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Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

Protein & Cell 2023年第6期14卷 398-415页

作者： Qian Zhao yandong zheng Dongxin Zhao Liyun Zhao Lingling Geng Shuai Ma Yusheng Cai Chengyu Liu Yupeng Yan Juan Carlos Izpisua Belmonte Si Wang Weiqi Zhang Guang-Hui Liu Jing Qu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciencesand China National Center for BioinformationBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China The Fifth People's Hospital of Chongqing Chongqing 400062China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China Altos Labs Inc.San DiegoCA 94022USA

Hair loss affects millions of people at some time in their life,and safe and efficient treatments for hair loss are a significant unmet medical *** report that topical delivery of quercetin(Que)stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in *** construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1αin endothelial *** administration of a HIF-1αagonist partially recapitulates the pro-angiogenesis and hair-growing effects of ***,these findings provide a molecular understanding for the efficacy of Que in hair regrowth,which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine,and suggest a route of pharmacological intervention that may promote hair regrowth.

关键词： single-cell RNA-sequencing Que hair follicle regeneration endothelial cells HIF-1α

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Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging

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Protein & Cell 2024年第8期15卷 612-632页

作者： Qinchao Hu Bin Zhang Yaobin Jing Shuai Ma Lei Hu jingyi Li yandong zheng Zijuan Xin Jianmin Peng Si Wang Bin Cheng Jing Qu Weiqi zhang Guang-Hui Liu Songlin Wang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou 510060China Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Laboratory of Oral Health and Beijing Stomatological HospitalCapital Medical UniversityBeijing 100050China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China Intemational Center for Aging and Cancer Hainan Medical UniversityHaikou 571199China Aging Biomarker Consortium Beijing 100101China

Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis,a worldwide prevalent inflammatory ***,a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still ***,we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed the first single-nucleus transcriptomic landscape of gingival aging,by which a panel of cell type-specific signatures were *** cells were identified as the most affected cell types by aging in the *** analyses pinpointed the crucial role of YAP in epithelial self-renew and homeostasis,which declined during aging in epithelial cells,especially in basal *** decline of YAP activity during aging was confrmed in the human gingival tissues,and downregulation of YAP in human primary gingival keratinocytes recapitulated the major phenotypic defects observed in the aged primate gingiva while overexpression of YAP showed rejuvenation *** work provides an in-depth understanding of gingival aging and serves as a rich resource for developing novel strategies to combat aging-associated gingival diseases,with the ultimate goal of advancing periodontal health and promoting healthy aging.

关键词： single-nucleus RNA-sequencing primate gingiva aging YAP

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Practical and privacy-preserving geo-social-based POI recommendation

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Journal of Information and Intelligence 2024年第2期2卷 148-166页

作者： Qi Xu Hui Zhu yandong zheng Fengwei Wang Le Gao School of Cyber Engineering Xidian UniversityXi'an 710126China Science and Technology on Communication Networks Laboratory Shijiazhuang 050081China Faculty of Intelligent Manufacturing Wuyi UniversityJiangmen 529020China

With the rapid development of location-based services and online social networks,POI recommendation services considering geographic and social factors have received extensive ***,the vigorous development of cloud computing has prompted service providers to outsource data to the cloud to provide POI recommendation ***,there is a degree of distrust of the cloud by service *** protect digital assets,service providers encrypt data before outsourcing ***,encryption reduces data availability,making it more challenging to provide POI recommendation services in outsourcing *** privacy-preserving schemes for geo-social-based POI recommendation have been presented,but they have some limitations in supporting group query,considering both geographic and social factors,and query accuracy,making these schemes *** solve this issue,we propose two practical and privacy-preserving geo-social-based POI recommendation schemes for single user and group users,which are named GSPR-S and ***,we first utilize the quad tree to organize geographic data and the MinHash method to index social ***,we apply BGV fully homomorphic encryption to design some private algorithms,including a private max/min operation algorithm,a private rectangular set operation algorithm,and a private rectangular overlapping detection *** that,we use these algorithms as building blocks in our schemes for efficiency *** to security analysis,our schemes are proven to be secure against the honest-but-curious cloud servers,and experimental results show that our schemes have good performance.

