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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第6期13卷 503-510页

作者： Xiao-ping HONG yan ZHU yan-zhen zhang Department of Chemistry Zhejiang UniversityHangzhou 310028China Department of Chemistry Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Stomatology the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

A highly sensitive amperometric sulfadiazine sensor fabricated by electrochemical deposition of poly(cobalt tetraaminophthalocyanine) (poly(Co II TAPc)) on the surface of a multi-walled carbon nanotubes-Nafion (MWCNTs-Nafion) modified electrode is *** electrode showed a very attractive performance by combining the advantages of Co II TAPc,MWCNTs,and *** with the bare glassy carbon electrode (GCE) and the MWCNTs-Nafion modified electrode,the electrocatalytic activity of poly(Co II TAPc)-coated MWCNTs-Nafion GCE generated greatly improved electrochemical detections toward sulfadiazine including low oxidation potential,high current responses,and good anti-fouling *** oxidation peak currents of sulfadiazine obtained on the new modified electrode increased linearly while increasing the concentration of sulfadiazine from 0.5 to 43.5 μmol/L with the detection limit of 0.17 μmol/L.

关键词： Sulfadiazine Electrochemical detection Cobalt tetraaminophthalocyanine Multi-walled carbon nanotubes

Enantioseparation of Racemic Anti-hepatitis New Drug Bicyclol with Crystallization

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Chinese Chemical Letters 2005年第11期16卷 1471-1473页

作者： Wei HU yan LI Chun zhen zhang Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050

The enantioseparation of anti-hepatitis new drug （±）-bicyclol was performed by optically active alkaloid. The alcoholic acid, the hydrolysate of bicyclol was reacted with optically active alkaloid, such as brucine, strychnine, quinidine etc., the diastereoisomeric salts were obtained by fractional recrystallization, then separately decomposed and esterified to obtain the two enantiomers of bicyclol. The pharmacological study showed that the effect of （-）-bicyclol was more potent than racemic bicyclol two times and the potency of （＋）-bicyclol was incative.

关键词： (±)-Bicyclol,4,4'-dimethoxy-2,3,2 3'-bis(methylenedioxy)-6-hydroxymethyl-6'-methoxy-carbonyl biphenyl anti-hepatitis resolution.

High-elevation landforms are experiencing more remarkable wetting trends in arid Central Asia

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Advances in Climate Change Research 2022年第4期13卷 489-495页

作者： Yong zhang Cheng-Bang AN Lu-Yu LIU yan-zhen zhang Chao LU Wen-Sheng zhang Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

Since the 1980s,a warming and weting trend in arid Central Asia(ACA)has been widely ***,no consistent knowledge has been presented about whether warming and weting trends are evenly distributed throughout ACA or whether there are noticeable topographical *** combined the ERA5-Land reanalysis dataset and data from Google Earth Engine to analyze the topographic differences of ACA from 1981 to *** findings indicate that significant(p<0.05)warming has a broader geographic scale in ACA and that warming rate of low-elevation landforms(high plains and hlls)is higher than that of high-elevation landforms(mountains and tablelands).However,the weting trend does not fllow this *** contrast,high-elevation landforms have a higher wetting rate than low-elevation landforms and are the main areas of ***,low-elevation landforms continue to maintain the warming and drying ***,the wetting trend of high-elevation landforms is amplified with ***,the wetting trend is negatively related to the warming trend(p<0.01)across the entire elevation ***,the findings provide new insights into the current research hotspot of warming-wetting"trend in ACA and highlight the differences in the responses of different landforms to climate change.

