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Asian Journal of Andrology 2020年第6期22卷 547-548页

作者： Shu-Jie Liao yan-ying xu Rui-Juan Sun Qun-yan Lyu Department of Health Science National Natural Science Foundation of ChinaBeijing 100085China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

"Reproductive health"was officially defined as humans and their individual activities related to reproduction throughout their lives,which should be in good health in physical,psychological,and social aspects.1 The basic research on male reproductive health in China can be traced back to the 1960s.2 Since the National Natural Science Foundation of China(NSFC)began systematic support for basic research on male reproductive health in 1988,the field has been systematically developed in *** this regard,we analyze the role of the NSFC on the development of basic research in the field of male reproductive health in China.

关键词： NSFC China. field

Female Fertility： Is it Safe to Freeze.

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Chinese Medical Journal 2015年第3期128卷 390-397页

作者： Lu Zhang Li-ying yan xu Zhi Jie Yah Jie Qiao Department of Obstetrics and Gynecology Center for Reproductive Medicine Peking University Third Hospital Key Laboratory of Assisted Reproduction Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Beijing 100191 China

Objective： To evaluate the safety and risk of cryopreservation in female fertility preservation. Data sources： The data analyzed in this review were the English articles from 1980 to 2013 from journal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as tbllowing：（ 1 ） human; embryo; cryopreservation/freezing/vitrification, （2） human; oocyte/immature oocyte; cryopreservation/freezing/vitrification, （3） human; ovarian tissue transplantation; cryopreservation/ freezing/vitrification, （4） human; aneuploidy/DNA damage/epigenetic; cryopreservation/freezing/vitrification, and （5） human; fertility preservation; maternal age. Study selection： The risk ratios based on survival rate, maturation rate, fertilization rate, cleavage rate, implantation rate. pregnancy rate. and clinical risk rate were acquired from relevant meta-analysis studies. These studies included randomized controlled trials or studies with one of tile primary outcome measures covering cryopreservation of human mature oocytes, embryos, and ovarian tissues within the last 7 years （from 2006 to 2013. since the pregnancy rates of oocyte vitrification were significantly increased due to the improved techniques）. The data involving immature oocyte cryopreservation obtained from individual studies was also reviewed by the at, thors. Results： Vitrifications of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared with fresh and slow-freezing procedures, respectively. Conclusions： Both embryo and oocyte vitrifications are safe applications in female fertility preservation.

关键词： Embryo Cryopreservation Oocyte Cryopreservation: Ovarian Tissue Cryopreservation

2002至2006年国家自然科学基金资助儿科学结题情况分析

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中华儿科杂志 2009年第5期47卷 376-381页

作者：徐令郝杰邓敏徐岩英中山大学附属第二医院医研中心广州510120 重庆医科大学附属第一医院医科处北京大学第三医院神经科国家自然科学基金委员会生命科学部

目的了解国家自然科学基金资助儿科学项目的完成情况和学科研究进展，客观公正地做好结题项目的绩效评估。方法本文总结与分析了2002年至2006年度国家自然科学基金临床医学Ⅱ处资助儿科学各类项目结题完成情况，报道部分项目取得的重要... 详细信息

目的了解国家自然科学基金资助儿科学项目的完成情况和学科研究进展，客观公正地做好结题项目的绩效评估。方法本文总结与分析了2002年至2006年度国家自然科学基金临床医学Ⅱ处资助儿科学各类项目结题完成情况，报道部分项目取得的重要研究成果和突出进展。结果2002—2006年儿科学52项结题项目共发表文章420篇，平均8．1篇／项，科学引文索引（SCI）收录56篇，平均1．1篇／项，共培养博士后10人，博士102人，硕士109人；获省部级一等奖2项，二等奖2项；申请专利4项，获准专利1项。儿科学分支专业中的呼吸病学、肾脏病学、心血管病学等7个专业为结题项目主要涉及领域，取得了较大的研究进展。结论2002—2006年儿科学52项结题项目在儿科学各专业、各资助项目类别间的分布及结题完成有一些差异；与其他的临床基础Ⅱ学科中某些学科相比还有一定的差距。结题项目总体完成情况较好，许多项目取得了研究成果，展示了国家自然科学基金在学科发展上的重要引领作用。

