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Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting

Chinese Chemical Letters 2024年第2期35卷 44-56页

作者： yan-long ma Shi yan Xiong-Jie Xu Hua Cao Ruibing Wang School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center Guangdong Pharmaceutical UniversityZhongshan 528458China State Key Laboratory of Quality Research in Chinese Medicine and the Institute of Chinese Medical ScienceUniversity of MacaoMacao 999078China

Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has shown a great application potential in ***, four bioorthogonal pairs as targeting tools, including (strept)avidin/biotin, antibody/antigen, oligonucleotide hybridization and IEDDA tools, have been developed and applied in targeted ***, all of these tools still suffer from some limitations, such as difficult modification, biochemical fragility and larger molecular weight for biological association tools, as well as chemical instability for IEDDA *** host-guest pairs with relatively small molecular sizes not only possess strong chemical stability, but also have the features of fast conjugation rate, tunable binding affinity , easy modification, and high ***, they can be used as a novel non-covalent bioorthogonal tool for *** order to further promote the development of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery, we firstly calculate their conversion rate to make researcher aware of their unique advantages;next, we summarize the recent research progress in this *** future perspectives and limitations of these unique tools will be *** review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting, and may serve as a “go for” resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting.

关键词： Bioorthogonal chemistry Synthetic host-guest pairs Pre-targeting Molecular recognition Biomedical applications

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Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1474-1480页

作者： Jun Sun Qing-Ning yang Yi Guo Ping Zeng long-yan ma Ling-Wen Kong Bo-Ying Zhao Chuan-Ming Li Department of Radiology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Pathology Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China Department of Cardiothoracic Surgery Chongqing University Central HospitalChongqing Emergency Medical CenterChongqing 400014China

BACKGROUND Multilocular thymic cyst(MTC)is a rare mediastinal lesion which is considered to occur in the process of acquired *** is usually characterized by well-defined cystic density and is filled with transparent *** SUMmaRY We report on a 39-year-old male with a cystic-solid mass in the anterior *** tomography(CT)imaging showed that the mass was irregular with unclear *** injection of contrast agent,there was a slight enhancement of stripes and *** to CT findings,it was diagnosed as thymic *** After surgery,MTC accompanied by bleeding and infection was confirmed by pathological *** main lesson of this case was that malignant thymic tumor and MTC of the anterior mediastinum sometimes exhibit similar CT *** is necessary in clinical work to avoid misdiagnosis.

关键词： Multilocular thymic cyst Computer tomography Misdiagnosis Hemorrhage Infection Case report

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Corrosion Resistance of Friction Stir Welded Al–Cu–Li Alloy AA2099-T8

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 127-134页

作者： yan-long ma Hui-Bin Xu Zhao-Yuan Liang Lei Liu College of materials Science and Engineering Chongqing University of TechnologyChongqing 400054China Chongqing Municipal Engineering Research Center of Institutions of Higher Education for Special Welding materials and Technology Chongqing University of TechnologyChongqing 400054China

In order to study the eff ect of friction stir welding(FSW)on corrosion resistance of Al–Cu–Li alloy AA2099-T8,the microstructure and microhardness of FSW joints were characterized,and then,the corrosion behavior of the FSW joints was investigated by the immersion and potentiodynamic polarization tests in a 3.5%NaCl solution at room *** is indicated that the alloy was softened by FSW,with the lowest hardness appearing at the boundary between the nugget zone and the thermo-mechanically aff ected *** exposed to the NaCl solution,the FSW joint was characterized by shallow pits and was free of severe localized corrosion,probably due to dissolution of T 1(A 2 CuLi)phase in the FSW *** is suggested that further work should be carried out to evaluate the galvanic coupling eff ect between the FSW joint and the base metal,as well as the stress corrosion cracking resistance of the FSW joint.

关键词： Frictions stir welding(FSW) Al–Cu–Li alloy AA2099 Localized corrosion

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碳酸锂溶液封闭处理对阳极氧化AA2099-T83合金耐蚀性能的影响

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1789-1803页

作者：朱彭舟麻彦龙黄伟九邹梦婷杨炳元廖益梁钊源重庆理工大学材料科学与工程学院重庆400054 重庆大学材料科学与工程学院重庆400044 重庆第二师范学院经济与工商管理学院重庆400067 中科(广东)炼油石化有限公司湛江524076

为开发一种新型铝锂合金表面处理技术,将经酒石酸−硫酸阳极氧化后的AA2099-T83合金浸泡在不同温度−浓度组合的碳酸锂(Li_(2)CO_(3))溶液中进行后处理。结果表明:经过Li_(2)CO_(3)溶液处理后,阳极氧化合金的耐蚀性能显著提高(耐中性盐雾... 详细信息

