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煤电机组多能互补灵活性改造技术分析

电力系统装备 2024年第1期 97-99页

作者：栾阳国家能源集团宿迁发电有限公司江苏宿迁223800

为深入理解并优化现有煤电机组在电力体系中的作用,并使其更好地适应可再生能源的增长,对多能互补灵活性改造技术进行了全面探讨,提出了煤电机组灵活性改造技术方案,包括智能控制系统的升级、提高锅炉的启停效率、增强汽轮机的负荷调节... 详细信息

为深入理解并优化现有煤电机组在电力体系中的作用,并使其更好地适应可再生能源的增长,对多能互补灵活性改造技术进行了全面探讨,提出了煤电机组灵活性改造技术方案,包括智能控制系统的升级、提高锅炉的启停效率、增强汽轮机的负荷调节能力、优化辅助机械的响应速度和对设备状态进行实时监测与评估。结果表明,这些改造能够显著提高煤电机组的运行效率,降低发电成本,平衡电网中的能源供需,并进一步推动绿色、低碳的电力发展。

关键词：煤电机组多能互补改造技术

Human AKR1A1 involves in metabolic activation of carcinogenic aristolochic acidⅠ

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中国药理学与毒理学杂志 2024年第9期38卷 641-651页

作者： GAO Zhenna YOU Xinyue LIU Weiying WU Jiaying XI Jing CAO Yiyi ZHANG Xiaohong ZHANG Xinyu luan yang School of Public Health School of MedicineShanghai JiaoTong UniversityShanghai 200025China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China

OBJECTIVE To investigate whether aldo-keto reductases(AKRs)can act as a nitrore⁃ductase(NR)and bioactivate aristolochic acidⅠ(AA-Ⅰ)to produce AA-Ⅰ-DNA ***①Human-induced hepatocytes(hiHeps)and human bladder RT4 cells were used as tool cells and treated with AA-Ⅰ0,0.5,1.0 and 2μmol·L^(-1)for 24 *** viability was detected using the CCK-8 method,and the half maximal inhibition concentration(IC_(50))was calculated using the CCK-8 method and the level of DNA adduct production was calculated.②hiHeps and RT4 cells were treated with AKR inhibitor luteotin(0,5,10 and 25μmol·L^(-1))+AA-Ⅰ0.2 and 1.0μmol·L^(-1)for 24 h,respectively,and the levels of DNA adducts were detected by a liquid chromatography-tandem mass spectrometer(LC-MS/MS).③hiHeps cells were incubated with 80 nmol·L^(-1)small interfering RNAs(si-AKRs)for 48 h and treated with AA-Ⅰ1.0μmol·L^(-1)for 24 ***-time qualitative PCR(RT-qPCR)method was used to detect the mRNA expression of AKRs gene and LC-MS/MS technology was used to investigate the effect of specific AKR gene knockdown on DNA adduct levels.④500 nmol·L^(-1)human AKR recombinant proteins AKR1A1 and AA-Ⅰwere incubated in vitro under anaerobic conditions and the formation of AA-Ⅰ-DNA adducts was ***①The IC_(50)of AA-Ⅰto hiHeps and RT4 cells was 1.9 and 0.42μmol·L^(-1),respec⁃*** level of DNA adduct production of the two cell lines was significantly different(P<0.01).②Luteolin≥5μmol·L^(-1)significantly inhibited the production of AA-Ⅰ-DNA adducts in both cells(P<0.05),and there was a concentration-dependent effect in hiHeps cells(P<0.01,R=0.84).③In the AKR family,the knockdown of AKR1A1 gene up to 80%inhibited the generation of AA-Ⅰ-DNA adducts by 30%-40%.④The AA-Ⅰ-DNA adducts were detected in the incubation of recombinant protein AKR1A1 and AA-Ⅰunder anaerobic conditions in vitro,approximately 1 adduct per 107 ***⁃SION AKR1A1 is involved in AA-Ⅰbioactivation,providing a reference for elucidation of the carci

