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Antidepressant effect of Xingnao Jieyu decoction mediated by alleviating neuroinflammation in a rat model of post-stroke depression

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Journal of Traditional Chinese Medicine 2019年第5期39卷 658-666页

作者： yan Yongmei li Tao Wang dou Zhao Bingbing Zhou Qi Department of Encephalopathy Affiliated hospital of Shaanxi University of Chinese Medicine

OBJECTIVE: To identify the antidepressant effect of Xingnao Jieyu (XNJY) decoction on a post-stroke depression (PSD) rat model and the underlying molecular mechanism. METHODS: We established a rat PSD model by middle cerebral artery occlusion (MCAO) combined with chronic unpredictable mild stress (CUMS). Healthy SD rats were randomly divided into six groups: sham, PSD, fluoxetine (Flu), and XNJY groups at low, middle, and high doses. The sham group underwent sham operation, while the other groups underwent MCAO+CUMS. The Flu and XNJY decoction groups were intragastrically administered with Flu or different doses of XNJY for 21 consecutive days. Histopathological changes in the cortex and hippocampus were observed by staining with hematoxylin and eosin and Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling. Iba1 positive cells were evaluated by immunofluorescence assay. The expressions of tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), interleukin-1β(IL-1β), 5-hydroxytryptamine (5-HT), and norepinephrine (NE) in the cortex and hippocampus were measured by enzyme linked immunosorbent assay. RESULTS: The PSD group rats had a significant decrease in body weight, consumption of sucrose water, and locomotor activity but an increase in immobility time during a forced swimming test (P < 0.01) compared with sham group. Flu and different doses of XNJY significantly recovered these indices (P < 0.01). XNJY also inhibited neuronal damage and apoptosis in the cortex induced by PSD (P < 0.01). Furthermore, XNJY reduced the number of Iba1 positive cells and the expressions of TNF-α, IL-6, and IL-1β, in addition to recovered the levels of 5-HT and NE in the cortex and hippocampus (P < 0.01). CONCLUSION: The alleviation of neuroinflammation might be an important mechanism of the XNJY decoction against PSD. Thus, XNJY might be a promising candidate for the treatment of PSD.

关键词： Depression Stroke Infarction, middle cerebral artery Stress Inflammation Antidepressive agents Xingnao Jieyu

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： yan Zhao Qiang Yuan liting yang Guisheng liang Yifeng Cheng limin Wu Chunfu lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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Self-assembly of Polyaniline： Mechanism Study

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Chinese Journal of Chemical Physics 2008年第2期21卷 187-192页

作者： Shi-yan Song li-jia Pan Yun li Yi Shi lin Pu Rong Zhang You-dou Zheng National Laboratory of Solid State Microstructures Nanjing Department of Physics Nanjing University Nanjing 210093 China

Anisotropic polyaniline （PAni） plates decorated with self-aligned nanofiber arrays were synthesized under the hydrothermaI conditions. The formation mechanism of the self-assembled structures was investigated by studying the effect on PAni micro-structure with additive electrolyte in reaction system, and numerical simulation for dependence of systematic electrostatic energy on cross angles of self-assembled nanofiber arrays in grid textured PAni plates. It is proposed that the electrostatic interaction based on ionic doping charges plays an important role in the formation of the self-assembled PAni structures.

关键词： Polyaniline Self-assembly Ionic charge

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The unique immune evasion mechanisms of the mpox virus and their implication for developing new vaccines and immunotherapies

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Virologica Sinica 2024年第5期39卷 709-718页

作者： Dong Fang yan liu dou dou Bin Su Department of Health Sciences National Natural Science Foundation of ChinaBeijing100085China Beijing Key Laboratory for HIV/AIDS Research Beijing Youan HospitalCapital Medical UniversityBeijing100069China Central Laboratory Beijing Youan HospitalCapital Medical UniversityBeijing100069China

