检索结果-南通市图书馆

Removal of intraocular foreign body in anterior chamber angle with prism contact lens and 23-gauge foreign body forceps

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第5期10卷 749-753页

作者： yan-ming huang Hua yan Jin-Hong Cai Hai-Bo Li Department of Ophthalmology Tianjin Medical University General Hospital Tianjin Neurological Institue Key Laboratory of Post-neuroinjury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Department of Ophthalmology Xiamen Eye Center Affiliated to Xiamen University

AIM：To introduce a novel approach in removal of anterior chamber angle foreign body（ACFB） using a prism contact lens and 23-gauge foreign body ***：Data of 42 eyes of 42 patients who had undergone removal of ACFB using a prism contact lens and 23-gauge foreign body forceps from January 2008 to October 2013 were collected and analyzed. Twenty eyes in group A received the conventional approach by using toothed forceps through corneal limbus incision, and 22 eyes in group B underwent the novel method through the opposite corneal limbus incision. RESULTS：The success rate of ACFB once removal was 75%（15/20） in group A, and 100%（22/22） in group B. The average operation time of group A was significantly longer compared with group B（34.9±9.88 min vs 22.13±8.85min; P〈0.05）. The average size of corneal limbus incision in group A was significantly larger than that of group B（4.85±1.89 mm vs 3.95±1.17 mm; P〈0.05）. The corneal limbus incision suturing were conducted in all eyes in group A, and only 5 eyes in group B. CONCLUSION：Removal of ACFB using a prism contact lens and 23-gauge foreign body forceps is a safer, more effective, and convenient technique compared with the conventional approach.

关键词： prism contact lens intraocular foreign body anterior chamber angle 23-gauge foreign body forceps

Differential degeneration of rod/cone bipolar cells during retinal degeneration in Royal College of Surgeons rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2021年第4期14卷 626-629页

作者： yan-ming huang Mei yang Rong-Di Yuan Department of Ophthalmology Xinqiao Hospital of Army Medical UniversityChongqing 400038China

Dear Editor,Royal college of surgeons(RCS)rat is an inherited retinal degeneration rat caused by mutation of Mertk in the retinal pigment epithelial(RPE)cells^([1]).In this dystrophic rat,the dysfunction of RPEs leads to the progressive death of photoreceptors,with rods initially *** studies have attempt to transplant various stem cells.

关键词： degeneration death initially

Endothelial nitric oxide synthase deficiency influences normal cell cycle progression and apoptosis in trabecular meshwork cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第6期9卷 799-803页

作者： Qiong Liao yan-ming huang Wei Fan Chan Li Hong yang Department of Ophthalmology Xinqiao Hospital of Third Military Medical University Department of Ophthalmology the First Affiliated Hospital of Chongqing Medical University of Chongqing Medical University Department of Ophthalmology Southwest HospitalThird Military Medical University

AIM： To clarify how the endothelial nitric oxide synthase （eNOS, NOS3） make effect on outflow facility through the trabecular meshwork （TM）. METHODS： Inhibition of NOS3 gene expression in human TM cells were conducted by three siRNAs. Then the mRNA and protein levels of NOS3 in siRNA-treated and negative control （NC） cells were determined, still were the collagen, type IV, alpha 1 （COL4A1） and fibronectin 1 by real-time PCR and Western blot analysis. In addition, NOS3 concentrations in culture supernatant fluids of TM cells were measured. Cell cycle and cell apoptosis analysis were performed using flow cytometry. RESULTS： The mRNA level of NOS3 was decreased by three different siRNA interference, similar results were obtained not only of the relative levels of NOS3 protein, but also the expression levels of COL4A1 and fibronectin 1. The number of cells in S phase was decreased, while contrary result was obtained in G2 phase. The number of apoptotic cells in siRNA-treated groups were significant increased compared to the NC samples. CONCLUSION： Abnormal NOS3 expression can make effects on the proteins levels of extracellular matrix component （e.g. fibronectin 1 and COL4A1）. Reduced NOS3 restrains the TM cell cycle progression at the G2/ M-phase transition and induced cell apoptosis.

关键词： endothelial nitric oxide synthase cell cycle cell apoptosis trabecular meshwork

Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第6期13卷 1009-1012页

作者： yan-ming huang Li Zhang Jin Liang Rong-Di Yuan Xinqiao Hospital of Army Medical University Chongqing 400038China

Dear Editor,Chorodial osteoma(CO) is a rare choroidal tumor characterized by the presence of mature bone tissue predominantly in the juxtapapillary or *** mostly affects young healthy females in the second or third decades of *** is unilateral in approximately 80%of cases[1],as patients have no obvious visual symptoms during the early stage of CO,and the growth of CO is *** patients usually visit the eye clinic during the later stages of CO and have poor *** decline in vision in CO patients is related to changes in retinal pigment epithelium(RPE)and photoreceptor *** neovascularization(CNV)and the resultant subretinal fluid and hemorrhage are the most frequent causes of sudden vision loss in CO[2].We report a rare case of bilateral CO with unilateral polypoidal choroidal vasculopathy(PCV)in a middle-aged male.

