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Multiple Isoforms of Olive Flounder (Paralichthys olivaceus) Pax3a and Pax3b Display Differential Regulations on Myogenic Differentiation

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Journal of Ocean University of China 2022年第5期21卷 1295-1306页

作者： jiao Shuang TAN Xungang YOU feng PANG Qiuxiang Anti-Aging&Regenerative Medicine Research Institution School of Life Sciences and MedicineShandong University of TechnologyZibo 255000China Laboratory of Developmental and Evolutionary Biology School of Life Sciences and MedicineShandong University of TechnologyZibo 255000China CAS and Shandong Province Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

Paired box 3(Pax3)is a critical upstream regulator of the onset of *** have previously identified two spliced isoforms of pax3a(pax3a-1 and pax3a-2)and three spliced isoforms of pax3b(pax3b-1,pax3b-2,and pax3b-3)in olive flounder,but their roles in myogenesis are *** this study,we investigated their cellular localization,transcriptional activity on myod gene regulation,and roles in *** Pax3a and Pax3b isoforms revealed various subcellular localizations,which were related to their corresponding protein ***3a-1,Pax3a-2,and Pax3b-1 promoted the transcriptional activity of myod to dif-ferent degrees,whereas Pax3b-2 and Pax3b-3 had a slight inhibitory or no *** pairwise interaction analysis demonstrated the synergistic effect of Pax3b-1 and Pax3b-3 on myod transcriptional *** overexpression of different pax3a and pax3b isoforms differentially altered the spatial expression patterns of myod and differentially regulated the expression levels of their target genes(myod,myf5,and c-met)in zebrafish embryonic *** addition,the different flounder myod promoter-driven pax3a/3b isoform expression vectors were successfully introduced into the skeletal muscles of juvenile flounder by ***-ever,none of them could change the mRNA expression levels of mstn,myf5,myod,myogenin,pax7a,and pax7b in the electroporated *** results suggest that different Pax3a and Pax3b isoforms may precisely and collaboratively regulate embryonic myogenesis,but their roles in juvenile myogenesis are uncertain.

关键词： Pax3a Pax3b isoforms myod myogenesis

OSL chronology reveals Late Pleistocene floods and their impact on landform evolution in the lower reaches of the Keriya River in the Taklimakan Desert

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Journal of Geographical Sciences 2023年第5期33卷 945-960页

作者： ZHANG feng WANG jiao MA Li Dilibaier TUERSUN College of Geography and Remote Sensing Sciences Xinjiang Key Laboratory of Oasis EcologyXinjiang UniversityUrumqi830046China

The impacts of climate change on the relationship between fluvial processes and dune landform evolution have been ***,the chronology data used to examine this relationship are *** Keriya River has a glacial origin in the Kunlun Mountains on the south margin of the Tarim *** river flows into the Taklimakan Desert,the second largest shifting-dune desert in the *** dry channels and shifting dunes in this area provide an ideal opportunity to investigate fluvial and aeolian landform evolution processes and their relationship with climate *** investigated this area during 2008-2011 and obtained 18 fluvial sediment samples from 16 sections for optically stimulated luminescence(OSL)*** results show that the ages ranged from 3.4-44.1 *** of the samples(13)were Holocene in age,around 11 ka,8-9 ka,5-6.5 ka,4.6 ka,and 3.4-3.7 ka and were distributed along ancient river channels around sites of Yuansha and *** samples close to the Hotan River(38-47 ka)fall within the Marine Isotope Stage 3(MIS3).Three samples(from one section)were located near ancient channels flowing towards the Yuansha Site and had ages of around 14.5 ka,i.e.,during the Last Glacial Maximum(LGM).The analyses of the sediment samples and OSL ages suggest that the Keriya River flooded in the Holocene,the LGM,and *** sediments provided the source material for the dunes,and fluvial processes affected the landform evolution in the lower Keriya *** results suggest that most of the dunes covered in fluvial sediments in the lower reaches and the area west of the Keriya River developed since the *** differs from the results of previous studies,which suggested that they developed since the Han(202BC-220AD)and Tang(618-907AD)*** OSL ages of the fluvial sediments are consistent with the reported deglaciation(after glacial advance)ages in the alpine mountains surrounding the Tarim *** suggests that climate fluctuations may h

关键词： Taklimakan Desert flood inundation dunes MIS3 LGM Holocene deglaciation

GTS40, an active fraction of Gou Teng-San (GTS), protects PC12 from H2O2-induced cell injury through antioxidative properties

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Chinese Journal of Natural Medicines 2017年第7期15卷 495-504页