Mpox is an infectious and contagious zoonotic disease caused by the mpox virus(MPXV),which belongs to the genus *** 2022,MPXV has posed a signiﬁcant threat to global public *** emergence of thousands of cases across the Western Hemisphere prompted the World Health Organization to declare an *** extensive coevolutionary history of poxviruses with humans has enabled these viruses to develop sophisticated mechanisms to counter the human immune ***ﬁcally,MPXV employs unique immune evasion strategies against a wide range of immunological elements,presenting a considerable challenge for treatment,especially following the discontinuation of routine smallpox vaccination among the general *** this review,we start by discussing the entry of the mpox virus and the onset of early infection,followed by an introduction to the mechanisms by which the mpox virus can evade the innate and adaptive immune *** caspase-1 inhibitory proteins and a PKR escape-related protein have been identiﬁed as phylogenomic hubs involved in modulating the immune environment during the MPXV *** respect to adaptive immunity,mpox viruses exhibit unique and exceptional T-cell inhibition capabilities,thereby comprehensively remodeling the host immune *** viral envelope also poses challenges for the neutralizing effects of antibodies and the complement *** unique immune evasion mechanisms employed by MPXV make novel multi-epitope and nucleic acid-based vaccines highly promising research directions worth ***,we brieﬂy discuss the impact of MPXV infection on immunosuppressed patients and the current status of MPXV vaccine *** review may provide valuable information for the development of new immunological treatments for mpox.

关键词： Immune response Immune evasion Mpox virus(MPXV) Immunopathology DNA sensing

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Asymptotic Behaviors for Critical Branching Processes with Immigration

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Acta Mathematica Sinica,English Series 2019年第4期35卷 537-549页

作者： dou dou li Mei ZHANG School of Mathematical Sciences Laboratory of Mathematics and Complex SystemsBeijing Normal University

In this paper, we investigate the asymptotic behaviors of the critical branching process with immigration {Z_n, n ≥ 0}. First we get some estimation for the probability generating function of Zn. Based on it, we get a large deviation for Z_(n+1)/Z_n. Lower and upper deviations for Zn are also studied. As a by-product, an upper deviation for max_(1≤i≤n) Z_i is obtained.

关键词： Critical branching process immigration large deviations

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CO_(2) corrosion of X80 steel welded joints under micro-turbulence induced by welding reinforcement height

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Journal of Iron and Steel Research International 2024年第4期31卷 1015-1032页

作者： Xiao-hui dou Bin li Zong-hao He Xin-wei Zhang Da-lei Zhang yan li School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Corrosion failure accidents owing to flow erosion and pipeline corrosion frequently occur during *** welding reinforcement height(WRH)can induce locally micro-turbulent flow field,which aggravates local corrosion of welded joints.A high wall shear stress(WsS)experimental setup was established to conduct the online electrochemical corrosion *** influence of WRH sizes on local corrosion of welded joints was studied at different flow *** electrochemical signals of the local corrosion of X80 welded joints at different flow rates were monitored in real time using electrochemical impedance spectroscopy and wire beam *** addition,the corrosion products composition and properties were *** results show that the micro-turbulent flow fields induced by the WRHs can enhance ion mass transfer near the welded *** corrosion products on the WRH surface also present different microscopic morphologies at different flow *** strong flow fields,the locally enhanced wsS can peel off the dense corrosion product partially,leading to the electrochemical distribution of large cathode and small anode,which accelerates the occurrence and development processes of the local corrosion of welded *** scientific guidelines for the corrosion protection of long-distance oil and gas pipelines can be potentially provided.

关键词： X80 steel welded joint Welding reinforcement height Micro-turbulence CO_(2)corrosion-Ion mass transfer

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang Hao Nian yan-Fang Wang li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong liping Huang Xiaoping Wang Wei Jiang liu-Pan yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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A systematic analysis of pneumatosis cystoids intestinalis

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World Journal of Gastroenterology 2013年第30期19卷 4973-4978页

作者： li-li Wu Yun-Sheng yang yan dou Qing-Sen liu Department of Gastroenterology and Hepatology Chinese People's Liberation Army Genaral Hospital

