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白藜芦醇延缓皮肤衰老的作用功效及应用研究进展

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轻工学报 2024年第3期39卷 119-126页

作者：石径姜燕飞赵春月北京青颜博识健康管理有限公司北京100085

在简要概述白藜芦醇理化特性和来源的基础上,从抗皮肤光老化、抗皮肤氧化、抗皮肤色素沉着和抗皮肤皱纹4个方面,对白藜芦醇在延缓皮肤衰老方面的作用功效及其在化妆品应用中的研究进展进行综述。指出,白藜芦醇具有显著的抗皮肤衰老功效... 详细信息

在简要概述白藜芦醇理化特性和来源的基础上,从抗皮肤光老化、抗皮肤氧化、抗皮肤色素沉着和抗皮肤皱纹4个方面,对白藜芦醇在延缓皮肤衰老方面的作用功效及其在化妆品应用中的研究进展进行综述。指出,白藜芦醇具有显著的抗皮肤衰老功效,并已在众多动物实验和临床实验研究中得到证实;在化妆品领域,白藜芦醇不仅以其保湿、紧致皮肤、美白及抗皱等多重抗衰老特性广泛应用于面霜、乳液及精华等多种产品剂型中,而且通过纳米脂质体系统对其进行包埋和递送,可以有效改善它的透皮渗透能力,进而提升其整体的护肤效果;然而,白藜芦醇仍存在稳定性较差、生物利用度低和高剂量口服具有一定毒性等问题,限制了其在化妆品中的更广泛应用。因此,未来还需对白藜芦醇进行全面科学的剂量研究和安全性评价,同时也需要开展更多的临床研究来验证其效果并推动其应用,从而为白藜芦醇作为化妆品和美容类产品中具有抗皮肤衰老的功能活性成分的开发和应用提供参考。

关键词：白藜芦醇延缓皮肤衰老抗皮肤光老化抗皮肤氧化抗皮肤色素沉着抗皮肤皱纹

Coordination-reduction leaching process of ion-adsorption type rare earth ore with ascorbic acid

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Journal of Rare Earths 2023年第8期41卷 1225-1233,I0004页

作者： Jinfa Chen jiang Qiu Li Huang Xin Chen Ying Yang yanfei Xiao Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Ganzhou Engineering Technology Research Center of Green Metallurgy and Process Intensification Ganzhou 341000China Key Laboratory of Ionic Rare Earth Resources and Environment Ministry of Natural ResourcesGanzhou 341000China Key Laboratory of Testing and Tracing of Rare Earth Products for State Market Regulation Ganzhou 341000China

The magnesium sulfate(MgSO_(4))-ascorbic acid(Vc)compound leaching technique can extract rare earth elements(REEs)existing in ion-exchangeable phase and colloidal phase from ion-adso rption type rare earth ore through the synergy effect of coordination and reduction,but its reaction process and mechanism remain *** this paper,the coordination-reduction leaching mechanism was analyzed from the perspectives of leaching thermodynamics and kinetics,which provide theoretical guidance for the compound leaching *** the case of neodymium,about 45%of dissolved neodymium will exist as the complex species of NdVc_(()3(aq))in Nd-Vc-sulfate *** on this,it is deduced that the Gibbs free energy of the leaching reaction of ion-exchangeable phase REEs will change to a more negative value through the coordination of REEs cations and Vc anions in the MgSO_(4)leaching *** addition,the E_(h)-pH diagrams of Ce-SO_(4)^(2-)-H_(2)O and Fe-SO_(4)^(2-)-H_(2)O together with the dissolution experiments confirm that the added Vc initiates the leaching process of colloidal phase REEs through reduction-dissolution *** the study of leaching kinetics,the leaching of REEs is controlled by diffusion and chemical reaction in the co mpound leaching system since colloidal phase REEs are ***,the addition of Vc can shift the leaching equilibrium to a more favorable state and accelerate leaching *** rare earth leaching efficiency of ion-exchangeable phase and colloidal phase can be effectively improved by increasing the reaction temperature,the conce ntrations of leaching agent and Vc,and the leaching agent acidity.

