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四氢喹啉并氮杂糖稠合化合物的绿色合成

化学研究与应用 2025年第1期37卷 237-242页

作者：庞彦龙武继来周利凯河北大学综合实验中心河北保定071002 河北大学化学与材料科学学院河北保定071002 河北省功能高分子材料研发与工程应用技术创新中心邢台学院化学工程与生物技术学院河北邢台054001

四氢喹啉多具有良好的生物活性,同时氮杂糖环上多羟基“类糖性”结构特点,赋予四氢喹啉氮杂糖稠合化合物在新药研发领域中潜在的应用价值。本文以对甲苯磺酰化的D-核糖和芳胺为原料,经aza DielsAlder反应机制,室温条件下,一步简便地立... 详细信息

四氢喹啉多具有良好的生物活性,同时氮杂糖环上多羟基“类糖性”结构特点,赋予四氢喹啉氮杂糖稠合化合物在新药研发领域中潜在的应用价值。本文以对甲苯磺酰化的D-核糖和芳胺为原料,经aza DielsAlder反应机制,室温条件下,一步简便地立体选择性地合成了系列新型稠杂四氢喹啉氮杂糖。苯胺间位或对位有取代基时,反应均能较好地生成预期产物。该反应具有条件温和、操作简单、产率高、无金属催化等特点。

关键词：四氢喹啉稠杂氮杂糖 aza Diels-Alder反应绿色合成

地夸磷索钠滴眼液治疗中重度干眼患者的疗效及安全性分析

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中国医学工程 2025年第1期33卷 120-123页

作者：张彩虹严凯卫东汇视眼科门诊部河南平顶山467021

目的探讨地夸磷索钠滴眼液在中重度干眼患者中的应用情况及安全性。方法根据随机数字表法,将在2022年10月至2023年9月间于卫东汇视眼科门诊部就诊的156例中重度干眼患者分为对照组(78例)和观察组(78例)。对照组施以0.1%玻璃酸钠滴眼液治... 详细信息

目的探讨地夸磷索钠滴眼液在中重度干眼患者中的应用情况及安全性。方法根据随机数字表法,将在2022年10月至2023年9月间于卫东汇视眼科门诊部就诊的156例中重度干眼患者分为对照组(78例)和观察组(78例)。对照组施以0.1%玻璃酸钠滴眼液治疗,观察组加之3%地夸磷索钠滴眼液,两组均连续治疗四周。比较两组临床疗效,治疗前后泪液分泌量、泪膜破裂时间及视力状态,对比敏感度,以及不良反应。结果观察组临床疗效更佳(P0.05)。结论地夸磷索钠滴眼液在中重度干眼患者的临床治疗中疗效确切,可有效改善患者泪液分泌量、泪膜破裂时间、对比敏感度,提高视力状态,安全性较高,在临床中具有较高的应用价值。

关键词：干眼地夸磷索钠滴眼液玻璃酸钠滴眼液临床疗效

Corrosion behavior of Gd_(2)Zr_(2)O_(7)thermal barrier coatings under Fe-containing environmental sediment attack

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Journal of Advanced Ceramics 2024年第4期13卷 447-462页

作者： Lei Guo yanyan Li kai yan School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Advanced Joining Technology Key Lab of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin 300072China Key Laboratory of Special Equipment Safety and Energy-saving for State Market Regulation China Special Equipment Inspection&Research InstituteBeijing 100029China