作者： CHEN Lei WEI Meng-Lin ZHAO jiao-jiao HONG Hao QU Wei feng feng LIU Wen-Yuan Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China Department of Pharmacology China Pharmaceutical University Nanjing 210009 China

Oxidative stress, a predominant cause of apoptosis cascades triggered in neurodegenerative disorders, has been regarded as a critical inducement in the pathogenesis of Alzheimer's disease(AD). Gou Teng-San(GTS) is a traditional Chinese herbs preparation commonly utilized to alleviate cognitive dysfunction and psychological symptoms of patients with dementia. The present study aimed to investigate the protective effects of GTS40, an active fraction of GTS, on H_2O_2-induced oxidative damage and identify the potential active ingredients. Our results revealed that GTS40 exhibited radical scavenging activity, elevated cell viability, decreased the levels of intracellular reactive oxygen species(ROS), and stabilized mitochondrial transmembrane potential(MMP) in H_2O_2-treated PC12 cells. In addition, GTS40 blocked the apoptotic cascade by reversing the imbalance of Bcl-2/Bax and inhibiting the activity of caspase-3. Furthermore, an HPLC-QTOFMS method was developed to characterize major chemical constituents in GTS40. Our results revealed twenty-seven identified or tentatively characterized compounds through comparing their retention time(t_R) and MS spectra with reference standards. These results suggested that GTS40 was a promising active fraction that may be beneficial in the prevention and treatment of oxidative stress-mediated neurodegenerative disorders.

关键词： GTS40 Oxidative stress Neuroprotective effects Apoptosis HPLC-QTOF-MS/MS

A Provable Positivity-Preserving Local Discontinuous Galerkin Method for the Viscous and Resistive MHD Equations

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Communications on Applied Mathematics and Computation 2024年第1期6卷 279-310页

作者： Mengjiao jiao yan Jiang Mengping Zhang School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026AnhuiChina

In this paper,we construct a high-order discontinuous Galerkin(DG)method which can preserve the positivity of the density and the pressure for the viscous and resistive magnetohydrodynamics(VRMHD).To control the divergence error in the magnetic field,both the local divergence-free basis and the Godunov source term would be employed for the multi-dimensional *** theoretical analyses are presented for one-dimensional and multi-dimensional DG schemes,respectively,showing that the scheme can maintain the positivity-preserving(PP)property under some CFL conditions when combined with the strong-stability-preserving time ***,general frameworks are established to construct the PP limiter for arbitrary order of accuracy DG *** tests demonstrate the effectiveness of the proposed schemes.

关键词： Viscous and resistive MHD equations Positivity-preserving Discontinuous Galerkin(DG)method High order accuracy

Anomalous Josephson current in quantum anomalous Hall insulator-based superconducting junctions with a domain wall structure

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Chinese Physics B 2020年第9期29卷 487-497页

作者： Qing yan yan-feng Zhou Qing-feng Sun International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Department of Physics University of Texas at DallasRichardsonTexas 75080USA CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

We theoretically study the Josephson effect in a quantum anomalous Hall insulator(QAHI)nanoribbon with a domain wall structure and covered by the *** anomalous Josephson current,the nonzero supercurrent at the zero superconducting phase difference,appears with the nonzero magnetization and the suitable azimuth angle of the domain *** on the configuration of the domain wall,the anomalous current peaks in the Bloch type but disappears in the Néel type because the y-component of magnetization is necessary to break symmetry to arouse the anomalous *** phase shift of the anomalous current is tunable by the magnetization,the azimuth angle,or the thickness of the domain *** introducing a bare QAHI region in the middle of the junction which is not covered by the superconductor,the anomalous Josephson effect is enhanced such that the phase shift can exceedπ.Thus,a continuous change between 0 andπjunctions is realized via regulating the configuration of the domain wall or the magnetization *** long as an s-wave superconductor is placed on the top of the QAHI with a domain wall structure,this proposal can be experimentally fabricated and useful for the phase battery or superconducting quantum bit.

关键词： anomalous Josephson current quantum anomalous Hall insulator domain wall Josephson junction

Lin28a is Essential for Synaptic Plasticity in Dentate Granule Cells and Spatial Memory

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Neuroscience Bulletin 2021年第2期37卷 261-266页

作者： Zhechun Hu jiao Ma yan Gu Center of Stem Cell and Regenerative Medicine Department of Neurology of Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of MedicineHangzhou 310029China Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine Hangzhou 310058China

Dear Editor,The dentate gyrus(DG),a subregion of the hippocampus,is involved in multiple physiological functions such as cognition and mood *** granule cells(DGCs),the primary neurons in the DG,are essential for coding spatial and contextual memories in the hippocampal neural *** entorhinal cortex provides a majority of cortical projections to the DG via the perforant path,and forms synaptic connections with DGCs within the outer two-thirds of the molecular layer of the DG[1].The plasticity of the perforant path-to-DGC synapses strengthens the connections of ensembles encoding spatial,contextual,or temporal information,and promotes the recall of related memories when certain perforant path inputs are reactivated[2].

