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Anomalous enhancement oxidation of few-layer MoS_(2)and MoS_(2)/h-BN heterostructure

Nano Research 2022年第8期15卷 7081-7090页

作者： Siming Ren yanbin shi Chaozhi Zhang Mingjun Cui Jibin Pu Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Key Laboratory of Impact and Safety Engineering Ministry of Education of ChinaSchool of Mechanical Engineering and MechanicsNingbo UniversityNingbo 315211China

Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial *** employ a precision muffle furnace at a series of increasing temperatures up to 340℃to study the oxidation behavior of continuous MoS_(2)films by either directly growing mono-and fewlayer MoS_(2)on SiO_(2)/Si substrate,or by mechanically transferring monolayer MoS_(2)or hexagonal boron nitride(h-BN)onto monolayer MoS_(2)*** show that monolayer MoS_(2)can withstand high temperature at 340℃with less oxidation while the few-layer MoS_(2)films are completely oxidized just at 280℃,resulting from the growth-induced tensile strain in few-layer MoS_(2).When the tensile strain of films is released by transfer method,the stacked few-layer MoS_(2)films exhibit superior thermal stability and typical layer-by-layer oxidation behavior at similarly high ***,for the MoS_(2)/h-BN heterostructure,the h-BN film itself stacked on top is not damaged and forms many bubbles at 340℃,whereas the underlying monolayer MoS_(2)film is oxidized *** comprehensively using various experimental characterization and molecular dynamics calculations,such anomalous oxidation behavior of MoS_(2)/h-BN heterostructure is mainly due to the increased tensile strain in MoS_(2)film at elevated temperature.

关键词： molybdenum disulfide hexagonal boron nitride heterostructure enhancement oxidation tensile strain

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Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

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Signal Transduction and Targeted Therapy 2020年第1期5卷 279-293页

作者： Xianglei Fu yanbin shi Tongtong Qi Shengnan Qiu Yi Huang Xiaogang Zhao Qifeng Sun Guimei Lin Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012 ShandongChina School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353 ShandongChina The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250033 ShandongChina

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final *** optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in ***,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular *** this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise ***,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.

关键词： therapeutic drugs precise

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The Cloud theory and its applications in the Spatial Data Mining and Knowledge Discovery

The Cloud theory and its applications in the Spatial Data Mi...

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2011 International Conference on Agricultural and NaturalResources Engineering (ANRE 2011)

作者： shi yanbin Dept.Electronic Engineering Aviation University of Air force

Cloud theory is a new theory handling uncertainty based on the uncertain transition between quality and quantityThe theory includes cloud model, virtual cloud, cloud operation, cloud transform and uncertainty reasoningIt provides new solutions for many basic problems in data mining and knowledge discovery, such as concept and knowledge representation, transition between quality and quantity, concept synthesization and resolution, concept and concept hierarchy generation from data, etcClod model is a model of the uncertain transition between a linguistic term of a qualitative concept and its numerical representationCloud model represents a qualitative concept with three digital characteristics, expected value, entropy and hyper entropy, which integrate the fuzziness and randomness of a linguistic term in a unified wayThis paper presents the fundamentals of cloud theory and its applications in spatial data mining and knowledge discovery, focusing on the cloud models and their algorithms.

关键词： Cloud model Spatial data mining and knowledge discovery Concept hierarchy

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Research and application of leek roots in medicinal field

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Chinese Herbal Medicines 2023年第3期15卷 391-397页

作者： Huaijian Wang Ying Tian Hao Tan Mengru Zhou Miao Li Yuchen Zhi yanbin shi Xuefeng Li School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000China School of Pharmacy Lanzhou UniversityLanzhou 730000China

Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food *** Chinese herbs are potential resource for research and development of new *** roots is a typical medicine of food and medicine *** has a long history of medicinal applications and edible food in *** this paper,the origin,biological active components,pharmacological action and clinical application of leek roots were *** hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications,as well as related health products.

关键词： Allium tuberosum Rottl.ex Spreng clinical application leek roots traditional Chinese medicine pharmacology

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柞蚕(幼虫)中β-蜕皮激素提取工艺的优化

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农业工程学报 2006年第5期22卷 173-175页

作者：阮美娟石艳宾天津科技大学食品工程与生物技术学院天津300457

应用响应面分析法研究温度、乙醇浓度、料液比和时间对柞蚕中β-蜕皮激素提取的影响。以β-蜕皮激素的得率为衡量指标,确定提取的最佳工艺参数为:提取温度80℃、40%乙醇溶液、料液比1∶20、提取时间2.5 h。按此最佳工艺条件提取β-蜕皮... 详细信息

应用响应面分析法研究温度、乙醇浓度、料液比和时间对柞蚕中β-蜕皮激素提取的影响。以β-蜕皮激素的得率为衡量指标,确定提取的最佳工艺参数为:提取温度80℃、40%乙醇溶液、料液比1∶20、提取时间2.5 h。按此最佳工艺条件提取β-蜕皮激素,用HPD 600型大孔树脂分离、纯化,冷冻干燥得β-蜕皮激素的提取物,经紫外分光光度法测定,β-蜕皮激素的得率为0.0842%。

关键词：柞蚕 β-蜕皮激素提取响应面分析

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Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 115-130页

作者： Xianglei Fu yanbin shi Zili Gu Hengchang Zang Lian Li Qingjie Wang Yongjun Wang Xiaogang Zhao Hang Wu Shengnan Qiu Yankun Zhang Jiamin Zhou Xiangqin Chen Hua Shen Guimei Lin Department of Pharmaceutics School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Department of Radiology Leiden University Medical CenterAlbinusdreef 22333 ZA LeidenNetherlands NMPA Key Laboratory for Technology Research and Evaluation of Drug Products School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Laboratory of Basic Medical Sciences Qilu HospitalShandong UniversityJinan 250063China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Thoracic Surgery The Second Hospital of Shandong UniversityJinan 250033China

Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment *** this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during ***,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in *** applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like ***,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell *** data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single ***@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers.