关键词： Arid Central Asia Warming and wetting Topographical differences ERA5 Google Earth Engine

Application of apical negative pressure irrigation in the nonsurgical treatment of radicular cysts:A case report

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World Journal of Clinical Cases 2023年第15期11卷 3612-3618页

作者： Gong-Pei Chen yan-zhen zhang Dan-Hua Ling Department of General Dentistry The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina

BACKGROUND Radicular cysts are one of the most common odontogenic cystic lesions found in the *** treatment of large radicular cysts is a topic of ongoing debate,and there is still no clear consensus on the most effective *** apical negative pressure irrigation system aspirates the cystic fluid and releases the static pressure in the radicular cyst,representing a minimally invasive approach for *** this case,the radicular cyst was in close proximity to the mandibular nerve *** used nonsurgical endodontic treatment with a homemade apical negative pressure irrigation system and the prognosis was *** SUMMARY A 27-year-old male presented to our Department of General Dentistry with complaints of pain in the mandibular right molar when *** patient had no history of drug allergies or systemic disease.A multidisciplinary management approach was designed and included root canal retreatment with a homemade apical negative pressure irrigation system,deep margin elevation and prosthodontic *** to a 1-year follow-up period,the patient showed a favorable *** This report reveals that nonsurgical treatment with an apical negative pressure irrigation system may provide new insights into the treatment of radicular cysts.

关键词： Apical negative pressure irrigation Radicular cyst Nonsurgical root canal treatment Case report

Management of the palato-radicular groove with a periodontal regenerative procedure and prosthodontic treatment:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5732-5740页

作者： Dan-Hua Ling Wei-Ping Shi yan-Hong Wang Dan-Ping Lai yan-zhen zhang Department of Comprehensive Dentistry The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310052Zhejiang ProvinceChina Department of Comprehensive Dentistry Jiangnan Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 311221Zhejiang ProvinceChina

BACKGROUND Palato-radicular groove(PRG)is defined as an anomalous formation of *** etiology of PRG remains *** prognosis of a tooth with a PRG is *** treatment of combined periodontal-endodontic lesions requires multidisciplinary management to control the progression of bone *** researchers reported cases that had short-term *** management of teeth with PRGs is of great clinical ***,to date,no case reports have been documented on the use of bone regeneration and prosthodontic treatment for *** SUMMARY This case reported the management of a 40-year-old male patient with the chief complaint of slight mobility and abscess in the upper right anterior tooth for 15 d and was diagnosed with type II PRG of tooth 12 with combined endodonticperiodontal *** accumulation of plaque and calculus caused primary periodontitis and a secondary endodontic infection.A multidisciplinary management approach was designed that included root canal therapy,groove sealing,a periodontal regenerative procedure,and prosthodontic *** a 2-year follow-up period,a good prognosis was *** This report indicates that bone regeneration and prosthodontic treatment may contribute to the long-term favorable prognosis of teeth with PRGs.

关键词： Palato-radicular groove Bone regeneration treatment Prosthodontic treatment Maxillary lateral incisor Dentistry Periodontology Case report

Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway

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World Journal of Gastroenterology 2019年第24期25卷 3044-3055页

作者： yan-zhen zhang Jian-Ning Yao Lian-Feng zhang Chun-Feng Wang Xue-Xiu zhang Bing Gao Department of Second Gastroenterology the First Affiliated Hospital of Zhengzhou University

BACKGROUND The formation of liver fibrosis is mainly caused by the activation of hepatic stellate cells(HSCs)and the imbalance of extracellular matrix(ECM)production and *** treatment of liver fibrosis mainly includes removing the cause,inhibiting the activation of HSCs,and inhibiting ***-like receptor(NLR)family,caspase activation and recruitment domain(CARD)domain containing 5/NOD27/CLR16.1(NLRC5)is a highly conserved member of the NLR family and is involved in inflammation and immune responses by regulating various signaling pathways such as nuclear factor-κB(NF-κB)*** has been found that NLRC5 plays an important role in liver fibrosis,but its specific effect and possible mechanism remain to be fully *** To investigate the role of NLRC5 in the activation and reversion of HSCs induced with transforming growth factor-β(TGF-β)and MDI,and to explore its relationship with liver *** A total of 24 male C57BL/6 mice were randomly divided into three groups,including normal,fibrosis,and recovery ***-four hours after a liver fibrosis and spontaneous reversion model was established,the mice were sacrificed and pathological examination of liver tissue was performed to observe the degree of liver fibrosis in each ***-2 cells were cultured in vitro and treated with TGF-β1 and ***-time quantitative PCR(qPCR)and Western blot were used to analyze the expression levels of NLRC5,α-smooth muscle actin(α-SMA),and collagen type I alpha1(Col1a1)in each *** activity of NF-κB in each group of cells transfected with NLRC5-siRNA was *** Compared with the normal mice,the expression level of NLRC5 increased significantly(P<0.01)in the fibrosis group,but decreased significantly in the recovery group(P<0.01).In in vitro experiments,the content of NLRC5 was enhanced after TGF-β1 stimulation and decreased to a lower level when treated with MDI(P<0.01).The expression ofα-SMA and Col1a1 proteins and mRN

