检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

沉积植物古DNA在第四纪植被重建中的应用

地球科学进展 2024年第8期39卷 801-812页

作者：徐海涛李泉赵艳中国科学院地理科学与资源研究所陆地表层格局与模拟院重点实验室北京100101 中国科学院大学北京100049

沉积植物古DNA是分析古植被信息的前沿手段,可以从分子生物学视角为古植被和古环境重建提供更开阔的视野。分析了沉积植物古DNA保存的主要影响因素;概述了沉积植物古DNA分析流程;综述了沉积植物古DNA在重建植物群落动态演变过程、气候... 详细信息

沉积植物古DNA是分析古植被信息的前沿手段,可以从分子生物学视角为古植被和古环境重建提供更开阔的视野。分析了沉积植物古DNA保存的主要影响因素;概述了沉积植物古DNA分析流程;综述了沉积植物古DNA在重建植物群落动态演变过程、气候与环境变化以及生态演化对人类活动的响应等领域的相关研究进展,沉积植物古DNA分析通过提供快速和高分辨率的古植物物种信息,能够重建植物群落演变过程,定量、半定量重建古气候,并探究人类农牧活动对生态系统的影响。未来的研究中应该构建更加完善的植物物种DNA分类参考数据库,加强沉积植物古DNA分子的埋藏学研究,推广其在第四纪古环境研究中的应用,同时构建多指标记录以获得更完整的古生态信息。沉积植物古DNA将在古植被与气候变化以及人类活动关系研究中发挥更广泛的作用。

关键词：沉积植物古DNA 第四纪植被重建古DNA分析

Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui quan Lu Yong Yin Jian-Hua Zhang Xiao-yan Dong Ying-Wen Wang Ying-Zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of Shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2.17 and 2.2. across all age groups[1].

关键词： pneumonia epidemic respiratory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于自适应聚合距离的多目标进化算法

控制与决策 2024年第4期39卷 1113-1122页

作者：曾亮曾维钧李燕燕全睿王珊珊湖北工业大学电气与电子工程学院武汉430068 太阳能高效利用及储能运行控制湖北省重点实验室武汉430068 襄阳湖北工业大学产业研究院湖北襄阳441100

随着目标数的增多,种群收敛性与分布性的冲突愈加激烈,传统的多目标进化算法的选择算子难以平衡种群的收敛性与分布性.对此,提出一种基于自适应聚合距离的多目标进化算法.首先,采用参考点支配关系替代原有的Pareto支配关系,以增加选择压... 详细信息

随着目标数的增多,种群收敛性与分布性的冲突愈加激烈,传统的多目标进化算法的选择算子难以平衡种群的收敛性与分布性.对此,提出一种基于自适应聚合距离的多目标进化算法.首先,采用参考点支配关系替代原有的Pareto支配关系,以增加选择压力,加强收敛性;其次,提出自适应聚合距离,通过动态变化的惩罚参数来自适应调整收敛性与分布性的比例;最后,设计一种带有淘汰算子的方法以改进小生境选择策略,根据自适应聚合距离的大小进行选择和淘汰操作.为验证算法的可行性,将所提出算法在测试问题上与其他4种优秀的多目标进化算法进行比较,并应用于两个实际应用中,仿真结果表明,所提出算法的综合性能更优,能有效平衡种群的收敛性与分布性.

关键词：多目标进化算法参考点支配自适应聚合距离淘汰算子收敛性与分布性

Investigation and analysis of the status of cancer health popularization in China,2.2.

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第10期15卷 1269-1279页

作者： Hai-Tao Hu Yu-Juan Jiang Xin-Xin Shao Yi-Ming Lu yan-Tao Tian quan Xu Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Cancer presents a significant public health challenge in China,necessitating broad collaboration across *** Chinese government has articulated a goal to increase the overall five-year survival rate for cancer by 15%by *** this objective requires not only advances in medical technology,but also an im-provement in the dissemination of knowledge pertaining to cancer prevention and *** To provide a comprehensive understanding of the status of cancer prevention and level of popularization in China in *** From January 2.2. to May 2.2.,online questionnaires were distributed to 3000 participants,including medical personnel,patients with cancer,their families,and the general *** were 2.11 valid responses,covering the entire *** A total of 102. medical personnel and 1691 patients with cancer,their family members,and the general public participated in the *** medical personnel,93.2.had popularized cancer *** addressed topics included cancer prevention(85.9%)and cancer screening(77.8%).Primary challenges included time constraints(73.9%),insufficient personnel and material support(66.7%),and uncertainty as to where to begin(49.3%).Among patients with cancer,their family members,and the general public,93.4%reported reading or watching cancer science popularization materials and 56.9%expressed a desire for deeper *** most sought-after topics in cancer science popularization included cancer screening(80.2.)and cancer prevention(75.8%).The greatest challenge encountered in accessing cancer health popularization was an abundance of misinformation(67.5%).CONCLUSION Most clinical doctors,patients,family,and the general public wish to participate in cancer ***,improvement in the quality of content in cancer prevention and treatment education is required.

