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Prolonged small vessel vasculitis with colon mucosal inflammation as first manifestations of Behet's disease

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World Journal of Gastroenterology 2014年第14期20卷 4110-4114页

作者： Xiao-Ning yang Zhen-Shi Ye yan-yun fan Yi-Qun Hu Department of Gastroenterology Zhongshan Hospital Xiamen University

Behet's disease is a chronic, relapsing, systemic vasculitis of unknown aetiology. Patients present manifestations of gastrointestinal complications, including mouth lesions, small and large intestinal lesions, and vascular lesions in the abdomen. In some cases, the intestinal ulcers of patients with Behet's disease are indistinguishable from those of Crohn's disease, tuberculosis, vasculitis and other diseases. In this article, we present a case of atypical Behet's disease with a complicated medical history and multisystem damage, for the purpose of better management of this disease.

关键词： Behet's disease Vasculitis Intestinal ulcers

双边政治关系与中国对亚欧国家出口贸易增长分析——基于三元边际视角

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国际经贸探索 2017年第7期33卷 60-73页

作者：魏昀妍樊秀峰西安交通大学经济与金融学院

双边政治关系被认为是国家间加强沟通、增进理解互信的重要因素。文章基于1996~2014年中国对亚欧国家出口的HS6分位商品数据分析发现:总体上看,高层互访能积极促进出口数量边际的增长,确实发挥了政治为经济服务的功能,其中元首互访产生... 详细信息

双边政治关系被认为是国家间加强沟通、增进理解互信的重要因素。文章基于1996~2014年中国对亚欧国家出口的HS6分位商品数据分析发现:总体上看,高层互访能积极促进出口数量边际的增长,确实发挥了政治为经济服务的功能,其中元首互访产生的积极效应更加显著;从不同地区和收入水平来看,高层互访对促进出口数量边际增长的作用显著,友好城市关系有助于对欧洲和高收入国家的出口数量和价格边际的增长,却对亚洲和中低收入国家的出口有抑制作用,双边政治冲突成为抑制三元边际的增长的重要因素;同时,"丝路"特征变量和欧洲对高收入国家的促进作用非常显著,"亚欧"合作特征变量对亚洲和中低收入国家影响显著。总之,要积极利用现有合作机制,发挥好双边政治关系对出口贸易的保障作用。

关键词：双边政治关系亚欧国家三元边际

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变频器共模电流对敏感数据线干扰的实验研究

电力电子技术 2016年第5期50卷 65-68页

作者：陈恒林严云帆浙江大学电气工程学院浙江杭州310027

变频器在运行过程中输出电缆上会产生共模电流,若数据通讯线离其较近,便会受到共模电流耦合,严重时会干扰到通讯线所连接处理器正常工作。这里对变频器输出线缆共模干扰进行测试,并阐述了变频器输出线缆共模电流的产生机理和特性。以变... 详细信息

变频器在运行过程中输出电缆上会产生共模电流,若数据通讯线离其较近,便会受到共模电流耦合,严重时会干扰到通讯线所连接处理器正常工作。这里对变频器输出线缆共模干扰进行测试,并阐述了变频器输出线缆共模电流的产生机理和特性。以变频器与可编程逻辑控制器(PLC)通讯为例,通过实验测试,定量比较了不同工作情况下通讯线上共模电流时域和频域特性,提出了用误码率来评估不同共模电流对通讯性能产生的干扰影响程度。研究表明通讯线所耦合的共模电流低于一定强度时,便不会干扰变频器与PLC的正常通讯。

关键词：变频器共模干扰可编程逻辑控制器敏感数据线

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夜戴型非球面角膜塑形镜对眼表微环境的影响

国际眼科杂志 2022年第4期22卷 570-573页

作者：樊艳云黄雄高赵楠楠海南医学院第一附属医院眼科中国海南省海口市570100

夜戴型非球面角膜塑形镜(night-wear aspheric orthokeratology lens),以下简称OK镜,利用夜间睡眠时间矫正视力,是目前为数不多的可以让近视的孩子白天不戴眼镜的方法,所以经常作为8~16岁近视人群临床上首选推荐。OK镜通过对眼表面产生... 详细信息