关键词： Spatial Essential outer

Prediction of undeformed chip thickness distribution and surface roughness in ultrasonic vibration grinding of inner hole of bearings

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 311-323页

作者： yanqin LI Daohui XIANG Guofu GAO feng jiao Bo ZHAO School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454000China

Ultrasonic vibration grinding differs from traditional grinding in terms of its material removal *** randomness of grain-workpiece interaction in ultrasonic vibration grinding can produce variable chips and impact the surface roughness of ***,previous studies used iterative method to calculate the unformed chip thickness(UCT),which has low computational *** this study,a symbolic difference method is proposed to calculate the *** UCT distributions are obtained to describe the stochastic interaction characteristics of ultrasonic grinding ***,the UCT distribution characteristics under different machining parameters are ***,a surface roughness prediction model is established based on the UCT ***,the correctness of the model is verified by *** study provides a quick and accurate method for predicting surface roughness in longitudinal ultrasonic vibration grinding.

关键词： Ultrasonic vibration grinding Undeformed chip thickness(UCT) Distribution characteristics Surface roughness

Effect of vegetation on soil bacteria and their potential functions for ecological restoration in the Hulun Buir Sandy Land,China

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Journal of Arid Land 2020年第3期12卷 473-494页

作者： yan Ru feng Wei yanchi Research Station School of Soil and Water ConservationBeijing Forestry UniversityBeijing 100083China Engineering Research Center of Forestry Ecological Engineering of the Ministry of Education Beijing Forestry UniversityBeijing 100083China

To date,much of research on revegetation has focused on soil microorganisms due to their contributions in the formation of soil and soil remediation ***,little is known about the soil bacteria and their functions respond to the diverse vegetational types in the process of vegetation *** of dominated vegetation,i.e.,Artemisia halodendron Turcz Ex Bess,Caragana microphylla Lam.,Hedysarum fruticosum *** Pinus sylvestris *** bacterial community structures and their potential functions in the Hulun Buir Sandy Land,China were determined using high-throughput 16S rRNA gene sequencing and phylogenetic investigation of communities by reconstruction of unobserved states(PICRUSt)in *** the dominant phyla of soil bacterial community among different types of vegetation,including Proteobacteria,Actinobacteria,Acidobacteria,Bacteroidetes and Firmicutes,were similar,the relative abundance of these dominant groups significantly differed,indicating that different types of vegetation might result in variations in the composition of soil bacterial *** addition,functional genes of bacterial populations were similar among different types of vegetation,whereas its relative abundance was significantly *** carbon fixation genes showed a high relative abundance in ***,*** carbon decomposition genes in ***,suggesting the variations in carbon cycling potential of different types of *** of assimilatory nitrate reduction genes was the highest in ***,*** nitrate reduction and nitrate reductase genes in ***,indicating higher nitrogen gasification loss and lower nitrogen utilization gene functions in *** structures and functional genes of soil bacterial community showed marked sensitivities to different plant species,presenting the potentials for regulating soil carbon and nitrogen cycling.

关键词： bacterial taxonomic composition functional gene vegetational type soil carbon and nitrogen 16S rRNA

Experimental investigation of vector static magnetic field detection using an NV center with a single first-shell ^(13)C nuclear spin in diamond

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Chinese Physics B 2018年第5期27卷 481-486页

作者： feng-Jian Jiang Jian-feng Ye Zheng jiao Jun Jiang Kun Ma Xin-Hu yan Hai-Jiang Lv School of Information Engineering Huangshan University Huangshan 245041 China

We perform a proof-of-principle experiment that uses a single negatively charged nitrogen–vacancy（NV） color center with a nearest neighbor ^13C nuclear spin in diamond to detect the strength and direction（including both polar and azimuth angles） of a static vector magnetic field by optical detection magnetic resonance（ODMR） technique. With the known hyperfine coupling tensor between an NV center and a nearest neighbor ^13C nuclear spin, we show that the information of static vector magnetic field could be extracted by observing the pulsed continuous wave（CW） spectrum.

关键词： color centers optical detection magnetic resonance (ODMR) magnetometer