Environmental sediments mainly consisting of CaO–MgO–Al_(2)O_(3)–SiO_(2)(CMAS)corrosion are a serious threat to thermal barrier coatings(TBCs),in which Fe element is usually ***_(2)Zr_(2)O_(7)TBCs are famous for their excellent CMAS *** this study,the characteristics of Fe-containing environmental sediments(CMAS-Fe)and their corrosiveness to Gd_(2)Zr_(2)O_(7)coatings were *** types of CMAS-Fe glass with different Fe contents were *** melting points were measured to be 1322–1344℃,and the high-temperature viscosity showed a decreasing trend with increasing Fe *** corrosion behavior of four types of CMAS-Fe to Gd_(2)Zr_(2)O_(7)coatings at 1350℃was *** the initial corrosion stage(0.1 h),anorthite was precipitated in CMAS-Fe with a high Ca:Si ratio,while Fe-garnet was formed in the melt with the highest Fe *** the corrosion time resulted in the formation of a reaction layer,which exhibited an interpenetrating network composed of Gd-oxyapatite,ZrO_(2),and residual *** spinel was precipitated within the reaction *** 1 h or even longer time,the reaction layers tended to be stable and compact,which had comparable hardness and fracture toughness to those of Gd_(2)Zr_(2)O_(7)*** the cyclic CMAS-Fe attack,the residual CMAS-Fe in the interpenetrating network provided a pathway for the redeposited CMAS-Fe infiltration,resulting in the continuous growth of the reaction *** a result,the Gd_(2)Zr_(2)O_(7)coatings had a large consumption in the thickness,degrading the coating ***,the Gd_(2)Zr_(2)O_(7)coatings exhibit unsatisfactory corrosion resistance to CMAS-Fe attack.

关键词： thermal barrier coatings(TBCs) Gd_(2)Zr_(2)O_(7) Fe-containing CaO-MgO-Al2O3-SiO_(2)(CMAS) corrosion resistance reaction layer

Active training sample selection and updating strategy for near-infrared model with an industrial application

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2749-2758页

作者： kaixun He kai Wang Yayun yan College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Advanced Control and Optimization for Chemical Processes Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

Training sample selection is widely accepted as an important step in developing a near-infrared(NIR) spectroscopic model. For industrial applications, the initial training dataset is usually selected empirically. This process is time-consuming, and updating the structure of the modeling dataset online is difficult. Considering the static structure of the modeling dataset, the performance of the established NIR model could be degraded in the online process. To cope with this issue, an active training sample selection and updating strategy is proposed in this work. The advantage of the proposed approach is that it can select suitable modeling samples automatically according to the process information. Moreover, it can adjust model coefficients in a timely manner and avoid arbitrary updating effectively. The effectiveness of the proposed method is validated by applying the method to an industrial gasoline blending process.

关键词： Near-infrared spectroscopy Chemical processes Process systems Soft sensor Gasoline blending

Lymph node metastatic patterns of gastric carcinoma with a combination of adenocarcinoma and neuroendocrine carcinoma components

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World Journal of Gastroenterology 2025年第8期31卷 24-37页

作者： kai Zhou Zhong-Wu Li yan Wu Zhi-Jie Wang Ling-Qian Wang Li-Xin Zhou Ling Jia Ke Ji Xue-Song yang Ji Zhang Xiao-Jiang Wu An-Qiang Wang Zhao-De Bu Department of Gastrointestinal Surgery Peking University Cancer Hospital and InstituteBeijing 100142China Department of Pathology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Gastric mixed-adenoneuroendocrine carcinoma(G-MANEC)is a subtype of gastric *** upon prior research findings,we propose that tumours containing both neuroendocrine carcinoma(NEC)and adenocarcinoma(AC)components,with each component ranging from 1%to 99%of the tumour,be classified as a distinct *** hereby term this adenoneuroendocrine mixed gastric cancer(G-ANEC).Research on lymph node(LN)involvement in GMANEC has focused mainly on metastasis status,with limited studies on metastatic *** To investigate the LN metastasis patterns of G-ANEC,the clinicopathological features associated with these metastasis patterns,and to explore adjuvant chemotherapy regimens for *** We analyzed 68 G-ANEC cases treated with radical surgery and confirmed LN metastasis at Peking University Cancer Hospital between August 2012 and June ***χ2 tests in IBM statistical product and service solutions statistics and R *** We identified three distinct LN metastasis patterns in G-ANEC that were significantly associated with the NEC proportion,tumour invasion depth,Lauren classification,and tumour location(P values:0.008,0.015,0.01,and 0.004,respectively).When the SOX/XELOX regimen was applied for adjuvant chemotherapy,patients with LN metastasis comprising only AC exhibited better overall survival(OS)(94.25±11.07 months vs 54.36±11.36 months)than did those with *** LN metastasis components contained NEC,there was a trend towards improved OS(64±10.77 months vs 54.35±11.36 months)and disease-free survival(71.28±9.92 months vs 66.28±11.93 months)in patients treated with the etoposide and cisplatin compared to those receiving the SOX/XELOX *** We found a significant correlation between the NEC percentage,tumour invasion depth,Lauren classification,and tumour location and LN metastasis patterns in *** G-ANEC,a lower proportion of NEC or AC in the primary lesion does not preclude the possibility of thes