关键词： Liposome Hydrogel Signal transducer and activator of transcription 3 Non-small cell lung cancer Macrophage

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Development, optimization and in vitro–in vivo evaluation of sustained-release granules of Dan′an mixture

Development, optimization and in vitro–in vivo evaluation o...

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2018年第十二届中国药物制剂大会

作者：陈娜娜 yanbin shi Jing′e Niu Haoyue Xue School of Pharmacy Lanzhou University

This study aimed to develop sustained-release granules of Dan′an mixture（SRG-DM） thereby improving bioavailability of Dan′an mixture（DM） which is an effective herbal medicine against chronic cholecystitis. SRG-DM was made using tragacanth gum（TG）, chitosan（CS） and ethylcellulose（EC） as retardants. Response surface methodology combined with Box-Behnken experimental design was applied to optimize the SRG-DM formulation. The in vitro and in vivo sustained-release properties of the optimized SRG-DM were separately evaluated in simulated biological fluids and by pharmacokinetic study in rabbits, respectively. The optimal SRG-DM formulation consisted of mass ratio of 67.98% freeze-dried DM powder, 5% TG, 14.48% CS and 12.54% EC. The gel layer was formed by TG and CS on the surface of insoluble skeleton（EC） to delay drug release. Baicalin release from SRG-DM in acid solution was slower than that in alkaline solution. The release mechanism of baicalin from SRG-DM was fitted to first-order in pH 1.2 and 7.0 dissolution medium, while followed the Fickian diffusion in pH 6.8 and 7.4. The biological half-time（t1/2） of SRG-DM was approximately two times longer than that of DM. The mean resident time（MRT） of SRGDM was prolonged significantly（42.06±5.25 h） compared to that of DM（14.32±1.7 h）. The area under the curve（AUC） of SRG-DM is approximately 3.5-fold higher than that of DM. The newly developed SRG-DM can effectively sustain the release of marker compound of baicalin, thus improving bioavailability of baicalin. SRG-DM is promising to be an alternative dose form to Dan′an mixture in practice.

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嵌入式学科服务:泛在知识环境下学科服务创新的新高地

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图书馆 2013年第6期 118-119页

作者：施燕斌敬丹榕国防科技大学图书馆湖南长沙410073 中南大学湘雅医学院湖南长沙410000

文章分析了泛在知识环境下图书馆服务泛在化、智能化和交流共享便捷等特点,借助国内图书馆嵌入式学科服务案例,从嵌入式咨询服务、嵌入式教学服务、嵌入式科研服务三个方面,对泛在知识环境背景下,图书馆嵌入式学科服务创新模式进行了探讨。

关键词：泛在知识环境泛在图书馆嵌入式学科服务图书馆服务

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New Approaches to Numerical Simulation of Two-Component Droplet Evaporation

New Approaches to Numerical Simulation of Two-Component Drop...

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2011 International Conference on Materials for Renewable Energy & Environment(ICMREE 2011)

作者： Lili Zhang yanbin shi School of Mechanical Engineering Shandong polytechnic University Jinan China

In order to indicate the droplet evaporating process directly,a new evaporation model for the drying of a single solution droplet into a solid,dense particle is present,taking account of the changing of temperature gradient and concentration *** are made to achieve a more fundamental understanding of the coupled relationship of solvent percentage,droplet specific heat,saturated vapor pressure and solvent diffusion *** to the moving boundary problem,the numerical method of droplet evaporation is constructed by the mesh-reconstruction technology,and the visualization of the simulation results is realized by *** the evaporation process of drop and ammonium nitrate solution for example,the transient variations of drop diameter,inner temperature gradient,inner solute concentration gradient are analyzed under different gas temperature and flow *** predictions are in good agreement with the experimental data,indicating that the model describes the most important physical phenomena of the evaporating process.

关键词： droplet specific heat saturated vapor pressure solvent diffusion coefficient,coupling moving boundary transient change

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小子样全寿命试验研究

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中国机械工程 2005年第13期16卷 1129-1132,1137页

作者：陈举华史岩彬安艳秋山东大学济南250061

针对机械系统中关键零件全寿命试验获取样本困难,提出两种小子样预测寿命方法,即模糊贴近度法和灰关联分析法。介绍了某材料齿轮大样本概率试验及基于概率论、模糊数学理论,通过已知概率分布的寿命大样本,开发寿命概率分布未知的小子样... 详细信息

针对机械系统中关键零件全寿命试验获取样本困难,提出两种小子样预测寿命方法,即模糊贴近度法和灰关联分析法。介绍了某材料齿轮大样本概率试验及基于概率论、模糊数学理论,通过已知概率分布的寿命大样本,开发寿命概率分布未知的小子样系统。利用系统的辅助信息,改变以消耗大量资源为代价的概率全寿命试验方法为小子样全寿命试验方法。利用两个工程应用实例加以验证。

关键词：小子样全寿命模糊贴近度灰关联分析

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