Study on the expression and prognostic relationship of MYL6B in liver cancer based on bioinformatics
作者机构：Department of General SurgeryBeidahuang Group General HospitalHarbin 150000Heilongjiang ProvinceChina Department of General SurgeryXianning Central HospitalXianning 437000Hubei ProvinceChina Department of Medical oncologyBeidahuang Group General HospitalHarbin 150000Heilongjiang ProvinceChina Department of General SurgeryDaqing Oilfield General HospitalDaqing 163000Heilongjiang ProvinceChina College of Clinical MedicineBengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of General SurgerySecond Affiliated Hospital of Harbin Medical UniversityHarbin 150000Heilongjiang ProvinceChina
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第9期
页 面：1188-1197页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：MYL6B Liver cancer Bioinformatics Prognosis Expression
摘 要：BACKGROUND Primary liver cancer is a prevalent and deadly cancer *** treatment advances,prognosis remains poor,with high recurrence *** detection is crucial but challenging due to the disease’s insidious *** proteins play significant roles in cancer development,influencing cell migration,invasion,and tumor ***6B,a myosin light chain,is involved in various cellular processes and has been associated with poor prognosis in colorectal adenocarcinoma and potential as a biomarker in breast *** To investigate the expression of MYL6B in liver hepatocellular carcinoma(LIHC)and its impact on prognosis and potential mechanisms of action using bioinformatics *** The expression of MYL6B in pan-cancer and normal tissues was analyzed using the gene expression profiling interactive analysis 2 and tumor immune estimation resource *** expression level of MYL6B in LIHC tissues and its relationship with prognosis were analyzed,immunohistochemical analysis of MYL6B and its effect on immune cell infiltration,and the protein network were further *** MYL6B was highly expressed in diffuse large b-cell lymphoma,LIHC,pancreatic adenocarcinoma,skin cutaneous melanoma,thymoma,uterine corpus endometrial carcinoma,uterine carcinosarcoma,and lowly expressed in kidney chromophobe,acute myeloid leukemia,testicular germ cell *** expression level of MYL6B was significantly different between cancer and normal *** had a significant impact on both overall survival and disease-free ***6B is highly expressed in hepatocellular carcinoma and its expression level increases with cancer *** MYL6B expression is associated with poor prognosis in terms of overall survival and recurrence-free *** immunohistochemical level of MYL6B is high in hepatocellular carcinoma tissues,and MYL6B has a high level of immune infiltration *** protein network analysis,MYL6B is correlated with MYL2
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