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Chinese Chemical Letters 2024年第4期35卷 481-485页

作者： Qiongqiong Wan yanan xiao Guifang Feng Xin Dong Wenjing Nie Ming Gao Qingtao Meng Suming Chen The Institute for Advanced Studies Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China

There is a close relationship between the biological functions of lipids and their structures, and various isomers greatly increases the complexity of lipid structures. The C=C bond location and sn-position are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Here, we develop a visible-light-activated aziridination reaction system, which enables the dual-resolving of the C=C bond location and sn-position isomerism of in lipids when combines with liquid chromatography-mass spectrometry(LC-MS). Based on the derivatization of C=C bonds with Ph I=NTs, their location in lipids could be easily identified by tandem MS. Especially, the sn-position isomers of unsaturated phosphatidylcholine(PC) can be separated and quantified by LC-MS after the derivatization. By using the proposed method, the significant changes of the sn-position isomers ratios of PC in mouse brain ischemia were revealed. This study offers a powerful tool for deep lipid structural biology.

关键词： Aziridination Lipid isomers C=C bond location sn-Position Mass spectrometry

Sarcocinerenoids A—J,Eight Rare Capnosane-Type and Two New Cage-Type Cembranoids with Promoting Angiogenesis Activity from the South China Sea Soft Coral Sarcophyton cinereum

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Chinese Journal of Chemistry 2024年第8期42卷 815-822页

作者： Yue Mi yanan Yang Xuli Tang xiao Han Guoqiang Li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong266003 China Laboratory of Marine Drugs and Biological Products National Laboratory for Marine Science and TechnologyQingdaoShandong266235 China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdaoShandong266100 China

Backgroundand Originality Content,Cembranoids are a structurally diverse class of diterpenoids commonly occurring in marine and terrestrial organisms.(+)-Cembrene was the first reported cembranoid diterpenoid discovered in 1962,l and more than 1400 cembranoid diterpenoids have been identified in the last six decades,[2]Cembranoids are characterized by a 14-membered carbocyclic ring,an isopropyl group and three methyl groups,which form their core carbon skeleton.Enzymatic processes such as oxidation,oxidative rearrangements and transannular cyclizations occur in organisms,leading to the formation of distinctive specialized metabolites such as epoxide,lactone,ester,furan,pyrane and other ringbased cembranoids.[2-3]

关键词： Soft coral Sarcophyton cinereum Capnosane-type cembranoids Absolute configurations Activities Natural products NMR spectroscopy Liquid chromatography X-raydiffraction Chiral resolution

Multi-omics analyses of G6PD deficiency variants in Chinese population

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Journal of Genetics and Genomics 2024年第1期51卷 100-104页

作者： He Ji Jiahuan Chen Peide Huang Zhimin Feng Weining Hu Mengyao Dai xiaohui Sun xiao Jin Guangquan Chen Guang Ning Lin Li Weiqing Wang yanan Cao Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesNational Clinical Research Centre for Metabolic DiseasesState Key Laboratory of Medical GenomicsResearch Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical SciencesRuijin Yangtze River Delta Health InstituteWuxi Branch of Ruijin HospitalRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China National Research Center for Translational Medicine National Key Scientific Infrastructure for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China SJTU-BGI Innovation Research Center Shanghai 200240China BGI-ShenZhen ShenzhenGuangdong 518083China

Glucose-6-phosphate dehydrogenase(G6PD)deficiency is one of the most prevalent hereditary and X-linked enzyme disorders caused by the pathogenetic G6PD(NM_001042351.2)variants(Yang et al.,2016).The clinical manifestations of G6PD deficiency offer a wide spectrum of diverse disease phenotypes(Hecker et al.,2013).Investigations of prevalence and molecular epidemiology demonstrate that G6PD deficiency affects over 400 milion individuals worldwide and leads to thousands of deaths annually(Mortality and Causes of Death,2015).

