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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

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Frontiers of Medicine 2023年第2期17卷 275-289页

作者： Jing yang yanfei yang Yuquan Wei Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Melanoma and Sarcoma Medical Oncology Unit State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Department of Gynecology and Obstetrics The Third Xiangya HospitalCentral South UniversityChangsha 410008China

The abnormal activation of HER family kinase activity is closely related to the development of human *** this study,we used HER kinases as targets for the treatment of nasopharyngeal carcinoma(NPC)and explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36B,alone or in combination with *** found that HER family proteins were positively expressed in tumor tissues of some NPC patients,and the high levels of those proteins were significantly related to poor ***781-36B inhibited NPC in vitro and in ***781-36B exerted synergistic effects with cisplatin on inhibiting proliferation and promoting apoptosis of NPC *** NPC xenograft models in nude mice,HM781-36B and cisplatin synergistically inhibited tumor *** the activity of HER family proteins and their downstream signaling pathways and regulating tumor microenvironment may explain the synergistic anti-tumor effects of HM781-36B and *** conclusion,our study provides evidence for HER family proteins as prognostic biomarkers and potential therapeutic targets for *** pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic effects for the treatment of NPC patients,which provides a new idea for the comprehensive treatment of NPC.

关键词： epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin

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Synergetic Improvement of Interlaminar Fracture Toughness in Carbon Fiber/Epoxy Composites Interleaved with PES/PEK‑C Hybrid Nanofiber Veils

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Advanced Fiber Materials 2022年第5期4卷 1081-1093页

作者： Jinli Zhou Chenyu Zhang Chao Cheng Ming Wang Zhihui yang yanfei yang Hongying yang Muhuo Yu Zhongyuan University of Technology Zhengzhou 450000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620China Shanghai University of Engineering Science Shanghai 201620China Henan University of Engineering Zhengzhou 450000China

In this study,two types of soluble thermoplastic resins were added to epoxy resin at a fixed weight ratio to prepare a three-phase cast *** cast was then manufactured into hybrid nanofiber as interleaves for interlaminar toughening of carbon fiber/epoxy resin(CF/EP)composites using a co-solvent *** results revealed that when the hybrid components reached 15 wt%,Polyethersulfone(PES)and polyaryletherketone cardo(PEK-C)exhibited the best synergistic toughening effect,and the fracture toughness increased by 99.8%and 39.8%,respectively,compared with the reference or the same proportion of the single PES toughened *** used PES/PEK-C hybrid nanofibers with an areal density of 19.2 g per square meter(gsm)as composite toughening *** from the lack of significant influence of PES nanofiber on CF/EP composites,the interlaminar fracture toughness of mode I and mode II layers increased by 88.3%and 46.9%,respectively,compared to the reference *** Electron Microscopy of the fracture surface and cross-section micromorphology of the laminate displayed that the thermoplastic microspheres of different sizes contribute differently to crack resistance:PEK-C consumes more energy due to the debonding and extraction of microspheres and resin,whereas the presence of the PES phase can induce more plastic deformation and crack deflection.

关键词： Carbon fiber/epoxy resin Polyethersulfone Polyaryletherketone cardo Interlaminar fracture toughness Nanofiber

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Ln3+(Ln=Eu,Dy)-doped Sr2CeO4 fine phosphor particles:Wet chemical preparation,energy transfer and tunable luminescence

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Journal of Rare Earths 2020年第12期38卷 1273-1280页

作者： Na Gao yanfei yang Shikao Shi Jiye Wang Shuping Wang Jibiao Li Lianshe Fu Key Laboratory of Inorganic Nanomaterials of Hebei Province College of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China Physics Department and CICECO-Aveiro Institute of Materials University of Aveiro3810-193AveiroPortugal

The Sr2 CeO4:Ln3+(Ln=Eu,Dy)fine phosphor particles were prepared by a facile wet chemical approach,in which the consecutive hydrothermal-combustion reaction was *** doping of Ln3+into Sr2 CeO4 has little influence on the structure of host,and the as-prepared samples display wellcrystallized spherical or elliptical shape with an average particle size at about 100-200 *** Eu3+ions-doped Sr2 CeO4,with the increase of Eu3+-doping concentration,the blue light emission band with the maximum at 468 nm originating from a Ce4+→O2-charge transfer of the host decreases obviously and the characteristic red light emission of Eu3+(5 D0→7 F2 transition at 618 nm)is enhanced ***,the fluorescent lifetime of the broadband emission of Sr2 CeO4 decreases with the doping of Eu3+,indicating an efficient energy transfer from the host to the doping Eu3+*** ene rgy transfer efficiency from the host to Eu3+was investigated in detail,and the emitting color of Sr2 CeO4:Eu3+can be easily tuned from blue to red by varying the doping concentration of Eu3+***,the luminescence of Dy3+-doped Sr2 CeO4 was also *** energy transfer pheno menon can be observed,and the incorporation of Dy3+into Sr2 CeO4 host leads to the characteristic emission of 4 F9/2→6 H15/2(488 nm,blue light)and 4 F9/2→6 H13/2(574 nm,yellow light)of Dy3+.The Sr2 CeO4:Ln3+fine particles with tunable luminescence are quite beneficial for its potential applications in the optoelectronic fields.

关键词： Wet chemistry preparation Sr2CeO4 Ln3+ion Phosphor Luminescence Energy transfer

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Multiplicative Perturbation Bounds for the SR Factorization

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Journal of Mathematical Research with Applications 2014年第4期34卷 423-434页

作者： yanfei yang Hanyu LI College of Mathematics and Statistics Chongqing UniversityChongqing 401331P. R. China

In this paper, we present the first order perturbation bounds for the SR factorization with respect to left multiplicative perturbation, and the first order and rigorous perturbation bounds for this factorization with respect to right multiplicative ***, taking the properties of SR factors into consideration, we also provide some refined perturbation bounds.

关键词： multiplicative perturbation SR factorization rigorous perturbation bound first order perturbation bound.

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Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer

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Genes & Diseases 2024年第3期11卷 400-416页

作者： Meijia Yu Yiming Wu Qingfang Li Weiqi Hong yang yang Xiaoyi Hu yanfei yang Tianqi Lu Xia Zhao Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Gynecology and Obstetrics Development and Related Disease of Women and Children Key Laboratory of Sichuan ProvinceKey Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology The First Affiliated HospitalArmy Medical UniversityChongqing 400038China

Ovarian cancer is the tumor with the highest mortality among gynecological *** have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages(TAMs)in the ***-stimu-lating factor 1(CSF-1)receptor(CSF-1R)plays a key role in regulating the number and differ-entiation of macrophages in certain solid *** are few reports on the effects of targeted inhibition of CSF-1R in combination with chemotherapy on ovarian cancer and the tu-mor ***,we explored the antitumor efficacy and possible mechanisms of the CSF-1R inhibitor pexidartinib(PLX3397)when combined with the first-line chemothera-peutic agent paclitaxel in the treatment of ovarian *** found that CSF-1R is highly ex-pressed in ovarian cancer cells and correlates with poor *** by PLX3397 in combination with paclitaxel significantly inhibited the growth of ovarian cancer both in vitro and in *** of CSF-1R altered the macrophage phenotype and reprogrammed the immunosuppressive cell population in the tumor microenvironment.

