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Faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating Th17 cell differentiation

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World Journal of Gastroenterology 2016年第22期22卷 5201-5210页

作者： Xiao-Li Huang Xin Zhang Xian-yan Fei Zhao-Gui Chen yan-Ping Hao Shu Zhang Ming-Ming Zhang yan-qiu yu Cheng-Gong yu Department of Gastroenterology Gulou School of Clinical Medicine Nanjing Medical University Nanjing 210008 Jiangsu Province China Department of Gastroenterology Nanjing Jiangbei People's Hospital Affiliated to Southeast University Medical School Nanjing 210048 Jiangsu Province China Nanjing University Medical School Nanjing 210093 Jiangsu Province China Department of Gastroenterology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing 210008 Jiangsu Province China

AIM: To explore the preventive and therapeutic effects of Faecalibacterium prausnitzii(F. prausnitzii) supernatant on dextran sulfate sodium(DSS) induced colitis in ***: Forty C57BL/6J male mice were randomlydivided into four groups: control group, model group, treatment group, and prevention group. Mice were weighed daily. On day 10, the colon length was measured, the colorectal histopathologic damage score(HDS) was assessed, and plasma interleukin(IL)-17 A, IL-6, and IL-4 levels were detected by enzyme-linked immunosorbent assay. The expression of transcription factor retinoic acid-related orphan receptor-γt(RORγt) and IL-17 A in colon inflammatory mucosa tissue were determined by immunohistochemical assay, and the expression levels of RORγt m RNA, IL-17 A m RNA, and IL-6 m RNA were detected by real-time quantitative polymerase chain reaction(PCR). The proportion of Th17 in mononuclear cells in spleen was assayed by fluorescence activated cell sorter. RESULTS: When compared with the model group, the colon length(P < 0.05) and body weight(P < 0.01) in the treatment and prevention groups were significantly increased, and the colon HDS was decreased(P < 0.05 and P < 0.01). There was no statistical difference between the treatment group and prevention group. After treatment with F. prausnitzii supernatant, the plasma levels of IL-17 A and IL-6(P < 0.05), the protein and m RNA expression of IL-17 A and RORγt, and the Th17 cell ratio of spleen cells(P < 0.01) were significantly decreased compared to the model group. Plasma IL-4 level in the prevention group was significantly higher than that in the model group(P < 0.05), but there was no significant difference between these two groups in the expression of IL-6 in both the plasma and colon mucosa ***: F. prausnitzii supernatant exerts protective and therapeutic effects on DSS-induced colitis in mice, probably via inhibition of Th17 differentiation and IL- 17A secretion in the plasma and colon muco

关键词： Faecalibacterium prausnitzii Ulcerative colitis Animal model Th17 cell Treatment Prevention

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Novel Efficient Method for Synthesis of N_(1,4)-Disubstituted-1,4-benzodiazepine-2,5-diones

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Chemical Research in Chinese Universities 2009年第3期25卷 312-316页

作者： WANG qiu-yan yu Jing-jun LU Cui-fen CHEN Zu-xing yanG Gui-chun Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education School of Chemistry and Chemical Engineering Hubei University Wuhan 430062 P. R. China

A novel and efficient method was developed for the liquid-phase synthesis of Nj,4-disubstitutedbenzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterifieation, ＂Ulmn reaction＂, acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.

关键词： 1,4-Benzodiazepine-2,5-dione Liquid-phase Dipeptides

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Value of ultrasound examination in differential diagnosis of pancreatic lymphoma and pancreatic cancer

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World Journal of Gastroenterology 2008年第43期14卷 6738-6742页

作者： Li qiu yan Luo yu-Lan Peng Department of Ultrasound,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China Author contributions:qiu L and Luo Y designed the research qiu L,Luo Y and Peng YL did the ultrasound examination qiu L and Peng YL collected the data qiu L and Luo Y drafted and revised the manuscript and approved the final version. Department of Ultrasound West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China. wsqiuli@***