关键词： NLRC5 Hepatic stellate cells Liver fibrosis Recovery

Radical organometallic nanocages with redox switchable poly-NHC ligands

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Nano Research 2023年第7期16卷 10678-10683页

作者： Guang-Feng Jin yan-zhen zhang Le Yu Wei-Ling Jiang yang Li Li-Ying Sun Peng Li Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200438China

Developing discrete radical organometallic nanocages is essential for fabricating functional *** this study,we construct a series of poly-NHC-based(NHC=N-heterocyclic carbene)organometallic nanocages 3a-3c with different sizes by employing redox-active bis(triarylamine)derivatives with differentπ-conjugated spacers as building *** varied sizes of nanocages 3a-3c modulate the distance of the redox-active centers and reversibly convert them to radical nanocages 3a^(2+)-3c^(2+)through chemical and electrochemical *** nanocages 3a^(2+)-3c^(2+)display clear bond and angle alteration and retention of their three-dimensional *** work not only merely proves that these nanocages are excellent stimulus-responsive materials but also opens a door to the rational design of novel radical organometallic nanocages.

关键词： stimuli-responsive organometallic nanocage N-heterocyclic carbene radical

Hemolymphangioma with multiple hemangiomas in liver of elderly woman with history of gynecological malignancy: A case report

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World Journal of Clinical Cases 2021年第32期9卷 9948-9953页

作者： Min Wang Hai-Feng Liu yan-zhen-Zi zhang Zhi-Qing Zou Zhou-Quan Wu Department of Anesthesiology Changzhou Second People's Hospital Affiliated to Nanjing Medical UniversityChangzhou 213003Jiangsu ProvinceChina Department of Radiology Third Affiliated Hospital of Soochow University and Changzhou First People's HospitalChangzhou 213003Jiangsu ProvinceChina Department of Pathology Third Affiliated Hospital of Soochow University and Changzhou First People’s HospitalChangzhou 213003Jiangsu ProvinceChina

BACKGROUND Hepatic hemolymphangioma is an extremely rare benign congenital malformation composed of cystically dilated lymphatic and blood vessels,and they have nonspecific clinical symptoms and laboratory *** this study,hepatic hemolymphangioma with multiple hemangiomas in an elderly woman was initially reported and *** SUMMARY A 61-year-old female patient,with a history of hysterectomy and bilateral adnexectomy,was referred to the hepatobiliary surgery department with the complaint of multiple hepatic hemangiomas that had been diagnosed 2 years prior in a preoperative contrast-enhanced computed tomography(CECT)*** entering our hospital,no abnormal physical examination and laboratory data were *** latest CECT revealed a new 7.0 cm×6.2 cm cystic-solid lesion with multiple internal divisions in segment II of the liver,with delayed CECT enhancement characteristics that presented as solid parts with internal *** the positron emission tomography(PET)/CT,no significant uptake of 18F-fluorodeoxyglucse was ***,hepatic hemolymphangioma was confirmed based on the pathological and immunohistochemical results after *** 1-year follow-up,her posthepatectomy evaluation was uneventful,and she had recovered full *** addition,no postoperative recurrent or residual lesion was found on CECT *** Hepatic hemolymphangioma with multiple hemangiomas was reported and observed by CECT and PET/CT imaging.