关键词： Cancer health popularization Patient education Science popularization Cancer prevention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

影响中国寒潮年代际变化的主要大气环流模态

兰州大学学报（自然科学版） 2024年第3期60卷 313-323页

作者：曾彦博李旭夏权李艳兰州大学大气科学学院兰州730000 兰州资源环境职业技术大学黄河流域生态环境产教融合研究院兰州730021

利用1951-2.2.年中国寒潮事件集和ERA5,分析中国寒潮的特征和变化趋势,通过自组织映射神经网络方法研究影响中国寒潮的主要模态,使用混合单粒子拉格朗日综合轨迹模型追踪寒潮冷空气路径.结果表明,1951-2.2.年,中国全国性寒潮的累计发生... 详细信息

利用1951-2.2.年中国寒潮事件集和ERA5,分析中国寒潮的特征和变化趋势,通过自组织映射神经网络方法研究影响中国寒潮的主要模态,使用混合单粒子拉格朗日综合轨迹模型追踪寒潮冷空气路径.结果表明,1951-2.2.年,中国全国性寒潮的累计发生天数呈显著下降趋势,特别是在80年代前后发生了年代际变化,80年代之前,影响寒潮的主要模态包括对应西北路径的贝湖低涡型和极涡东南延伸型、对应偏北路径的阻高极涡型、对应偏西路径的北极涛动负位相型和对应偏东路径的北大西洋涛动正位相型;80年代以后,寒潮的累积发生天数急剧减少,且入侵位置东移.主要模态变为对应西北路径的阻高极涡型、对应偏北路径的北极高压和阻塞高压打通型、对应偏西路径的北极涛动负位相型和对应偏东路径的西部极涡型,其中西北路径冷空气入侵位置东移,且占比减小;偏东路径的冷空气占比增大;新出现的北极高压和阻塞高压打通型模态对应的冷空气路径偏北,入侵距离偏短.北极高压和阻塞高压打通型可能对中国冬季天气气候产生影响,这种模态下在乌拉尔山地区有阻塞高压,同时期在新地岛至北地群岛一带存在北极高压,两者为同位相打通,高压脊为东北西南走向,使得西伯利亚高压的位置偏北、强度偏强、影响范围偏大,易于产生影响范围广、降温幅度大的北路或东路型寒潮,降温范围覆盖中国西北、华北以及华南等多个地区,降温中心强度可达到8~10℃.

关键词：寒潮北极高压阻塞高压自组织映射网络

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting yan yantao Ren Xiaobing Chen Mengmeng Xiao Xi Li Zhe Xi Gen Zhang Dongmei Qin Kunrong yang Zhigang Zheng quan Zhang Xiaogang Xia Peng Li Lingwei Gu Ting Wu Chenghua Luo Shu-Hai Lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2.deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2.inhibitor RG7112.and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

An universal in-situ phosphating strategy to fabricate high-performance Co2.-based bifunctional oxygen electrocatalyst derived from conjugated polyaniline-phytic acid copolymer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第11期 5823-5834页

作者： Wen-Xue Chen Yue Du Li-Na Zhou Zhi-Yi Zhong Zhi-Xian Shi yan Mao Zi-quan Zhou Hao-Yue Feng Yu Su Hai-yan Hu Shi Li Dong-Bin Xiong Jian-Qin Zhou Yi-Si Liu Yao Xiao Hubei Key Laboratory of Photoelectric Materials and Devices School of Material Science and EngineeringHubei Normal University College of Chemistry and Materials Engineering Wenzhou University Hangzhou Hangyang Chemical and Medical Engineering Lo. Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Innovative Centre for Flexible Devices (iFLEX) Max Planck-NTU Joint Lab for Artificial SensesSchool of Materials Science and EngineeringNanyang Technological University

Electrocatalysts play a crucial role in the performance of rechargeable Zn-air batteries（ZABs）,but it is still difficult to produce nonprecious materials with excellent bifunctional oxygen reduction reactions（ORR） and oxygen evolution reactions（OER）.Herein,conjugated polyaniline-phytic acid polymer（pANI-PA） was directly calcined to fabricate Co2. nanoparticles embedded in N,P-doped carbon network composites（Co2.@pDC-PA） for metal-air *** resulting pANI-PA derived Co2.based carbon composite exhibits exceptional bifunctional ORR/OER activities with a half-wave potential of 0.79 V for ORR and 1.62.V of over-potential for OER at 10mA·*** to the synergistic effect of its unique three-dimensional（3D） structure,N,P-doped carbon framework,and encapsulated Co2. nanoparticles,as-fabricated composite can be used as a highly efficient air cathode in the rechargeable metal-air *** assembled rechargeable ZAB demonstrates a high-power density of 190.0 mW·cm-2.nd remarkable cycling stability over1000 *** study introduced a novel approach that paves the way for the efficient,cost-effective,and scalable production of bifunctional electrocatalysts for rechargeable ZABs.