关键词： metabolic activation nitro-reduction aldo-keto reductase superfamily aristolochic acidⅠ

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高模量沥青路面结构力学响应及适用层位分析

交通科技 2024年第5期 13-18页

作者：牛倩栾扬孟会林石家庄市交建高速公路建设管理有限公司石衡分公司石家庄050000 河北省交通规划设计研究院有限公司石家庄050091

为探究高模量沥青混合料在半刚性基层沥青路面结构中的合理应用层位,明确高模量沥青层的引入对路面结构受力影响的变化规律,文中选用BISAR3.0路面力学计算程序,以中下面层材料抗压模量变化、下面层材料差异、层间黏结状态、路基不同工... 详细信息

为探究高模量沥青混合料在半刚性基层沥青路面结构中的合理应用层位,明确高模量沥青层的引入对路面结构受力影响的变化规律,文中选用BISAR3.0路面力学计算程序,以中下面层材料抗压模量变化、下面层材料差异、层间黏结状态、路基不同工况四类别主要影响因素开展不同深度与计算点位的路面结构受力状态的全面考察。结果表明,对于半刚性基层沥青路面,高模量沥青层的引入不会对基层的应力、应变状态产生较大影响,将高模量沥青混凝土设置在下面层的效果优于中面层,下面层模量的提高有助于减小沥青层层底的拉应变,降低幅度在40%左右,同时路面沥青面层不同深度的抗剪切变形和抗疲劳损伤能力也均有所提升;提高高模量沥青层与半刚性基层的层间接触强度可显著改善路面结构的整体受力性能,有效降低各结构层的拉应变与剪切应变;提高路基抗压模量可有效改善基层受力状态,降低半刚性基层开裂风险及由此产生的沥青面层反射裂缝问题。

关键词：高模量沥青路面半刚性基层适用层位应力应变分析 BISAR3.0

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成人临床表现不典型丛状血管瘤2例

皮肤性病诊疗学杂志 2024年第2期31卷 113-117页

作者：杨娈于晓静孙青山东大学齐鲁医院山东济南250012

报告2例成人临床表现不典型丛状血管瘤。患者1,男,41岁,颈部疼痛性红色斑块2年。皮肤科检查:颈部散在分布红色斑块,最大面积约7 cm×3.5 cm,上覆簇性暗红色丘疹,质韧,部分呈假性水疱样损害。实验室检查:血小板83×10^(9)/L;凝血功能异... 详细信息

报告2例成人临床表现不典型丛状血管瘤。患者1,男,41岁,颈部疼痛性红色斑块2年。皮肤科检查:颈部散在分布红色斑块,最大面积约7 cm×3.5 cm,上覆簇性暗红色丘疹,质韧,部分呈假性水疱样损害。实验室检查:血小板83×10^(9)/L;凝血功能异常。皮损组织病理:真皮及皮下组织见结节性内皮细胞呈丛状增生,似“炮弹样”外观。免疫组化:CD31、CD34阳性,D2-40局灶阳性。诊断:丛状血管瘤。治疗:建议口服普萘洛尔,患者拒绝,随访观察。患者2,女,30岁,左足背褐色结节伴痛痒2月余。皮肤科检查:左足背分布一直径约0.8 cm的褐色结节,质硬,表面粗糙。实验室检查:血常规、凝血功能正常;IgG 23.70 g/L,C30.888 g/L;ANA 1∶640(+)。皮损组织病理:真皮见内皮细胞排列致密,呈丛状增生。免疫组化:CD31、CD34阳性,D2-40局灶阳性。诊断:丛状血管瘤。予手术切除,术后随访一年,无复发。

关键词：丛状血管瘤鉴别诊断卡梅现象治疗

Is it really the ＂dark side＂ of herbal medicine？

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Science China(Life Sciences) 2018年第9期61卷 1118-1119页

作者： yang luan Shuangcheng Ma Yimin Mao Hongqiao International Institute of Medicine Shanghai Tong Ren Hospital and Faculty of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025 China National Institutes for Food and Drug Control Beijing 100050 China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127 China

Aristolochic acids （AAs）, previously rarely mentioned compounds, have been brought into the public eye several times since the beginning of this century; and currently, they have drawn even greater attention due to their association with liver cancer, as was recently reported by Ng et al.（Ng et al., 2017）. The authors sequenced the whole exomes of 98patients with hepatocellular carcinomas （HCC） from Taiwan and reported that 78%of the cases carried the AAs mutational signature, A：T〉T：A transversion.

