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Chinese Journal of Integrative Medicine 2022年第6期28卷 560-566页

作者： SHEN Feng-lin ZHAO yan-na YU Xiao-ling WANG Bo-lin WU Xiao-long LAN Gao-chen GAO Rui-lan Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310006China

Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies(HMs).Targeted therapy,aiming for DNA methylation,is an effective mainstay of modem medicine;however,many issues remain to be *** progress of epigenetic studies and the proposed theory of"state-target medicine"have provided conditions to form a new treatment paradigm that combines the"body state adjustment"of CM with targeted *** discussed the correlation between Chinese medicine(CM)syndromes/states and DNA methylation in this ***,the latest research findings on the intervention and regulation of DNA methylation in HMs,including the core targets,therapy status,CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of"state-target synchronous conditioning"pattern of integrative medicine for HMs,simultaneously leading a new perspective in clinical diagnosis and therapy.

关键词： haematological malignancies DNA methylation Chinese medicine state-target medicine

Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis

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Journal of Integrative Medicine 2021年第6期19卷 545-554页

作者： Meng-ya Shan Ying Dai Xiao-dan Ren Jing Zheng Ke-bin Zhang Bin chen Jun yan Zi-hui Xu Department of Integrative Medicine Xinqiao HospitalArmy Medical UniversityChongqing 400037China National Drug Clinical Trail Institution Xinqiao HospitalArmy Medical UniversityChongqing 400037China Department of Biochemistry and Molecular Biology Army Medical UniversityChongqing 400038China Department 1 Research Institute of Surgery&Daping HospitalArmy Medical Center of Chinese People’s Liberation ArmyArmy Medical UniversityChongqing 400042China

Objective:To investigate effects of berberine(BBR)on cholesterol synthesis in HepG2 cells with free fatty acid(FFA)-induced steatosis and to explore the underlying ***:A steatosis cell model was induced in HepG2 cell line fed with FFA(0.5 mmol/L,oleic acid:-palmitic acid=2:1),and then treated with three concentrations of BBR;cell viability was assessed with cell counting kit-8 *** accumulation in cells was observed through oil red O staining and total cholesterol(TC)content was detected by TC *** effects of BBR on cholesterol synthesis mediators were assessed by Western blotting and quantitative polymerase chain *** addition,both silent information regulator 1(SIRT1)and forkhead box transcription factor O1(FoxO1)inhibitors were employed for ***:FFA-induced steatosis was successfully established in HepG2 *** accumulation and TC content in BBR groups were significantly lower(P<0.05,P<0.01),associated with significantly higher m RNA and protein levels of SIRT1(P<0.05,P<0.01),significantly lower sterol regulatory elementbinding protein 2(SREBP2)and 3-hydroxy 3-methylglutaryl-Co A reductase levels(P<0.05,P<0.01),as well as higher Acetyl-FoxO1 protein level(P<0.05,P<0.01)compared to the FFA only *** SIRT1 inhibitor SIRT1-IN-1 and FoxO1 inhibitor AS1842856 blocked the BBR-mediated therapeutic *** showed that the increased SIRT1 expression increased FoxO1 deacetylation,and promoted its nuclear ***:BBR can mitigate FFA-induced steatosis in HepG2 cells by activating SIRT1-FoxO1-SREBP2 signal *** may emerge as a potential drug candidate for treating nonalcoholic hepatic steatosis.

关键词： Berberine Nonalcoholic fatty liver disease Lipid metabolism SIRT1-FoxO1-SREBP2

Influence of voids on interlaminar shear strength of carbon/epoxy fabric laminates

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Transactions of Nonferrous Metals Society of China 2009年第S02期19卷 470-475页

作者： ZHU Hong-yan LI Di-hong ZHANG Dong-xing WU Bao-chang chen Yu-yong School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Harbin Aircraft Industry Co. Ltd.Harbin 150060China

The effects of voids(void content,void shape and size)on the interlaminar shear strength of[(±45)_(4)/(0,90)/(±45)_(2)]_(S) and [(±45)/0_(4)/(0,90)/0_(2)]_(S) composite laminates were *** with void contents in the range of 0.2%-8.0%for [(±45)_(4)/(0,90)/(±45)_(2)]_(S) and 0.2%-6.1%for[(±45)/0_(4)/(0,90)/0_(2)]_(S) were fabricated from carbon/epoxy fabric through varying autoclave *** characteristics of the voids were studied by using optical image analysis to explain the interlaminar shear strength *** influences of voids on the interlaminar shear strength of the two stacking sequences were compared in terms of the void content and size and shape of the *** effect of voids on the initiation and propagation of interlaminar failure of both stacking sequence composites was found.