关键词： CSF-1R Ovariancancer Paclitaxel PLX3397 Targeted therapy Tumor-associated macrophages

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基于不同总线协议的DMA控制器研究进展

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半导体技术 2025年第2期50卷 117-126页

作者：任小龙杨延飞王立涵严登辉张浩李飞飞李连碧西安工程大学理学院西安710048 苏州飞盈微电子有限公司江苏苏州215100

随着计算机技术的飞速发展,对大规模数据传输和处理效率的要求越来越高。直接存取存储(DMA)控制允许设备和存储器之间直接进行高速数据传输,有效提升了数据传输效率,因而得到广泛的研究。综述了基于不同总线架构的DMA控制器的研究进展... 详细信息

随着计算机技术的飞速发展,对大规模数据传输和处理效率的要求越来越高。直接存取存储(DMA)控制允许设备和存储器之间直接进行高速数据传输,有效提升了数据传输效率,因而得到广泛的研究。综述了基于不同总线架构的DMA控制器的研究进展。首先,在分析传统中央处理器(CPU)传输数据局限性的基础上,阐述了DMA控制器与总线结合的重要性。其次,重点探讨了基于高级微控制器总线架构(AMBA)和高速外设部件互连标准(PCIe)两种常用总线协议的DMA控制器的研究进展,从频率、传输速率、功耗等方面进行性能比较和分析总结,并在此基础上展望了未来基于这两种总线协议的DMA技术的发展方向。最后,介绍了基于其他总线协议的DMA控制器的研究进展,在分析其性能优势的基础上为新型DMA控制器设计提供新思路。

关键词：直接存取存储(DMA)控制器高级微控制器总线架构(AMBA) 高级高性能总线(AHB) 高级可拓展接口(AXI)总线高速外设部件互连标准(PCIe)总线 CoreConnect总线片内总线(ICB)

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2型糖尿病患者采用度拉糖肽联合双歧杆菌四联活菌片治疗对降低心血管病发生风险的价值研究

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中国医药 2025年第2期20卷 211-215页

作者：田金霞杨燕飞于子娟宗晓春河北省张家口市第一医院内分泌科张家口075000

目的探讨度拉糖肽联合双歧杆菌四联活菌片治疗2型糖尿病(T 2DM)对降低心血管病发生风险的价值。方法选取2021年3月至2022年3月河北省张家口市第一医院内分泌科收治的60例T 2DM患者作为研究对象,按照随机数字表法分为对照组和观察组,各3... 详细信息

目的探讨度拉糖肽联合双歧杆菌四联活菌片治疗2型糖尿病(T 2DM)对降低心血管病发生风险的价值。方法选取2021年3月至2022年3月河北省张家口市第一医院内分泌科收治的60例T 2DM患者作为研究对象,按照随机数字表法分为对照组和观察组,各30例。对照组采用常规药物治疗,观察组在对照组的基础上加用度拉糖肽联合双歧杆菌四联活菌片进行治疗,2组均接受饮食及运动干预。检测2组患者血糖水平、胰岛功能指标、炎症因子指标,比较2组心血管病的发生风险。结果治疗后,2组患者的空腹血糖、糖化血红蛋白及平均血糖水平均低于治疗前,且观察组血糖水平均低于对照组(均P<0.05)。治疗后,2组患者的稳态模型胰岛β细胞功能指数、0.5 h胰岛素生成指数、2 h胰岛素生成指数均高于治疗前,稳态模型胰岛素抵抗指数均低于治疗前,且与对照组相比,观察组变化幅度更大(均P<0.05)。治疗后,2组患者的白细胞介素6、高敏C反应蛋白、脂多糖水平均低于治疗前,且观察组各指标水平均低于对照组(均P<0.05)。观察组治疗后Framingham危险评分及心血管病10年风险均低于治疗前,且低于对照组[(12.0±0.6)分比(13.1±0.8)分、(4.1±2.3)%比(6.2±5.3)%](均P<0.05)。结论度拉糖肽联合双歧杆菌四联活菌片治疗T 2DM,可减轻胰岛素抵抗,改善胰岛β细胞功能,控制炎症反应,降低心血管事件发生风险。

关键词：度拉糖肽双歧杆菌四联活菌片 2型糖尿病心血管病发生风险

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Enhanced methane production in an anaerobic digestion and microbial electrolysis cell coupled system with co-cultivation of Geobacter and Methanosarcina

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Journal of Environmental Sciences 2016年第4期28卷 210-214页

