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FGF2 is overexpressed in asthma and promotes airway in airway epithelial cells

Military Medical Research 2022年第6期9卷 639-654页

作者： Yuan-yang Tan Hui-Qin Zhou Yu-Jing Lin Liu-Tong Yi Zhuang-Gui Chen Qing-Dong Cao yan-rong guo Zhao-Ni Wang Shou-Deng Chen yang Li De-Yun Wang Yong-Kang Qiao yan yan Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center the Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000GuangdongChina Department of Pathology the Fifth Affiliated HospitalSun Yat-SenUniversityZhuhai 5190ooGuangdongChina Department of Pediatrics the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Cardiothoracic Surgery the Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000GuangdongChina Department of Otolaryngology Yong Loo Lin School of MedicineNational University HealthSystemNational University of SingaporeSingapore 119228Singapore BGI-Shenzhen Shenzhen 518083GuangdongChina Central Laboratory the Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000GuangdongChina

Background: Airway inflammation is the core pathological process of asthma, with the key inflammatory regulators incompletely defined. Recently, fibroblast growth factor 2(FGF2) has been reported to be an inflammatory regulator;however, its role in asthma remains elusive. This study aimed to investigate the immunomodulatory role of FGF2 in asthma.Methods: First, FGF2 expression was characterised in clinical asthma samples and the house dust mite(HDM)-induced mouse chronic asthma model. Second, recombinant mouse FGF2(rm-FGF2) protein was intranasally delivered to determine the effect of FGF2 on airway inflammatory cell infiltration. Third, human airway epithelium-derived A549 cells were stimulated with either HDM or recombinant human interleukin-1β(IL-1β) protein combined with or without recombinant human FGF2. IL-1β-induced IL-6 or IL-8 release levels were determined using enzyme-linked immunosorbent assay, and the involved signalling transduction was explored via Western blotting.Results: Compared with the control groups, the FGF2 protein levels were significantly upregulated in the bronchial epithelium and alveolar areas of clinical asthma samples [(6.70±1.79) vs.(16.32±2.40), P=0.0184;(11.20±2.11) vs.(21.00±3.00), P=0.033, respectively] and HDM-induced asthmatic mouse lung lysates [(1.00±0.15) vs.(5.14±0.42),P<0.001]. Moreover, FGF2 protein abundance was positively correlated with serum total and anti-HDM IgE levels in the HDM-induced chronic asthma model(R^(2)=0.857 and 0.783, P=0.0008 and 0.0043, respectively). Elevated FGF2protein was mainly expressed in asthmatic bronchial epithelium and alveolar areas and partly co-localised with infiltrated inflammatory cell populations in HDM-induced asthmatic mice. More importantly, intranasal instillation of rm-FGF2 aggravated airway inflammatory cell infiltration [(2.45±0.09) vs.(2.88±0.14), P=0.0288] and recruited more subepithelial neutrophils after HDM challenge [(110.20±29.43) cells/mm^(2) vs.(238.10±42.77) cells/mm^(2), P=0.0392]without affecting serum IgE level

关键词： Airway epithelial cell Airway inflammation Asthma Fibroblast growth factor 2(FGF2) House dust mite chronic model

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The origin, transmission and clinical therapies on coronavirus disease 2019(COVID-19) outbreak——an update on the status

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Military Medical Research 2020年第1期7卷 93-103页

作者： yan-rong guo Qing-Dong Cao Zhong-Si Hong Yuan-yang Tan Shou-Deng Chen Hong-Jun Jin Kai-Sen Tan De-Yun Wang yan yan Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging Zhuhai 519000GuangdongChina Department of Cardiothoracic Surgery the Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000GuangdongChina Center of Infectious Disease the Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000GuangdongChina Department of Otolaryngology Yong Loo Lin School of MedicineNational University of SingaporeNational University Health SystemSingapore 119228Singapore Center for Interventional Medicine the Fifth Affiliated HospitalSun Yat-Sen UniversityZhuhai 519000GuangdongChina

