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Clinical outcomes of using three gonadatropins and medroxyprogestrone acetate(MPA) during ovarian stimulation in normal ovulatory women undergoing IVF/ICSI treatments

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Journal of Reproduction and Contraception 2015年第1期26卷 22-30页

作者： Xiu-xian ZHU Qiu-ju CHEN yan-ping kuang Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine

Objective To compare the clinical characteristics in a gonadotropin （Gn） and medroxyprogestrone acetate （MPA） protocol using three types of Gn in normal ovulatory women undergoing IVF/ICSI treatments. Methods A total of 258 normal ovulatory IVF/ICSI patients undergoing ovarian stimulation in a Gn and MPA protocol were analyzed in this retrospective study and allocated into three groups according to the Gn used： group A, hMG-A （brand name： Fengyuan, n=105）; group B, hMG-B （brand name： Lebaode, n=90）; group C： u-FSH （brand name： Lishenbao, n=63）. The hormone profile, embryological characteristics, and the pregnant results after frozen-thawed embryo transfer （FET） were compared among the three groups. Results There was no significant difference in the number of oocytes retrieved among the three groups （12.1± 6.9 vs 12.1±5.6 vs 13.1 ±8.8, P〉0.05）. Other indicators such as the number of mature oocyte, fertilization, cleavage and viable embryo were similar （P〉0.05）. No premature LH surges were detected, with a range of 0.04-7.38 IU/L. No differences were found in the clinical pregnancy rate per transfer （43.48% vs 37.93% vs 40. 74%, P〉0.05） and the implantation rate （34.88% vs 22.22% vs 26.42%, P〉O.05）. Conclusion MPA is an effective oral alternative for the prevention of premature LH surges. Progestin-primed ovarian stimulation （PPOS） is a novel regimen of ovarian stimulation in combination with embryo cryopreservation, in which the two types of hMG are as effective as u-FSH.

关键词： human menopausal gonadtropin(h MG) urinary follicle stimulation hormone(u-FSH) medroxyprogestrone acetate(MPA) luteinizing hormone(LH) surge frozen-thawed embryo transfer(FET)

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The Clinical Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Treatments in 43 Women with a History of Gestational Trophoblastic Disease

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Reproductive and Developmental Medicine 2018年第1期2卷 38-45页

作者： Xi Shen yan-ping kuang Department of Reproductive Medicine Shanghai Ninth People’s Hospital Affiliated Shanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Ninth People’s Hospital Affiliated Shanghai JiaoTong University School of Clinical Medicine Shanghai 200011China

Background:To analyze the clinical outcomes of in vitro fertilization(IVF)/intracytoplasmic sperm injection treatments in women with a history of gestational trophoblastic disease(GTD).Methods:This retrospective study included 43 patients with a history of GTD as the study group and 43 matched patients as the control *** patients in the study group were divided into two groups according to the therapy *** in Subgroup A(n=32)underwent uterine curettage treatment *** in Subgroup B(n=11)underwent uterine curettage combined with *** characteristics of ovarian stimulation and outcomes of embryos and pregnancy were ***:In the first cycle,there was a higher number of retrieved oocytes and normal fertilized oocytes in the control group than those in the study group(9.2 vs.6.2 and 6.0 vs.4.0,respectively;P0.05).There was no difference in the outcomes between Subgroup A and Subgroup *** was a significant difference in thickness of the endometrium between the control group and study group(10.9 mm vs.9.2 mm,respectively;P<0.05).The biochemical pregnancy rate and ongoing pregnancy rate in the control group were significantly higher than those in the study group(51.4%vs.31.7%and 37.8%vs.18.3%,respectively;P<0.05).In the study group,28(93.3%)patients had intrauterine adhesion(IUA)and 23(76.7%)patients used an intrauterine device(IUD),which were both significantly higher than those in control group(P<0.05).In addition,the rate of IUA in second-look hysteroscopy was lower than that in the first surgery in the study group(P<0.05).Conclusions:Patients with a history of GTD can present with a similar normal fertilization rate and number of viable ***,patients with a history of GTD may have a thinner endometrium and lo

关键词： Chemotherapy Gestational Trophoblastic Disease In Vitro Fertilization/Intracytoplasmic Sperm Injection Uterine Curettage Treatment

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Clomiphene Citrate as An Adjuvant to hMG Stimulation of the Ovaries in Mid-to-late Follicular Phase and Subsequently Pregnancy Outcome of Frozen-thawed Embryo Transfers

