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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2646-2656页

作者： yan-qing lv Mei-Lan Wang Tong-Yu Tang Yu-Qin Li Department of Hepatobiliary and Pancreatic Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Gastroenterology Jilin Provincial People's HospitalChangchun 130021Jilin ProvinceChina Department of Gastroenterology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Cronkhite–Canada syndrome(CCS)is a rare sporadic polyposis syndrome that presents with gastrointestinal and ectodermal symptoms in addition to nutritional *** combined with hypothyroidism is an even rarer condition,with no standard treatment *** SUMMARY The present study described 2 patients with CCS:A 67-year-old woman with concomitant hypothyroidism and 68-year-old man treated with endoscopic mucosal resection(EMR).Both patients had multiple gastrointestinal symptoms and ectodermal changes,along with multiple gastrointestinal *** examination showed that the mucosa in both patients was hyperemic and edematous,with pathologic examination showing distorted,atrophic,and dilated *** 1 had concomitant hypothyroidism and was treated with *** to her self-reduction of hormone dose,her disease *** 2 underwent EMR,but refused further hormonal or biological ***,he was treated with an oral Chinese medical *** Pharmacotherapy can induce and maintain remission in CCS patients,with adjuvant EMR,long-term follow-up,and endoscopic surveillance being *** 1:Based on the aforementioned findings,Patient 1 was diagnosed with CCS and *** 2:Based on the aforementioned findings,Patient 2 was diagnosed with CCS.

关键词： Cronkhite–Canada syndrome Clinical features Gastrointestinal polyps Hypothyroidism Case report

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Maternal and fetal death associated with acute pancreatitis during pregnancy:A case report

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World Journal of Clinical Cases 2025年第10期13卷 53-58页

作者： Jin Li qing-yan Zhang Mei-Hong Zhang Shan-Yun Jiang Department of Anesthesiology Kaihua County People’s HospitalQuzhou 324300Zhejiang ProvinceChina Center for Clinical Inspection and Quarantine Kaihua County Center for Clinical Inspection and QuarantineQuzhou 324300Zhejiang ProvinceChina

BACKGROUND Acute pancreatitis in pregnancy is a rare but serious condition that can lead to high maternal mortality and fetal *** of pregnancy complicated by severe acute pancreatitis,particularly with subsequent respiratory and cardiac arrest,are rarely *** SUMMARY We present the case of a 35-year-old woman,at 36+5 weeks of gestation,who presented with paroxysmal epigastric pain accompanied by low back pain,nausea,and *** to the clinical symptoms,B-ultrasound imaging and biochemical indicators,the patient was diagnosed with acute pancreatitis and initially managed ***,3 hours after admission,the patient experienced respiratory and cardiac arrest,and the fetus *** this case,the adverse outcomes occurred due to the lack of aggressive fluid resuscitation and an active surgical *** Implementing aggressive fluid resuscitation to sustain tissue perfusion,alongside the proactive evaluation of pharmacological agents that suppress gastric acid secretion and inhibit pancreatic enzyme activity,may be beneficial in mitigating the risk of a severely adverse *** management of acute pancreatitis during pregnancy requires careful timing of surgical intervention,a thorough evaluation of the risks and benefits regarding the continuation or termination of pregnancy,and a focus on safeguarding both maternal and fetal health.

关键词： Severe acute pancreatitis Pregnancy Cardiac arrest Fetal death Case report

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou Yuan-yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun yan Han-qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu lv Tao Long Hui-Wen Pan Jun-qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Effect of pre-oxidation degree on gaseous reduction of pre-oxidized ilmenite concentrate by CO

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Journal of Iron and Steel Research International 2022年第6期29卷 881-890页

作者： Shi-qing Zhao Xiao-dong lv Zhi-ming yan Xue-wei lv Wei lv Chen-guang Bai College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Advanced Manufacturing&Materials Centre University of WarwickCoventry CV47ALUK School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The effect of pre-oxidation degree of Panzhihua ilmenite concentrate on the gaseous reduction by carbon monoxide was *** raw ilmenite concentrates were pre-oxidized at 600,700,800,900,and 1000°C for 2 h,*** phase change,FeO content,and morphology after the oxidation at various temperatures were *** oxidation degree was calculated according to the change of FeO *** was performed on the oxidized ilmenite concentrate samples(oxidized at 600,800,and 1000°C)at 850,900,and 950°C,*** results show that the pre-oxidation of ilmenite concentrate can accelerate the reduction process:the higher pre-oxidation degree,the faster reduction *** high pre-oxidation degree of ilmenite concentrate is beneficial to accelerate the subsequent reduction process in two *** stages of the reduction process were divided via the first derivatives of reduction degree,and the reduction mechanism and apparent activation energy were discussed subsequently.