作者： Qi Yin Xiaoyu Zhu Guoqiang Zhan Tao Bo yanfei yang Yong Tao Xiaohong He Daping Li Zhiying Yan Key Laboratory of Environmental and Applied Microbiology Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China Environmental Microbiology Key Laboratory of Sichuan Province Chengdu 610041 China

The anaerobic digestion（AD）and microbial electrolysis cell（MEC）coupled system has been proved to be a promising process for biomethane *** this paper,it was found that by co-cultivating Geobacter with Methanosarcina in an AD–MEC coupled system,methane yield was further increased by 24.1%,achieving to 360.2 m L/g-COD,which was comparable to the theoretical methane yield of an anaerobic *** the presence of Geobacter,the maximum chemical oxygen demand（COD）removal rate（216.8 mg COD/（L·hr））and current density（304.3 A/m3）were both increased by 1.3 and 1.8 fold compared to the previous study without Geobacter,resulting in overall energy efficiency reaching up to 74.6%.Community analysis demonstrated that Geobacter and Methanosarcina could coexist together in the biofilm,and the electrochemical activities of both were confirmed by cyclic *** study observed that the carbon dioxide content in total gas generated from the AD reactor with Geobacter was only half of that generated from the same reactor without Geobacter,suggesting that Methanosarcina may obtain the electron transferred from Geobacter for the reduction of carbon dioxide to *** together,Geobacter not only can improve the performance of the MEC system,but also can enhance methane production.

关键词： AD–MEC coupled system Geobacter Methanosarcina Co-cultivation Methane production

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Midbrain dopaminergic neurons mediate modafinil-induced arousal

Midbrain dopaminergic neurons mediate modafinil-induced arou...

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中国睡眠研究会第十一届全国学术年会

作者： yanfei yang Hui Dong Zhili Huang Fudan University

Introduction 2-[（Diphenylmethyl） sulfinyl] acetamide（modafinil）, a widely used wake-promoting agent, interacts with dopamine systems. Here, we investigated the modafinil action on identified dopaminergic neurons in the midbrain, to understand the precise mechanism of modafinil. Materials and methods We used pharmacological means, polysomnographic recording, calcium activities and dopamine release detections to identify dopaminergic neurons in the midbrain. Results When dopaminergic neurons in VTA and SN were abolished, the robust wake-promoting effects were totally blocked even at a high dose（180 mg/kg）. In calcium signal detections of VTA dopaminergic neurons, modafinil i.p. significantly inhibited the population activities. Then, dopamine release in NAC were detected across the spontaneous sleep-wake cycle, which showed that modafinil increased releases in a dose-dependent manner. Finally, we found that the inhibitory effects of modafinil on VTA dopaminergic neurons was antagonized by D2R shRNA. Conclusions Our findings demonstrated that midbrain dopaminergic neurons mediate modafinil induced arousal.

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我国高校招生计划分配制的法理透视与制度反思——基于教育平等的考量

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国家教育行政学院学报 2016年第7期 27-32页

作者：杨艳飞南京工程学院江苏南京211167

我国高校招生计划分配制旨在一定程度上修正形式平等的制度设计所可能造成的入学机会实质不平等的结果,目前已基本形成了以地区分配制为主、民族分配制和城乡分配制为辅的高校招生计划分配格局。把招生计划分配制置于"目的—手段"分析... 详细信息

我国高校招生计划分配制旨在一定程度上修正形式平等的制度设计所可能造成的入学机会实质不平等的结果,目前已基本形成了以地区分配制为主、民族分配制和城乡分配制为辅的高校招生计划分配格局。把招生计划分配制置于"目的—手段"分析框架进行检视,地区分配制中的分省分配制无论在事实上还是在法理上存有宪法上歧视的质疑,城乡分配制、民族分配制以及"协作计划"则具有符合正当目的的纠偏性质。发挥高校招生计划分配制的平等实现功能,应以现存分配制的格局重组为核心,以程序正义和信息公开保障"纠偏政策"的精准化,从而实现高等教育入学机会的平等。

关键词：招生计划分配纠偏政策教育平等

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