Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies:A New Paradigm of"State-Target Medicine"

作     者：SHEN Feng-lin ZHAO Yan-na YU Xiao-ling WANG Bo-lin WU Xiao-long LAN Gao-chen GAO Rui-lan SHEN Feng-lin;ZHAO Yan-na;YU Xiao-ling;WANG Bo-lin;WU Xiao-long;LAN Gao-chen;GAO Rui-Ian

作者机构：Institute of Hematology ResearchThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310006China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2022年第28卷第6期

页      面：560-566页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the National Natural Science Foundation of China(No.81774068) the Natural Science Foundation of Zhejiang Province(No.LY20H290004) Youth Project of the Natural Science Foundation of Zhejiang Province(No.LQ19H290002)。 

主　　题：haematological malignancies DNA methylation Chinese medicine state-target medicine 

摘      要：Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies(HMs).Targeted therapy,aiming for DNA methylation,is an effective mainstay of modem medicine;however,many issues remain to be addressed.The progress of epigenetic studies and the proposed theory ofstate-target medicinehave provided conditions to form a new treatment paradigm that combines thebody state adjustmentof CM with targeted therapy.We discussed the correlation between Chinese medicine(CM)syndromes/states and DNA methylation in this paper.Additionally,the latest research findings on the intervention and regulation of DNA methylation in HMs,including the core targets,therapy status,CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation ofstate-target synchronous conditioningpattern of integrative medicine for HMs,simultaneously leading a new perspective in clinical diagnosis and therapy.