AIM:To increase the understanding,diagnosis and treatment of pneumatosis cystoides intestinalis(PCI)and to find the characteristics and potential cause of the disease in ***:We report here one case of PCI in a 70-year-old male patient who received a variety of treatment ***,we systematically searched the PCI eligible literature published from an available Chinese database from May 2002 to May 2012,including CBM,CBMDisc,CMCC,VIP,Wanfang,and *** key words were pneumatosis cystoides intestinalis,pneumatosis,pneumatosis intestinalis,pneumatosis coli and mucosal *** patients' information,histories,therapies,courses,and outcomes were ***:The study group consisted of 239 PCI cases(male:female = 2.4:1)from 77 reported *** mean age was 45.3 ± 15.6 years,and the median illness course was 6 *** hundred and sixty patients(66.9%)were in high altitude *** addition,43.5%(104/239)of the patients had potential PCI-related disease,and 16.3% had complications with intestinal obstruction and *** most common symptom was abdominal pain(53.9%),followed by diarrhea(53.0%),distention(42.4%),nausea and vomiting(14.3%),bloody stool(12.9%),mucous stool(12.0%)and constipation(7.8%).Most multiple pneumocysts developed in the submucosa of the colon(69.9%).The efficacy of the treatments by combined modalities,surgery,endoscopic treatment,conservative approach,oxygen,and antibiotics were 100%,100%,100%,93.3%,68.3% and 26.3%,***:PCI can be safely managed by conservative treatments,presents more frequently in males,in the large bowel and submucosa,than in females,in the small intestine and *** altitude residence maybe associated with the PCI etiology.

关键词： Pneumatosis cystoides intestinalis Pneumatosis Cyst Intestinal Colon

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One-step modification method of a superhydrophobic surface for excellent antibacterial capability

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Friction 2023年第4期11卷 524-537页

作者： ling LAN Yue-lan DI Hai-dou WANG yan-fei HUANG li-na ZHU Xu-hang li School of Engineering and Technology China University of Geosciences(Beijing)Beijing 100083China National Key Laboratory for Remanufacturing Academy of Army Armored ForcesBeijing 100072China National Engineering Research Center for Remanufacturing Army Academy of Armored ForcesBeijing 100072China

In this study,micro/nanostructures are fabricated on the surface of 3Cr13 stainless steel via laser etching,and a superhydrophobic coating with silver nanoparticles(AgNPs)is prepared by utilizing the reduction–adsorption properties of polydopamine(PDA).We investigate the effect of soaking time from the“one-step method”on the reduction of nano-Ag,surface wettability,and antibacterial *** electron microscopy is performed to analyze the distribution of nano-Ag on the surface,whereas X-ray energy dispersive spectroscopy and X-ray photoelectron spectroscopy are used to analyze the crystal structures and chemical compositions of different *** deposited with PDA on their surface are soaked in a 1H,1H,2H,2H-perfluorodecyltriethoxysilane water–alcohol solution containing AgNO3 for 3 ***,a“one-step method”is used to prepare low-adhesion superhydrophobic surfaces containing *** immersion progresses,more AgNPs are deposited onto the *** with the polished surface,the samples prepared via the“one-step method”show significant antibacterial properties against both gram-negative Escherichia coli and gram-positive Staphylococcus *** antibacterial properties of the surface improve as immersion progresses.

关键词： laser etching one-step modification polydopamine(PDA)processing silver nanoparticles(AgNPs) antibacterial superhydrophobic coating

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自营产品优先推荐策略对价格竞争的影响——基于移动健康平台场景

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管理工程学报 2025年第1期39卷 182-195页

作者：尹秋菊李佩伦颜志军北京理工大学管理学院

拥有自营产品的在线平台往往也允许竞争对手在其平台上销售同类型的产品,但可能优先将自营产品推荐给用户。现有文献分析了市场价格竞争受平台推荐策略的影响,但忽略了具有市场支配地位的平台可以采取主推自营产品的推荐策略。本文以移... 详细信息

拥有自营产品的在线平台往往也允许竞争对手在其平台上销售同类型的产品,但可能优先将自营产品推荐给用户。现有文献分析了市场价格竞争受平台推荐策略的影响,但忽略了具有市场支配地位的平台可以采取主推自营产品的推荐策略。本文以移动健康平台为场景,构建了一个平台与第三方商家竞争下的价格博弈模型,分析了自营产品优先推荐策略对平台和第三方商家间价格竞争的影响,提出了最优策略并讨论了其如何受推荐系统的用户信任与用户不匹配成本的影响。研究表明,自营产品优先推荐策略在市场竞争中起着关键作用,有利于自营产品的推荐策略也不一定损害第三方商家。当用户对自营产品和第三方产品的认知差异性较小时,平台与第三方商家均可从适度的自营产品优先推荐策略中获益。但当用户认知差异性较大时,过度的优先推荐策略会导致第三方商家不愿意入驻平台。另外,用户对推荐系统的过度信任和过高的用户不匹配成本均可能导致平台丧失推荐第三方产品的动机。

关键词：自营产品推荐策略价格竞争移动健康

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