关键词： carbon fibre reinforced polymer(CFRP)composite void content void size void shape interlaminar shears strength

Effect of deformation twinning on high-temperature performance of cold-rolled S31042 steel

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Journal of Iron and Steel Research International 2019年第7期26卷 704-711页

作者： yan-mo Li Yong-chang Liu Li-ming Yu chen-xi Liu Chong Li Yuan Huang Hui-jun Li Zong-qing Ma State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and Engineering Tianjin University Tianjin 300354 China

Influence of deformation twinning on high-temperature instantaneous performance of cold-rolled S31042 steel was investigated by optical microscopy, scanning electron microscopy, transmission electron microscopy, and high-temperature tensile test. An increasing number of deformation twins have formed as the cold rolling reduction degree increases during the cold rolling process. During the tensile process at 700 ℃, M23C6 particles generated along the deformation twin boundaries, and NbCrN nanoparticles dispersedly precipitated throughout the austenite grains. For the high-temperature tensile sample subjected to cold reduction for 80%, it is observed from the fractured cross section that numerous defor-mation twin boundaries were decorated by discontinuous M23C6 particles. Therefore, austenite grains were divided into several independent zones by the deformation twins, and the grains were refined. Due to the grain refinement strengthening and precipitation strengthening, the high-temperature temporal strength of the 80% cold-rolled sample was significantly improved, and simultaneously, this sample exhibited favorable high-temperature elongation.

关键词： S31042 steel Cold rolling Deformation twinning Carbide precipitation High-temperature performance

Observation of magnetic domain evolution in constrained epitaxial Ni–Mn–Ga thin films on MgO(0 0 1) substrate

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Journal of Materials Science & Technology 2022年第7期102卷 56-65页

作者： Bo yang Ivan Soldatov Fenghua chen Yudong Zhang Zongbin Li Haile yan Rudolf Schäfer Dunhui Wang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China Institute for Metallic Materials Leibniz Institute for Solid State and Materials Research(IFW)DresdenHelmholtzstrasse 2001069 DresdenGermany Institute of Natural Sciences Ural Federal University620002 EkaterinburgRussia Department of Physics School of Applied ScienceTaiyuan University of Science and TechnologyTaiyuan 030024China Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux(LEM3) CNRS UMR 7239Universitéde Lorraine57045 MetzFrance Institute for Materials Science Dresden University of Technology01062 DresdenGermany National Laboratory of Solid State Microstructures and Jiangsu Key Laboratory for Nanotechnology and Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Epitaxial Ni–Mn–Ga thin films have promising application potential in micro-electro-mechanical sensing and actuation systems. To date, large abrupt magnetization changes have been observed in some epitaxial Ni–Mn–Ga thin films, but their origin-either from magnetically induced martensite variant reorientation(MIR) or magnetic domain evolution-has been discussed controversially. In the present work, we investigated the evolutions of the magnetic domain and microstructure of a typical epitaxial Ni–Mn–Ga thin film through wide-field magneto-optical Kerr-microscopy. It is demonstrated that the abrupt magnetization changes in the hysteresis loops should be attributed to the magnetic domain evolution instead of the MIR.

关键词： Ni–Mn–Ga thin films Magnetic field-induced variant reorientation Magnetic domains Magnetization process Magneto-optical Kerr microscopy

Mechanical and Corrosion Behavior of a Biomedical Mg–6Zn–0.5Zr Alloy Containing a Large Number of Twins

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Acta Metallurgica Sinica(English Letters) 2023年第3期36卷 439-455页

作者： Chang‑Jian yan Bo Guan Yun‑Chang Xin Ling‑Yu Zhao Guang‑Jie Huang Rui Hong Xiao‑Bo chen Paul K.Chu Institute of Corrosion Science and Technology Guangdong 510070China International Joint Laboratory for Light Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400030China Key Laboratory for Light‑Weight Materials Nanjing Tech UniversityNanjing 210009China School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China School of Engineering RMIT UniversityCarlton 3053VICAustralia Department of Physics Department of Materials Science&EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

The strong texture of Mg alloys can lead to strong tension–compression yield asymmetry and corrosion anisotropy,and this will consequently affect the effectiveness of hard tissue implants.A biomedical Mg–6Zn–0.5Zr alloy containing a large number of{1012}primary twins and{1012}–{1012}secondary twins is successfully prepared by cross *** dual twin structure not only removes the tension–compression yield asymmetry completely,but effectively reduces the corrosion anisotropy without compromise of corrosion *** difference between the largest corrosion rate and smallest one is~1.2 times compared to~1.6 times of the original *** is found that the reduced corrosion anisotropy is related to re-distribution of crystallographic orientations by twins.

