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Microstructure and mechanical properties of F_(GBA)/B_G air cooling bainitic steels containing niobium

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International Journal of Minerals,Metallurgy and Materials 2010年第4期17卷 429-434页

作者： Chun Feng Hong-sheng Fang Bing-zhe Bai yan-kang zheng Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

The effect of different Nb additions on the mechanical properties and microstrucmre evolution of grain boundary allotriomorphic ferrite （FGBA） / granular bainite （BG） air cooling bainitic steels was investigated. The results indicate that the tensile strength and yield strength increase by 157 and 97 MPa, respectively with the addition of 0.02wt% Nb. The steel acquires superior strength and toughness with the addition of 0.06wt% Nb. The results of scanning electron microscopy and transmission electron microscopy reveal that the addition of Nb not only refines the size of granular bainite but also increases the volume fraction of granular bainite in FGBA/BG steels. The refinement effect of granular bainite is improved with the increase of Nb content.

关键词： granular bainite microstructure evolution mechanical properties Nb

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

CYP2C19 and PON1 genetic variants as potential predictors for the risk of bleeding in antiplatelet-treated patients

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中国病理生理杂志 2012年第11期 2094-2094页

作者： ZHONG Shi-long,WU Hong,ZHANG Bin,kang yan-hong,zheng Zhi-wei,WANG Ling,LIN Qiu-xiong,SHAN Zhi-xin,CHEN Ji-yan,YU Xi-yong(Research Center of Medical Sciences,Guangdong General Hospital,Guangdong Provincial Cardiovascular Institute,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

AIM:Bleeding has emerged as an important outcome in antiplatelet treatment after percutaneous coronary intervention(PCI),but the study on the relationship between genetic variations with inter-patient variability of b... 详细信息

关键词： CYP2C19 and PON1 genetic variants as potential predictors for the risk of bleeding in antiplatelet-treated patients PCI PON

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大米蛋白渣除脂方法的研究

食品科技 2011年第9期36卷 190-192页

作者：刘柳袁江兰高金瑾靳艳康旭吴正奇湖北工业大学生物工程学院武汉430068

探究大米蛋白渣除脂的方法和条件。以余脂、油脂提取率为评价指标,分别采用密度分离法、溶剂复合法、超临界CO2萃取法对米渣中油脂进行萃取分离。结果表明密度分离法脱脂效果最差;溶剂复合法脱脂效果较好,油脂提取率达85.12%;超临界CO2... 详细信息

探究大米蛋白渣除脂的方法和条件。以余脂、油脂提取率为评价指标,分别采用密度分离法、溶剂复合法、超临界CO2萃取法对米渣中油脂进行萃取分离。结果表明密度分离法脱脂效果最差;溶剂复合法脱脂效果较好,油脂提取率达85.12%;超临界CO2萃取的脱脂效果最好,其最佳条件为:萃取温度45℃、萃取压力25MPa、萃取时间60min、夹带剂无水乙醇用量200mL,油脂提取率可达98.62%。

关键词：密度分离法溶剂复合法超临界CO2萃取法大米蛋白渣除脂

Urban garbage disposal and management in China

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Journal of Environmental Sciences 2003年第4期15卷 531-540页

作者： JIANG Yuan kang Mu yi LIU zheng ZHOU yan fang Institute of Resources Science Beijing Normal UniversityBeijing 100875China.

This paper, probing into the present situation of urban domestic garbage by analyzing its growing trend, compositional change and regional difference, reveals the problems existing in its disposal and management in China. Meanwhile, a questionnaire was conducted in five big cities around China for surveying urban residents' attitudes towards garbage disposal and management policies and measures. Results showed the output of urban domestic garbage in Chinese cities is ever increasing, and the recoverable materials and energy in garbage composition are also increasing. The population growth, economic development, and increase of residents' expenditure level are the main factors influencing the growing output and changing composition of the garbage. Information acquired from the questionnaire showed that majority of the urban residents are in favor of the garbage reduction policies and managerial measures and are willing to collaborate with municipal government in battling against garbage. Based on the analysis and questionnaire, some policymaking oriented suggestions such as operating the garbage disposal from a social welfare service to a sector of profit gaining enterprises, transferring the garbage management from passive end control to active source control, promoting the classified garbage collection in cities around China, and charging garbage fees for its cleanup and disposal, have also been put forward in the paper.

