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Clinical application of eight-zone laparoscopic dissection strategy for rectal cancer:Experience and discussion

World Journal of Gastroenterology 2024年第30期30卷 3574-3583页

作者： Chang Chen Xiang Zhang Xin Li yan-lei wang Department of General Surgery Rongchang People's HospitalChongqing 250012China Department of Colorectal Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Huantai Branch of Qilu Hospital of Shandong UniversityZibo 255000Shandong ProvinceChina

BACKGROUND The incidence of rectal cancer is increasing worldwide,and surgery remains the primary treatment *** the advent of total mesorectal excision(TME)technique,the probability of tumor recurrence post-surgery has significantly ***'focus has gradually shifted towards minimizing the impact of surgery on urinary and sexual *** these concerns,the optimal dissection of the rectal lateral ligaments and preservation of the pelvic floor neuro-vascular bundle have become *** explore the optimal surgical technique for TME and establish a standardized surgical protocol to minimize the impact on urinary and sexual functions,we propose the eight-zone dissection strategy for pelvic floor *** To compare the differences in surgical specimen integrity and postoperative quality of life satisfaction between the traditional pelvic floor dissection strategy and the innovative eight-zone dissection *** We analyzed the perioperative data of patients who underwent laparoscopic radical resection of rectal cancer at Qilu Hospital of Shandong University between January 1,2021 and December 1,*** study included a total of 218 patients undergoing laparoscopic radical surgery for rectal cancer,among whom 109 patients underwent traditional pelvic floor dissection strategy,and 109 patients received the eight-zone dissection *** There were no significant differences in general characteristics between the two *** in the eight-zone dissection group had higher postoperative specimen integrity(88.1%vs 78.0%,P=0.047).At the 3-month followup,patients in the eight-zone surgery group had better scores in urinary issues(6.8±3.3 vs 5.3±2.5,P=0.045)and male sexual desire(2.2±0.6 vs 2.5±0.5,P=0.047)compared to the traditional surgery strategy *** This study demonstrates that the eight-zone dissection strategy for laparoscopic lateral ligament dissection of rectal cancer is safe and ***

关键词： Eight-zone dissection strategy Rectal cancer Lateral ligament dissection Nerve injury Total mesorectal excision surgery

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Heterotopic ossification beneath the upper abdominal incision after radical gastrectomy:Two case reports

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World Journal of Clinical Cases 2022年第17期10卷 5805-5809页

作者： Xiang Zhang Ping-Tian Xia yan-Chao Ma Yong Dai yan-lei wang Department of Colorectal Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Radiology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Colorectal and Anal Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Heterotopic ossification(HO)is a rare clinical phenomenon that refers to bone formation in nonossifying *** SUMMARY This report presents two cases of HO beneath the upper abdominal median incision after radical *** first patient had postoperative pain below the incision *** were no signs of anastomotic leakage,and the wound *** tomography(CT)findings 2 wk postoperatively were negative for HO,but the 6-wk CT showed HO beneath the *** patient refused reoperation,and after conservative therapy,the pain was gradually relieved after 2 *** the second case,postoperative recovery was uneventful,and HO was only detected on routine follow-up CT after 4 *** anti-adhesion membrane was applied beneath the peritoneum in both *** findings suggest that HO beneath the abdominal incision might form at approximately 1 mo *** may cause intractable pain;however,reoperation is usually not *** In our cases,we suspect that HO may be related to the use of foreign materials beneath the peritoneum,which needs to be further investigated.

