Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli

作     者：Ying ZHU Yi ZHENG Yuan-yuan SHEN Xin CHEN Xin-yu ZHANG Hao-ming LIN Yan-rong GUO Tian-fu WANG Si-ping CHEN Ying ZHU;Yi ZHENG;Yuan-yuan SHEN;Xin CHEN;Xin-yu ZHANG;Hao-ming LIN;Yan-rong GUO;Tian-fu WANG;Si-ping CHEN;National-Regional Key Technology Engineering Laboratory for Medical Ultrasound,Department of Biomedical Engineering,School of Medicine,Shenzhen University;Department of Electrical and Computer Engineering,St. Cloud State University

作者机构：National-Regional Key Technology Engineering Laboratory for Medical UltrasoundDepartment of Biomedical EngineeringSchool of MedicineShenzhen University Department of Electrical and Computer EngineeringSt. Cloud State University 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2014年第15卷第4期

页      面：375-381页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.61031003,81271651,and 61101025) the Shenzhen Basic Research Project(No.JC201005280501A),China 

主　　题：Biological mechanics Rheological properties Liver fibrosis Viscoelasticity Shear modulus Elasticity Viscosity Zener model Voigt model 

摘      要：The process of liver fibrosis changes the rheological properties of liver *** study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic *** two viscoelastic models,the Zener model and Voigt model,were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis *** results demonstrate that moderate fibrosis（≤F2） has a good correlation with liver *** mean Zener elasticity E1 increases from（0.452±0.094） kPa（F0） to（1.311±0.717） kPa（F2）,while the mean Voigt elasticity E increases from（0.618±0.089） kPa（F0） to（1.701±0.844） kPa（F2）.The mean Zener viscosity increases from（3.499±0.186） Pa·s（F0） to（4.947±1.811） Pa·s（F2） and the mean Voigt viscosity increases from（3.379±0.316） Pa·s（F0） to（4.625±1.296） Pa·s（F2）.Compared with viscosity,the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is ***,the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.