关键词： HCC of herbal medicine Is it really the dark side

Targeting ferroptosis and ferritinophagy:new targets for cardiovascular diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 1-22页

作者： Yi luan yang yang Ying luan Hui LIU Han XING Jinyan PEI Hengdao LIU Bo QIN Kaidi REN Clinical Systems Biology Research Laboratories Translational Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of PhysicsPeking UniversityBeijing100871China School of Laboratory Medicine Xinxiang Medical UniversityXinxiang453003China Quality Management Department Henan No.3 Provincial People’s HospitalZhengzhou450052China Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Center for Translational Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China Henan Engineering Research Center for Application&Translation of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China

Cardiovascular diseases(CVDs)are a leading factor driving mortality ***,an essential trace mineral,is important in numerous biological processes,and its role in CVDs has raised broad discussion for ***-mediated cell death,namely ferroptosis,has attracted much attention due to its critical role in cardiomyocyte damage and ***,ferritinophagy is the upstream mechanism that induces ferroptosis,and is closely related to *** review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy,and the regulatory pathways and molecular targets involved in ferritinophagy,and to determine their roles in ***,we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating ***,this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

关键词： Cardiovascular disease Iron Ferroptosis Ferritinophagy Therapeutic target

Dexamethasone implant in naive versus refractory patients with diabetic macular edema:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1898-1904页

作者： Qian Xu Chao yang Jie luan Department of Ophthalmology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of the intravitreal dexamethasone implant in naive and refractory patients with diabetic macular edema(DME).METHODS:PubMed,Embase,Web of Science,and Medline databases were *** main outcomes were best-corrected visual acuity(BCVA)and central retinal thickness(CRT).The secondary outcomes included mean number of injections,intraoperative or postoperative complications including intraocular pressure(IOP)elevation and ***:Ten comparative studies involving a total of 1000 DME eyes including 402 naive eyes and 598 refractory eyes were *** postoperative BCVA in the naive group was significantly better than in the refractory group[mean difference(MD)-0.11,95%confidence interval(CI)-0.17 to-0.05,P=0.0003;MD 8.69,95%CI 5.08 to 12.30,P<0.00001].Additionally,the naive group got greater improvement of BCVA change as well as more gains of BCVA letters than the refractory group[MD 7.71,95%CI 2.02 to 13.40,P=0.008;odds ratio(OR)2.99,95%CI 2.05 to 4.37,P<0.00001].The subgroup analysis revealed that the naive group had significantly higher BCVA gains of≥5,≥10,and≥15 letters compared to the refractory group(P=0.002,0.0001,0.003,respectively).No significant difference was detected between the two groups in either postoperative CRT(MD-22.36,95%CI-46.39 to 1.66,P=0.07)or the overall mean number of injections(MD-0.08,95%CI-0.38 to 0.22,P=0.61).Intraoperative and postoperative complications including the elevation of IOP(OR 0.47,95%CI 0.20 to 1.13,P=0.09)and cataract(OR 1.78,95%CI 0.97 to 3.24,P=0.06)showed no significant differences between the two groups during the follow-up ***:Intravitreal dexamethasone implants for DME can improve anatomical and functional outcomes in both naive and refractory eyes and have a well-acceptable safety ***,naive eyes maintain better visual outcomes than refractory *** provides further evidence of better visual response when used for naive eyes as firstline t