关键词： Heterotopic ossification Upper abdominal incision Radical gastrectomy Case report

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Effects of decompression joint Governor Vessel electro-acupuncture on rats with acute upper cervical spinal cord injury

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Neural Regeneration Research 2018年第7期13卷 1241-1246页

作者： yan-lei wang Ying-Na Qi Wei wang Chun-Ke Dong Ping Yi Feng yang Xiang-Sheng Tang Ming-Sheng Tan Beijing University of Chinese Medicine Beijing China Department of Spine Surgery China-Japan Friendship Hospital Beijing China

Decompression is the major therapeutic strategy for acute spinal cord injury,but there is some debate about the time window for decompression following spinal cord *** important goal and challenge in the treatment of spinal cord injury is inhibiting or reversing secondary *** Vessel electroacupuncture can improve symptoms of spinal cord injury by inhibiting cell apoptosis and improving the microenvironment of the injured spinal *** this study,Governor Vessel electroacupuncture combined with decompression at different time points was used to treat acute spinal cord *** rat models were established by inserting a balloon catheter into the atlanto-occipital *** upper cervical spinal cord was compressed for 12 or 48 hours prior to *** was conducted at the acupoints Dazhui（GV14） and Baihui（GV 20）（2 Hz,15 minutes） once a day for 14 consecutive *** with decompression alone,hind limb motor function recovery was superior after decompression for 12 and 48 hours combined with ***,the recovery of motor function was not significantly different at 14 days after treatment in rats receiving decompression for 12 ***-activating factor levels and caspase-9 protein expression were significantly reduced in rats receiving electroacupuncture compared with decompression *** findings indicate that compared with decompression alone,Governor Vessel electroacupuncture combined with delayed decompression（48 hours） is more effective in the treatment of upper cervical spinal cord *** Vessel electroacupuncture combined with early decompression（12 hours） can accelerate the recovery of nerve movement in rats with upper cervical spinal cord ***,further studies are necessary to confirm whether it is possible to obtain additional benefit compared with early decompression alone.

关键词： nerve regeneration acute spinal cord injury decompression Governor Vessel electroacupuncture platelet-activating factor apoptosis methylprednisolone caspase family upper cervical spine animal model Basso,Beattie and Bresnahan locomotor scale neural regeneration

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Comparison of modified gunsight suture technique and traditional interrupted suture in enterostomy closure

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World Journal of Gastroenterology 2023年第29期29卷 4571-4579页

作者： Chang Chen Xiang Zhang Zhi-Qiang Cheng Bin-Bin Zhang Xin Li Ke-Xin wang Yong Dai yan-lei wang Department of Colorectal Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of Nursing Qilu Hospital of Shandong University De Zhou HospitalDezhou 254300Shandong ProvinceChin Department of General Surgery Huantai Branch of Qilu Hospital of Shandong UniversityZibo 255000Shandong ProvinceChina

BACKGROUND Prophylactic enterostomy surgery is a common surgical approach used to reduce the risk of anastomotic leakage in patients who have undergone partial intestinal resection due to trauma or ***,the traditional interrupted suturing technique used in enterostomy closure surgery has several issues,including longer surgical incisions and higher incision tension,which can increase the risk of postoperative *** address these issues,scholars have proposed the use of a“gunsight suture”*** technique involves using a gunsight incision instead of a traditional linear incision,leaving a gap in the center for the drainage of blood and fluid to reduce the risk of *** on this technique,we propose an improved gunsight suture technique.A drainage tube is placed at the lowest point of the incision and close the gap in the center of the gunsight suture,which theoretically facilitates early postoperative mobility and reduces the burden of dressing changes,thereby reducing the risk of postoperative *** To compare the effectiveness of improved gunsight suture technique with traditional interrupted suture in closing intestinal *** In this study,a retrospective,single-center case analysis was conducted on 270 patients who underwent prophylactic ileostomy closure surgery at the Department of Colorectal Surgery of Qilu Hospital from April 2017 to December *** patients were divided into two groups:135 patients received sutures using the improved gunsight method,while the remaining 135 patients were sutured with the traditional interrupted suture *** collected data on a variety of parameters,such as operation time,postoperative pain score,body temperature,length of hospital stays,laboratory indicators,incidence of incisional complications,number of wound dressing changes,and hospitalization ***-parametric tests and chi-square tests were utilized for data *** There were no statistica

关键词： Enterostomy Abdominal wound closure technique Suture techniques Surgical wound infection Hospital costs Hospital stay

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Fusobacterium Nucleatum Is a Risk Factor for Metastatic Colorectal Cancer

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Current Medical Science 2022年第3期42卷 538-547页