关键词： urban domestic garbage garbage collection garbage disposal garbage management

Fluorescent probes for detection of biothiols based on “aromatic nucleophilic substitution-rearrangement” mechanism

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Chinese Chemical Letters 2019年第10期30卷 1791-1798页

作者： yan-Fei kang Li-Ya Niu Qing-zheng yang Hebei Key Laboratory of Quality&Safety Analysis-Testing for Agro-Products and Food and College of Laboratory MedicineHebei North UniversityZhangjiakou 075000China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

Biothiols,including cysteine(Cys),homocysteine(Hey),and glutathione(GSH) play important roles in physiological processes,and the detection of thiol using fluorescent probes has attracted attention due to their high sensitivity and selectively and invasive on-time ***,the similar structures and reactivity of these biothiols present great challenges for selective *** review focused on the the "aromatic nucleophilic substitution-rearrangement(SNAr-rearrangement) mechanism",which provided a powerful tool to design fluorescent probes for the discrimination between *** classify the fluorescent probes according to types of fluorophores,such as difluoroboron dipyrromethene(BODIPY),nitrobenzoxadiazole(NBD),cyanine,pyronin,naphthalimide,coumarin,and so *** hope this review will inspire exploration of new fluorescent probes for biothiols and other relevant analytes.

关键词： Biothiols Fluorescent probes Aromatic nucleophilic substitution Rearrangement Fluorophores Bioapplication

Impact angle constrained fuzzy adaptive fault tolerant IGC method for Ski-to-Turn missiles with unsteady aerodynamics and multiple disturbances

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Journal of Systems Engineering and Electronics 2022年第5期33卷 1210-1226页

作者： GUO Hang WANG zheng FU Bin CHEN kang FU Wenxing yan Jie Research Center for Unmanned System Strategy Development Northwestern Polytechnical UniversityXi’an 710072China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China

An impact angle constrained fuzzy adaptive fault tolerant integrated guidance and control method for Ski-to-Turn(STT)missiles subject to unsteady aerodynamics and multiple disturbances is *** aerodynamics appears when flight vehicles are in a transonic state or confronted with unstable ***,actuator failures and multisource model uncertainties are ***,the boundaries of these multisource uncertainties are assumed *** target is assumed to execute high maneuver movement which is unknown to the ***,impact angle constraint puts forward higher requirements for the interception accuracy of the integrated guidance and control(IGC)*** impact angle constraint and the precise interception are established as the object of the IGC ***,the boundaries of the lumped disturbances are estimated,and several fuzzy logic systems are introduced to compensate the unknown nonlinearities and ***,a series of adaptive laws are developed so that the undesirable effects arising from unsteady aerodynamics,actuator failures and unknown uncertainties could be ***,an impact angle constrained fuzzy adaptive fault tolerant IGC method with three loops is constructed and a perfect hit-to-kill interception with specified impact angle can be ***,the numerical simulations are conducted to verify the effectiveness and superiority of the proposed method.

关键词： integrated guidance and control(IGC) impact angle constraint unsteady aerodynamics fault tolerant control(FTC) actuator failures

Comparative Study of Earing Behavior in Cold Rolled-batch Annealed and Cold Rolled-Continuous Annealed of DoubleReduced (DR) Tinplate Steels

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Journal of Harbin Institute of Technology(New Series) 2019年第2期26卷 48-54页

作者： Xiaofei zheng yan yan Yonglin kang School of Materials Science and Engineering University of Science and Technology Beijing Shougang Jingtang Iron and Steel United Co. Ltd.