AIM： To investigate the value of clinical manifestations and ultrasound examination in the differential diagnosis of pancreatic lymphoma and pancreatic cancer. METHODS： The clinical and ultrasonic characteristics of 12 cases of pancreatic lymphoma and 30 cases of pancreatic cancer were retrospectively analyzed. RESULTS： Statistically significant differences were found in the course of disease, back pain, jaundice, carcino-embryonic antigen （CEA） and CA19-9 increase, palpable abdominal lump, superficial lymph node enlargement, fever and night sweats, lesion size, bile duct expansion, pancreatic duct expansion, vascular involvement, retroperitoneal （below the renal vein level） lymph node enlargement, and intrahepatic metastasis between pancreatic lymphoma and pancreatic cancer. There were no significant differences in age of onset, gender ratio, weight loss, nausea and vomiting, lesion position, the echo of the lesion, and the blood flow of the lesion. CONCLUSION： Pancreatic lymphoma should be considered for patients with long lasting symptoms, superficial lymph node enlargement, palpable abdominal lump, fever and night sweats, relatively large lesions, and retroperitoneal （below the level of the renal vein） lymph node enlargement. A diagnosis of pancreatic cancer should be considered more likely in the patients with relatively short disease course, jaundice, back pain, CEA and CA19-9 increase, relatively small lesions, bile duct expansion, obvious pancreatic duct expansion, peripheral vascular wrapping and involvement, or intrahepatic metastases.

关键词： Ultrasound Pancreatic lymphoma Pancreatic cancer

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Treatment-seeking behaviour and barriers to service access for sexually transmitted diseases among men who have sex with men in China:a multicentre cross-sectional survey

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Infectious Diseases of Poverty 2017年第1期6卷 118-127页

作者： Jun-Jie Xu yan-qiu yu Qing-Hai Hu Hong-Jing yan Zhe Wang Lin Lu Ming-Hua Zhuang Xi Chen Ji-Hua Fu Wei-Ming Tang Wen-Qing Geng Yong-Jun Jiang Hong Shang Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory MedicineThe First Affiliated HospitalChina Medical UniversityShenyangChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouChina Jiangsu Provincial Centers for Disease Control and Prevention NanjingChina He’nan Provincial Centers for Disease Control and Prevention ZhengzhouChina yunnan Provincial Centers for Disease Control and Prevention KunmingChina Shanghai Municipal Centers for Disease Control and Prevention ShanghaiChina Hu’nan Provincial Centers for Disease Control and Prevention ChangshaChina Shandong Provincial Centers for Disease Control and Prevention JinanChina University of North Carolina Project-China GuangzhouChina

Background:Delayed or inappropriate treatment for sexually transmitted diseases(STDs)increases the risk of HIV acquisition and may cause other harmful ***,studies on STD treatment-seeking behaviour and correlated factors in men who have sex with men(MSM)are *** information is crucial for the promotion of STD treatment-seeking behaviour and reduction of HIV transmission among Chinese ***:During 2012-2013,a multicentre cross-sectional study was conducted in 7 Chinese *** completed an interview-questionnaire and gave venous blood samples,which were then tested for antibodies to HIV,syphilis,and herpes simplex virus-2(HSV-2).MSM who tested positive for syphilis/HSV-2 or had obvious STD-related symptoms within the last 12 months were defined as suspected STD-infected ***:Of the 4496 eligible MSM who completed this survey,24.4%(1096/4496)were categorized as suspected STD-infected MSM.35.7%(391/1096)of these MSM with suspected STD infections sought STD treatment in clinics within the last 12 *** MSM who did not attend STD clinics for treatment,the prevalence of syphilis and HSV-2 was significantly higher;the HIV prevalence and incidence within this subpopulation reached as high as 14.5%and 12.2/100 person-years,*** logistic regression analysis indicated that having 7-12 years of education(vs.≤6 years;aOR,2.5;95%CI,1.0-6.1),≥13 years of education(vs.≤6 years:aOR,2.8;95%CI,1.2-7.0),monthly income>500 USD(vs.≤500 USD:aOR,1.5;95%CI,1.1-2.1),obvious STD-related symptoms within last 12 months(aOR,5.3;95%CI,3.7-7.5),being HIV infected(aOR,1.7;95%CI,1.1-2.6),currently syphilis infected(aOR,0.6;95%CI,0.4-0.9)and HSV-2 infected(aOR,0.6;95%CI,0.5-0.9)were independent correlates with seeking STD treatment in clinics among Chinese ***:The high prevalence of STD infection coupled with a low proportion of individuals who exhibit appropriate treatment-seeking behaviour create a high risk of a g

