取与模式识别等方面的优势与潜力不断显现,深度学习与传统贝叶斯滤波相结合的研究也随之兴起.为此,梳理了不同领域融合深度学习的贝叶斯滤波方法的应用案例,从中剖析不同类型动态系统下贝叶斯滤波存在的局限性和共性难题.在此基础上,总结了当前贝叶斯滤波存在的几类不确定性问题,以深度学习的视角将这些问题归纳为特征提取和参数辨识两大基本问题,进而介绍深度学习为贝叶斯滤波所提供的解决方案.其次,归纳整理了两类深度学习与贝叶斯滤波结合的具体方法,着重介绍了深度卡尔曼滤波和融合深度学习的自适应卡尔曼滤波.最后,综合考虑深度学习方法和贝叶斯滤波方法的优势,讨论了融合深度学习的贝叶斯滤波方法的开放问题和未来研究方向.

关键词：深度学习贝叶斯滤波卡尔曼滤波状态估计状态空间模型

马铃薯磺肽素基因StPSK4的克隆及其抗病功能分析

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西北植物学报 2024年第8期44卷 1218-1228页

作者：王翔牛洋薛晓菲程声阳卢海彬西北农林科技大学农学院/旱区作物逆境生物学国家重点实验室陕西杨凌712100

【目的】探究马铃薯磺肽素基因StPSK4特征及其在马铃薯抗病性中的功能分析,为马铃薯抗病育种提供理论依据。【方法】用生物信息学技术对StPSK4进行系统分析,转录组测序分析StPSK4的组织特异性、生物胁迫和非生物胁迫处理下的表达模式,检... 详细信息

【目的】探究马铃薯磺肽素基因StPSK4特征及其在马铃薯抗病性中的功能分析,为马铃薯抗病育种提供理论依据。【方法】用生物信息学技术对StPSK4进行系统分析,转录组测序分析StPSK4的组织特异性、生物胁迫和非生物胁迫处理下的表达模式,检测StPSK4过表达植株对植物先天免疫反应情况和对青枯菌的敏感性。【结果】StPSK4基因的cDNA全长457 bp,编码100个氨基酸;StPSK4含有信号肽,其高级结构多由α-螺旋和无规则卷曲组成;PSK4的C端含有磺肽素序列DYIYTQ,StPSK4与茄科作物相似性均在80%以上;StPSK4在马铃薯芽和叶柄中高表达,对非生物胁迫(高温、盐)和生物胁迫(青枯菌、疮痂病菌)等响应剧烈;构建并获得过表达StPSK4的转基因马铃薯植株;过量表达StPSK4抑制马铃薯的ROS爆发、防御标记基因表达和对青枯病的抗病性。【结论】StPSK4可以响应高温和青枯病等多种逆境胁迫,过表达StPSK4抑制马铃薯的活性氧爆发、防御标记基因表达和对青枯病的抗性,证实StPSK4抑制马铃薯的抗病功能。

关键词：马铃薯植物磺肽素 StPSK4 PTI GMI1000

复合菌剂提高青藏高原羊粪和尾菜混合堆肥微生物多样性并加快堆肥腐熟

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植物营养与肥料学报 2024年第2期30卷 406-416页

作者：杨紫祎黄祎晨杨妞梅燕张琨徐丽萍吴明王海英中南民族大学生命科学学院湖北武汉430074 西宁市蔬菜服务技术中心青海西宁810016 青海省专用肥料有限公司青海西宁810005

【目的】研究添加自行筛选制备的复合菌剂对青藏地区羊粪尾菜混合堆肥进程和发酵品质的作用效果,为高原地区羊粪尾菜的资源化利用提供高效菌剂。【方法】将羊板粪和尾菜以质量比8∶1混合组成堆料,分为3份用于设置处理:自然发酵(CK),添... 详细信息

【目的】研究添加自行筛选制备的复合菌剂对青藏地区羊粪尾菜混合堆肥进程和发酵品质的作用效果,为高原地区羊粪尾菜的资源化利用提供高效菌剂。【方法】将羊板粪和尾菜以质量比8∶1混合组成堆料,分为3份用于设置处理:自然发酵(CK),添加市售堆肥菌剂(T2),添加自行筛选制备的复合菌剂(T3),堆体均为锥形,高度在1.5 m左右,每个堆体堆料量5 t,发酵持续60天。在开始发酵后测定堆肥温度,在0、7、14、20、25、50、60天,取样分析pH、含水率、电导率(EC)值及总氮、铵态氮、硝态氮和亚硝态氮含量,腐熟期样品用于种子发芽率(GI)试验。在0、20、60天取样,结合扩增子测序,分析堆肥细菌群落结构。【结果】添加复合菌剂的T3处理升温速度最快,在发酵第3天就达到47.8℃,在发酵第17天,T3处理首先进入高温期(>50℃),比CK处理提前5天;复合菌剂加速了羊粪尾菜堆肥中有机碳的分解,对有机质降解有一定的促进作用。发酵结束时CK、T2、T3处理全氮含量分别为21.4、23.1、19.7 g/kg,NH_(4)^(+)-N含量分别为155、144、45.6mg/kg,NO_(3)^(-)-N含量分别为218、283、344 mg/kg,T3处理堆肥全氮和铵态氮含量较CK组与T2组下降明显,但硝态氮含量高于CK和T2组,最终其GI值达到129.2%,高于CK组与T2组处理。菌群分析发现高原环境中Psychrobacter在堆肥初始阶段有着优势地位。加入自制的复合菌剂改变了堆肥过程中微生物的群落结构,增加了细菌多样性和特定细菌丰度,T3处理中Actinobacteriota水平明显升高。【结论】与不使用菌剂和使用商品菌剂相比,添加自行筛选制备的复合菌剂有效促进了青藏地区富含纤维素的羊粪尾菜混合堆肥的腐熟,延长了高温期,促进了有机质降解,同时减弱腐熟阶段的反硝化作用。加入的复合菌剂增加了堆肥中的细菌多样性,较高的嗜冷杆菌(Psychrobacter)相对丰度有助于堆肥初始阶段的升温,具有高效纤维素降解能力的放线菌(Streptomyces sp.)的加入有助于纤维素的降解。因此,使用复合菌剂是实现西藏地区羊粪及尾菜混合堆肥处理的有效措施。

关键词：青藏高原羊粪尾菜堆肥复合菌剂细菌多样性

血清细胞程序性死亡蛋白5、信号转导与转录激活因子1水平与宫颈鳞状细胞癌患者临床特征及预后的关系

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癌症进展 2024年第14期22卷 1570-1572,1600页

作者：张亚娟牛阳白晶郑州大学第一附属医院妇产科郑州467500

目的探讨血清细胞程序性死亡蛋白5(PDCD5)、信号转导与转录激活因子1(STAT1)水平与宫颈鳞状细胞癌(CSCC)患者临床特征及预后的关系。方法选取68例CSCC患者和60例健康体检者,分别纳入CSCC组和健康组。比较两组受试者及不同临床特征CSCC... 详细信息

目的探讨血清细胞程序性死亡蛋白5(PDCD5)、信号转导与转录激活因子1(STAT1)水平与宫颈鳞状细胞癌(CSCC)患者临床特征及预后的关系。方法选取68例CSCC患者和60例健康体检者,分别纳入CSCC组和健康组。比较两组受试者及不同临床特征CSCC患者血清PDCD5、STAT1水平。CSCC患者预后的影响因素采用多因素Cox回归模型分析。结果CSCC组患者血清PDCD5、STAT1水平均明显低于健康组,差异均有统计学意义(P﹤0.01)。有淋巴结转移、分化程度为低分化、临床分期为Ⅲ+Ⅳ期CSCC患者血清PDCD5、STAT1水平分别低于无淋巴结转移、分化程度为中高分化、临床分期为Ⅰ+Ⅱ期患者,差异均有统计学意义(P﹤0.05)。随访12个月,68例CSCC患者中,生存62例,死亡6例。多因素Cox分析结果显示,血清PDCD5﹤0.75 ng/ml、STAT1﹤54.69μg/L、淋巴结转移均是CSCC患者预后不良的独立危险因素(P﹤0.05)。结论CSCC患者血清PDCD5、STAT1水平较低,血清PDCD5﹤0.75 ng/ml、STAT1﹤54.69μg/L、淋巴结转移均是CSCC患者预后不良的独立危险因素。