关键词： Gastric mixed-adenoneuroendocrine carcinoma Lymph node metastatic patteren Clinicopathological features Adjuvant chemotherapy regimens Prognosis

Complexity estimation of image sequence for automatic target track

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Journal of Systems Engineering and Electronics 2019年第4期30卷 672-683页

作者： WANG Xiaotian ZHANG kai yan Jie School of Astronautics Northwestern Polytechnical University

In the field of automatic target recognition and tracking,traditional image complexity metrics,such as statistical variance and signal-to-noise ratio,all focus on single-frame ***,there are few researches about the complexity of image *** solve this problem,a criterion of evaluating image sequence complexity is ***,to characterize this criterion quantitatively,two metrics for measuring the complexity of image sequence,namely feature space similarity degree of global background(FSSDGB)and feature space occultation degree of local background(FSODLB)are ***,FSSDGB reflects the ability of global background to introduce false alarms based on feature space,and FSODLB represents the difference between target and local background based on feature ***,the feature space is optimized by the grey relational method and relevant features are removed so that FSSDGB and FSODLB are more reasonable to establish complexity of single-frame ***,the image sequence complexity is not a linear sum of the single-frame image *** tracking errors often occur in high-complexity images and the tracking effect of low-complexity images is very *** nonlinear transformation based on median(NTM)is proposed to construct complexity of image *** experimental results show that the proposed metric is more valid than other metrics,such as sequence correlation(SC)and interframe change degree(IFCD),and it is highly relevant to the actual performance of automatic target tracking algorithms.

关键词： complexity of image sequence feature space similarity degree of global background(FSSDGB) feature space occultation degree of local background(FSODLB) grey relational method nonlinear transformation based on median(NTM)

基于网络药理学、分子对接和动物实验探讨枳术汤调控巨噬细胞极化改善儿童肥胖脂肪组织炎症的作用机制

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中国中药杂志 2025年第1期50卷 228-237页

作者：殷永凯牛昶淼梁莉婷淡漠高天启秦艳虹燕小宁山西中医药大学第三临床学院山西省中西医结合医院山西晋中030619 山西中医药大学第一临床学院山西晋中030619

运用网络药理学和分子对接技术探讨枳术汤调控巨噬细胞极化改善儿童肥胖脂肪组织炎症的作用机制,并进行动物实验验证。使用中药系统药理学数据库与分析平台(TCMSP)筛选枳术汤的活性成分和作用靶点;通过GeneCards、OMIM、DisGeNET数据库... 详细信息