关键词： Sexually transmitted diseases(STDs) Men who have sex with men(MSM) Treatment-seeking behaviour HIV China

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Sclerosing epithelioid fibrosarcoma of the pancreas:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5983-5989页

作者： Meng-Qing Sun Li-Na Guo yan You yan-yu qiu Xiao-Dong He Xian-Lin Han Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND A sclerosing epithelioid fibrosarcoma(SEF)is a rare malignant fibroblastic soft tissue tumor that rarely occurs in intra-abdominal organs.A case of a SEF in the pancreatic head is reported herein,including its clinical manifestations,preoperative imaging features,gross specimen and pathological *** SUMMARY A 33-year-old male patient was admitted to Peking Union Medical College Hospital in December 2023 due to a one-year history of intermittent upper abdominal pain and the discovery of a pancreatic *** patient underwent an enhanced computed tomography scan of the abdomen,which revealed a welldefined,round mass with clear borders and calcifications in the pancreatic *** mass exhibited progressive,uneven mild enhancement,measuring approximately 6.6 cm×6.3 *** patient underwent laparoscopic pylorus-preserving *** pathological examination revealed that the lesion was consistent with a *** the 3-month postoperative follow-up,the patient did not report any short-term complications,and there were no signs of tumor *** SEFs are rare malignant fibrous soft tissue *** rarely develop in the pancreas,and its preoperative diagnosis depends on imaging findings,with confirmation depending on pathological examination and ***,only four cases of pancreatic SEF have been reported in studies written in *** case is the first reported case of a pancreatic SEF by a clinical physician.

关键词： Sclerosing epithelioid fibrosarcoma of the pancreas Abdominal malignant fibroblastic soft tissue tumor Abdominal enhanced computed tomography Laparoscopic pancreaticoduodenectomy Case report

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Molecular and Crystal Structure of 1-(4-Chlorophenyl)-3-(4-Nitrophenyl)-1-Triazene

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Chinese Journal of Structural Chemistry 2000年第1期19卷 19-22页

作者： ZHANG De\|Chun a\ FEI Zheng\|Hao b\ ZHANG yan\|qiu a\ yu Kai\|Bei c a(Department of Chemistry, Suzhou University, Suzhou 215006) b(Department of Chemistry, yancheng Teacher’s College, yancheng 224002) c(Chengdu Center of Analysis and 苏州大学江苏苏州 2 1 50 0 6 盐城师范学院江苏盐城 224002 中科院成都分析测试中心四川成都 610041

The title compound,1\|(4\|Chlorophenyl)\|3\|(4\|Nitrophenyl)\|1\|Triazene, crystallized in the orthorhombic system, space group Pbca, with a=13.793(2), b=10.843(2), c=16.851(2), V=2520.2(7) 3 D c =1.458g/cm 3, Z =8, C 12 H 9ClN 4O 2, M r=276.68, μ (Mo Kα )=0.306mm -1 , F (000)=1136. The structure was refined to R=0.0372, wR =0.0786 for 1216 reflections ( I>2σ(I )). The title molecule has trans geometry about the central triazenyl linkage. The dihedral angle between the two phenyl rings is only 5.8(2)°. They are also nearly coplanar with the triazenyl. The screw related molecules are connected by hydrogen bond N(3)-H…O(2) and form the zigzag chains. The polar molecular chains are antiparallelly stacked through π…π interactions. The interstack interaction is mainly van der Waals force.

关键词： diaryltriazene synthesis crystal structure

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Crystal and Molecular Structure of 4-Hydroxy-3-Methoxy-4-N-Methylstilbazonium Iodide C15 H16 NO2 +·I-CrystalandMolecularS

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Chinese Journal of Structural Chemistry 2000年第1期19卷 6-10页

作者： ZHANG Tian Zhu a GE Li Qin b ZHANG De Chun b ZHANG yan qiu b yu Kai Bei c a(Department of Preventive Medicine, Suzhou Medical College, Suzhou,215007) b(Department of Chemistry, Suzhou University, Suzhou,215006) c(Chengdu Institute of Or 苏州医学院江苏苏州 2 1 50 0 7 苏州大学江苏苏州 2 1 50 0 6 中科院成都有机化学所四川成都 6 1 0 0 41

The crystal structure of the title compound C 15 H 16 NO 2 +·I - ( M r =369.19) has been determined by single crystal X ray diffraction analysis. The crystal belongs to the monoclinic system with space group P2 1/c, a=8.957(1), b=21.8117(2), c=7.8760(10), β=103.94(1)°, V=1493.8(3) 3, Z=4, D c= 1.642g/m 3, μ =2.141mm -1 , F (000)=728, final R =0.0264, and R w=0.0644(I>2σ(I)) for 2938 independent reflections. The results show that in the crystal structure of the title compound the planar cations have two configurations, and these cations are anti parallelly packed through the strong π…π interaction.