An acute respiratory disease,caused by a novel coronavirus(SARS-CoV-2,previously known as 2019-nCoV),the coronavirus disease 2019(COVID-19)has spread throughout China and received worldwide attention.On 30 January 2020,World Health Organization(WHO)officially declared the COVID-19 epidemic as a public health emergency of international concern.The emergence of SARS-CoV-2,since the severe acute respiratory syndrome coronavirus(SARSCoV)in 2002 and Middle East respiratory syndrome coronavirus(MERS-CoV)in 2012,marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century.As of 1 March 2020,a total of 87,137 confirmed cases globally,79,968 confirmed in China and 7169 outside of China,with 2977 deaths(3.4%)had been reported by WHO.Meanwhile,several independent research groups have identified that SARS-CoV-2 belongs toβ-coronavirus,with highly identical genome to bat coronavirus,pointing to bat as the natural host.The novel coronavirus uses the same receptor,angiotensin-converting enzyme 2(ACE2)as that for SARS-CoV,and mainly spreads through the respiratory tract.Importantly,increasingly evidence showed sustained human-tohuman transmission,along with many exported cases across the globe.The clinical symptoms of COVID-19 patients include fever,cough,fatigue and a small population of patients appeared gastrointestinal infection symptoms.The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes,which may be associated with acute respiratory distress syndrome(ARDS)and cytokine storm.Currently,there are few specific antiviral strategies,but several potent candidates of antivirals and repurposed drugs are under urgent investigation.In this review,we summarized the latest research progress of the epidemiology,pathogenesis,and clinical characteristics of COVID-19,and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.

关键词： Clinical characteristics Coronavirus disease 2019(COVID-19) Origin SARS-CoV-2 Therapy Transmission

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新疆冬小麦籽粒品质性状遗传差异与关联分析

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作物学报 2024年第6期50卷 1394-1405页

作者：马艳明娄鸿耀王威孙娜颜国荣张胜军刘杰倪中福徐麟新疆农业科学院农作物品种资源研究所新疆乌鲁木齐830091 中国农业大学农学院北京100193 北京市农林科学院杂交小麦研究所北京100097 新疆伊犁哈萨克自治州农业科学研究所新疆伊宁835011

小麦籽粒品质与面粉加工的食品品质密切相关,是小麦早期品质选择的重要依据。本研究以产自新疆的134个冬小麦地方品种和54个育成品种为材料,对连续2年种植收获于新疆乌鲁木齐市、新疆伊宁市共计4个试验点的小麦籽粒进行品质检测与全基... 详细信息

小麦籽粒品质与面粉加工的食品品质密切相关,是小麦早期品质选择的重要依据。本研究以产自新疆的134个冬小麦地方品种和54个育成品种为材料,对连续2年种植收获于新疆乌鲁木齐市、新疆伊宁市共计4个试验点的小麦籽粒进行品质检测与全基因组关联分析。结果表明,7个小麦籽粒品质性状的广义遗传力在62.14%~85.35%之间,由大到小排序依次为:硬度(85.35%)>湿面筋含量(78.44%)>出粉率(73.13%)>容重(72.50%)>沉降值(66.70%)>籽粒蛋白质含量(65.24%)>淀粉含量(62.14%)。在4个不同环境下,7个小麦籽粒品质性状表现为蛋白质含量、湿面筋含量、沉降值的变异相对较大,籽粒硬度的变异居中,淀粉含量、出粉率、容重的变异较小,多数籽粒品质性状间呈极显著相关性。设定阈值P<0.01,经关联分析,7个性状共检测到6605个显著性SNP标记,可解释6.021%~31.467%的变异。4个环境下检测到2个以上性状共有的多性状位点12个,可以解释6.233%~17.708%的表型变异。分别是蛋白质含量/沉降值、蛋白质含量/容重共有位点各1个,分别位于6A、2B上;蛋白质含量/湿面筋含量共有位点5个,分别位于3A、1B、6B、7B和7D上;沉降值/容重/籽粒硬度3个性状共有位点1个,位于5B上;蛋白质含量/沉降值/湿面筋含量3个性状共有位点3个,位于7A、3B和2D上,蛋白质含量/沉降值/湿面筋含量/容重4个性状共有位点1个,染色体位置未知。筛选出11个多性状、多环境品质相关基因,其中TraesCS6B01G347500编码一种储运蛋白,TraesCS1B01G395400编码碳水化合物转运蛋白/糖转运蛋白,TraesCS2D01G246500基因编码具有耐冷、耐盐、节水相关的蛋白ESKIMO1,可作为候选基因进行等位变异分析和标记开发,为小麦标记辅助选择育种提供分子工具。

关键词：新疆冬小麦籽粒品质遗传差异关联分析

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Experimental Study on Impingement Processes of Fuel Sprays on Biomimetic Structured Surfaces

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Journal of Bionic Engineering 2024年第1期21卷 362-373页

