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关于检验住培基地分年度递进式培养模式的实践与思考

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标记免疫分析与临床 2024年第1期31卷 185-188页

作者：罗盈邸玉玮孟玥陈敏静姚亚男李晖甘慧泉顾兵南方医科大学附属广东省人民医院(广东省医学科学院)检验科广州510000

目的探讨检验住培基地对分年度递进式的培养模式如何具体实施,为检验基地教学管理者提供参考。方法从住培基地轮转制度、教学活动、考核方式、师资管理、日常活动多维度的构建递进式的培养模式。对检验住培基地的二年级和三年级学员的... 详细信息

目的探讨检验住培基地对分年度递进式的培养模式如何具体实施,为检验基地教学管理者提供参考。方法从住培基地轮转制度、教学活动、考核方式、师资管理、日常活动多维度的构建递进式的培养模式。对检验住培基地的二年级和三年级学员的形态学、技能操作、检验结果判读、人文沟通、临床思维5个方面进行了考核,分析比较不同学年学员不同学科的成绩;比较递进式培养模式实施前后学员的住培结业考成绩;并对在培学员进行问卷性调查。结果三年级学员在形态学、技能操作成绩略高于二年级学员,而检验结果判读、人文沟通、临床思维方面显著高于二年级学员。自2019年实施递进式培养模式后,住培学员结业考成绩显著提高。学员对本基地递进式培养模式的实施给了较高的评分,师资培训方面还需加强。结论检验基地递进式培养模式的建立需要教学管理者与全体师资共同合作,多方面落实。科学构建递进式培养模式有助达到培养高质量检验医师的总目标。

关键词：住培检验基地分年度递进式

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关于精准发现问题狠抓落实的实践与思考

江汉石油职工大学学报 2024年第3期37卷 97-98页

作者：罗冰中国石油长庆油田分公司坪北石油合作开发项目经理部陕西延安717408

在全面从严治党的大背景下,精准发现问题狠抓落实不仅是治标之策的深化,更是治本之道的体现。通过严肃党内政治生活、加强中央八项规定精神贯彻落实、强化选人用人制度建设、推动形成常态长效机制等措施办法,精准发现治理管党治党不严... 详细信息

在全面从严治党的大背景下,精准发现问题狠抓落实不仅是治标之策的深化,更是治本之道的体现。通过严肃党内政治生活、加强中央八项规定精神贯彻落实、强化选人用人制度建设、推动形成常态长效机制等措施办法,精准发现治理管党治党不严、纪律作风宽松软、选人用人风气不正等方面的突出问题,从而营造风清气正的良好政治生态,为企业高质量发展提供坚强的纪律保证。

关键词：党风企风监督执纪长效机制

不同见习模式在医学诊断学免疫及生化课程的探索和思考

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标记免疫分析与临床 2024年第1期31卷 181-184页

作者：陈敏静姚亚男刘长钰甘慧泉黄锦维廖亚龙顾兵罗盈南方医科大学附属广东省人民医院(广东省医学科学院) 广东广州510080

目的旨在探究不同教育模式对于见习教学实践的影响,为见习教育模式创新提供支持。通过对传统教育(lecture based learning, LBL)模式与混合式教育(blended learning, BL)模式对比研究,探究其优缺点及适用场景,促进教育教学模式的创新... 详细信息

目的旨在探究不同教育模式对于见习教学实践的影响,为见习教育模式创新提供支持。通过对传统教育(lecture based learning, LBL)模式与混合式教育(blended learning, BL)模式对比研究,探究其优缺点及适用场景,促进教育教学模式的创新。方法选择华南理工大学临床专业见习学生96人,通过对LBL和BL不同模式的见习教学的研究,深入分析不同教学模式的特点及应用效果。结果通过从实践案例可以看出,LBL模式学生学到的知识更全面,考核成绩更理想;而BL模式学生参与度更高,对课程的评价更好。将不同教学模式有机结合可以使见习教学实践更具有成效。结论不同教学模式在不同情境中具有不同的优劣势,应根据情境选择适当的教学模式。为今后的见习教学模式创新指明了方向。

关键词：传统教育混合式教育见习教学实践

川中地区中二叠统栖霞组优质白云岩储层特征及发育模式

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天然气勘探与开发 2024年第1期47卷 12-23页

作者：徐会林罗文军杨东凡兰雪梅杨亚男闫梦楠付蕾唐思哲中国石油西南油气田公司勘探开发研究院四川成都610041

四川盆地中部地区(简称“川中地区”)中二叠统栖霞组白云岩储层薄、非均质性强,白云岩储层发育模式尚不完全明确,亟须准确掌握白云岩储层特征及发育模式,以期实现川中地区栖霞组强非均质性薄储层效益开发。基于川中地区栖霞组实钻井的... 详细信息