Two double cold reduction-drawn and redrawn(DRD) tinplate steels of the same chemistries that have been processed by continuous and batch annealing line have been researched. The composition of fibers were studied through X-ray diffraction. The results indicate that a strong intensity of {114} was formed in the continuous annealing steel and a strong intensity of {111} was formed in the batch annealing steel; not only that but the γ fiber slowly rotated to the low angel α fiber with the angel being about 30° nearly {112}texture owing to the higher second reduction.

关键词： earing behavior annealing process texture double cold reduction-drawn and redrawn(DRD)

神经营养因子3经受体切换促进大鼠脊髓损伤后神经功能的恢复

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中国组织工程研究 2025年第11期29卷 2268-2276页

作者：丛岩于健孙志德康大伟承德医学院附属医院急诊科河北省承德市067000

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明... 详细信息

背景:神经营养因子是治疗脊髓损伤的新方法,调控自噬是其发挥作用的机制之一,但具体的信号通路尚不明确。目的:探讨神经营养因子3如何通过P75NTR/Trk C受体切换来调节少突胶质细胞的自噬以及促进脊髓损伤后神经功能恢复的作用,进一步明确具体的分子机制。方法:将24只SD大鼠随机分为3组:假手术组、脊髓损伤组和神经营养因子3组,通过大鼠后肢神经功能评分来评估神经营养因子3对脊髓损伤大鼠的治疗效果,采用Western blot检测各组大鼠脊髓组织中神经营养因子3、Olig1、MBP蛋白以及自噬标记蛋白LC3B的表达水平。在细胞实验中,将少突胶质细胞接种在培养皿中,分为糖氧剥夺组、糖氧剥夺+神经营养因子3组、糖氧剥夺+神经营养因子3+P75NTR质粒组、糖氧剥夺+神经营养因子3+Trk C质粒组、糖氧剥夺+3-甲基腺嘌呤(自噬抑制剂)组及糖氧剥夺+雷帕霉素(自噬激活剂)组。光学显微镜观察少突胶质细胞形态变化,TUNEL染色观察细胞凋亡现象,Western blot检测Trk C受体、P75NTR、LC3B表达及PI3K/AKT/m TOR和AMPK/m TOR信号途径的磷酸化状态。结果与结论:(1)动物实验显示,与假手术组相比,脊髓损伤后神经营养因子3的表达显著增加(P<0.05);与脊髓损伤组相比,外源性神经营养因子3治疗能够加快大鼠神经功能的恢复(P<0.05),并增加Olig1和MBP蛋白的表达(P<0.05);(2)细胞实验发现,3 h是损伤早期与中后期的分界点,与糖氧剥夺组相比,糖氧剥夺+神经营养因子3组少突胶质细胞能够更长时间地维持其形态,Trk C受体在早期表达水平较低而中后期显著上调(P<0.05),P75NTR则在早期上调而中后期下调(P<0.05),自噬水平呈现出先升高后降低的趋势(P<0.05);(3)通过对比糖氧剥夺+神经营养因子3组、糖氧剥夺+雷帕霉素组和糖氧剥夺+3-甲基腺嘌呤组的细胞形态和TUNEL染色结果,发现单独促进或抑制自噬对少突胶质细胞的存活均有不利影响,而类似神经营养因子3这样调节自噬的方法则能最大限度地维持细胞存活;(4)神经营养因子3在早期通过P75NTR/AMPK/m TOR信号通路促进自噬,而在后期通过Trk C/PI3K/AKT/m TOR信号通路抑制自噬。根据上述结果,得到如下结论,即神经营养因子3可以通过P75NTR/Trk C受体的切换能够双向调控少突胶质细胞的自噬,从而维持细胞存活,有助于脊髓损伤后大鼠的神经功能恢复。

关键词：神经营养因子3 自噬少突胶质细胞受体切换凋亡脊髓损伤