关键词： Ion-adsorption type rare earth ore Ascorbic acid Coordination Reduction Leaching Mechanism

Study on sintering process and characteristic of nanosized soft magnetic MnZn ferrite powders

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Rare Metals 2006年第z1期25卷 531-535页

作者： WANG Yongming WANG Xin jiang yanfei HAO Shunli LIU Chunjing School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China

The effect of sintering process (especially the sintering temperature) on the magnetic property and microstructure of sintered sample of nanosized soft magnetic MnZn ferrite powder was investigated. The sintered sample of MnZn ferrite was prepared by both traditional pressing and cool isostatic pressing on MnZn ferrite nanoparticals. The sintering process of which was segmented. The density, microstructure and phase composition of sintered sample were analyzed by Archimedes′law, scanning electron microscopy (SEM) and X-ray diffraction (XRD). The grain growth and densification in sintering process of MnZn ferrite were investigated. The magnetic property was measured by vibrating sample magnetometer (VSM) and Nim2000 magnetic material testing system. The results show that the better sintering temperature is 850 ℃, at which the better magnetic property and microstructure of sintered compact were obtained.

关键词： MnZn ferrite sintering temperature microstructure magnetic property

Progress on grain growth dynamics in sintering of nano-powders

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Rare Metals 2006年第z1期25卷 471-475页

作者： LIU Chunjing WANG Xin jiang yanfei WANG Yongming HAO Shunli School of Material and Engineering Hebei University of Technology Tianjin 300130 China School of Material and Engineering Hebei University of Technology Tianjin 300130 China School of Material and Engineering Hebei University of Technology Tianjin 300130 China School of Material and Engineering Hebei University of Technology Tianjin 300130 China School of Material and Engineering Hebei University of Technology Tianjin 300130 China

Nanostructured materials, characterized by an ultrafine grain size, have stimulated much research interest by virtue of their unusual mechanical, electrical, optical, and magnetic properties. In this paper, the sintering process of nano-powders were reviewed, to which sintering of the traditional materials compared. The microstructural development, i.e., grain growth and densification during sintering as well as the mechanism of crystal surface diffusion and boundary migration were analyzed, and the dynamic models on sintering process were summarized by the relationship of grain growth and pores size, interface diffusion, densification rate, and sintering temperature. Finally, the research tendency of this major on the basis of above models was discussed.

关键词： nano-powders sintering grain boundary grain growth dynamics

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铁死亡在自身免疫性疾病中的研究进展

国际生物制品学杂志 2024年第1期47卷 49-55页

作者：张欣薇江妍斐(综述) 张进安(审校) 上海中医药大学研究生院上海201203 上海健康医学院附属周浦医院内分泌-风湿科上海201318 上海中医药大学上海201203

铁死亡作为一种独特的调节性细胞死亡形式,其特征是铁依赖的脂质过氧化物的清除受损或过度产生导致其积累达到致死水平.近年来铁死亡在临床疾病领域的研究成为了热点,在自身免疫性疾病中的研究也逐渐增多.此文就铁死亡的重要概念、调控... 详细信息

铁死亡作为一种独特的调节性细胞死亡形式,其特征是铁依赖的脂质过氧化物的清除受损或过度产生导致其积累达到致死水平.近年来铁死亡在临床疾病领域的研究成为了热点,在自身免疫性疾病中的研究也逐渐增多.此文就铁死亡的重要概念、调控机制以及铁死亡在几种常见自身免疫性疾病中的作用进行综述.

关键词：铁死亡自身免疫疾病谷胱甘肽过氧化物酶4 关节炎类风湿红斑狼疮系统性

基于AHM赋权联合TOPSIS法的参麦注射液临床合理用药评价标准的建立与应用

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世界临床药物 2024年第2期45卷 217-222页

作者：舒波蒋艳菲陈光华幸婷婷川北医学院附属医院药剂科四川南充637000

目的建立参麦注射液药物利用评价细则,探讨层次分析模型(analytic hierarchy process model,AHM)赋权联合逼近理想值排序(technique for order preference by similarity to solution,TOPSIS)法在参麦注射液药物利用合理性评价中的应用。方法以参麦注射液说明书为基础,结合相关指南,制定参麦注射液药物利用评价标准;采用AHM与TOPSIS相结合的方法对2022年1月至2022年12月川北医学院附属医院(以下简称“本院”)220例使用参麦注射液患者的用药合理性进行回顾性评价。结果220份评价病历中用药合理病历(C_(i)≥0.8)6例(2.73%),用药基本合理(0.6≤C_(i)<0.8)185例(84.09%),用药不合理(C_(i)<0.6)35例(15.91%)。疾病诊断、溶媒选择、给药浓度、特殊人群、不良反应监测与处理、注意事项以及病程记录是导致参麦注射液用药不合理的主要因素。结论AHM赋权联合TOPSIS法所得评价结果量化、科学可信,可用于参麦注射液药物利用合理性评价。

关键词：参麦注射液属性层次模型逼近理想解排序法药物利用合理性评价

Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer

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BIOCELL 2024年第8期48卷 1265-1273页

作者： SHAN jiang XIUFENG LIN yanfei CHEN XINNING LI JIALI KANG Department of Gynecology and Obstetrics The First Affiliated Hospital of Jinan UniversityGuangzhou510180China Reproductive Medical Center Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Guangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou510180China

Background:Despite improvements in objective response rates to cisplatin-based combination chemotherapy,the majority of advanced ovarian cancer remains suboptimal,resulting in poor *** has been found that non-coding RNAs(ncRNAs)not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses,thereby regulating tumor occurrence and ***,the function and detailed mechanism of ultraconserved RNA(ucRNA)in ovarian cancer chemoresistance is still ***:Western blotting assay,Quantitative real-time PCR analysis(qPCR),and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis of uc.243 in ovarian *** assay and Annexin V assay were performed to analyze the function of uc.243 in cisplatin resistance in ovarian cancer *** pull-down and qPCR experiments were performed to explore the molecular mechanism of uc.243 enhancing cisplatin resistance in ovarian cancer ***:Herein,we found that uc.243 was remarkably upregulated and correlated with patient survival in chemoresistance ovarian cancer patients compared with chemo-sensitive ovarian *** experiment displayed that uc.243 induced cisplatin resistance on ovarian cancer cells by facilitating the efflux of cisplatin(CDDP);but inhibiting the expression of uc.243 significantly reverses this ***,uc.243 can inhibit the binding of RNA binding protein DGCR8 microprocessor complex subunit to pri-miR-155,thereby inhibiting the cleavage of pri-miR-155 and decrease in mature miR-155,subsequently upregulates the expression of ATP binding cassette subfamily B member(ABCB1,ABCC2).Conclusion:Our research findings indicate that uc.243 can induce chemotherapy resistance in ovarian cancer,suggesting that it may become a new prognostic biomarker for malignant ovarian cancer.

关键词： Ultra-conserved non-coding RNA uc.243 Drug efflux Drug transporters Chemoresistance Ovarian cancer

High Temperature Deformation of Al_2O_3/Cu Composites

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Journal of Materials Science & Technology 2001年第3期17卷 325-328页

作者： Jianjun WU. Yun ZHANG, yanfei jiang and Meiyun XUE Department of Material Science and Engineering, Hebei University of Technology, Tianjin 300130, China Tingquan LEI School of Materials Science and Engineering, Harbin Institute of Technology, Uarbin 15000 Dept. of Mat. Sci. and Eng. Hebei Univ. of Technol. Tianjin 300130 China

This work concerns with the high temperature deformation of internally oxidized Al2O3/Cu composites. The investigation revealed that dispersive alumina can obstruct dislocation sliding and define the subgrain size thereby improve significantly the strength of the materials at high temperature. The sliding of dislocations is a main deformation mechanism in the given temperature range. The sliding of grain boundary and diffusive creep play important roles at high temperature and low strain rate. The dispersoids can raise the recrystallization temperature to higher than 1223 K. Dynamic recovery is a main softening way under the experimental conditions. Higher deformation rate and lower deformation temperature imply a higher flow stress.

关键词： High Temperature Deformation of Al2O3/Cu Composites Cu Al

审前程序中辩护权运作的实践生态与立法完善——以我国新《律师法》文本为基点的分析

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法学杂志 2011年第3期32卷 86-89页

作者：江雁飞东华理工大学江西抚州344000

新修订的我国《律师法》扩展了律师在审前程序中享有的辩护权利,然而,辩护权运作的实践效果却不甚理想,长期存在的会见难、阅卷难以及调查取证难等问题依然没有真正解决。从立法的角度来看,其原因在于新《律师法》尚存在不足,主要体现... 详细信息

新修订的我国《律师法》扩展了律师在审前程序中享有的辩护权利,然而,辩护权运作的实践效果却不甚理想,长期存在的会见难、阅卷难以及调查取证难等问题依然没有真正解决。从立法的角度来看,其原因在于新《律师法》尚存在不足,主要体现为侦查阶段律师的地位不明确,缺失合理的辩护权利救济机制以及与刑事诉讼法存在冲突。为解决这些问题,需要完善《律师法》,明确赋予侦查阶段的律师以辩护人的地位,建构合理的救济机制,协调与《刑事诉讼法》的内在冲突。

关键词：审前程序辩护权律师法