关键词： Cloud computing Geo-social-based data MinHash POI recommendation Privacy preservation

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京津冀地区农业劳动生产率的分异特征及其影响因素

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北京大学学报（自然科学版） 2017年第1期53卷 101-110页

作者：刘玉郑艳东陈秧分北京农业信息技术研究中心北京100097 河北省土地整理服务中心石家庄050051 中国农业科学院农业经济与发展研究所北京100081

以京津冀地区171个县域为研究单元,利用GIS空间分析等方法,分析1994,2000,2006和2012年农业劳动生产率的空间分异特征,并借助地理加权回归模型揭示2000和2012年县域农业劳动生产率空间分异的影响因素,得到以下结果。1)县域农业劳动生产... 详细信息

以京津冀地区171个县域为研究单元,利用GIS空间分析等方法,分析1994,2000,2006和2012年农业劳动生产率的空间分异特征,并借助地理加权回归模型揭示2000和2012年县域农业劳动生产率空间分异的影响因素,得到以下结果。1)县域农业劳动生产率发展不均衡,空间分异显著。京津唐地区的农业劳动生产率较高,但近年来北京所辖区县的农业劳动生产率提升较慢,高高集聚单元数明显减少;石家庄市周边出现新的高高集聚类型区;张家口、承德、保定和邢台所辖多数县域的农业劳动生产率处于较低水平。2)县域农业劳动生产率快速提升,并且两极分化趋势不明显;4个年份中,县域农业劳动生产率存在显著的正向相关性,但空间集聚程度减弱。3)地理加权回归模型的拟合结果明显优于普通最小二乘法。171个县域各控制变量的参数估计结果和回归系数均不相同,县域农业劳动生产率的驱动因素呈现非均衡联动的局域性特征,其中,上期农业劳动生产率的影响最显著。因此,应结合县域农业劳动生产率的现状和影响因子的效应,因地制宜地采取相应措施,优化和提升区域农业劳动生产率。

关键词：农业劳动生产率时空格局影响因素地理加权回归京津冀地区

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Single-cell transcriptomic atlas of mouse cochlear aging

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Protein & Cell 2023年第3期14卷 180-201页

作者： Guoqiang Sun yandong zheng Xiaolong Fu Weiqi Zhang Jie Ren Shuai Ma Shuhui Sun Xiaojuan He QiaoranWang zhejun ji Fang Cheng KaowenYan Ziyi Liu Juan Carloszpisuaemonte Jing Qu Si Wang Renjie Chai Guang-Hui Liu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Bioelectronics Jiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSchool of Life Sciences and TechnologySoutheast UniversityNanjing 211189China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical University.Beijing100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital MedicalUniversityBeijing100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China China National Center for Bioinformation Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Gene Expression Laboratory Salk Institute for Biological StudiesLa JollaCA 92037USA Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Shandong Provincial Hospital and School of Laboratory Animal Science Shandong First Medical UniversityJinan 250000China

Progressive functional deterioration in the cochlea is associated with age-related hearing loss(ARHL).However,the cellular and molecular basis underlying cochlear aging remains largely ***,we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging,in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time ***,our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging,highlights unexpected age-related transcriptional fluctuations in intermediate ceils localized in the stria vascularis(SV)and demonstrates that upregulation of endoplasmic reticulum(ER)chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with *** work suggests that targeting unfolded protein response pathways may help alleviate aging-related sVatrophyand hencedelay theprogressionofARHL.

关键词： single-cell transcriptomic atlas mouse cochlea aging

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Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging

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Protein & Cell 2023年第4期14卷 279-293页

作者： Yiyuan Zhang yandong zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi Zhang Shuai Ma Jing Qu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 10o101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China

Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged ***,the cell type-specific changes underlying cardiac aging are far from being ***,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with *** found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional *** transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac ***,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived ***,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases.

关键词： single-nucleus RNA-sequencing primate aging FOxP1 cardiomyocyte

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基于适宜性-规划-等级的村庄整治类型划分研究

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农业机械学报 2022年第4期53卷 218-227页

作者：唐林楠刘玉潘瑜春郑艳东北京市农林科学院信息技术研究中心北京100097 国家农业信息化工程技术研究中心北京100097 河北省国土整治中心石家庄050031

科学划分村庄整治类型并制定合理的优化策略,是实现大城市村镇体系合理布局和乡村空间高效利用的重要措施。本文基于POI、土地利用现状数据等多源数据,综合运用适宜性评价、引力模型等方法,构建了基于布局适宜性-规划约束-村庄等级(简... 详细信息