关键词： al. G6PD epidemiology

农户视角下乡村感知韧性的作用机制及提升路径——以山东省曲阜市为例

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地理学报 2024年第2期79卷 321-336页

作者：王亚男吕晓张学波东北大学文法学院沈阳110169 曲阜师范大学地理与旅游学院日照276826

从感知韧性视角提升乡村可持续发展能力对全面推进乡村振兴至关重要。本文基于乡村感知韧性概念内涵,从“压力—状态—感知—行为—响应”层面论述乡村感知韧性的运作逻辑,并基于山东省曲阜市3镇12村的农户调查问卷数据,从“状态—感知... 详细信息

从感知韧性视角提升乡村可持续发展能力对全面推进乡村振兴至关重要。本文基于乡村感知韧性概念内涵,从“压力—状态—感知—行为—响应”层面论述乡村感知韧性的运作逻辑,并基于山东省曲阜市3镇12村的农户调查问卷数据,从“状态—感知”“行为—响应”视角构建指标体系,在评估乡村感知韧性的同时,运用结构方程模型论证乡村感知韧性作用机制。结果表明:(1)乡村感知韧性是指乡村系统依靠其资源要素水平,促使农户主动利用乡村资源预测、吸收、适应乡村变化,推动乡村要素结构重组和生产生活方式变革的能力;(2)社会网络多元化响应和生产建设状态已经成为乡村感知韧性的主要组成部分,而生计多样化和物质资本富裕化的响应路径未完全形成;(3)乡村系统响应压力的方式能否促进传统乡村向现代化转型取决于农户对乡村状态的感知和行为决策,农户对乡村状态的感知越好,其越偏向主动利用资源促进乡村要素结构重组,从根本上实现乡村转型发展;(4)应从空间治理优化、促进“状态—感知”到“行为—响应”的转化、精准调控乡村“压力”等方面出发,提高乡村感知韧性。

关键词：乡村韧性农户满意度压力—状态—感知—行为—响应乡村感知韧性曲阜市

Elucidating the Molecular Mechanism of Dynamic Photodamage of Photosystem II Membrane Protein Complex by Integrated Proteomics Strategy

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CCS Chemistry 2022年第1期4卷 182-193页

作者： Ye Zhou Zheyi Liu Mingdong Yao Jun Chen yanan xiao Guangye Han Jian-Ren Shen Fangjun Wang CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023 State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023 Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjin 300072 Science and Technology on Surface Physics and Chemistry Laboratory Jiangyou 621908 University of Chinese Academy of Sciences Beijing 100049 Photosynthesis Research Center Key Laboratory of PhotobiologyInstitute of BotanyChinese Academy of SciencesBeijing 100093 Research Institute for Interdisciplinary Science Graduate School of Natural Science and TechnologyOkayama UniversityOkayama 700-8530

Photosystem II(PSII),as a multiple-subunit chloroplast membrane-associated pigment-protein complex on the thylakoid membrane,is a primary target of light-induced photodamage.However,the overall molecular details of the conformation and composition dynamics of PSII photodamage are still controversial.In this study,we investigated systematically the dynamic conformation,degradation,and oxidation processes of PSII photodamage by integrating chemical cross-linking and top-down proteomics strategies.

关键词： photosystem II dynamic photodamage chemical cross-linking top-down proteomics mass spectrometry

Study on Toughening Phenolic Foams in Phosphorus-Containing Tung Oil-Based Derivatives

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Journal of Renewable Materials 2019年第10期7卷 1011-1021页

作者： Fei Song Puyou Jia yanan xiao Caiying Bo Lihong Hu Yonghong Zhou Institute of Chemical Industry of Forest Products Chinese Academy of Forestry(CAF)National Engineering Laboratory for Biomass Chemical UtilizationCo-Innovation Center of Efficient Processing and Utilization of Forest ResourcesKey Laboratory of Chemical Engineering of Forest ProductsNational Forestry and Grassland AdministrationKey Laboratory of Biomass Energy and MaterialsNanjing210042China School of Petroleum and Chemical Engineering Dalian University of TechnologyDalian124221China