关键词：宫颈鳞状细胞癌细胞程序性死亡蛋白5 信号转导与转录激活因子1 临床特征预后

A Preliminary Calculation of Three-Dimensional Unsteady Underwater Cavitating Flows Near Incompressible Limit

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Communications in Computational Physics 2008年第9期4卷 894-910页

作者： yang-Yao niu Wei-Yuan Hsu Department of Mechanical Engineering Chung-Hua UniversityHsin-ChuTaiwan30067ROC.

Recently,cavitated flows over underwater submerged bodies have attracted researchers to simulate large scale *** Computational Fluid Dynamics(CFD)approaches have been used widely and successfully to model developed ***,it is still a great challenge to accurately predict cavitated flow phenomena associated with interface capturing,viscous effects,unsteadiness and *** this study,we consider the preconditioned three-dimensional multiphase Navier-Stokes equations comprised of the mixture density,mixture momentum and constituent volume fraction equations.A dual-time implicit formulation with LU Decomposition is employed to accommodate the inherently unsteady ***,we adopt the Roe flux splitting method to deal with flux discretization in ***,time-derivative preconditioning is used to ensure well-conditioned eigenvalues of the high density ratio two-phase flow system to achieve computational *** cases include an unsteady 3-D cylindrical headform cavitated flow and an 2-D convergent-divergent nozzle channel cavity-problem.

关键词： Cavitation incompressible Roe Riemann solver dual-time stepping

Function of male and hermaphroditic flowers and size-dependent gender diphasy of Lloydia oxycarpa (Liliaceae) from Hengduan Mountains

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Plant Diversity 2017年第4期39卷 187-193页

作者： yang niu Qiangbang Gong Deli Peng Hang Sun Zhimin Li School of Life Sciences Yunnan Normal University 650500 Kunming Yunnan China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences 132 Lanhei Road 650201 Kunming Yunnan China

Although hermaphroditism is common in flowering plants, unisexual flowers occur in many plant taxa,forming various sexual systems. However, the sexual system of some plants is difficult to determine morphologically, given that their sex expression may be influenced by both genetic and environmental factors. Specifically, androdioecy(the coexistence of both male and hermaphroditic individuals in the same population) has often been confused with the gender diphasy, a gender strategy in which plants change their sex expression between seasons. We studied the reproductive function of male and hermaphroditic flowers of Lloydia oxycarpa(Liliaceae), in order to investigate its sexual system and determine whether it is a gender-diphasic species. We found that although male flowers occur in a considerable number of plants, relative to hermaphrodites, they did not exhibit any significant reproductive advantage in terms of flower size, pollen quantity, attractiveness to visitors or siring success. In addition, this plant has spontaneous self-pollination and showed no inbreeding depression. These results render the maintenance of male individuals almost impossible. Furthermore, a considerable number of individuals changed their sex in successive years. The sex expression was found to be related to bulb size and dry weight, with larger individuals producing hermaphroditic flowers and smaller individuals producing male flowers. These results suggest that L. oxycarpa is not an androdioecious plant but represents a rare case of size-dependent gender diphasy.

关键词： Gender diphasy Lloydia Reproductive ecology Sexual system Size-dependent sex allocation

Biometric-based personal identity-authentication system and security analysis

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 43-47页

作者： LI Chao yang Yi-xian niu Xin-xin Information Security Centre Key Laboratory of Networking and Switching Technologies Beijing University of Posts and Telecommunications Beijing 100876 China

The traditional authentication system is based on the secret key, and is mainly based on public key infrastructure （PKI）. Unfortunately, a key has many disadvantages, for example, the key can be forgotten or stolen, and can be easily cracked. Nowadays, authentication systems using biometric technology have become more prevalent because of the advantages over password-based authentication systems. In this article, several biometfic authentication models are presented, upon which most biometric authentication systems are based. Biometric authentication systems based-on these models provide high security for access control in non-face-to-face environment such as e-commerce, over open network.

关键词： biometric identity authentication PKI security