作者： Wen-dan CHEN Xin ZHANG Ya-ping ZHANG Cong-bo YUE yan-lei wang Hong-wei PAN yan-li ZHANG Hui LIU Yi ZHANG Department of Clinical Laboratory Qilu Hospital of Shandong UniversityJinan 250012China Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Clinical Laboratory Shandong Provincial Third HospitalJinan 250031China

Objective Increasing evidence has indicated that there is a correlation between Fusobacterium nucleatum(***)abundance and poor prognosis of colorectal cancer(CRC).Furthermore,tumor metastasis plays a decisive role in the prognosis of CRC ***,it was hypothesized that the abundance of *** in CRC tissues affects the tumor *** In the present study,*** DNA obtained from 141 resected CRC samples was quantified by qPCR to determine whether there were differences in *** abundance between groups with and without CRC *** The results revealed that *** was more abundant in CRC patients with metastasis,and CRC tissues enriched with *** had a higher risk of lymph node metastasis and distant *** receiver operating characteristic curve indicated that *** in CRC tissues could be used as an indicator for CRC metastasis,to some ***,the in vitro experiments(electron microscopy,and migration and invasion trials)revealed that *** was a highly invasive bacterial strain,and could significantly enhance the invasion and migration capacity of SW480 and SW620 *** addition,a meta-analysis comprehensively indicated a slight correlation between *** abundance and advanced CRC stage(RR=1.17,95%CI:1.00–1.37,P=0.04,random effect).Conclusion There is a correlation between *** abundance and CRC metastasis,and *** may serve as a metastasis biomarker for CRC patients.

关键词： Fusobacterium nucleatum colorectal cancer metastasis

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Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway

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World Journal of Gastroenterology 2022年第31期28卷 4328-4337页

作者： Zhi-Qiang Cheng Tong-Ming Liu Peng-Fei Ren Chang Chen yan-lei wang Yong Dai Xiang Zhang Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Colorectal and Anal Surgery Feicheng Hospital Affiliated to Shandong First Medical UniversityFeicheng 271600Shandong ProvinceChina Department of General Surgery Lincheng People’s HospitalDezhou 253500Shandong ProvinceChina

BACKGROUND Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass(DJB).Serum bile acids are elevated ***,the clinical relevance is not *** acids in the peripheral circulation reflect the amount of bile acids in the ***,a further investigation of luminal bile acids following DJB is of great *** To investigate changes of luminal bile acids following *** Salicylhydroxamic acid(SHAM),DJB,and DJB with oral chenodeoxycholic acid(CDCA)supplementation were performed in a high-fat-diet/streptozotocininduced diabetic rat *** weight,energy intake,oral glucose tolerance test,luminal bile acids,serum ceramides and intestinal ceramide synthesis were analyzed at week 12 *** Compared to SHAM,DJB achieved rapid and durable improvement in glucose tolerance and led to increased total luminal bile acid concentrations with preferentially increased proportion of farnesoid X receptor(FXR)-inhibitory bile acids within the common *** ceramide synthesis was repressed with decreased serum ceramides,and this phenomenon could be partially antagonized by luminal supplementation of FXR activating bile acid *** DJB significantly changes luminal bile acid composition with increased proportion FXR-inhibitory bile acids and reduces serum ceramide *** observations suggest a novel mechanism of bile acids in metabolic regulation after DJB.

关键词： Bariatric surgery Duodenal-jejunal bypass Farnesoid X receptor Ceramide Bile acids Liver fat accumulation

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Application of modified primary closure of the pelvic floor in laparoscopic extralevator abdominal perineal excision for low rectal cancer

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World Journal of Gastroenterology 2018年第30期24卷 3440-3447页

作者： yan-lei wang Xiang Zhang Jia-Jia Mao Wen-Qiang Zhang Hao Dong Fan-Pei Zhang Shuo-Hui Dong Wen-Jie Zhang Yong Dai Department of Colorectal and Anal Surgery Qilu Hospital of Shandong University