关键词： Biomedical Mg alloy Corrosion Mechanical anisotropy Texture Twins

Bifunctional noble-metal-free cocatalyst coating enabling better coupling of photocatalytic CO_(2)reduction and H_(2)O oxidation on direct Z-scheme heterojunction

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Nano Research 2024年第6期17卷 5022-5030页

作者： Wei Zhao Weihao Mo yan Zhang Lingxuan Hu Yiyi Zheng Zhulei chen Xiangyue Niu Yuling Zhao Lichun Liu Shuxian Zhong Song Bai Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China College of Biological Chemical Sciences and Engineering and Nanotechnology Research InstituteJiaxing UniversityJiaxing 314001China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058China School of Biological and Chemical Engineering Panzhihua UniversityPanzhihua 617000China

Selective loading of spatially separated redox cocatalysts on direct Z-scheme heterojunctions holds great promise for advancing the efficiency of artificial photosynthesis,which however is limited to the photodeposition of noble metal cocatalysts and the fabrication of hollow double-shelled semiconductor ***,the co-exposure of discrete cocatalyst and semiconductor increases the product diversity when both the exposed sites of which participate in CO_(2)***,we present a facile and versatile protocol to overcome these limitations via surface coating of Z-scheme heterojunctions with bifunctional noble-metal-free *** Cu_(2)O/Fe_(2)O_(3)(CF)as a model heterojunction and layered Ni(OH)_(2)as a model cocatalyst,it is found that Ni(OH)_(2)lying on the surfaces of Cu_(2)O and Fe_(2)O_(3)separately co-catalyzes the CO_(2)reduction and H_(2)O *** experimental and theoretical investigation reveals that the Ni(OH)_(2)outer layer:(i)mitigates the charge recombination in CF and balances their transfer and consumption;(ii)reduces the rate-determining barriers for CO_(2)-to-CO and H_(2)O-to-O_(2)conversion,(iii)suppresses the side proton reduction occurring on CF,and(iv)protects the CF from component *** expected,the redox reactions stoichiometrically proceed,and significantly enhanced photocatalytic activity,selectivity,and stability in CO generation are achieved by the stacked Cu_(2)O/Fe_(2)O_(3)@Ni(OH)_(2)in contrast to *** study demonstrates the significance of the synergy between bifunctional cocatalysts and Z-scheme heterojunctions for improving the efficacy of overall redox reactions,opening a fresh avenue for the rational design of artificial photosynthetic systems.

关键词： Z-scheme heterojunction bifunctional cocatalyst CO_(2)reduction H_(2)O oxidation stoichiometric redox reaction

Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load

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Research 2022年第2期2022卷 41-45页

作者： Yasen Maimaitiyiming Tao yang Qian Qian Wang yan Feng Zhi chen Mikael Bjorklund Fudi Wang Chonggao Hu Chih-Hung Hsu Hua Naranmandura Deparment of Public Healh and Department of Hematology of First Afilated Hospital Zhejiang Unvrsity Schoo of MedicineHangzhou 310058China Zhejiang University Cancer Cenler Hangzhou 310058China Deparment of Neurobiology and Depariment of Neurology of the First Afiliated Hospital Zhejiang University School of Medicire.NHC and CAMS Key Laboratory of Medical Neurobiology School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China Zhejing Provincial Center for Disease Control and Prevention Hangzhou 310051China State Key Laboratory for Diagrosis and Treatment of Infectious Diseases Collaborative Innovation Center for DigHosis and Treatment of Infectious DiseaseThe First filiated HospitalZhejiang University School of MedicineHangzhouChina Zhejing Unversity-Univrsity of Edinburgh(ZJU-UoE)Institute Haining 314499ZhejiangChina The First Afiliated Hospital Institute of Trarslational MedicineSchoo of Public HealthZhejiang University School of Medicine.Hangzhou 310058Chima Hengvang Medical School University of South ChinaHengvang 421001China Women's Hospital Institut of Gencticsand Departmrent of Enwironmental Medicine.Zhejiang Universty School of MedicineHangzhou 310006China