夜戴型非球面角膜塑形镜(night-wear aspheric orthokeratology lens),以下简称OK镜,利用夜间睡眠时间矫正视力,是目前为数不多的可以让近视的孩子白天不戴眼镜的方法,所以经常作为8~16岁近视人群临床上首选推荐。OK镜通过对眼表面产生逆向几何作用力的压迫作用,使得角膜曲率降低,从而达到暂时性的矫正近视的作用。目前作为一种公认的治疗青少年近视的非手术方法之一,非球面角膜塑形镜的镜片材质和验配水平一直在不断的创新和升级。OK镜片直接覆盖于眼表,长期配戴会对眼表微环境造成一定影响,比如睑板腺、泪膜、结膜、角膜以及眼表微生物等,甚至可能造成眼表微环境的失衡,从而导致眼表疾病的发生和发展。本文旨在分析配戴非球面角膜塑形镜对眼表睑板腺形态、泪膜的形态与功能、结膜微循环、角膜细胞形态、眼表微生物等因素的影响,以指导临床医生对青少年配戴角膜塑形镜时给予全面考量,增加夜戴型非球面角膜塑形镜的安全性和有效性。

关键词：夜戴型非球面角膜塑形镜眼表微环境角膜结膜泪膜

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang Jie Chen Hai-Di fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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量子阱数量变化对双波长LED作用的研究

物理学报 2011年第7期60卷 814-821页

作者：张运炎范广涵华南师范大学光电子材料与技术研究所广州510631

采用软件理论分析的方法分析了InGaN/GaN量子阱数量变化对双波长发光二极管发光光谱、内量子效率、电子空穴浓度分布、溢出电流等产生的影响.分析结果表明,量子阱数量的增加会引起载流子分配不均的现象,所以量子阱数量的增加并不能有效... 详细信息

采用软件理论分析的方法分析了InGaN/GaN量子阱数量变化对双波长发光二极管发光光谱、内量子效率、电子空穴浓度分布、溢出电流等产生的影响.分析结果表明,量子阱数量的增加会引起载流子分配不均的现象,所以量子阱数量的增加并不能有效地提升载流子复合率、内量子效率和发光强度,还会引起开启电压升高的现象,影响能量转化效率.此外,不同发光波长的量子阱数量的增加会引起发光光谱强度的变化.

关键词：量子阱数量数值模拟双波长发光二极管

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang yun-Feng Wang fan yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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大学生学业自我效能感对学习投入间的影响

山西大同大学学报（自然科学版） 2020年第1期36卷 68-70页

作者：肖海雁李媛闫云帆付政山西大同大学心理健康教育与咨询中心山西大同037009 山西师范大学教育科学学院山西临汾041000

目的考察学业自我效能感和学习投入的作用机制。方法采用学业自我效能感量表、心理弹性量表和学习投入量表对大学生进行调查。结果学业自我效能感、心理弹性和学习投入两两之间呈显著正相关(r=0.28,r=0.58,r=30);心理弹性在学业自我效... 详细信息

目的考察学业自我效能感和学习投入的作用机制。方法采用学业自我效能感量表、心理弹性量表和学习投入量表对大学生进行调查。结果学业自我效能感、心理弹性和学习投入两两之间呈显著正相关(r=0.28,r=0.58,r=30);心理弹性在学业自我效能感和学习投入之间的中介效应为10.71%。结论心理弹性在学业自我效能感和学习投入间起着部分中介作用。

关键词：学业自我效能感心理弹性学习投入

甲硝唑联合阴道抑菌凝胶治疗细菌性阴道病的临床疗效观察

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中国实用医药 2016年第29期11卷 20-21页

作者：陈艳欧阳云英范建美广东省佛山市南海区第七人民医院 528247

目的探讨甲硝唑联合阴道抑菌凝胶治疗细菌性阴道病的临床疗效。方法 100例细菌性阴道病患者,随机分为对照组和治疗组,各50例。对照组给予甲硝唑进行阴道填塞治疗,治疗组在此基础上加用阴道抑菌凝胶填塞,观察治疗1周后两组患者治疗的有... 详细信息

目的探讨甲硝唑联合阴道抑菌凝胶治疗细菌性阴道病的临床疗效。方法 100例细菌性阴道病患者,随机分为对照组和治疗组,各50例。对照组给予甲硝唑进行阴道填塞治疗,治疗组在此基础上加用阴道抑菌凝胶填塞,观察治疗1周后两组患者治疗的有效率及停药1周后复发率情况,并进行比较。结果治疗1周后,治疗组有效率为90%,对照组有效率为84%,比较差异无统计学意义(P>0.05);停药1周后,治疗组复发率为30%,明显低于对照组的50%(P<0.05)。结论甲硝唑联合阴道抑菌凝胶用于治疗细菌性阴道病,经观察治疗效果好、副作用少、复发率低等特点,值得临床推广应用。

关键词：甲硝唑细菌性阴道病阴道抑菌凝胶