检索结果-南通市图书馆

The changes in the annual distribution of mountain runoff during the period of 1965-2018 in Hexi Corridor,Northwest China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Cold and Arid Regions 2024年第2期16卷 73-83页

作者： yan Luo ZhiXiang Lu Qi Feng Meng zhu JinBo Zhang Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China cCollege of Resources and Environmental Sciences Gansu Agricultural UniversityLanzhouGansu 730000China

The annual distribution characteristics of river runoff in arid regions have significant implications for water resource stability and *** on the mountain runoff data from 1965 to 2018,this study examines the annual change characteristics of monthly runoff of the Shiyang River Basin,Heihe River Basin,and Shule River Basin in the Hexi Corridor,Northwest *** indexes are used and analyzed,including the coefficient of variance,the complete regulation coefficient,the concentration degree and concentration period,the magnitude of change,the skewness coefficient,and the kurtosis coefficient of the annual distribution *** results reveal the following:(1)The inhomogeneity of annual runoff distribution in the Taolai River and the rivers to the west of it,except the Shiyou River,show an increasing ***,the inhomogeneity of the rivers to the east of the Taolai River generally show a downward trend,but the coefficient of variance value is still very high.(2)In the Shiyang River Basin,the annual distribution of the concentration period is characterized by a relatively discrete ***,the Heihe River Basin exhibits a relatively concentrated pattern,and the distribution pattern of the Shule River Basin is quite ***,all concentration periods in the three basins have shifted backward after the 2000s.(3)The Shiyang River Basin exhibits disordered annual distribution curves of runoff in different *** contrast,the Heihe River Basin presents a typical‘single-peak’pattern with a prominent *** Shule River Basin has regular distribution curves,with a gradually significant‘double-peak’pattern from east to ***,there has been a slight change in runoff in the Shiyang River Basin,while the Heihe River Basin and Shule River Basin have experienced significant increases in *** annual distribution curves of runoff in the Liyuan River and the rivers to the east of it exhibit a gentle peak pattern,and th

关键词： Hexi Corridor Inland rivers Mountain runoff Annual distribution characteristics of runoff

Constructing globally consecutive 3D conductive network using P-doped biochar cotton fiber for superior performance of silicon-based anodes

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第6期173卷 181-191页

作者： Jun Cao Jianhong Gao Kun Wang zhuoying Wu Xinxin zhu Han Li Min Ling Chengdu liang Jun Chen Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University-Quzhou Zheda Road 99Quzhou 324000China

The inferior conductivity and drastic volume expansion of silicon still remain the bottleneck in achieving high energy density Lithium-ion Batteries(LIBs).The design of the three-dimensional structure of electrodes by compositing silicon and carbon materials has been employed to tackle the above challenges,however,the exorbitant costs and the uncertainty of the conductive structure persist,leaving ample room for ***,silicon nanoparticles were innovatively composited with eco-friendly biochar sourced from cotton to fabricate a 3D globally consecutive conductive *** network serves a dual purpose:enhancing overall electrode conductivity and serving as a scaffold to maintain electrode *** conductivity of the network was further augmented by introducing P-doping at the optimum doping temperature of 350℃.Unlike the local conductive sites formed by the mere mixing of silicon and conductive agents,the consecutive network can affirm the improvement of the conductivity at a macro ***,first-principle calculations further validated that the rapid diffusion of Li^(+)is attributed to the tailored electronic microstructure and charge rearrangement of the *** prepared consecutive conductive Si@P-doped carbonized cotton fiber anode outperforms the inconsecutive Si@Graphite anode in both cycling performance(capacity retention of 1777.15 mAh g^(-1) vs.682.56 mAh g^(-1) after 150 cycles at 0.3 C)and rate performance(1244.24 mAh g^(-1) vs.370.28 mAh g^(-1) at 2.0 C).The findings of this study may open up new avenues for the development of globally interconnected conductive networks in Si-based anodes,thereby enabling the fabrication of high-performance LIBs.