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Journal of Reproduction and Contraception 2013年第1期24卷 10-20页

作者： yan KANG Qing-qing HONG Wei-ran CHAI Yong-lun FU Ai AI Qiu-ju CHEN yan-ping kuang Department of Assisted Reproduction the 9th Hospital Shanghai Jiaotong University School of Medicine

Objective To compare the results of a novel regimen of human menopausal gonadotrophin （hMG） in combination with clomiphene citrate （CC） in mid-to-late follicular phase with those of a short protocol of GnRH agonist （GnRHa） and hMG used for IVF. Methods In the retrospective study, 842 patients undergoing IVF were collected and classified into two groups： hMG in combination with CC in mid-to-late follicular phase （group A, n=319） and short protocol of GnRHa-hMG （group B, n=523）. The main outcome measures were ovarian responses in stimulation cycles and pregnancy outcomes in subsequent frozen-thawed embryo transfer （FET） cycles. Results In group A, the serum LH concentration on day 8 -10 was similar with that on the day of hCG administration （2.43 ± 1.92 IU vs 2.51 ±2.05 IU）. The number of mature follicles and oocytes retrieved was significantly lower in group A than in group B while the fertilization rate and the cleavage rate were comparable. The clinical pregnancy rate （47. 79% vs 48.04%）, the implantation rate （32.49% vs 33.11%） and the cumulative pregnancy rate （58.09% vs 60.22%） were respectively similar in group A and group B. Conclusion hMG in combination with CC in mid-to-late follicular phase results in the same pregnancy outcome as short protocol. The novel protocol may take the advantage of eliminating the occurrehce of a premature endogenous LH Surge.

关键词： clomiphene citrate (CC) human menopausal gonadotrophin (hMG) frozen-thawed embryo transfer (FET) short protocol

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Different endometrial preparation protocols yield similar pregnancy outcomes for frozen-thawed embryo transfer in patients with advanced endometriosis

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Journal of Reproduction and Contraception 2016年第1期27卷 1-11页

作者： Hai-yan GUO Yun WANG Qiu-ju CHEN Wei-ran CHAI Li-hua SUN Ai AI Yong-lun FU Qi-feng LYU yan-ping kuang Department of Assisted Reproduction Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine

Objective To explore the different endometrial preparation for frozen-thawed embryo transfer （FET） in women with advanced endometriosis （EMS）. Methods The pregnancy outcomes of patients with advanced EMS （542 cycles）, who were prepared for FET, were retrospectively assessed. Included patients underwent a total of 233 FET cycles （180 patients） using natural cycle （NC）, a total of 142 FET cycles （115 patients） using letrozole （LE） ovulation induction, and a total of 167 FET cycles （137 patients） using hormonal replacement treatment （HRT） for endometrial *** There were no significant diffenences in the clinical pregnancy rate （LE： 49.30%, NC： 50.21%, and HRT： 43.11~/o, P=0.343）, the implantation rate （LE： 29.26%, NC： 36.03%, and HRT： 29.55%, P=0.084）, and the live birth rate （LE： 38.02%, NC： 39.11%, and HR T.＂ 35.33 %, P=O. 648） among the three groups. No statistically signifi- cant differences were observed in the ongoing pregnancy rate, the miscarriage rate, and the pregnancy complication rate. The single birth weight in patients using NC- FET was lower than that in patients using HRT-FET （P=0.044） and a higher twin birth weight in patients using LE-FET were observed compared with other groups （P=O. 022）. The rate of birth weight 〈2 500 g was also higher in the NC-FET group than in other groups. No congenital birth defects were found in the three groups. Conclusion Different endometrial preparation protocols without ultra-long GnRH-a down-regulation for FET yield similar pregnancy outcomes in patients with EMS. A tailored endometrial preparation protocol should be recommended according to different patients＇ situation.

关键词： clinical pregnancy outcomes endometrial preparation endometriosis (EMS) frozen-thawed embryo transfer (FET)

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Designing Bioorthogonal Reactions for Biomedical Applications

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Research 2024年第3期2023卷 625-650页

作者： Qingfei Zhang Gaizhen kuang Li Wang ping Duan Weijian Sun Fangfu Ye Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China. Department of Obstetrics and Gynecology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China. Department of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China.

Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency. Since the first proposal of the conception by Professor Carolyn Bertozzi in 2003, bioorthogonal chemistry has attracted great attention and has been quickly developed. As an important chemical biology tool, bioorthogonal reactions have been applied broadly in biomedicine, including bio-labeling, nucleic acid functionalization, drug discovery, drug activation, synthesis of antibody–drug conjugates, and proteolysis-targeting chimeras. Given this, we summarized the basic knowledge, development history, research status, and prospects of bioorthogonal reactions and their biomedical applications. The main purpose of this paper is to furnish an overview of the intriguing bioorthogonal reactions in a variety of biomedical applications and to provide guidance for the design of novel reactions to enrich bioorthogonal chemistry toolkits.

关键词： orthogonal summarized chemistry

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Prediction of discharge in a tidal river using the LSTM-based sequence-to-sequence models

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Acta Oceanologica Sinica 2024年第7期43卷 40-51页

作者： Zhigao Chen yan Zong Zihao Wu Zhiyu kuang Shengping Wang Key Laboratory of Mine Environmental Monitoring and Improving around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China

The complexity of river-tide interaction poses a significant challenge in predicting discharge in tidal *** short-term memory(LSTM)networks excel in processing and predicting crucial events with extended intervals and time delays in time series ***,the sequence-to-sequence(Seq2Seq)model,known for handling temporal relationships,adapting to variable-length sequences,effectively capturing historical information,and accommodating various influencing factors,emerges as a robust and flexible tool in discharge *** this study,we introduce the application of LSTM-based Seq2Seq models for the first time in forecasting the discharge of a tidal reach of the Changjiang River(yangtze River)*** study focuses on discharge forecasting using three key input characteristics:flow velocity,water level,and discharge,which means the structure of multiple input and single output is *** experiment used the discharge data of the whole year of 2020,of which the first 80%is used as the training set,and the last 20%is used as the test *** means that the data covers different tidal cycles,which helps to test the forecasting effect of different models in different tidal cycles and different *** experimental results indicate that the proposed models demonstrate advantages in long-term,mid-term,and short-term discharge *** Seq2Seq models improved by 6%-60%and 5%-20%of the relative standard deviation compared to the harmonic analysis models and improved back propagation neural network models in discharge prediction,*** addition,the relative accuracy of the Seq2Seq model is 1%to 3%higher than that of the LSTM *** assessment of the prediction errors shows that the Seq2Seq models are insensitive to the forecast lead time and they can capture characteristic values such as maximum flood tide flow and maximum ebb tide flow in the tidal cycle *** indicates the significance of the Seq2Seq models.

关键词： discharge prediction long short-term memory networks sequence-to-sequence(Seq2Seq)model tidal river back propagation neural network Changjiang River(yangtze River)Estuary

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Reducing the Trigger Dose of Human Chorionic Gonadotrophin Does Not Affect Final Oocyte Maturation and Subsequently Pregnancy Outcome of Frozen-thawed Embryo Transfer

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Journal of Reproduction and Contraception 2013年第3期24卷 151-158页

作者： Yun WANG Yong-lun FU Shao-feng CAO Qiu-ju CHEN Song-guo XUE Qi-feng LYU yan-ping kuang Department of Assisted Reproductive Shanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine

To compare the efficacy of human chorionic gonadotrophin （hCG） at reduced doses of 2 000 IU and 3 000 IU for moderate or high responders with the dose of 5 000 IU in term of inducing final oocyte maturation for IVF/ICSI and the subsequent pregnancy outcome in frozen-thawed embryo transfer （FET）. Methods In the retrospective cohort study, 2 166patients undergoing IVF/ICSI with moderate or high response were recruited and classified into three groups according to the trigger dose of hCG： 2 000 IU （group A, n=722）, 3 000 IU （group B, n=722） and 5 000 IU （group C, n= 722）. The main outcome was the proportion of mature oocytes retrieved, fertilization rates, clinical pregnancy rates, cumulative pregnancy rates and incidence of ovarian hyperstimulation syndrome （OHSS）. Results No evidence of statistically difference was found in the proportion of mature oocytes retrieved （89.92%, 91.40%, 90.20%, respectively） and fertilization rate （79.8%, 80.07%, 80.51%, respectively） among groups A, B and C. Serum E2 level on the day of hCG injection, the number of mature oocytes retrieved and good-quality embryos in group A were significantly higher than those in group B and group C. Clinical pregnancy rates per transfer cycle （45.95%, 43.97% and 44.25%）, ongoing pregnancy rates （43.17%, 40.91% and 42,53%）, implantation rates （30, 74%, 2Z 78% and 29.86%） and cumulative pregnancy rates per patient （58.31%, 53.6% and 54.85%）A reduced hCG dose of 2 000 IUfor moderate or high responders leads

关键词： human chorionic gonadotropin (hCG) controlled ovarian hyperstimulation (COH) ovarian hyperstimulation syndrome (OHSS) frozen-thawed embryo transfer (FET) cumulative pregnancy rate (CPR)

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Channel assignment and power allocation for throughput improvement with PPO in B5G heterogeneous edge networks

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Digital Communications and Networks 2024年第1期10卷 109-116页

作者： Xiaoming He Yingchi Mao Yinqiu Liu ping ping yan Hong Han Hu The College of Computer and Information Hohai UniversityNanjingChina The Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing China The School of Computer Science and Engineering Nanyang Technological UniversitySingapore The College of Textile and Clothing Engineering Soochow UniversitySuzhouChina The College of Internet of Things Nanjing University of Posts and TelecomurunicationsNanjingChina

In Beyond the Fifth Generation(B5G)heterogeneous edge networks,numerous users are multiplexed on a channel or served on the same frequency resource block,in which case the transmitter applies coding and the receiver uses interference ***,uncoordinated radio resource allocation can reduce system throughput and lead to user inequity,for this reason,in this paper,channel allocation and power allocation problems are formulated to maximize the system sum rate and minimum user achievable *** the construction model is non-convex and the response variables are high-dimensional,a distributed Deep Reinforcement Learning(DRL)framework called distributed Proximal Policy Optimization(PPO)is proposed to allocate or assign ***,several simulated agents are trained in a heterogeneous environment to find robust behaviors that perform well in channel assignment and power ***,agents in the collection stage slow down,which hinders the learning of other ***,a preemption strategy is further proposed in this paper to optimize the distributed PPO,form DP-PPO and successfully mitigate the straggler *** experimental results show that our mechanism named DP-PPO improves the performance over other DRL methods.

关键词： B5G Heterogeneous edge networks PPO Channel assignment Power allocation Throughput

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Correlations of Sperm Mitochondrial Membrane Potential with Semen Parameters and Male Obesity

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Reproductive and Developmental Medicine 2018年第2期2卷 116-119页

作者： Ying yang Yong Fan yan-ping kuang Qi-Feng Lyu Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background:To investigate the correlations of sperm mitochondrial membrane potential(MMP)with semen parameters and body mass index(BMI)in males with ***:Semen samples were obtained by masturbation after 3-7 days of sexual abstinence from males who visited semen collect room of Shanghai Ninth People’s *** semen analyses were performed by computer-aided sperm analysis(CASA),and sperm morphology was analyzed by modified Papanicolaou *** were stained by JC-1 to evaluate MMP through flow ***:Sperm MMP of asthenozoospermia group(41.24%±9.71%)was significantly lower than that in control group(56.68%±11.13%).MMP was negatively correlated with BMI(r=−0.25,P<0.01),but positively correlated with total sperm motility(r=0.63,P<0.01),motility of progressive sperm(r=0.64,P<0.01),and normal sperm morphology rate(r=0.37,P<0.01).In addition,MMP showed no significant correlations with age,volume of semen,sperm concentration,sperm count,and other ***:Sperm MMP is an important index in the evaluation of sperm function,and detection of MMP may provide references for the diagnosis and treatment of male infertility.

关键词： Body Mass Index Conventional Semen Analyses JC-1 Mitochondrial Membrane Potential

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Quantum squeezing induced nonreciprocal phonon laser

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 20-30页

作者： Tian-Xiang Lu yan Wang Keyu Xia Xing Xiao Le-Man kuang Hui Jing College of Physics and Electronic Information Gannan Normal UniversityGanzhou 341000China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China

Phonon lasers or coherent amplifications of mechanical oscillations are powerful tools for fundamental studies on coherent acoustics and hold potential for diverse applications,ranging from ultrasensitive force sensing to phononic information ***,we propose the use of an optomechanical resonator coupled to a nonlinear optical resonator for directional phonon *** find that by pumping the nonlinear optical resonator,directional optical squeezing can occur along the pump *** a result,we can achieve the directional mechanical gain using directional optical squeezing,thereby leading to nonreciprocal phonon lasing with a well-tunable directional power *** work proposes a feasible way to build nonreciprocal phonon lasers with various nonlinear optical media,which are important for a wide range of applications,such as directional acoustic amplifiers,invisible sound sensing or imaging,and one-way phononic networks.

关键词： nonreciprocal phonon laser directional quantum squeezing optomechanics

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