作者： yanling Chen Liang guo Wanchen Sun Yuying yan rong Xuan Junfeng Zhang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025China Faculty of Engineering University of NottinghamNottingham NG72RDUK

To improve the controllability of the wall-wetting process after the fuel spray-wall impingement in internal combustion engines,the methods of laser etching,chemical etching and surface free energy modification are used to prepare biomimetic structured surfaces with different wettability.The impingement processes of diesel and n-butanol sprays on the walls under different conditions are experimentally investigated.As the surface oleophilicity increases,the spreading radius of wall-impinging sprays decreases.At about 5 s after the fuel injections,the fuel spray droplets hit the walls for the first time,and the secondary breakup and rebound occur.The mixture concentrations of different fuels hitting the various walls reach the peak value.Under a higher surface temperature,the peak value of the mixture concentration is mainly related to the heat flux to the fuel droplets in different boiling regimes from the metal surfaces.The concentration of the air–fuel mixture in the near wall region increases with increasing surface oleophilicity,increasing wall temperature and decreasing ambient pressure.Compared with diesel,n-butanol presents a higher air–fuel mixture concentration in the near wall region.

关键词： Spray-wall impingement Morphological development Air-fuel mixture concentration Surface wettability Wall temperature:Ambient pressure

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Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai yan-yan Xue Weigang Ge Liang Yue Xiao-yan Li rong-rong Lin guo-Ping Peng Wenhao Jiang Sainan Li Kun-Mu Zheng Bin Jiang Jian-Ping Jia Tiannan guo Zhi-Ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic biomarkers.More ADspecific early diagnostic and disease staging biomarkers are needed.In this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 participants.Candidate biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 participants.We quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,respectively.In the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,respectively.Separate 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,respectively.The 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative diseases.Moreover,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD stages.Our findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

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Coupled dynamic response analysis of multi-column floating offshore wind turbine with low center of gravity

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Journal of Ocean Engineering and Science 2024年第1期9卷 25-39页

作者： Jie yang yan-ping He Yong-sheng Zhao Xiao-yan yang guo-rong Zhang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China

To realize the application of the floating offshore wind turbine(FOWT)from deep to relatively shallow waters,a new concept of multi-column floating wind turbine platform with low center of gravity(CG)is designed and validated.The multi-column low CG platform is designed to support a 6MW wind turbine class and operated at a water depth of 50m in the South China Sea.The frequency domain software WADAM and time domain software NREL-FAST are used to simulate coupled dynamic responses of the floating wind turbine system with second-order wave loads considering.The dynamic behaviors of multi-column low CG FOWT system under normal operation and parked conditions are presented.The influence of second-order wave force on the motion responses of the multi-column platform,fore-aft force and moment of the tower base and mooring force are researched respectively.The results demonstrate that the coupled dynamic responses at rated operating condition and extreme condition meet the normal operating requirements and extreme survival requirements of FOWT system in the shallow water(50m)of South China Sea.In addition,it is found that,the wave frequency response gradually replaces the second-order low frequency response as the main influencing factor of the coupled dynamic response of the FOWT system with the increasing severity of the sea states.However,in general,the magnitude of second-order low frequency response increases with the increasing severity of the design load case.Thus,in the subsequent design of the shallow water FOWT system,the second-order effects should be paid enough attention.

关键词： Floating offshore wind turbine Multi-column platform Second-order wave force Concept design Coupled dynamic response

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利用剪切黏弹性模量对大鼠肝纤维化流变特性进行分析和建模(英文)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第4期15卷 375-381页

作者： Ying ZHU Yi ZHENG Yuan-yuan SHEN Xin CHEN Xin-yu ZHANG Hao-ming LIN yan-rong guo Tian-fu WANG Si-ping CHEN National-Regional Key Technology Engineering Laboratory for Medical Ultrasound Department of Biomedical EngineeringSchool of MedicineShenzhen University Department of Electrical and Computer Engineering St. Cloud State University

研究目的:肝脏的纤维化进程改变肝脏组织的流变属性。创新要点:本文利用剪切黏弹性模量描绘并比较了大鼠肝脏F0期到F4期的纤维化过程。研究方法:两个黏弹性模型,即Zener模型和Voigt模型用于解释流变力学测试得到的实验数据,由此得到每... 详细信息

