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Isolation of boswelliains A-E,Cembrane-Type Diterpenoids from boswellia papyifera,and an Evaluation of Their Wound Healing Properties

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Chinese Journal of Chemistry 2021年第9期39卷 2451-2459页

作者： Qi-Hua Yu Madhu Babu Sura Dai-Wei Wang Danling huang Yong-Ming yan Ya-Bin Jiao Qing Lu Yong-Xian Cheng Guangdong Pharmaceutical University GuangzhouGuangdong 510006China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhenGuangdong 518060China Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products School of Life Sciences and Food EngineeringHanshan Normal UniversityChaozhouGuangdong 521041China

boswelliai ns A-E(1-5),five new cembra ne-type diterpenoids,were isolated from the resin of boswellia *** structures,determined by using spectroscopic,computational and chemical methods,demonstrate that 2-5 are novel 4,5-seco-,4,5-seco-,9,10-seco-,and 6,7-seco-cembrane diterpenoids,and that 1,4 and 5 bear aldehyde *** evaluation of the wound healing properties of these natural products along with a derivative of 2 shows that compounds 2 and 3 significantly stimulate proliferation,mobility and tuber formation of human umbilical vein endothelial cells(HUVECs)at the concentration of 20μmol/L.

关键词： boswellia papyifera Natural products Structure elucidation seco-Cembrane diterpenoids Wound healing

Diverse sesquiterpenoids from Litsea lancilimba *** potential neuroprotective effects against H_(2)O_(2)-induced SH-SY5Y cell injury

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Chinese Journal of Natural Medicines 2022年第9期20卷 701-711页

作者： ZHANG Yi-Jie BAI Ming LI Jia-Yi QIN Shu-yan LIU Yu-yang huang Xiao-Xiao ZHENG Jiang SONG Shao-Jiang Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Provincial Key Laboratory of PharmaceuticsGuizhou Medical UniversityGuiyang 550004China

Five undescribed sesquiterpenoids(1–5),and nine known sesquiterpenoids(6–14)were obtained from the fruits of Litsea lancilimba *** LC-MS/MS molecular networking *** A(1)possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of *** structures were elucidated by spectroscopic techniques including IR,UV,NMR,HR-ESI-MS,and their absolute configurations were assigned by ECD *** isolated sesquiterpenoids were analyzed by bioinformatics and evaluated for their neuroprotective effects against H_(2)O_(2)-induced injury in human neuroblastoma SH-SY5Y cells.

关键词： Litsea lancilimba Lauraceae Sesquiterpenoids Neuroprotective effect

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多核信息融合模型及其应用

仪器仪表学报 2010年第2期31卷 248-252页

作者：杨勃卜英勇黄剑飞中南大学机械电子工程学院长沙410083 湖南理工学院岳阳414000

针对单核学习方法不能充分获取对象非线性特征的问题,提出一种核采样空间中的多核融合模型。与工作于隐式核空间的常见多核融合模型不同,该融合模型本质上是一种矩阵融合模型,其融合参数不受融合核矩阵半正定性要求的约束。在该模型基础... 详细信息

针对单核学习方法不能充分获取对象非线性特征的问题,提出一种核采样空间中的多核融合模型。与工作于隐式核空间的常见多核融合模型不同,该融合模型本质上是一种矩阵融合模型,其融合参数不受融合核矩阵半正定性要求的约束。在该模型基础上,进一步提出一种多核正则化Ho-Kashyap分类器,并设计了相应的迭代优化算法。最后,将该多核融合算法应用到水下钴结壳超声识别领域。实验结果表明,与单核学习方法相比,采用核采样空间多核信息融合模型的钴结壳超声识别分类正确率提高了7%,说明了该融合模型的有效性。

关键词：多核学习多核信息融合 Ho-Kashyap分类器水下钴结壳识别

Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis

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Journal of Traditional Chinese Medicine 2021年第3期41卷 478-484页

作者： QI Qin Hyoyoung Im LI Kunshan GU Muen WU huangan yanG Ling huang yan ZHAO Jimeng CUI Yunhua LIU Huirong WU Luyi Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China

OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) ***: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and ***: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway.

关键词： colitis ulcerative moxibustion toll-like receptors 4 Mayo score Baron score

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Underwater Image Bidirectional Matching for Localization Based on SIFT

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Journal of Marine Science and Application 2014年第2期13卷 225-229页

作者： yan Lin bo Liu State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology Dalian 116024 China Department of Naval Architecture and Ocean Engineering Dalian University of Technology Dalian 116024 China

For the purpose of identifying the stern of the SWATH （Small Waterplane Area Twin Hull） availably and perfecting the detection technique of the SWATH ship＇s performance, this paper presents a novel bidirectional image registration strategy and mosaicing technique based on the scale invariant feature transform （SIFT） algorithm. The proposed method can help us observe the stern with a great visual angle for analyzing the performance of the control fins of the SWATH. SIFT is one of the most effective local features of the scale, rotation and illumination invariant. However, there are a few false match rates in this algorithm. In terms of underwater machine vision, only by acquiring an accurate match rate can we find an underwater robot rapidly and identify the location of the object. Therefore, firstly, the selection of the match ratio principle is put forward in this paper; secondly, some advantages of the bidirectional registration algorithm are concluded by analyzing the characteristics of the unidirectional matching method. Finally, an automatic underwater image splicing method is proposed on the basis of fixed dimension, and then the edge of the image＇s overlapping section is merged by the principal components analysis algorithm. The experimental results achieve a better registration and smooth mosaicing effect, demonstrating that the proposed method is effective.