关键词： Ilmenite Pre-oxidation Reduction Kinetic Titanium slag

Modified artificial neural network model with an explicit expression to describe flow behavior and processing maps of Ti2AlNb-based superalloy

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Journal of Iron and Steel Research International 2021年第11期28卷 1451-1462页

作者： yan-qi Fu qing Zhao Man-qian lv Zhen-shan Cui School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Forming Technology and Equipment Shanghai Jiao Tong UniversityShanghai 200030China

The elevated-temperature deformation behavior of Ti2AlNb superalloy was observed by isothermal compression experiments in a wide range of temperatures(950–1200°C)and strain rates(0.001–10 s^(-1)).The flow behavior is nonlinear,strongly coupled,and *** constitutive models,namely the double multivariate nonlinear regression model,artificial neural network model,and modified artificial neural network model with an explicit expression,were applied to describe the Ti2AlNb superalloy plastic deformation *** comparative predictability of those constitutive models was further evaluated by considering the correlation coefficient and average absolute relative *** comparative results show that the modified artificial network model can describe the flow stress of Ti2AlNb superalloy more accurately than the other developed constitutive *** explicit expression obtained from the modified artificial neural network model can be directly used for finite element *** modified artificial neural network model solves the problems that the double multivariate nonlinear regression model cannot describe the nonlinear,strongly coupled,and multivariable flow behavior of Ti2AlNb superalloy accurately,and the artificial neural network model cannot be embedded into the finite element software ***,the modified artificial neural network model is mainly dependent on the quantity of high-quality experimental data and characteristic variables,and the modified artificial neural network model has not physical ***,the processing maps were applied to obtain the optimum processing parameters.

关键词： Modified artificial neural network model Ti2AlNb superalloy Double multivariate nonlinear regression model Explicit expression Processing map

Introducing hydroxyl groups to tailor the d-band center of Ir atom through side anchoring for boosted ORR and HER

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Journal of Energy Chemistry 2024年第3期90卷 144-151,I0005页

作者： qing lv Meiping Li Xiaodong Li Xingru yan Zhufeng Hou Changshui Huang Science Center for Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringInstitute of Frontier and Interdisciplinary ScienceShandong UniversityJinan 250100ShandongChina Institute of Chemistry Chinese Academy of ScienceBeijing 100191China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina

Tuning the coordination atoms of central metal is an effective means to improve the electrocatalytic activity of atomic ***,iridium(Ir) is proposed to be asymmetrically anchored by sp-N and pyridinic N of hydrogen-substituted graphdiyne(HsGDY),and coordinated with OH as an Ir atomic catalyst(Ir_(1)-N-HsGDY).The electron structures,especially the d-band center of Ir atom,are optimized by these specific coordination ***,the as-synthesized Ir_(1)-N-HsGDY exhibits excellent electrocatalytic performances for oxygen reduction and hydrogen evolution reactions in both acidic and alkaline *** from the unique structure of HsGDY,IrN_(2)(OH)_(3) has been developed and demonstrated to act as the active site in these electrochemical *** those indicate the fresh role of the sp-N in graphdiyne in producing a new anchor way and contributing to promote the electrocatalytic activity,showing a new strategy to design novel electrochemical catalysts.

关键词： Oxygen reduction reaction D-band center Graphdiyne Hydroxyl group Electrocatalysis

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou lv-Feng Zhang qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

Magnetic flux control of chiral Majorana edge modes in topological superconductor

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Science China(Physics,Mechanics & Astronomy) 2018年第12期61卷 89-94页

作者： yan-Feng Zhou Zhe Hou Peng lv XinCheng Xie qing-Feng Sun International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

We study the transport of chiral Majorana edge modes(CMEMs) in a hybrid quantum anomalous Hall insulator-topological superconductor(QAHI-TSC) system in which the TSC region contains a Josephson junction and a cavity. The Josephson junction undergoes a topological transition when the magnetic flux through the cavity passes through half-integer multiples of magnetic flux quantum. For the trivial phase, the CMEMs transmit along the QAHI-TSC interface as without magnetic flux. However, for the nontrivial phase, a zero-energy Majorana state appears in the cavity, leading to that a CMEM can resonantly tunnel through the Majorana state to a different CMEM. These findings may provide a feasible scheme to control the transport of CMEMs by using the magnetic flux and the transport pattern can be customized by setting the size of the TSC.

关键词： Majorana fermions Josephson junction topological superconductor non-equilibrium Green's function