Phenolic foams(PFs)as thermal insulation material with outstanding flame retardancy are required to match society’s ever-expanding safety expectations;however,a trade-off exists between flame retardancy and toughness.Here,for the first time,we synthesized a novel reactive phosphorus-containing tung-oil-based derivative and used it to toughen PF,resulting in PFs with a combination of excellent mechanical properties and flame retardancy.Compared with pure PF,the modified PFs exhibit enhanced mechanical properties,with specific compressive and flexural strengths as high as 5.67 MPa and 12.46 MPa,which represent increases of 90.67%and 178.7%over those of pure PF,respectively.Meanwhile,the limiting oxygen index(LOI)values of the modified PFs are improved as much as 40.83%.Scanning electron microscopy micrographs show that the microstructure of the modified PFs is better than that of pure PF,with a more uniform cell morphology,a narrower pore size distribution range,and a smaller average pore size,all of which are beneficial to the foam’s mechanical properties.This study provides a scientific paradigm for the development of advanced PFs based on renewable biological resources.

关键词： Tung oil phenolic foams toughen mechanical properties LOI

Future climate change decreases multi-pathway but increases respiratory human health risks of PAHs across China

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National Science Open 2024年第2期3卷 128-147页

作者： Jiaao Bao Xinghui Xia Ying Zhu Bingxiang Zhao Erxue Gu yanan Liu xiao Yun Zhenrui Zhang Nannan Xi Yong Geng Ying Xu Zhifeng Yang Derek C.G.Muir Key Laboratory of Water and Sediment Sciences of Ministry of Education State Key Laboratory of Water Environment SimulationSchool of EnvironmentBeijing Normal UniversityBeijing 100875China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Urban and Environmental Sciences Laboratory for Earth Surface ProcessesSino-French Institute for Earth System SciencePeking UniversityBeijing 100871China National Climate Center China Meteorological AdministrationBeijing 100081China Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education Institute of Environmental and Ecological EngineeringGuangdong University of TechnologyGuangzhou 510006China Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlington L7S 1A1Canada

Future climate change will affect the environmental fate of hydrophobic organic contaminants(HOCs)and associated human health risks,yet the extent of these effects remains unknown.Here,we couple a high-resolution environmental multimedia model with a bioaccumulation model to study the multimedia distribution of 16 priority polycyclic aromatic hydrocarbons(PAHs),a group of HOCs,and assess future PAH-related human health risks under varying climate change scenarios over China at a continental scale.After removing the effects of PAH emission changes,we find that the total PAH concentrations would decrease in the air,freshwater,sediment,soil,and organisms,while the high-molecular-weight PAH would increase in the air with climate warming from 1.5°C to 4°C.Consequently,the multi-pathway exposure human health risks predominately influenced by dietary ingestion are expected to decrease by 1.7%–20.5%,while the respiratory risks are projected to rise by 0.2%–5.8%in the future.However,the persistently high multi-pathway human health risks underscore the need for reducing future PAH emissions by 69%compared with 2009 levels in China.Our study demonstrates the urgency of limiting PAH emissions under future climate change for public health and highlights the importance of including the contribution of dietary ingestion in human health risk assessment.

关键词： polycyclic aromatic hydrocarbons future climate change human health risks emission reduction

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基于土地类型的西峡县农用地适宜性评价

中国农业资源与区划 2024年第1期45卷 45-56页

作者：李潇吴克宁刘亚男高先虎中国地质大学(北京)土地科学技术学院北京100083 自然资源部土地整治重点实验室北京100035 扬州大学商学院江苏扬州225125

[目的]土地类型反映了自然地理特征的同质性。为做好农用地保护工作,贯彻落实党中央、国务院及自然资源部关于“宜耕则耕”“宜园则园”“宜林则林”等要求,有必要开展以土地类型为单元的农用地适宜性评价研究。[方法]文章首先,在构建... 详细信息

[目的]土地类型反映了自然地理特征的同质性。为做好农用地保护工作,贯彻落实党中央、国务院及自然资源部关于“宜耕则耕”“宜园则园”“宜林则林”等要求,有必要开展以土地类型为单元的农用地适宜性评价研究。[方法]文章首先,在构建的西峡县土地类型的三级分类框架的基础上,采用自上而下的叠置法与自下而上的合并法划分土地类型。其次,以土地类型的最小单元为评价单元,综合自然条件、社会经济和生态环境因素,分别建立了针对耕地、园地和林地的适宜性评价体系。最后,运用层次分析法和加权求和法相结合的方法评价西峡县各类农用地的适宜性。[结果](1)西峡县的土地类型有3个等级,包括14个土地类、299个土地亚类和570个土地单元。(2)西峡县86%以上的区域为林地适宜区,约47%的区域适宜园地,而只有13%的区域适宜耕地。(3)各类农用地的高度适宜区(S1)主要分布于研究区南部河流谷地地带。各类农用地的勉强适宜区(S3)在空间分布不均匀,且研究区北部的大部分山地区域均不适宜(N)作为耕地。[结论]基于土地类型的适宜性评价可以识别潜在适宜作为农业利用的土地,并可为农用地的布局优化提供参考。

关键词：土地类型划分适宜性评价农用地伏牛山地区布局优化

宫腔观察吸引手术技术在剖宫产瘢痕妊娠治疗中应用的初探

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中华生殖与避孕杂志 2024年第1期44卷 73-76页

作者：史亚楠王晓高艳飞单淑芝江静石彬河北医科大学第二医院妇产科石家庄050000

目的了解宫腔观察吸引手术技术在剖宫产瘢痕妊娠(cesarean scar pregnancy,CSP)治疗中的应用效果及安全性。方法回顾性分析2019年4月至2022年6月期间于河北医科大学第二医院妇产科采用宫腔观察吸引手术技术作为初始治疗的7例CSP患者的... 详细信息

目的了解宫腔观察吸引手术技术在剖宫产瘢痕妊娠(cesarean scar pregnancy,CSP)治疗中的应用效果及安全性。方法回顾性分析2019年4月至2022年6月期间于河北医科大学第二医院妇产科采用宫腔观察吸引手术技术作为初始治疗的7例CSP患者的临床资料。所有患者均使用一次性摄像吸引管同步观察吸引,术前3 h放置一次性宫颈扩张器,术后3 d复查血β-人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)及超声检查,必要时进行宫腔镜治疗。结果7例CSP患者中Ⅰ型3例,Ⅱ型4例,年龄为(33.9±4.7)岁,范围为27~40岁,停经时间范围为38~47 d,中位时间是43 d。所有患者手术过程均顺利,术中中位出血量30 mL,术后中位出血量20 mL,术后中位出血时间3 d,无子宫穿孔和术中大出血发生,术后所有患者血β-hCG均下降满意,6例复查超声未见明显异常,1例Ⅱ型患者因超声提示瘢痕部位强回声伴随丰富血流信号行宫腔镜电切术。结论宫腔观察吸引手术技术借助其内置于吸引管头端的高清摄像头,能真正做到观察与吸引同步,有望应用于停经≤47 d的Ⅰ型及部分Ⅱ型CSP的治疗。

关键词：剖宫产瘢痕妊娠宫腔观察吸引手术技术一次性摄像吸引管

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麻醉药物对术后睡眠障碍影响的研究进展

医学研究与战创伤救治 2024年第4期37卷 439-443页

作者：肖悦曹雅男(综述) 胡益民(审校) 南京医科大学附属常州第二人民医院麻醉科常州213003

保持人体生理和心理功能的正常运作,需要遵循规律的睡眠模式和周期,而围手术期出现的睡眠障碍近年来关注度也不断提升。全身麻醉会改变睡眠结构,导致睡眠障碍,继而可能会引起患者痛觉过敏、术后恢复不良等情况。越来越多的证据表明,围... 详细信息

保持人体生理和心理功能的正常运作,需要遵循规律的睡眠模式和周期,而围手术期出现的睡眠障碍近年来关注度也不断提升。全身麻醉会改变睡眠结构,导致睡眠障碍,继而可能会引起患者痛觉过敏、术后恢复不良等情况。越来越多的证据表明,围手术期的多种因素与术后的睡眠障碍相关,全麻药物作为一个独立危险因素可能导致全身麻醉后的睡眠障碍。文章主要以临床实验和基础实验,就不同的麻醉药物对患者术后睡眠阶段及睡眠质量的影响进行综述。

关键词：全身麻醉麻醉药物睡眠障碍