关键词： crystal structure stilbazonium salt engineering

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Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： yan-Heng yu Sai Wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

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High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study

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Infectious Diseases of Poverty 2016年第1期5卷 753-763页

作者： Jun-Jie Xu Wei-Ming Tang Hua-Chun Zou Tanmay Mahapatra Qing-Hai Hu Geng-Feng Fu Zhe Wang Lin Lu Ming-Hua Zhuang Xi Chen Ji-Hua Fu yan-qiu yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing Geng Xiao-Xu Han Hong Shang Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory MedicineThe First Affiliated HospitalChina Medical UniversityShenyang 110001People’s Republic of China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouPeople’s Republic of China University of North Carolina at Chapel Hill Project-ChinaNo.2 Lujing RoadGuangzhou 510085People’s Republic of China Guangdong Provincial Center for Skin Diseases and STIs Control Guangzhou 510085People’s Republic of China Kirby Institute the University of New South WalesSydneyNSW 2052Australia Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos Angeles 90095USA Jiangsu Provincial Centers for Disease Control and Prevention NanjingChina He’nan Provincial Centers for Disease Control and Prevention ZhengzhouChina yunnan Provincial Centers for Disease Control and Prevention KunmingChina Shanghai Municipal Centers for Disease Control and Prevention ShanghaiChina Hu’nan Provincial Centers for Disease Control and Prevention ChangshaChina Shandong Provincial Centers for Disease Control and Prevention JinanChina

Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in *** of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive ***:Mixed methods were used to recruit MSM from seven cities in China between 2012 and *** and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme *** and herpes simplex virus-2(HSV-2)were also ***:A total of 4496 eligible MSM were *** majority was aged≤35 years(77.5%),migrants(60.3%),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2)/100 *** prevalence of history HSV-2 and syphilis were 12.5%and 8.5%,*** HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2,95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3)and history HSV-2 infection(aOR=2.3,95%CI 1.5-3.3).Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in *** interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour.

关键词： Men who have sex with men(MSM) HIV Incidence BED HIV-1 capture enzyme immunoassay(BED-CEIA)

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PI3K催化亚基p110α小干扰RNA对小鼠受精卵发育的影响

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生殖与避孕 2010年第9期30卷 577-581,587页

作者：徐小燕于艳秋张哲宿文辉于秉治中国医科大学基础医学院病理生理学教研室沈阳110001 中国医科大学附属第一医院泌尿科沈阳110001 中国医科大学基础医学院生物化学与分子生物学教研室沈阳110001

目的:利用特异性小发夹RNA(shRNA)表达质粒,研究IA型磷脂酰肌醇3-激酶(PI3Ks)催化亚基p110α对小鼠受精卵发育的影响。方法:把p110αshRNA表达质粒显微注射到受精卵中。确定能干扰p110α表达的shRNA的最适浓度。通过检测RNA干扰后的p110... 详细信息

目的:利用特异性小发夹RNA(shRNA)表达质粒,研究IA型磷脂酰肌醇3-激酶(PI3Ks)催化亚基p110α对小鼠受精卵发育的影响。方法:把p110αshRNA表达质粒显微注射到受精卵中。确定能干扰p110α表达的shRNA的最适浓度。通过检测RNA干扰后的p110αmRNA水平和蛋白表达情况,证明干扰是否成功。在确定成功干扰p110α后,观察受精卵的形态变化、分裂率以及对MPF活性的影响。结果:p110α表达受到干扰后,MPF的活性明显降低,受精卵第一次有丝分裂受到干扰,卵裂率明显降低。结论:p110α可能通过影响MPF的活性,调控小鼠受精卵的早期发育,为进一步探讨PI3K信号转导通路在小鼠胚胎中的作用奠定了基础。

关键词： p110α shRNA MPF 小鼠受精卵

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