关键词：

Study on the expression and prognostic relationship of MYL6B in liver cancer based on bioinformatics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第9期15卷 1188-1197页

作者： Hai-Bing Lv Qing-Yun Wu Yu-Jiao Zhang Sheng-Wei quan Ning Ma Yu-Qing Dai yan Sun Department of General Surgery Beidahuang Group General HospitalHarbin 150000Heilongjiang ProvinceChina Department of General Surgery Xianning Central HospitalXianning 437000Hubei ProvinceChina Department of Medical oncology Beidahuang Group General HospitalHarbin 150000Heilongjiang ProvinceChina Department of General Surgery Daqing Oilfield General HospitalDaqing 163000Heilongjiang ProvinceChina College of Clinical Medicine Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of General Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbin 150000Heilongjiang ProvinceChina

BACKGROUND Primary liver cancer is a prevalent and deadly cancer *** treatment advances,prognosis remains poor,with high recurrence *** detection is crucial but challenging due to the disease’s insidious *** proteins play significant roles in cancer development,influencing cell migration,invasion,and tumor ***6B,a myosin light chain,is involved in various cellular processes and has been associated with poor prognosis in colorectal adenocarcinoma and potential as a biomarker in breast *** To investigate the expression of MYL6B in liver hepatocellular carcinoma(LIHC)and its impact on prognosis and potential mechanisms of action using bioinformatics *** The expression of MYL6B in pan-cancer and normal tissues was analyzed using the gene expression profiling interactive analysis 2.and tumor immune estimation resource *** expression level of MYL6B in LIHC tissues and its relationship with prognosis were analyzed,immunohistochemical analysis of MYL6B and its effect on immune cell infiltration,and the protein network were further *** MYL6B was highly expressed in diffuse large b-cell lymphoma,LIHC,pancreatic adenocarcinoma,skin cutaneous melanoma,thymoma,uterine corpus endometrial carcinoma,uterine carcinosarcoma,and lowly expressed in kidney chromophobe,acute myeloid leukemia,testicular germ cell *** expression level of MYL6B was significantly different between cancer and normal *** had a significant impact on both overall survival and disease-free ***6B is highly expressed in hepatocellular carcinoma and its expression level increases with cancer *** MYL6B expression is associated with poor prognosis in terms of overall survival and recurrence-free *** immunohistochemical level of MYL6B is high in hepatocellular carcinoma tissues,and MYL6B has a high level of immune infiltration *** protein network analysis,MYL6B is correlated with MYL2

关键词： MYL6B Liver cancer Bioinformatics Prognosis Expression

鼻内针刺联合调神针治疗中重度持续性变应性鼻炎的临床疗效

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

针刺研究 2024年第9期49卷 964-971页

作者：董博洋李丙泉李岩黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院耳鼻喉科哈尔滨150040

目的:观察鼻内针刺联合调神针对中重度持续性变应性鼻炎(AR)患者的治疗效果,同时探讨其调控炎性反应的机制。方法:将135例持续性AR患者随机分为西药组45例、鼻内针刺组45例、联合组45例。西药组采用布地奈德鼻喷雾剂治疗;鼻内针刺组采... 详细信息

目的:观察鼻内针刺联合调神针对中重度持续性变应性鼻炎(AR)患者的治疗效果,同时探讨其调控炎性反应的机制。方法:将135例持续性AR患者随机分为西药组45例、鼻内针刺组45例、联合组45例。西药组采用布地奈德鼻喷雾剂治疗;鼻内针刺组采用鼻内针刺治疗,取穴内迎香、鼻丘,每次2. min;联合组采用鼻内针刺联合调神针治疗,调神针取穴百会、四神聪、大陵、神门、印堂、神庭、安眠、迎香,每次2. min。各组均每日治疗1次,连续2.。分别观察各组治疗前后鼻部症状总积分(TNSS)、鼻部伴随症状总分量表(TNNSS)、鼻结膜炎生存质量量表(RQLQ)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分。用ELISA法检测治疗前后血清总免疫球蛋白E(IgE)、P物质(SP)、神经肽Y(NPY)、血管活性肠肽(VIP)含量。用体液血液分析仪检测外周静脉血中的嗜酸性粒细胞(EOS)数量。评价3组的临床疗效。结果:与本组治疗前比较,3组患者治疗后TNSS、TNNSS、RQLQ、SAS、SDS评分及EOS数量、IgE、SP、VIP含量均降低(P<0.05),血清NPY含量升高(P<0.05)。治疗后,鼻内针刺组患者TNSS、TNNSS、RQLQ、SAS、SDS评分及EOS数量、IgE、SP、VIP含量较西药组降低(P<0.05),血清NPY含量较西药组升高(P<0.05);联合组患者TNSS、TNNSS、RQLQ、SAS、SDS评分及EOS数量、IgE、SP、VIP含量较其他两组降低(P<0.05),血清NPY含量较其他两组升高(P<0.05)。联合组总有效率(40/45,88.89%)高于(P<0.05)鼻内针刺组(35/45,77.78%)和西药组(33/45,73.33%)。结论:鼻内针刺联合调神针可改善AR患者鼻部临床症状及伴随症状,降低EOS、IgE,抑制超敏反应的形成,同时调控神经肽分泌,缓解焦虑抑郁负性情绪。

关键词：鼻内针刺调神针变应性鼻炎临床疗效