关键词： RPE Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept PCV

Research on a New Kind of ES Based on XML/Web

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

厦门大学学报（自然科学版） 2002年第S1期41卷 266-267页

作者： LAI Chao-an, SUN yan-ming, huang Ping, ZHENG Shi-xiong (College of Machine Engineering, South China University of Technology, Guangzhou 510640, China)

A new knowledge acquisition methodology for mechani ca l knowledge Web was put forward in this paper after discussed the backwards of k nowledge acquisition method for technical document: natural language understandi ng and ES. A kind of united knowledge representation model, which can include ma ny sorts of knowledge carriers and knowledge representation methods, was advance d firstly, and then mechanical knowledge XML tag was designed based on it. Thus, knowledge still stay in primary electronic document, and knowledge document bec ome document knowledge base based on Web with hierarchy. A corresponding method was advanced and a knowledge acquisition system was developed. It can understand user’s questions in natural language and then find the relevant knowledge and execute reasoning and answer the user’s questions according the result of reaso ning and realized the automatic knowledge acquisition from Web knowledge documen t.

关键词： knowledge acquisition knowledge representation XML WWW

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Correlation between Egg Production Traits and Broodiness Traits in Shiqiza,Langya and Luqin B2 Chickens

在线全文

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2010年第2期2卷 10-11,14页

作者： LI Fu-wei CAO Ding-guo LEI Qiu-xia HAN Hai-xia ZHOU yan LI Gui-ming huang Bao-hua LU yan Poultry Research Institute Shandong Academy of Agricultural Sciences and Poultry Breeding Engineering Technology Center of ShandongProvince Jinan 250023 China

[ Objective] To investigate the relationship between the egg production traits and broodiness of Shiqiza, Langya and Luqin B2 chickens. E Method] Three chicken breeds, Shiqiza chickens （a breed preserved by Shandong Academy of Agricultural Sciences）, Langya chickens （a local breed in Shandong Province） and Luqin B2 chickens （a cultivated breed） were selected. Then their broodiness traits were observed and the egg productions were analyzed. Finally, the relationships between the egg production traits and broodiness were analyzed by SAS software. [ Result] The Shiqiza, Langya and Luqin B2. chickens were broody and their broodiness rate was 15.80%, 2.24% and 6.95%, respectively. Compared with the non-broody chickens, the egg productions of Shiqiza, Langya and Luqin B2 chickens were respectively decreased by 17.16%, 1.53% and 10.8% at the age of 43 weeks. The three breeds had significant differences in repeats of broody cycles （ P 〈 0.05）, and extremely significant differences in the broodiness duration, the the first day of broodiness, the age at the first egg, total amount of abnormal eggs and amount of double- yolked eggs （P 〈 0.01 ）. [Conclusion] The broodiness is a main factor affecting egg production traits. The degree of effects of broodiness on egg production traits is decreased successively in Shiqiza chicken, Luqin B2 chicken and Langya chicken.

关键词： Shiqiza chicken Langya chicken Luqin B2 chicken Egg production traits Broodiness

改良法制作的视网膜切片内核层神经元的形态和电学特性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际眼科杂志 2020年第5期20卷 778-781页

作者：黄艳明杨梅袁容娣中国人民解放军陆军军医大学第二附属医院眼科中国重庆市400037

目的:探讨低温琼脂包埋振动切片机切片法制作的大鼠视网膜切片内核层神经元的形态和基本电生理学特性。方法:采用低温琼脂包埋振动切片机切片的方法制作大鼠视网膜切片,对内核层的神经元进行膜片钳全细胞记录,同时在胞内液中加入荧光黄... 详细信息

目的:探讨低温琼脂包埋振动切片机切片法制作的大鼠视网膜切片内核层神经元的形态和基本电生理学特性。方法:采用低温琼脂包埋振动切片机切片的方法制作大鼠视网膜切片,对内核层的神经元进行膜片钳全细胞记录,同时在胞内液中加入荧光黄观察记录细胞的形态。结果:该方法制作的视网膜切片切面平整、细胞活性好、保留了细胞之间的突起联系,能够根据细胞胞体的大小、位置初步辨别细胞的种类。在视网膜切片上荧光黄显示的细胞形态表明,双极细胞胞体呈梭形,突起主要沿纵向延伸;而水平细胞和无长突细胞胞体圆形或椭圆形、胞体较大,分别位于内核层的最外层和最内层。水平细胞和无长突细胞的静息膜电位(RMP)和膜电容(Cm)明显高于双极细胞。给予时程40ms,步阶10mV从-60mV至+40mV的电压刺激,41.7%的视锥双极细胞和64.7%的无长突细胞表现出内向钠电流和外向钾电流,其他细胞则只表现出外向钾电流。结论:采用低温琼脂包埋振动切片机切片的方法操作简单,制作的切片质量稳定可靠,使得在视网膜切片上对包括水平细胞在内的不同内核层神经元进行膜片钳记录成为可能。进一步研究视网膜内核层神经元的电生理学特性,有助于揭示视觉信号的发生、传导和调控机制。

关键词：视网膜切片膜片钳内核层细胞内染色全细胞记录

Empirical study of the cell proliferating effects after central nervous system injury

在线全文

学校读者我要写书评

暂无评论

Empirical study of the cell proliferating effects after cent...