研究目的:肝脏的纤维化进程改变肝脏组织的流变属性。创新要点:本文利用剪切黏弹性模量描绘并比较了大鼠肝脏F0期到F4期的纤维化过程。研究方法:两个黏弹性模型,即Zener模型和Voigt模型用于解释流变力学测试得到的实验数据,由此得到每个纤维化分期的肝脏弹性和黏性值。重要结论:肝脏中度纤维化(≤F2期)与黏弹性值密切相关。Zener模型的弹性均值E1从F0期的(0.452±0.094)kPa增加到F2期的(1.311±0.717)kPa,而Voigt模型的弹性均值E从F0期的(0.618±0.089)kPa增加到F2期的(1.701±0.844)kPa。Zener模型的黏性均值从F0期的(3.499±0.186)Pa·s增加到F2期的(4.947±1.811)Pa·s,而Voigt模型的黏性均值从F0期的(3.379±0.316)Pa·s增加到F2期的(4.625±1.296)Pa·s。无论选用哪个黏弹性模型,在F1期和F2期,肝脏弹性值的标准差比黏性值的标准差变化要小。因此,测得的弹性比黏性更有效地区分肝纤维化F0期到F2期。

关键词：生物力学流变属性肝纤维化黏弹性剪切模量弹性黏性 Zener模型 Voigt模型

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Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU Li WANG guo-rong WAN Min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

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Bilayer Compounded Polytetrafluoroethylene Membrane for Enhanced Oil-Water Emulsion Separation

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Chinese Journal of Polymer Science 2024年第6期42卷 838-850页

作者： Yu-Liang yang Tai-Ran Zhang yan-Ting Han Shao-Yun guo Qin-Gong rong Jia-Bin Shen State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversitySichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyChengdu610065China West China Hospital/West China School of Nursing Sichuan UniversityChengdu610041China Shandong Senrong New Materials Co. Ltd.Zibo256401China

In order to achieve efficient and durable oil-water emulsion separation,the membranes possessing high separation efficiency and mechanical strength attract extensive attention and are in great demand.In present study,a kind of polytetrafluoroethylene(PTFE)-based bilayer membrane was fabricated by electrospinning fibrous PTFE(fPTFE)on an expanded PTFE(ePTFE)substrate.The morphological observation revealed that the fibrous structure of the fPTFE layer could be tailored by controlling the formulation of spinning solution.The addition of appropriate polyoxyethylene(PEO)would make the fibers in the fPTFE layer finer and more uniform.As a result,the compounded membrane exhibited a small pore size of approximately 1.25µm and a substantial porosity nearing 80%.This led to super-hydrophobicity,characterized by a high water contact angle(WCA)of 149.8°,and facilitated rapid oil permeation.The water-in-oil emulsion separation experiment further confirmed that the compounded membrane not only had a high separation efficiency closing 100%,but such an outstanding separation capacity could be largely retained,either through multiple cycles of use or through strong acid(pH=1),strong alkali(pH=12),or high-temperature(100°C)treatment.Additionally,the mechanical behavior of the bilayer membrane was basically contributed by that of each layer in terms of their volume ratio.More significantly,the poor creep resistance of fPTFE layer was suppressed by compounding with ePTFE substrate.Hence,this study has laid the groundwork for a novel approach to create PTFE-based compounded membranes with exceptional overall characteristics,showing promise for applications in the realm of emulsion separation.

关键词： ePTFE Electrospinning membrane Bilayer compounding Emulsion separation

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SEMI-IMPLICIT SPECTRAL DEFERRED CORRECTION METHODS BASED ON SECOND-ORDER TIME INTEGRATION SCHEMES FOR NONLINEAR PDES

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Journal of Computational Mathematics 2024年第1期42卷 111-133页

作者： Ruihan guo yan Xu School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

In[20],a semi-implicit spectral deferred correction(SDC)method was proposed,which is efficient for highly nonlinear partial differential equations(PDEs).The semi-implicit SDC method in[20]is based on first-order time integration methods,which are corrected iteratively,with the order of accuracy increased by one for each additional iteration.In this paper,we will develop a class of semi-implicit SDC methods,which are based on second-order time integration methods and the order of accuracy are increased by two for each additional iteration.For spatial discretization,we employ the local discontinuous Galerkin(LDG)method to arrive at fully-discrete schemes,which are high-order accurate in both space and time.Numerical experiments are presented to demonstrate the accuracy,efficiency and robustness of the proposed semi-implicit SDC methods for solving complex nonlinear PDEs.

关键词： Spectral deferred correction method Nonlinear PDEs Local discontinuous Galerkin method Second-order scheme

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