关键词：儿科学科研课题管理结题情况研究成果国家自然科学基金

基于线路信息和QoS上下文转移的无缝切换方案

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铁道学报 2009年第3期31卷 100-106页

作者：彭军严旭影原小六张伟中南大学信息科学与工程学院湖南长沙410075

在高速客运专线环境中,信息传输的实时性和可靠性是保障铁路系统运营安全和提高客运系统无线接入服务的前提和基础。本文将分层移动IPv6网络拓扑结构应用于高速客运专线移动通信网。为减少其中实时业务的切换延迟和资源预留信息重建延迟... 详细信息

在高速客运专线环境中,信息传输的实时性和可靠性是保障铁路系统运营安全和提高客运系统无线接入服务的前提和基础。本文将分层移动IPv6网络拓扑结构应用于高速客运专线移动通信网。为减少其中实时业务的切换延迟和资源预留信息重建延迟,提出基于线路信息和QoS上下文转移的分层移动IPv6切换方案。首先,利用客运专线固定的线路信息和接入路由信息,事先建立顺序接入路由表;综合接收到的信号强度及位置信息和时间信息预知列车移动通信网的切换,从顺序接入路由表中主动选择合适的切换目的路由器,在此基础上有目的地进行提前切换。其次,利用上下文机制实现在切换之前将QoS信息传递给目标接入路由器,对新接入路由器扩展移动代理功能,提前为移动主机建立资源预留信息。仿真结果分析表明此方案减少了切换延迟,降低了数据丢包率。

关键词：分层移动IPv6 上下文转移 QoS 移动切换

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun xu Delong Jiang Jiayang Hou ying Liang Zhongyue Zou xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu ying Wang yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

The Proton Affitity and the Stability of the N-Glycosidic Bond for 8-oxo-2'-Deoxyguanosine

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The Proton Affitity and the Stability of the N-Glycosidic Bo...

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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作者： yan Zheng~a ying xu~(a,b*) Guo Sen yan~a a College of Chemistry,Sichuan University,Chengdu 610064 b State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041,P.R.China

This study is an attempt to evaluated the abilities of protonation on 8-oxodG and the N-glycosidic bond stabilities of the protonation products by means of computational studies. Because of the electron-deficient effect and the“anumeric effect”,geometrical variations in 8-oxodG can be understood and differ depending on the *** all cases,as compared to the neutral system 8-oxodG,the N9-C1’bond length increases with the variations from 0.0256(?)to 0.0382(?)and the changs are much more obvious for the dicationic and tricationic systems;the bond length of C2-N2 decreases and the values of H2rH2e-N2-C2 dihedral angle tend to about 180.0°.When the 2’-deoxyribose is taken into account,the C4’-O4’ bond distance in all systems increases,but the C1’-04’ bond distance decreases except for those in 8-oxodG(HC)and 8-oxodG(H).The analysis for proton affinity energies hints that those systems including protoned at 08 atoms with trans- type are more favorable to protonate as well as the protonation to 06 and N3 for mono-positive charged *** respect to binding energies,it has been found that,for these systems,the “anumeric effect” in the deoxyribose ring and the electron-deficient effect for the presence of positive charge(s)introduced in 8-oxoG favor significantly the heterolytic dissociation,especially for the dicationic and tricationic systems in which the dissociation energy values are ***,the heterolytic dissociation is the more favorable *** analysis for energies suggest that those systems including protoned at 08 atoms with trans-type are more favorable to protonate,and the heterolytic dissociation is the more favorable process for all systems.

关键词： 8-oxo-2’-deoxyguanosine proton affinity energy heterolytic dissociation homolytic dissociation

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue Han yan Su Yiming Zhou Minhui xu Jiyan xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1