运用网络药理学和分子对接技术探讨枳术汤调控巨噬细胞极化改善儿童肥胖脂肪组织炎症的作用机制,并进行动物实验验证。使用中药系统药理学数据库与分析平台(TCMSP)筛选枳术汤的活性成分和作用靶点;通过GeneCards、OMIM、DisGeNET数据库搜集儿童肥胖脂肪组织炎症相关靶点,绘制药物-疾病靶点交集图;利用STRING数据库构建蛋白-蛋白互作(PPI)网络筛选核心靶点;通过R语言进行基因本体论(Gene Ontology,GO)功能和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析;利用AutoDock软件对核心靶点和活性成分进行分子对接分析。将24只SPF级6周龄C57B/6J雄性小鼠适应性饲养1周,随机选取8只作为空白组,其余16只通过8周的高脂饲料喂养构建高脂肪饮食诱导小鼠肥胖模型,造模成功后将16只小鼠随机分为模型组和枳术汤组,每组8只。枳术汤组灌胃给药干预14 d,每日1次,空白组和模型组给予等量无菌双蒸水(ddH2O)灌胃。末次灌胃后取小鼠血清和腹股沟脂肪组织进行检测。通过苏木素-伊红(HE)染色观察腹股沟脂肪组织形态,酶联免疫吸附(ELISA)法检测炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)含量,免疫荧光染色检测巨噬细胞标记分子一氧化氮合酶(iNOS)和表皮生长因子样激素受体1(F4/80)蛋白表达。网络药理学显示,从枳术汤中筛选出木犀草素、柚皮素、川陈皮素等主要活性成分,核心靶点15个;KEGG通路富集分析发现涉及核因子κB(NF-κB)关键信号通路;分子对接显示,枳术汤活性成分与核心靶点结合良好;动物实验显示,与模型组相比,枳术汤组小鼠腹股沟脂肪组织中炎症细胞分布明显减少,血清TNF-α、IL-6含量明显降低(P<0.05,P<0.01),巨噬细胞标记分子iNOS和F4/80蛋白表达明显降低(P<0.05)。结果表明,枳术汤中的活性成分木犀草素、柚皮素和川陈皮素通过抑制脂肪组织巨噬细胞的聚集,下调其经典激活的巨噬细胞(M1)型极化,减少炎症因子IL-6和TNF-α的表达,从而改善肥胖小鼠脂肪组织炎症。

关键词：枳术汤儿童肥胖脂肪组织炎症巨噬细胞网络药理学

Facile synthesis of monodispersed copper oxalate flaky particles in the presence of EDTA

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 762-769页

作者： Xing Chert kai Huang Cheng-yan Wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Lab of Green Recycling and Extraction of Metals University of Science and Technology BeijingBeijing 100083China

Monodispersed copper oxalate paxticles with flaky morphology were prepared via a simple one-pot synthesis method. Scanning electron microscope （SEM）, X-ray diffraction （XRD）, and fourier tza^sform infraJced （FTIR） spectra were used to characterize paxticle mor- phology, size, phase composition, and functional groups. It was found that the presence of ethylenediaminetetzaacetic acid （EDTA） and the solution pH value had strong influence on the morphological and size evolution of the precipitated particles. On the basis of controlled re- lease of copper ions from a Cu2＋-EDTA complex and Weimazn＇s law, a stzategy for the controlled synthesis of monodispersed copper oxa- late paxticles was designed by refemng to the basic mode of the St0ber method. The inherent nature of crystallization to form the flaky solid in the early stage of precipitation as well as the driving force of the long-lasting low supersaturation in the growth stage was proposed to ex- plain the size and morphological evolution of the copper oxalate precipitates. Thermodynamic equilibrium concentrations of copper（II） spe- cies in the Cu（II）-EDTA-oxalate-H20 solution system were calculated to help explain the possible formation mechaNsm of copper oxalate precipitates.

关键词： copper oxalate flaky morphology ethylenediaminetetzaacetic acid one-pot synthesis

Drag Effects of Solute and Second Phase Distributions on the Grain Growth Kinetics of Pre-Extruded Mg-6Zn Alloy

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Journal of Materials Science & Technology 2016年第12期32卷 1260-1266页

作者： Zhaoyang Jin Donghua Yu Xintong Wu kai Yin kai yan College of Mechanical Engineering Yangzhou University

In order to control the grain size during hot forming,grain growth behavior of a pre-extruded Mg-6Zn magnesium alloy and its correlation with solute and second phase distribution were *** annealing was conducted on a Gleeble-1500 thermo-mechanical *** mean grain size Dg of each annealed specimen was measured by the quantitative metallography *** grain growth kinetics of the Mg-6Zn alloy annealed at 473-623 K was obtained as Dg^4- Dg0^4=2.25 ×10^11 exp（-95450）by the least square linear regression *** deviation of grain growth exponent n = 4 from the theoretical value of 2 may be attributed to the presence of solute zinc and second phases which will retard the boundary *** observations show that the non-uniform distribution of grain size for samples pre-extruded or annealed at low temperatures is closely related to the non-uniform distribution of fine and dispersed second phases but not to the non-uniform distribution of solute *** indicates that second phase pinning effect plays an important role in microstructure refinement.

关键词： Grain growth kinetics Second phase distribution Solute dragging Magnesium alloys