关键词： diabetic macular edema dexamethasone implant refractory eyes systemic review

经会阴与经直肠前列腺穿刺活检对前列腺癌的诊断效能和并发症比较

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临床外科杂志 2024年第7期32卷 753-756页

作者：岳敏栾阳阮亚俊郝晓东彭昊湖北省武穴市第一人民医院超声科 435400 华中科技大学同济医学院附属同济医院泌尿外科

目的分析磁共振和超声融合影像引导的经会阴和经直肠途径的前列腺穿刺的诊断效能。方法湖北省武穴市第一人民医院和武汉同济医院2022年1月~2023年11月行融合影像引导的前列腺穿刺的病人271例,根据穿刺路径分为两组,经直肠途径132例,经... 详细信息

目的分析磁共振和超声融合影像引导的经会阴和经直肠途径的前列腺穿刺的诊断效能。方法湖北省武穴市第一人民医院和武汉同济医院2022年1月~2023年11月行融合影像引导的前列腺穿刺的病人271例,根据穿刺路径分为两组,经直肠途径132例,经会阴途径139例。比较不同穿刺途径,不同前列腺影像报告和数据系统(PI-RADS)评分和病灶定位对前列腺癌(PCa)和有临床意义前列腺癌(clinical significant prostate cancer,csPCa)检出率的差异。结果经会阴穿刺组和经直肠穿刺组中PCa的检出率分别为68.3%和59.8%,csPCa检出率分别为64.7%和55.3%,两者比较差异无统计学意义,但经会阴穿刺组并发症较少。对PI-RADS评分4的病人,经会阴联合穿刺比经直肠联合穿刺的PCa(77.2%和56.1%)和csPCa(71.9%和48.8%)的检出率更高(P<0.05)。对于尖端(PCa:84.3%vs.48.7%,P=0.001;csPCa:81.8%vs.48.7%,P=0.004)和前部(PCa:77.1%vs.46.5%,P=0.006;csPCa:68.6%vs.44.2%,P=0.031)的前列腺病灶,经会阴联合穿刺相较于经直肠路径的PCa和csPCa检出率更高。结论对于PI-RADS 4分或前列腺病灶位于尖端或前部的病人,经会阴途径穿刺活检是更合适的方法。

关键词：前列腺癌并发症穿刺

Expression of Eph-Ephrin A Molecules in Endometrium During Swine Embryo Implantation Examined Using Real-Time RT-PCR

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Agricultural Sciences in China 2011年第9期10卷 1445-1451页

作者： FU Yan-feng FU Jin-luan yang Lu TIAN Ming-ming CHEN Wen-cheng WANG Ai-guo College of Animal Science and Technology China Agricultural University/Key Laboratory of Animal Genetics and Breeding Ministry of Agriculture Beijing 100193 P.R. China

Erythropoietin-producing hepatocellular receptor and its membrane-bound ligands （Eph-Ephrin） system could regulate some mammalian blastocyst attachment and spreading. In order to investigate the involvement of the Eph-Ephrin system in swine embryo attachment, mRNA expression of Eph-Ephrin molecules in endometrium was examined by real-time RT- PCR during embryo implantation in pigs. The results indicated that mRNA expressions of Eph A5, A7 and Ephrin A5 all continually increased from pregnancy day 13 to 24. Ephrin A3 mRNA expression significantly increased from day 13 to 18 and decreased from day 18 to 24, and the expression was the lowest on pregnancy day l 3 and the highest on day 18. However, Ephrin A4 mRNA expression was the lowest on pregnancy day 18 and the highest on day 24, and the expression decreased from day 13 to 18 and increased from day 18 to 24. Furthermore, mRNA expressions of Eph A5 and A7 were both found in other tissues, such as brain, muscle, intestine, stomach, etc. These findings suggest that the Eph-Ephrin system may play an important role in regulating the contact between blastocysts and endometrium during swine embryo implantation.

关键词： Eph-Ephrin real-time RT-PCR endometrium implantation pig