四川盆地中部地区(简称“川中地区”)中二叠统栖霞组白云岩储层薄、非均质性强,白云岩储层发育模式尚不完全明确,亟须准确掌握白云岩储层特征及发育模式,以期实现川中地区栖霞组强非均质性薄储层效益开发。基于川中地区栖霞组实钻井的岩心观察、薄片鉴定、阴极发光和地球化学分析等方法,对白云岩储层特征及发育模式进行研究。研究结果表明:①川中地区霞组为滩相白云岩储层,储层岩性以细—中晶残余砂屑云岩为主;②白云岩储层单层厚度薄,平均单井厚度仅5.8 m,低孔隙度、低渗透率,可划分为裂缝-孔洞型、孔洞型和孔隙型3种类型,其中裂缝-孔洞型、孔洞型为优质白云岩储层;③颗粒滩是白云岩储层发育的物质基础,滩体受到准同生期岩溶作用和准同生期白云石化作用形成白云岩储层,在埋藏期断裂系统进一步叠加改造白云岩储层从而形成更加优质的缝洞发育的白云岩储层,即“滩体控有无、白云石化控规模、断裂控品质”的“三控”优质白云岩储层发育机理。结论认为:川中地区栖霞组白云岩储层存在“高能滩相+准同生期岩溶作用和准同生期白云石化作用”“高能滩相+准同生期岩溶作用和准同生期白云石化作用+断裂叠加改造作用”两种优质白云岩储层发育模式。

关键词：准同生白云石化准同生期岩溶作用优质白云岩储层发育模式栖霞组川中地区

Study of Furoxan Derivatives for Energetic Applications

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Chinese Journal of Chemistry 2013年第4期31卷 520-524页

作者： yanan Li Zhizhong Zhang Zhongxue Ge BozhouWang Weipeng Lai Yifen luo Xi'an Modern Chemistry Research Instritute Xi'an Shannxi 710065 China

Two novel energetic compounds, 3,4-bis（1＇,2＇,4＇-triazole-3＇-yl）furoxan （BTAF） and 3,4-bis（1＇-nitro-l＇,2＇,4＇-tri- azole-3＇-yl）furoxan （BNTAF）, were prepared and their structures were characterized by IR, ^1H NMR, ^13C NMR, MS techniques and elemental analysis. The properties of BTAF and BNTAF were estimated. The predicted per- formance data of BTAF are as follows： density （measured） is 1.75 g/cm3, nitrogen content 50.9%, detonation veloc- ity 7277 m/s, detonation pressure 20.1 GPa and enthalpy of formation ＋419.7 kJ/mol. The predicted performance data of BNTAF are as follows： density is 1.84 g/cm3, nitrogen content 45.2%, enthalpy of formation ＋841.5 kJ/mol, detonation velocity 8490 rn/s and detonation pressure 32.4 GPa. The main themal properties of BTAF and BNTAF were analyzed by DSC and TG techniques, the results show that BTAF melts with concomitant decompo- sition at 188.8℃, the melting point of BNTAF is at 99.2 ℃ and its first decomposition temperature is 139.2 ℃.

关键词： furoxanes triazoles N-nitration energetic materials

Time-Programmed Delivery of Sorafenib and Anti-CD47 Antibody via a Double-Layer-Gel Matrix for Postsurgical Treatment of Breast Cancer

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Nano-Micro Letters 2021年第9期13卷 223-237页

作者： Liping Huang Yiyi Zhang yanan Li Fanling Meng Hongyu Li Huimin Zhang Jiasheng Tu Chunmeng Sun Liang luo College of Life Science and Technology National Engineering Research Center for NanomedicineHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Natural Medicines NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipientsand Department of PharmaceuticsSchool of PharmacyChina Pharmaceutical University24 Tong Jia XiangNanjing 210009China Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023People’s Republic of China

The highly immunosuppressive microenvironment after surgery has a crucial impact on the recurrence and metastasis in breast cancer patients.Programmable delivery of immunotherapy-involving combinations through a single drug delivery system is highly promising,yet greatly challenging,to reverse postoperative immunosuppression.Here,an injectable hierarchical gel matrix,composed of dual lipid gel(DLG)layers with different soybean phosphatidylcholine/glycerol dioleate mass ratios,was developed to achieve the time-programmed sequential delivery of combined cancer immunotherapy.The outer layer of the DLG matrix was thermally responsive and loaded with sorafenib-adsorbed graphene oxide(GO)nanoparticles.GO under manually controlled near-infrared irradiation generated mild heat and provoked the release of sorafenib first to reeducate tumor-associated macrophages(TAMs)and promote an immunogenic tumor microenvironment.The inner layer,loaded with anti-CD47 antibody(aCD47),could maintain the gel state for a much longer time,enabling the sustained release of aCD47 afterward to block the CD47-signal regulatory proteinα(SIRPα)pathway for a long-term antitumor effect.In vivo studies on 4T1 tumor-bearing mouse model demonstrated that the DLG-based strategy efficiently prevented tumor recurrence and metastasis by locally reversing the immunosuppression and synergistically blocking the CD47-dependent immune escape,thereby boosting the systemic immune responses.