关键词： Hepatic hemolymphangioma Hemangiomas Contrast-enhanced computed tomography Positron emission tomography/computed tomography Case report

Central environmental protection inspection and carbon emission reduction: A tripartite evolutionary game model from the perspective of carbon neutrality

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Petroleum Science 2024年第3期21卷 2139-2153页

作者： zhen-Hua zhang Dan Ling Qin-Xin yang yan-Chao Feng Jing Xiu School of Economics Lanzhou UniversityLanzhou 730000GansuChina Institute of Green Finance Lanzhou UniversityLanzhou 730000GansuChina School of Management Lanzhou UniversityLanzhou 730000GansuChina School of Business Zhengzhou UniversityZhengzhou 450001HenanChina Institute of Economics Jilin Academy of Social SciencesChangchun130033JilinChina

Since the carbon neutrality target was proposed,many countries have been facing severe challenges to carbon emission reduction *** study is conducted using a tripartite evolutionary game model to explore the impact of the central environmental protection inspection(CEPI)on driving carbon emission reduction,and to study what factors influence the strategic choices of each party and how they interact with each *** research results suggest that local governments and manufacturing enterprises would choose strategies that are beneficial to carbon reduction when CEPI *** the initial willingness of all parties increases 20%,50%—80%,the time spent for the whole system to achieve stability decreases from 100%,60%—30%.The evolutionary result of“thorough inspection,regulation implementation,low-carbon management”is the best strategy for the tripartite evolutionary ***,the smaller the cost and the larger the benefit,the greater the likelihood of the three-party game stability strategy *** study has important guiding significance for other developing countries to promote carbon emission reduction by environmental policy.

关键词： Central environmental protection inspection Local government Manufacturing enterprise Tripartite evolutionary game Carbon emission reduction

Photochemical Production of Methyl Halides with Guaiacol as the Precursor

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Journal of Ocean University of China 2024年第5期23卷 1275-1286页

作者： yanG Fan zhang yan WU Guanyu HE zhen yanG Guipeng Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Laboratory for Marine Ecology and Environmental Science Qingdao Marine Science and Technology Center Institute of Marine Chemistry Ocean University of China

Methyl halides are crucial trace greenhouse gases in the atmosphere, playing a significant role in global climate change and the atmospheric environment. This study investigated the photochemical production of methyl halides in an artificial seawater system using guaiacol as a precursor through laboratory simulation experiments. The influences of various environmental factors, including illumination time, radiation wavebands, illumination intensity, concentrations of guaiacol and halide ions（X-）, Fe3+, salinity, dissolved oxygen（DO）, and pH value on the photochemical production of methyl halides were examined. We demonstrated that increased illumination intensity and duration promote the photochemical production of methyl halides, with a notable enhancement under UV-B radiation. Guaiacol and halide ions were identified as key precursors, and their high concentrations facilitated the formation of methyl halides. Additionally, different types of halide ions exhibited a competitive relationship in producing methyl halides. The study found that an increase in pH inhibited the photochemical formation of CH3I due to the reaction between OH-and ·CH3. Dissolved oxygen was found to inhibit the photochemical formation of CH3I while promoting the formation of CH3Cl. Conversely, an appropriate concentration of Fe3+enhanced the photochemical production of methyl halides. Field observations indicated a high photochemical production of methyl halides in the natural waters near Qingdao's coastal area, likely due to the high concentration of dissolved organic matter（DOM）, which supports photochemical reactions. Furthermore, the photochemical production of methyl halides in natural seawater was significantly higher than in dark conditions, underscoring the importance of illumination in promoting these photochemical processes in seawater.

关键词： dissolved organic matter guaiacol methyl halides photochemical production