科学划分村庄整治类型并制定合理的优化策略,是实现大城市村镇体系合理布局和乡村空间高效利用的重要措施。本文基于POI、土地利用现状数据等多源数据,综合运用适宜性评价、引力模型等方法,构建了基于布局适宜性-规划约束-村庄等级(简称适宜性-规划-等级)的村庄整治类型划分方案,并以密云区为例进行实证分析。结果表明:在经济发展、生活便利和环境宜居等多因素综合作用下,密云区村庄布局适宜性呈现由西南向东北衰减的特征。借助引力模型,将研究区332个村庄划分为57个中心村、103个次中心村和172个一般村。基于适宜性规划等级的村庄整治内涵,将密云区村庄确定为城镇集建、特色提升、整治完善Ⅰ、整治完善Ⅱ和整体搬迁5种整治类型。整体搬迁类村庄未来的整治方向为可复垦型,其他村庄均为可盘活型。结合村庄布局适宜性评价、等级划分、土地利用形态和整治潜力,着眼于减量规划思路,因地制宜地提出5类村庄的整治策略。研究成果可为区域村庄用地布局优化和减量发展以及全域土地综合整治等提供参考。

关键词：多源数据引力模型村庄分类村庄整治布局适宜性评价密云区

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矿山环保型充填工艺的应用

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黄金 2010年第11期31卷 20-24页

作者：刘志山郑延东河北中金黄金有限公司黑龙江金铭能源投资有限公司

介绍了矿山尾矿对于环境的危害以及改善矿山环境保护的必要性,评述了目前尾矿综合利用和尾矿胶结充填工艺的现状,叙述了高水全尾胶固充填材料与充填工艺的研究结果和使用情况,并分析了该工艺目前在岩金矿山应用存在问题和今后研究方向。

关键词：尾矿充填高水胶固材料充填工艺研究方向

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考虑温度影响的能源桩桩–土界面荷载传递模型

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岩石力学与工程学报 2019年第1期38卷 171-179页

作者：骆湘勤刘干斌郑言东钱峰周敏宁波大学岩土工程研究所浙江宁波315211

为深入揭示温度对能源桩力学特性的影响,考虑能源桩桩–土界面法向温度应力增量对初始剪切刚度的影响,对传统桩–土界面荷载传递双曲线模型进行修正,并通过合理假设桩身及桩周土中温度场分布,计算得到桩–土界面法向温度应力,建立考虑... 详细信息

为深入揭示温度对能源桩力学特性的影响,考虑能源桩桩–土界面法向温度应力增量对初始剪切刚度的影响,对传统桩–土界面荷载传递双曲线模型进行修正,并通过合理假设桩身及桩周土中温度场分布,计算得到桩–土界面法向温度应力,建立考虑温度影响的桩–土界面荷载传递模型。同时,选取宁波地区典型软黏土开展不同温度下能源桩承载力特性模型试验,将计算结果与模型试验结果进行对比,结果表明:升温有助于提高能源桩单桩的承载力;桩周土温度、Q-s曲线计算结果与实测值较为一致,验证了能源桩桩–土界面荷载传递模型的合理性;能源桩运行使得桩、土体温度升高,桩、土之间的法向应力增大,相同条件下能源桩上部(0.7 m以上)桩侧摩阻力随温度的升高(30℃→45℃→60℃)有一定的增大,发挥充分,下部反之。

关键词：桩基础能源桩桩-土界面荷载传递模型侧摩阻力

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特殊工况下采煤机截割稳态特性的研究

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机械管理开发 2020年第7期35卷 132-133页

作者：郑艳栋大同煤炭集团有限公司安全监管五人小组管理部山西大同037003

针对采煤机在特殊工况过程中出现的稳定性差、易过载的现状,以MG100型采煤机为研究对象,利用MATLAB仿真分析软件对其进行仿真分析,结果表明在特殊工况下采煤机的截割系统均会产生剧烈的耦合冲击,导致采煤机的截割系统出现较大的非线性... 详细信息

针对采煤机在特殊工况过程中出现的稳定性差、易过载的现状,以MG100型采煤机为研究对象,利用MATLAB仿真分析软件对其进行仿真分析,结果表明在特殊工况下采煤机的截割系统均会产生剧烈的耦合冲击,导致采煤机的截割系统出现较大的非线性冲击作用,因此在采煤机设计中应加大截割系统的安全使用系数,确保在不同工况下的使用稳定性。

关键词：采煤机电机堵转稳定性

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