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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian wu Xiaohui Huang Ajing Xu yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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江苏省人口分布的时空动态分析

测绘科学 2015年第3期40卷 30-35页

作者：刘永伟闫庆武黄珊姜春雷蒋龙中国矿业大学环境与测绘学院江苏徐州221116 江苏师范大学城市与环境学院江苏徐州221116

为了探寻江苏省人口分布的时空动态特征以提供人口动态管理的决策依据,该文以2000年第五次人口普查和2010年第六次人口普查数据为基础,应用GIS空间分析功能结合人口地理学方法,对江苏省两次普查的人口分布特征进行分析。结果表明,江苏... 详细信息

为了探寻江苏省人口分布的时空动态特征以提供人口动态管理的决策依据,该文以2000年第五次人口普查和2010年第六次人口普查数据为基础,应用GIS空间分析功能结合人口地理学方法,对江苏省两次普查的人口分布特征进行分析。结果表明,江苏省人口空间分布不均,存在着苏南、苏中、苏北以及市县之间的差异;人口空间分布不均衡的趋势不断增强,市域与县域人口分布特征存在差异,人口分布呈现出由苏北向苏南转移的特点。

关键词：人口分布时空动态江苏省 GIS

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脉冲中子氧活化测井仪的改进及应用

大庆石油地质与开发 2005年第3期24卷 99-100,i008页

作者：孙秀梅严青伍王佳平崔杰大庆石油管理局测井公司黑龙江大庆163412

改进后的脉冲中子氧活化测井仪将原来的上、下水流氧活化测井仪组合在一起,一次下井,不但能够节省测井时间,降低测井成本,而且减少了测井过程中的系统误差。通过推广应用,该技术在油田动态监测中,解决了生产中出现的许多难题。

关键词：氧活化测井注入剖面实际应用

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玄武岩纤维加筋土的动本构特性试验研究

中国农村水利水电 2020年第12期 211-216,223页

作者：李胜男骆亚生严武庆 Samnang Phoak 尹倩西北农林科技大学水利与建筑工程学院陕西杨凌712100

为了从动力学角度研究玄武岩纤维对土的加筋作用,将长为6 mm的玄武岩纤维分别按一定的质量比掺入黄土中,通过动三轴试验研究纤维含量、含水率以及固结围压对玄武岩纤维加筋土的动应力-应变关系、动弹性模量和阻尼比的影响。试验结果表明... 详细信息

为了从动力学角度研究玄武岩纤维对土的加筋作用,将长为6 mm的玄武岩纤维分别按一定的质量比掺入黄土中,通过动三轴试验研究纤维含量、含水率以及固结围压对玄武岩纤维加筋土的动应力-应变关系、动弹性模量和阻尼比的影响。试验结果表明:①玄武岩纤维加筋土和无筋土的动应力-应变关系曲线可以用H-D双曲线模型拟合;②与无筋土相比,当动应变相同时玄武岩纤维加筋土的动应力增大;③提升固结围压或减小试样含水率均可增大玄武岩纤维加筋土的动弹性模量,但该模量受纤维含量的影响不明显;④可通过增加纤维含量,或在有效区间内增大含水率来增大玄武岩纤维加筋土的阻尼比。

关键词：玄武岩纤维加筋土动应力-应变关系动弹性模量阻尼比 H-D模型

基于DMSP/OLS与NDVI的江苏省碳排放空间分布模拟

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世界地理研究 2016年第4期25卷 102-110页

作者：郭忻怡闫庆武谭晓悦刘思佳中国矿业大学环境与测绘学院江苏徐州221116

结合江苏省经济结构和自然环境情况,选择合适的碳排放模型进行核算,得到江苏省各区县的碳排放量,综合DMSP/OLS夜间灯光影像和NDVI数据,再结合人口、GDP和工业生产总值数据,构建碳排放的空间滞后回归模型并开展江苏省碳排放的空间分布模... 详细信息

结合江苏省经济结构和自然环境情况,选择合适的碳排放模型进行核算,得到江苏省各区县的碳排放量,综合DMSP/OLS夜间灯光影像和NDVI数据,再结合人口、GDP和工业生产总值数据,构建碳排放的空间滞后回归模型并开展江苏省碳排放的空间分布模拟,得到大小为1km×1km的碳排放空间格网,并对模拟结果纠正,用以研究江苏省各区县的碳排放量分布情况。结果表明,江苏省碳排放清晰地呈现出"苏南>苏北>苏中"的格局,苏南地区分布着以苏州、无锡为中心和以南京市区为中心的碳排放高值集聚的"热点"区域;在各区县内部,碳排放的空间分布与人口、GDP产值等密切相关,明显集中于人口、工业聚集的市区和县城区域。

关键词：夜间灯光数据归一化植被指数碳排放空间滞后回归江苏省

1-quasiconformal mappings on a (2,2)-type quadric

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Applied Mathematics(A Journal of Chinese Universities) 2009年第1期24卷 65-75页

作者： wu qing-yan Dept. of Math. Zhejiang Univ. Hangzhou 310027 China

This paper gets the Beltrami equations satisfied by a 1-quasiconformal mapping, which are exactly CR or anti-CR equations on （2,2）-type quadric Q0. This means a 1-quasiconformal mapping on Q0 is CR or anti-CR. This reduces the determination of 1- quasiconformal mappings to a problem on the theory of several complex analysis. The result about the group of CR automorphisms is used to determine the unit component of group of 1-quasiconformal mappings.

关键词： Beltrami equation quasiconformal mapping quadric CR automorphism

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

多层螺旋CT曲面成像在关节突关节的应用价值

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实用放射学杂志 2008年第11期24卷 1516-1518页

作者：王清华岳军艳吴清武陈杰周凤梅李强新乡医学院第一附属医院放射科

目的探讨MSCT曲面成像对关节突关节的显示技术及诊断价值。方法回顾性分析了50例患者100组(颈椎28组,胸椎44组及腰椎28组)关节突关节的曲面成像图像及多平面成像图像,并将两者做配对t检验。结果总体组、退变组及脊柱侧弯或后突组关节突... 详细信息

目的探讨MSCT曲面成像对关节突关节的显示技术及诊断价值。方法回顾性分析了50例患者100组(颈椎28组,胸椎44组及腰椎28组)关节突关节的曲面成像图像及多平面成像图像,并将两者做配对t检验。结果总体组、退变组及脊柱侧弯或后突组关节突关节在1幅曲面成像图像上的显示率分别为99.30%、100%及98.99%,在MPR图像上显示率为89.30%、81.39%及67.17%(P=0.00)。结论曲面图像是显示关节突关节及椎弓峡部的最佳方法,具有重要诊断价值。

关键词：脊椎关节突关节体层摄影术,X线计算机曲面成像

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou Yuan-yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun yan Han-qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology