The Clinical Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Treatments in 43 Women with a History of Gestational Trophoblastic Disease

作     者：Xi Shen Yan-Ping Kuang 

作者机构：Department of Reproductive MedicineShanghai Ninth People’s Hospital Affiliated Shanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Ninth People’s Hospital Affiliated Shanghai JiaoTong University School of Clinical MedicineShanghai 200011China 

出 版 物：《Reproductive and Developmental Medicine》 (生殖与发育医学（英文版）)

年 卷 期：2018年第2卷第1期

页      面：38-45页

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Chemotherapy Gestational Trophoblastic Disease In Vitro Fertilization/Intracytoplasmic Sperm Injection Uterine Curettage Treatment 

摘      要：Background:To analyze the clinical outcomes of in vitro fertilization(IVF)/intracytoplasmic sperm injection treatments in women with a history of gestational trophoblastic disease(GTD).Methods:This retrospective study included 43 patients with a history of GTD as the study group and 43 matched patients as the control *** patients in the study group were divided into two groups according to the therapy *** in Subgroup A(n=32)underwent uterine curettage treatment *** in Subgroup B(n=11)underwent uterine curettage combined with *** characteristics of ovarian stimulation and outcomes of embryos and pregnancy were ***:In the first cycle,there was a higher number of retrieved oocytes and normal fertilized oocytes in the control group than those in the study group(9.2 vs.6.2 and 6.0 vs.4.0,respectively;P0.05).There was no difference in the outcomes between Subgroup A and Subgroup *** was a significant difference in thickness of the endometrium between the control group and study group(10.9 mm vs.9.2 mm,respectively;P0.05).The biochemical pregnancy rate and ongoing pregnancy rate in the control group were significantly higher than those in the study group(51.4%vs.31.7%and 37.8%vs.18.3%,respectively;P0.05).In the study group,28(93.3%)patients had intrauterine adhesion(IUA)and 23(76.7%)patients used an intrauterine device(IUD),which were both significantly higher than those in control group(P0.05).In addition,the rate of IUA in second-look hysteroscopy was lower than that in the first surgery in the study group(P0.05).Conclusions:Patients with a history of GTD can present with a similar normal fertilization rate and number of viable ***,patients with a history of GTD may have a thinner endometrium and lo