Despite extensive eforts,COVID-19 pandemic caused by the SARS-CoV-2 virus is still at *** is an eftive approach to curb virus spread,but several variants(***,delta plus,omicron,and IHU)appear to weaken or possibly escape immune ***,novel and quickly scalable approaches to restrain SARS-CoV-2 are urgently *** evidences showed thermal sensitivity of SARS-CoV-2 and negative correlation between environmental temperature and COVID-19 transmission with unknown *** reveal a potential mechanism by which mild heat treatment destabilizes the wild-type RNA-dependent RNA polymerase(also known a nonstructural protein 12(NSP12))of SARS-CoV-2 as well as the P323L mutant commonly found in SARS-CoV-2 variants,including omicron and ***,heat treatment promotes E3 ubiquitin ligase ZNF598-dependent NSP12 ubiquitination leading to proteasomal degradation and significantly decreases SARS-CoV-2 RNA copy number and viral titer.A mild daily heat Ireatment maintains low levels of both wild-type and P323L mutant of NSP12,sugesting clinical ***',this novel mechanism,heat-induced NSP12 degradation,suggests a prospective heat-based intervention against SARS-CoV-2.

关键词： NSP1 mechanism delta

Controlled synthesis of ultrasmall RuP_(2) particles on N,P-codoped carbon as superior pH-wide electrocatalyst for hydrogen evolution

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Rare Metals 2021年第5期40卷 1040-1047页

作者： Ying-Hua Wang Rui-Qing Li Hai-Bo Li Hong-Li Huang Zeng-Jing Guo Hong-yan chen Yao Zheng Kong-Gang Qu School of Chemistry and Chemical Engineering Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage and Novel Cell TechnologyLiaocheng UniversityLiaocheng 252059China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Electrocatalytic hydrogen evolution reaction(HER)is a highly potential strategy to massively produce green hydrogen ***,the employment of costly Pt-based electrocatalyst in the cathode of electrolyzer greatly hampers the development of hydrogen *** phosphide catalysts have recently drawn wide attention due to the Pt-like activity but relatively lower ***,a facile strategy was proposed for the controlled preparation of the ultrasmall RuP_(2) nanoparticles on N,P-codoped carbon from common precursors of Ru(Ⅱ)complex and phytic *** taking advantage of simple mixing and pyrolysis,the as-synthesized RuP_(2) nanoparticles were uniformly embedded onto the N,P-codoped carbon *** composite catalyst shows better activity than Pt/C for alkaline HER and comparable activity for acidic and neutral *** superior activity can be ascribed to the ultrasmall-size and efficient RuP_(2) together with good mass and charge transfer ability assured by N,P-codoped carbon *** advantages including low-cost and simple synthesis in this work present an encouraging substitute to replace commercial Pt/C for hydrogen-related practical applications.

关键词： RuP_(2) N P-codoped carbon Hydrogen evolution Electrocatalyst

Blast response of full-size concrete walls with chemically reactive enamel （CRE）-coated steel reinforcement

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第9期17卷 689-701页

作者： Dong-ming yan Hua-wei YIN cheng-lin WU yan-long LI Jason BAIRD Gen-da chen School of Civil and Architectural Engineering Zhejiang University Hangzhou 310058 China College of Civil Engineering Hunan University Changsha 410082 China Department of Civil Architectural and Environmental Engineering Missouri University of Science and Technology Rolla 654009 USA State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi'an University of Technology Xi'an 710048 China Rock Mechanics and Explosives Missouri University of Science and Technology Rolla 654009 USA Center for Infrastructure Engineering Studies Missouri University of Science and Technology Rolla 654009 USA

In this study, two full-size concrete wails were tested and analyzed to demonstrate the effectiveness of a chemically reactive enamel （CRE） coating in improving their mechanical behavior under blast loading： one with CRE-coated rebar and the other with uncoated rebar. Each wall was subjected in sequence to four explosive loads with equivalent 2, 4, 6-trinitrotoluene （TNT） charge weights of 1.82, 4.54, 13.6, and 20.4 kg. A finite element model of each wall under a close-in blast load was developed and validated with pressure and strain measurements, and used to predict rebar stresses and concrete surface sWain distributions of the wall. The test results and visual inspections consistently indicated that, compared with the barrier wall with uncoated reinforcement, the wall with CRE-coated rebar has fewer concrete cracks on the front and back faces, more effective stress transfers from concrete to steel rebar, and stronger connections with its concrete base. The concrete surface strain distributions predicted by the model under various loading conditions are in good agreement with the crack patterns observed during the tests.

关键词： Chemically reactive enamel (CRE) coating Blast loading Crack pattern Bond strength Finite element model