为开发一种新型铝锂合金表面处理技术,将经酒石酸−硫酸阳极氧化后的AA2099-T83合金浸泡在不同温度−浓度组合的碳酸锂(Li_(2)CO_(3))溶液中进行后处理。结果表明:经过Li_(2)CO_(3)溶液处理后,阳极氧化合金的耐蚀性能显著提高(耐中性盐雾试验长达1300 h)。此外,高温/低浓度和低温/高浓度组合的封孔过程明显不同,在高温模式下阳极氧化膜仅部分封孔,而在低温模式下阳极氧化膜的封孔更加完全。封孔处理合金的高耐腐蚀性主要归因于在阳极氧化膜表面和内部形成的封孔产物(即Li−Al−LDH和/或勃姆石)对腐蚀介质的阻隔作用。

关键词：铝锂合金阳极氧化耐蚀性能碳酸锂锂−铝层状双氢氧化物封闭处理

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Optimized Auxiliary Frequency Control of Wind Farm Based on Piecewise Reduced-order Frequency Response Model

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 791-802页

作者： Xu Zhang Chen Zhao Junchao ma long Zhang Dan Sun Chenxu Wang yan Peng Heng Nian the School of Electrical Engineering Zhejiang UniversityHangzhou 310058China Electric Power Research Institute of State Grid Zhejiang Electric Power Corporation Hangzhou 310014China

With the increasing wind power penetration in the power system,the auxiliary frequency control(AFC)of wind farm(WF)has been widely *** traditional system frequency response(SFR)model is not suitable for the wind power generation system due to its poor accuracy and *** this paper,a piecewise reduced-order frequency response(PROFR)model is proposed,and an optimized auxiliary frequency control(O-AFC)scheme of WF based on the P-ROFR model is ***,a full-order frequency response model considering the change in operating point of wind turbine is established to improve the *** order to simplify the fullorder model,a P-ROFR model with second-order structure and high accuracy at each frequency response stage is *** on the proposed P-ROFR model,the relationship between the frequency response indexes and the auxiliary frequency controller coefficients is expressed ***,an OAFC scheme with the derived explicit expression as the optimization objective is proposed in order to improve the frequency support capability on the premise of ensuring the full release of the rotor kinetic energy and the full use of the effect of time delay on frequency ***,the effectiveness of the proposed P-ROFR model and the performance of the proposed OAFC scheme are verified by simulation studies.

关键词： Frequency response piecewise reduced-order wind farm auxiliary frequency control

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-long ma Xue-yan Feng Li-Na ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(Pmatory factors(Pmatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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Gut liver brain axis in diseases:the implications for therapeutic interventions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao yan Shuli man Benyue Sun long ma Lanping Guo Luqi Huang Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODmaP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

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Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： Guang-long ma Wei-Feng Lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the *** the same time,success drives more attention from scientists to improve ***,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their *** nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery *** successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB *** this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

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Numerical Simulation of Rainfall-induced Xianchi Reservoir Landslide in Yunyang,Chongqing,China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 505-517页

作者： yan Jinkai ma yan LIU Lei WANG Zhihui REN Tianxiang Chinese Academy of Geological Sciences Beijing 100037China Urban Construction School Beijing City UniversityBeijing 100083China

A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 *** landslide volume comprised 1.44 million m^(3) of material in the source area and 0.4 million m^(3) of shoveled *** debris flow runout extended 400 m vertically and 1600 m *** Xianchi reservoir landslide event has been investigated as follows:(1)samples collected from the main body of landslide were carried out using GCTS ring shear apparatus;(2)the parameters of shear and pore water pressure have been measured;and(3)the post-failure characteristics of landslide have been analyzed using the numerical simulation *** excess pore-water pressure and erosion in the motion path are considered to be the key reasons for the long-runout motion and the scale-up of landslides,such as that at Xianchi,were caused by the heavy *** aim of this paper is to acquired numerical parameters and the basic resistance model,which is beneficial to improve simulation accuracy for hazard assessment for similar to potentially dangerous hillslopes in China and elsewhere.

关键词： geohazards landslide post-failure rapid and long runout ring shear test

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Achieving Strong Positive Cooperativity by Waking up Weak Non-Covalent Interactions

Achieving Strong Positive Cooperativity by Waking up Weak No...

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中国化学会第十二届全国物理有机化学学术会议

作者： yan-long ma Hua Ke Wei Jiang Department of Chemistry South University of Science and Technology of China Institute of Chinese Medical Science University of MacauAvenida da Universidade

Inpresentwork,wehaveintroducedanothertypeofcooperativitywhichisnot-existentinsingle system,but can be can be waked up or even amplified hundred times by the multiple unconventional weak C-H···O-C interactions under...

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