关键词： 3D conductive network Biochar carbon-silicon anode Heteroatoms doping strategy DFT calculation Lithium-ion battery

TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 589-602页

作者： An-bang SUN Fang-hua LI Lin zhu Xi-xi ZENG Min zhu Qing-hua LEI yan-hong LIAO Department of Anatomy School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Transfusion Medicine Wuhan Hospital of Traditional Chinese and Western MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China National Basic Medical Teaching Demonstration Center Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Neurological Diseases of Ministry of Education Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Renal fibrosis is the ultimate pathway of various forms of acute and chronic kidney ***,the knockout of transient receptor potential channel 6(TRPC6)has shown promise in alleviating renal ***,the regulatory impact of TRPC6 on renal fibrosis remains *** In vivo,TRPC6 knockout(TRPC6−/−)mice and age-matched 129 SvEv(WT)mice underwent unilateral renal ischemia-reperfusion(uIR)injury surgery on the left renal pedicle or sham *** and serum were collected on days 7,14,21,and 28 after *** vitro,primary tubular epithelial cells(PTECs)were isolated from TRPC6−/−and WT mice,followed by treatment with transforming growth factorβ1(TGFβ1)for 72 *** anti-fibrotic effect of TRPC6−/−and the underlying mechanisms were assessed through hematoxylin-eosin staining,Masson staining,immunostaining,qRT-PCR,and Western *** Increased TRPC6 expression was observed in uIR mice and PTECs treated with TGFβ***6−/−alleviated renal fibrosis by reducing the expression of fibrotic markers(Col-1,α-SMA,and vimentin),as well as decreasing the apoptosis and inflammation of PTECs during fibrotic progression both in vivo and in ***,we found that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/glycogen synthase kinase 3 beta(GSK3β)signaling pathway,a pivotal player in renal fibrosis,was down-regulated following TRPC6 *** These results suggest that the ablation of TRPC6 may mitigate renal fibrosis by inhibiting the apoptosis and inflammation of PTECs through down-regulation of the PI3K/AKT/GSK3β*** TRPC6 could be a novel therapeutic strategy for preventing chronic kidney disease.

关键词： transient receptor potential channel 6 ischemia-reperfusion injury renal fibrosis renal tubular epithelial cells

Brain mechanism of acupuncture for children with anisometropic amblyopia: a resting functional magnetic resonance imaging study based on voxel-mirrored homotopic connectivity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第2期17卷 339-347页

作者： Jue Wang Jing Jia yan Sun Chong-Bing Ma Yu-zhu Chen An-Guo Liu Xing-Ke yan College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730101Gansu ProvinceChina Department of Ophthalmology Lanzhou Purui Ophthalmology HospitalLanzhou 730050Gansu ProvinceChina

AIM:To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxelmirror homotopic connectivity(VMHC)analysis method of resting functional magnetic resonance imaging(rs-fMRI)technology based on clinical ***:Eighty children with anisometropic monocular amblyopia were randomly divided into two groups:control(40 cases,1 case of shedding)and acupuncture(40 cases,1 case of shedding)*** control group was treated with glasses,red flash,grating,and visual stimulations,with each procedure conducted for 5min per *** on routine treatment,the acupuncture group underwent acupuncture of“regulating qi and unblocking meridians to bright eyes”,Jingming(BL1),Cuanzhu(BL2),Guangming(GB37),Fengchi(GB20)acupoints were taken on both sides,with the needle kept for 30min each *** groups were treated once every other day,three times per week,for a total of *** the treatment,the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were *** the same time,nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rsfMRI before and after *** differences in the brain regions between the two groups were compared and analyzed with ***:Chi-square test showed a notable difference in the total efficiency rate between the acupuncture(94.87%)and control groups(79.49%).Regarding the P100 wave latency and amplitude,the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control ***,the VMHC values of the bilateral temporal lobe,superior temporal gyrus,and middle temporal gyrus were notably increased in the acupuncture group after ***:Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic ***

关键词： resting functional magnetic resonance imaging voxel-mirror homotopy connection anisometropic amblyopia acupuncture

Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 427-442页

作者： Shuo Han Tao Wei Sijia Wang yanlong zhu Xingtong Guo liang He Xiongzhuang Li Qing Huang Daifen Chen School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China

Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell ***,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas *** solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output *** work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical ***,the challenges and future development of tubular SIS-SOFCs are also *** findings of this work can help guide the direction and inspire innovation of future development in this field.