AIM To introduce a novel,modified primary closure technique of laparoscopic extralevator abdominal perineal excision(LELAPE) for low rectal *** We retrospectively analyzed data from 76 patients with rectal cancer who underwent LELAPE from March 2013 to May *** were classified into the modified primary closure group(32 patients) and the biological mesh closure group(44 patients).The total operating time,reconstruction time,postoperative stay duration,total cost,postoperative complications and tumor recur-rence were *** All surgery was successfully *** pelvic reconstruction time was 14.6 ± 3.7 min for the modified primary closure group,which was significantly longer than that of the biological mesh closure group(7.2 ± 1.9 min,P < 0.001).The total operating time was not different between the two groups(236 ± 20 min vs 248 ± 43 min,P = 0.143).The postoperative hospital stay duration was 8.1 ± 1.9 d,and the total cost was 9297 ± 1260 USD for the modified primary closure ***,both of these categories were significantly lower in this group than those of the biological mesh closure group(P = 0.001 and P = 0.003,respectively).There were no differences observed between groups when comparing other perioperative data,long-term complications or oncological *** The modified primary closure method for reconstruction of the pelvic floor in LELAPE for low rectal cancer is technically feasible,safe and cost-effective.

关键词： Extralevator abdominoperineal excision Rectal cancer Pelvic floor Laparoscopy

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Subarachnoid disseminative hemangiopericytoma of the spinal cord

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Chinese Medical Journal 2010年第11期123卷 1485-1488页

作者： LIN Guo-zhong wang Zhen-yu LI Zhen-dong ZHONG yan-feng wang lei-ming Department of Neurosurgery Peking University Third HospitalPeking University Beijing 100191 China

Hemangiopericytomas （HPCs） originating from central nervous system were increasingly reportedrecently. Intravertebral HPCs are preclomlnanuy eplaural. Primary intradural HPCs of spinal cord are rare. Little subarach... 详细信息

关键词： hemangiopericytoma cervical spinal cord subarachnoid disseminateion

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Application of Laparoscopic Extralevator Abdominoperineal Excision in Locally Advanced Low Rectal Cancer

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Chinese Medical Journal 2015年第10期128卷 1340-1345页

作者： yan-lei wang Yong Dai Jin-Bo Jiang Hui-yang Yuan San-Yuan Hu Department of General Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China

Background：When compared with conventional abdominoperineal resection （APR）,extralevator abdominoperineal excision （ELAPE） has been demonstrated to reduce the risk of local recurrence for the treatment of locally advanced low rectal *** with the laparoscopic technique,laparoscopic ELAPE （LELAPE） has the potential to reduce invasion and hasten postoperative *** this study,we aim to investigate the advantages of LELAPE in comparison with conventional ***：From October 2010 to February 2013,23 patients with low rectal cancer （T3-4N0-2M0） underwent LELAPE;while during the same period,25 patients were treated with conventional *** patient characteristics,intraoperative data,postoperative complications,and follow-up results were retrospectively compared and ***：The basic patient characteristics were similar;but the total operative time for the LELAPE was longer than that of the conventional APR group （P =0.014）.However,the operative time for the perineal portion was comparable between the two groups （P =0.328）.The LELAPE group had less intraoperative blood loss （P =0.022）,a lower bowel perforation rate （P =0.023）,and a positive circumferential margin （P =0.028）.Moreover,the patients,who received the LELAPE,had a lower postoperative Visual Analog Scale,quicker recovery of bowel function （P =0.001）,and a shorter hospital stay （P =0.047）.However,patients in the LELAPE group suffered more chronic perineal pain （P =0.002）,which may be related to the coccygectomy （P =0.033）.Although the metastasis rate and mortality rate were similar between the two groups,the local recurrence rate of the LELAPE group was statistically improved （P =0.047）.Conclusions：When compared with conventional APR,LELAPE has the potential to reduce the risk of local recurrence,and decreases operative invasion for the treatment of locally advanced low rectal cancer.

关键词： Abdominoperineal Resection Circumferential Margin Extralevator Abdominoperineal Excision Laparoscopy Low Rectal Cancer

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li yan wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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