关键词： SWATH underwater image registration SIFT bidirectional matching strategy automatic stitching

Very late stent thrombosis due to multiple stent fracture and stent malapposition

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Chinese Medical Journal 2013年第1期126卷 186-189页

作者： huang Zhe-yong QIAN Ju-ying GE Jun-bo Shanghai Institute of Cardiovascular Diseases ZhongshanHospital Fudan University Shanghai 200032 China

Coronary stent fracture （SF） is a rare but potentially serious complication of coronary arterystenting. Here we report a case of acute myocardial infarction as a consequence of very late in-stent thrombosis due to multiple stent fractures at 8 sites and multiple stent malapposition formation four years after a sirolimus-eluting stent implantation （Firebird, Microport, Shanghai, China）.

关键词： coronary artery disease myocardial infarction stentfracture interventional stent thrombosis stent malapposition

Combination of Recombinant Adenovirus-p53 with Radiochemotherapy in Unresectable Pancreatic Carcinoma

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Chinese Journal of Cancer Research 2011年第3期23卷 194-200页

作者： Jin-luan Li Yong Cai Shan-wen Zhang Shao-wen Xiao Xiao-fan Li You-jia Duan Yong-heng Li bo Xu Kun yan Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） 1Department of Radiotherapy2Department of UltrasonographyPeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：To assess the safety and efficacy of the combination of recombinant adenovirus-p53 （rAd-p53） with radiochemotherapy for treating unresectable pancreatic ***：The eligible patients received concurrent rAd-p53 intratumoral injection and *** injection of rAd-p53 was guided by B *** consisted of intensity-modulated radiotherapy （IMRT） at two dose levels and intravenous gemcitabine （Gem）.For radiotherapy,gross target volume （GTV） and clinical target volume （CTV） were 55-60 Gy and 45-55 Gy in 25-30 fractions,*** intravenous gemcitabine was administered at 350 mg/m2,weekly,for 6 *** primary end points included toxicity,clinical benefit response （CBR） and disease control rate （DCR）.The secondary end points included progression-free survival （PFS） and overall survival （OS）.Results：Fifteen eligible patients were *** patients （53.3%） were evaluated as CBR and 12 （80%） achieved *** median PFS and OS were 6.7 and 13.8 months,***-year PFS and OS were 40.0% and 51.1%,*** were 8 （53.3%） patients reported grade 3 toxicities including neutropenia （6 patients,40%）,fever （1 patient,6.7%） and fatigue （1 patient,6.7%）.There was no grade 4 toxicity ***：Combination of rAd-p53 in unresectable pancreatic carcinoma showed encouraging efficacious benefit and was well ***-term follow-up is needed to confirm the improvement of PFS and OS.

关键词： Recombinant adenovirus-p53 Radiochemotherapy Pancreatic carcinoma

Growth of Zinc Blende GaAs/AlGaAs Radial Heterostructure Nanowires by a Two-Temperature Process

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Chinese Physics Letters 2011年第3期28卷 140-143页

作者： GUO Jing-Wei huang Hui REN Xiao-Min yan Xin CAI Shi-Wei GUO Xin huang Yong-Qing WANG Qi ZHANG Xia WANG Wei Key Laboratory of Information Photonics and Optical Communications(Ministry of Education) Beijing University of Posts and TelecommunicationsBeijing 100876

Zinc blende structure GaAs/AlGaAs core-multishell nanowires(NWs)are grown on a GaAs(111)B substrate by a two-temperature process using an Au-catalyzed vapor-liquid-solid mechanism and metal organic chemical vapor deposition,***-free radial heterostructure NWs are *** can be concluded that the NWs are grown with the main contributions from the direct impingement of the precursors onto the alloy droplets and little from adatom *** results indicate that the droplet acts as a catalyst rather than an adatom *** photoluminescence spectra reveal that the grown NWs have much higher optical efficiency than bare GaAs NWs.

关键词： GaAs/AlGaAs nanowires Zinc

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基于数字图像处理的LPG喷雾特性试验研究

内燃机学报 2007年第1期25卷 60-65页

作者：许伯彦齐运亮山东建筑大学机电工程学院山东济南250101

使用高速纹影摄影和数字图像处理方法研究了具有相同喷孔直径的两个分别带有和不带双孔分流套的单喷孔喷嘴在MPI喷射条件下液态LPG燃料的自由喷雾过程,测量了喷雾贯穿距离、投影喷雾面积、喷雾体积和喷雾锥角等喷雾特性。通过与手工测... 详细信息

使用高速纹影摄影和数字图像处理方法研究了具有相同喷孔直径的两个分别带有和不带双孔分流套的单喷孔喷嘴在MPI喷射条件下液态LPG燃料的自由喷雾过程,测量了喷雾贯穿距离、投影喷雾面积、喷雾体积和喷雾锥角等喷雾特性。通过与手工测量结果对比证明了数字图像处理方法测量结果的有效性。试验结果表明:喷射压力越高,喷雾贯穿距离、投影喷雾面积和喷雾体积越大,而喷雾锥角越小;带有双孔分流套的喷嘴雾化效果好,更有利于形成均匀混合气;在喷雾中期和后期,不带双孔分流套的喷嘴的喷雾贯穿距离长,但在喷雾初期的一段时间内,却比带有双孔分流套的喷嘴的喷雾贯穿距离短。

关键词： LPG 喷雾纹影图像处理