关键词： solid oxide fuel cell segmented-in-series tubular experimental study numerical study

Regulating interfacial behavior of zinc metal anode via metal-organic framework functionalized separator

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 213-220,I0006页

作者： Ruotong Li liang Pan Ziyu Peng Ningning Zhao Zekun Zhang Jing zhu Lei Dai Ling Wang Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshan 063210HebeiChina

Aqueous zinc ion batteries(AZIBs)are one of the promising energy storage ***,uncontrolled dendrite and side reactions have seriously hindered its further *** this study,the metal-organic framework(MOF)functionalized glass fiber separator(GF-PFC-31)was used to regulate interfacial behavior of zinc metal anode,enabling the development of high-performance *** PFC-31,there areπ-πinteractions between two adjacent benzene rings with a spacing of 3.199 *** spacing can block the passage of[Zn(H_(2)O)_6]^(2+)(8.6 A in diameter)through the GF-PFC-31 separator to a certain extent,which promotes the deposition process of Zn *** addition,the sulfonic acid group(-S03H)contained in GF-PFC-31 can form a hydrogen bonding network with H_(2)O,which can provide a desolvation effect and reduce the side ***,GF-PFC-31 separator achieves uniform deposition of Zn *** Zn‖GF-PFC-31‖Zn symmetric cell exhibits stable cycle life(3000 h at 1.2 mA cm^(-2),2000 h at 0.3 mA cm^(-2),and 2000 h at 5.0 mA cm^(-2)),and Zn‖GF-PFC-31‖MnO_(2) full cell with GF-PFC-31 separator can cycle for 1000 cycles at 1.2 A g^(-1)with capacity retention rate of 82.5%.This work provides a promising method to achieve high-performance AZIBs.

关键词： Aqueous zinc ion batteries Interfacial behavior Metal-organic framework Sulfonic acid group Separator

Network Pharmacology and Experimental Study of MomordicineⅠand MomordicineⅡfrom Bitter Melon Saponins in Inhibiting Fat Accumulation

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第5期37卷 526-530页

作者： HUANG Shi Ting LI Shang Yuan LI Xin Yu zhu Ying zhu Lin ZHANG Jia yan ZHAO yan Sheng DAGLIA Maria XIAO Xiang BAI Juan School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Department of Pharmacy University of Napoli FedericoⅡVia D.Montesano 4980131 NaplesItaly International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013JiangsuChina

Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical ***,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).

关键词： melon Momordica subtropical

AKT2^(S128)/CCTα^(S315/319/323)-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 782-796页

作者： Jie Chen Lingyuan Zhang Yuheng zhu Di Zhao Jing Zhang yanmeng zhu Jingyuan Pang Yuanfan Xiao Qingnan Wu yan Wang Qimin Zhan Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina Peking University International Cancer Institute Peking University100191 BeijingChina Research Unit of Molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer Institute Suzhou 215000China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518107China

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic *** study employed multi-omics,including phosphoproteomics,untargeted metabolomics and lipidomics,to demonstrate that the pAKT2 Ser128 and pCCTαSer315/319/323-positive cancer-associated fibroblasts(CAFs)substantially release phosphatidylcholines(PCs),contributing to the resistance of focal adhesion kinase(FAK)inhibitors in esophageal squamous cell carcinoma(ESCC)***,we observed extremely low levels of FAK Tyr397 expression in CAFs,potentially offering no available target for FAK inhibitors playing their anti-growth role in ***,FAK inhibitor increased the intracellular concentration of Ca2+in CAFs,promoting the formation of AKT2/CCTαcomplex,leading to phosphorylation of CCTαSer315/319/323 sites and eventually enhancing stromal PC *** activation could stimulate the intratumoral Janus kinase 2(JAK2)/Signal transducer and activator of transcription 3(STAT3)pathway,triggering resistance to FAK *** of clinical samples demonstrated that stromal pAKT2 Ser128 and pCCTαSer315/319/323 are related to the tumor malignancy and reduced patient ***-targeted lipidomics and further validation cohort quantitatively showed that plasma PCs enable to distinguish the malignant extent of ESCC *** conclusion,inhibition of stroma-derived PCs and related pathway could be possible therapeutic strategies for tumor therapy.

关键词： CAFs metabolism resistance

Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan zhu Zuo-Kang Lin Hai-yan Yu Ye Dai Zhi-Min Dai Xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation