Diverse sesquiterpenoids from Litsea lancilimba *** potential neuroprotective effects against H_(2)O_(2)-induced SH-SY5Y cell injury

作     者：ZHANG Yi-Jie BAI Ming LI Jia-Yi QIN Shu-Yan LIU Yu-Yang HUANG Xiao-Xiao ZHENG Jiang SONG Shao-Jiang ZHANG Yi-Jie;BAI Ming;LI Jia-Yi;QIN Shu-Yan;LIU Yu-Yang;HUANG Xiao-Xiao;ZHENG Jiang;SONG Shao-Jiang

作者机构：Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&DevelopmentLiaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyang 110016China Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Functions and Applications of Medicinal PlantsGuizhou Provincial Key Laboratory of PharmaceuticsGuizhou Medical UniversityGuiyang 550004China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2022年第20卷第9期

页      面：701-711页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.U1812403) the Science and Technology Planning Project of Liaoning Province(No.2021JH1/10400049) 

主　　题：Litsea lancilimba Lauraceae Sesquiterpenoids Neuroprotective effect 

摘      要：Five undescribed sesquiterpenoids(1–5),and nine known sesquiterpenoids(6–14)were obtained from the fruits of Litsea lancilimba *** LC-MS/MS molecular networking *** A(1)possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of *** structures were elucidated by spectroscopic techniques including IR,UV,NMR,HR-ESI-MS,and their absolute configurations were assigned by ECD *** isolated sesquiterpenoids were analyzed by bioinformatics and evaluated for their neuroprotective effects against H_(2)O_(2)-induced injury in human neuroblastoma SH-SY5Y cells.