关键词： Hierarchical hydrogel Sorafenib Postoperative immunosuppression reversal Tumor-associated macrophages Anti-CD47 antibody

Natural Cocoons Enabling Flexible and Stable Fabric Lithium–Sulfur Full Batteries

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Nano-Micro Letters 2021年第5期13卷 204-217页

作者： yanan An Chao luo Dahua Yao Shujing Wen Peitao Zheng Shangsen Chi Yu Yang Jian Chang Yonghong Deng Chaoyang Wang Research Institute of Materials Science South China University of TechnologyGuangzhou 510640China Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Energy Materials for Electric PowerSouthern University of Science and TechnologyShenzhen 518055China College of Materials and Energy Guangdong Laboratory for Lingnan Modern AgricultureSouth China Agricultural UniversityGuangzhou 510642China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China

Lithium–sulfur batteries are highly appealing as highenergy power systems and hold great application prospects for flexible and wearable electronics.However,the easy formation of lithium dendrites,shuttle effect of dissolved polysulfides,random deposition of insulating lithium sulfides,and poor mechanical flexibility of both electrodes seriously restrict the utilization of lithium and stabilities of lithium and sulfur for practical applications.Herein,we present a cooperative strategy employing silk fibroin/sericin to stabilize flexible lithium–sulfur full batteries by simultaneously inhibiting lithium dendrites,adsorbing liquid polysulfides,and anchoring solid lithium sulfides.Benefiting from the abundant nitrogen-and oxygen-containing functional groups,the carbonized fibroin fabric serves as a lithiophilic fabric host for stabilizing the lithium anode,while the carbonized fibroin fabric and the extracted sericin are used as sulfiphilic hosts and adhesive binders,respectively,for stabilizing the sulfur cathode.Consequently,the assembled Li–S full battery provided a high areal capacity(5.6 mAh cm−2),limited lithium excess(90%),a high volumetric energy density(457.2 Wh L^(−1)),high-capacity retention(99.8%per cycle),and remarkable bending capability(6000 flexing cycles at a small radius of 5 mm).

关键词： Lithium-sulfur batteries Flexible batteries Carbonized silk fabric Lithium dendrite Shuttle effect

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1901-1915页

作者： Shuxin Liang Changlei Bao Zi Yang Shiyun Liu yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangdong Key Laboratory of Vascular DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina College of Veterinary Medicine Northwest A&F UniversityYanglingShaanxiChina Department of Cellular Biology&Pharmacology Herbert Wertheim College of MedicineMiamiFLUSA Department of Environmental Health Sciences Robert Stempel College of Public Health and Social Work and Center for Translational ScienceFlorida International UniversityPort St.LucieFLUSA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisINUSA Department of Biology The Catholic University of AmericaWashingtonDCUSA Krannert Institute of Cardiology Department of MedicineIndiana UniversityIndianapolisINUSA Guangzhou Laboratory GuangzhouChina

Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets.

关键词： NLRP3 expression cardiopulmonary

Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction

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Neural Regeneration Research 2013年第28期8卷 2641-2648页

作者： yanan Zhang Sha Yang Xiaonong Fan Shu Wang Nina He Lingxin Li Ding luo Xuemin Shi First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture & Moxibustion Science Three-level Laboratory of Acupuncture Dose-Effect Relationship State Administration of Traditional Chinese Medicine Wuhai Hospital of Traditional Chinese Medicine Department of Rehabilitation Medicine West China Medical SchoolWest China Hospital Sichuan University Postgraduate School Tianjin University of Traditional Chinese Medicine

The individual difference and non-repeatability in acupuncture have not only restricted the devel- opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan （PC6） with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume. In- teractions between frequency and duration play a critical role in quantified acupuncture therapy.

关键词： neural regeneration acupoint quantified acupuncture Neiguan middle artery occlusion injury lift-ing and thrusting method orthogonal design lifting and thrusting frequency acupuncture duration grants-supported paper neuroregeneration