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An efficient numerical shape analysis for light weight membrane structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第4期15卷 255-271页

作者： Chao yanG yan-bin shen Yao-zhi LUO Space Structures Research Center Zhejiang University Hangzhou 310058 China

The determination of initial equilibrium shapes is a common problem in research work and engineering applications related to membrane structures. Using a general structural analysis framework of the finite particle method （FPM）, this paper presents the first application of the FPM and a recently-developed membrane model to the shape analysis of light weight mem- branes. The FPM is rooted in vector mechanics and physical viewpoints. It discretizes the analyzed domain into a group of parti- cles linked by elements, and the motion of the free particles is directly described by Newton＇s second law while the constrained ones follow the prescribed paths. An efficient physical modeling procedure of handling geometric nonlinearity has been developed to evaluate the particle interaction forces. To achieve the equilibrium shape as fast as possible, an integral-form, explicit time integration scheme has been proposed for solving the equation of motion. The equilibrium shape can be obtained naturally without nonlinear iterative correction and global stiffness matrix integration. Two classical curved surfaces of tension membranes pro- duced under the uniform-stress condition are presented to verify the accuracy and efficiency of the proposed method.

关键词： Tension membranes Finite particle method (FPM) Shape analysis Explicit time integration Initial equilibriumshape

Active structures integrated with wireless sensor and actuator networks： a bio-inspired control framework

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第4期17卷 253-272页

作者： Peng-cheng yanG yan-bin shen Yao-zhi LUO Zhejiang Provincial Key Laboratory of Space Structures Zhejiang University Hangzhou 310058 China

One of the main problems in controlling the shape of active structures （AS） is to determine the actuations that drive the structure from the current state to the target state. Model-based methods such as stochastic search require a known type of load and relatively long computational time, which limits the practical use of AS in civil engineering. Moreover, additive errors may be produced because of the discrepancy between analytic models and real structures. To overcome these limitations, this paper presents a compound system called WAS, which combines AS with a wireless sensor and actuator network （WSAN）. A bio-inspired control framework imitating the activity of the nervous systems of animals is proposed for WAS. A typical example is tested for verification. In the example, a triangular tensegrity prism that aims to maintain its original height is integrated with a WSAN that consists of a central controller, three actuators, and three sensors. The result demonstrates the feasibility of the proposed concept and control framework in cases of unknown loads that include different types, distributions, magnitudes, and directions. The proposed control framework can also act as a supplementary means to improve the efficiency and accuracy of control frameworks based on a common stochastic search.

关键词： Active structures (AS) Wireless sensor and actuator networks (WSAN) Shape control Bio-inspired control

Static control method using gradient-genetic algorithm for grillage adaptive beam string structures based on minimal internal force

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第9期23卷 721-732页

作者： yan-bin shen Hao-song SUN An-dong LEI Xiao-yuan YING Guang yanG Yao-zhi LUO College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China China State Construction Engineering(Hong Kong)Limited Hong Kong 999077China

The grillage adaptive beam string structure(GABSS)is a new type of smart structure that can self-adjust its deformation and internal forces through a group of active struts(actuators)in response to changes in environmental *** this paper,an internal force control method based on a gradient–genetic algorithm(GGA)is proposed for the static control of a tensioned structure(especially the GABSS).Specifically,an optimization model of the GABSS is established in which the adjustment values of the actuators are set as the control variables,and the internal force of the beam is set as the objective *** improved algorithm has the advantage of the global optimization ability of the genetic algorithm and the local search ability of the gradient *** examples are provided to illustrate the application of the GGA *** results show that the proposed method is practical for solving the internal force control problem of the GABSS.

关键词： Grillage adaptive beam string structure(GABSS) Gradient-genetic algorithm(GGA) Structural control Adaptive structure Actuator

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong yang Haochen shen Xiaoming Xiao Zhichao Li Qi Zhou Wei yang bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： Ultraviolet photoelectron spectroscopy

Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process

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Energy Engineering 2025年第1期122卷 331-347页

作者： Jie Lin Hongchi shen Tingting Pei yan Wu School of Electrical Engineering and Information Engineering Lanzhou University of TechnologyLanzhou730050China

Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unitpower generation *** service life of these modules directly affects these costs. Over time, the performanceof PV modules gradually declines due to internal degradation and external environmental *** cumulativedegradation impacts the overall reliability of photovoltaic power generation. This study addresses the complexdegradation process of PV modules by developing a two-stage Wiener process model. This approach accountsfor the distinct phases of degradation resulting from module aging and environmental influences. A powerdegradation model based on the two-stage Wiener process is constructed to describe individual differences inmodule degradation processes. To estimate the model parameters, a combination of the Expectation-Maximization(EM) algorithm and the Bayesian method is employed. Furthermore, the Schwarz Information Criterion (SIC) isutilized to identify critical change points in PV module degradation trajectories. To validate the universality andeffectiveness of the proposed method, a comparative analysis is conducted against other established life predictiontechniques for PV modules.

关键词： Photovoltaic modules degradation stochastic processes lifetime prediction

PKA reduces neuronal apoptosis by phosphorylation of Kv1.4

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PKA reduces neuronal apoptosis by phosphorylation of Kv1.4

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

华东六省一市生物化学与分子生物学会2003年学术交流会

作者： yan-mei TAO, Dong yan, bin shen, Rui ZENG, Yi-zheng WANG (Institute of Neuroscience, CAS 200031)

Neuronal apoptosis induced by serum deprivation or by staurosporine was associated with an early enhancementof potassium efflux and loss of total intracellular potassium. The apoptosis is reduced by TEA, a non-selective po-tassium channel blocker, or by elevated extracellular potassium. In our experiments, treatment of neurons with TEAor elevated extracellular potassium caused phosphorylation of Tl domain in Kv1. 4. Further, forskolin, the agonistof PKA, stimulated the same phosphorylation in the Tl domain. We found that the phosphorylation of Tl domain in

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua yan Dingding shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury