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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping Guo yan-mei lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(PluSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

The dynamics of a memristor-based Rulkov neuron with fractional-order difference

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Chinese Physics B 2022年第6期31卷 30-38页

作者： yan-mei lu Chun-Hua Wang Quan-Li Deng Cong Xu College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China

The exploration of the memristor model in the discrete domain is a fascinating *** electromagnetic induction on neurons has also begun to be simulated by some discrete ***,most of the current investigations are based on the integer-order discrete memristor,and there are relatively few studies on the form of fractional *** this paper,a new fractional-order discrete memristor model with prominent nonlinearity is constructed based on the Caputo fractional-order difference ***,the dynamical behaviors of the Rulkov neuron under electromagnetic radiation are simulated by introducing the proposed discrete *** integer-order and fractional-order peculiarities of the system are analyzed through the bifurcation graph,the Lyapunov exponential spectrum,and the iterative *** results demonstrate that the fractional-order system has more abundant dynamics than the integer one,such as hyper-chaos,multi-stable and transient *** addition,the complexity of the system in the fractional form is evaluated by the means of the spectral entropy complexity algorithm and consequences show that it is affected by the order of the fractional *** feature of fractional difference lays the foundation for further research and application of the discrete memristor and the neuron map in the future.

关键词： discrete memristor Rulkov neuron fractional-order difference dynamics

Hedgehog signaling pathway regulated the target genes for adipogenesis in silkworm Bombyx moil

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Insect Science 2015年第5期22卷 587-596页

作者： Shuang Liang Rui-Ting Chen Deng-Pan Zhang Hu-Hu Xin yan lu mei-Xian Wang Yun-Gen Miao Key Laboratory of Animal Virology of Ministry of Agriculture College of Animal Sciences Zhejiang University Hangzhou 310058 China

Hedgehog （Hh） signals regulate invertebrate and vertebrate development, yet the role of the pathway in adipose development remains poorly understood. In this report, we found that Hh pathway components are expressed in the fat body of silkworm larvae. Functional analysis of these components in a BmN cell line model revealed that activa- tion of the Hh gene stimulated transcription of Hh pathway components, but inhibited the expression of the adipose marker gene AP2. Conversely, specific RNA interference- mediated knockdown of Hh resulted in increased AP2 expression. This further showed the regulation of Hh signal on the adipose marker gene. In silkworm larval models, enhanced adipocyte differentiation and an increase in adipocyte cell size were observed in silkworms that had been treated with a specific Hh signaling pathway antagonist, cyclopamine. The fat-body-specific Hh blockade tests were consistent with Hh signaling inhibiting silkworm adipogenesis. Our results indicate that the role of Hh signaling in inhibiting fat formation is conserved in vertebrates and invertebrates.

关键词： adipocyte differentiation adipogenesis Bombyx mori Hedgehog (Hh) signaling pathway silkworm

Detection of lymphocyte subsets and regulatory T cells in peripheral blood of patients with acute leukemia and its clinical significance

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中国现代医学杂志 2011年第3期21卷 348-353页

作者： Hai-xia Tong Qiu-shi Wang Chun-wei lu mei-yan lu Department of Blood Transfusion Shengjing Hospital China Medical University Shenyang Liaoning 110022 P.R.China Section of Health Testing College of Public Health China Medical University Shenyang Liaoning 110001 P.R.China Section of Oral Technology College of Oral Medicine Medical University of Dalian Dalian Liaoning 116027 P.R.China

Objective To study the changes of lymphocyte subsets and regulatory T cells in peripheral blood of patients with acute leukemia(AL) and its clinical *** The different levels of peripheral blood lymphocyte subsets and regulatory T cells of 60 AL patients and 40 normal controls were detected with flow *** Compared with the normal controls,the percentages of CD3+ T cells,CD4+ T cells,CD16+CD56+ NK cells and the ratio of CD4+ /CD8+ obviously decreased in newly diagnosed AL group(P lusion Cellular immune function is significantly abnormal in patients with *** with AML patients,ALL patients had poorer cellular immune *** increased CD4 + CD25high Treg cells might be one of the important reasons of immunosuppression in *** of lymphocyte subsets and regulatory T cells is of clinical value on the evaluation of therapeutic effect and prognosis in AL patients.

关键词： acute leukemia lymphocyte subset regulatory T cell

Ventricular tachycardia as the initial symptom of cardiac hydatidosis

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Chinese Medical Journal 2019年第22期132卷 2765-2766页

作者： yan-mei lu Ling Zhang Qiang Xing Xian-Hui Zhou Yao-Dong Li Jiang-Hua Zhang Tuerhong Zukela Bao-Peng Tang Department of Pacing Electrophysiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830054China

To the Editor:A 44-year-old female presented at the local hospital for repeated episodes of having palp Nations,accompanied with cold sweats,amaurosis,vomiting,and limb weakness in the previous 2 *** electrocardiogram indicated "ventricular tachycardia" when she was not feeling *** symptoms alleviated significantly after injections of"amiodarone"(dose unknown),after which the patient was discharged.A local physician recommended ablation,so the patient was transferred to our *** patient was generally healthy and had lived in a region with *** to the patient5 self-report,she had been diagnosed as having liver hydatidosis 30 years ago,but had recovered after surgical treatment at the local ***,the patient claimed to have no other medical history.

关键词： tachycardia transferred claimed

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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民族音乐学习的实践探究

湖北函授大学学报 2017年第20期30卷 134-136页

作者：刘畅张艳陆梅梅铜陵学院安徽铜陵244000

随着世界多元文化的发展,我国的民族音乐文化遇到了前所未有的挑战,当前许多大学生热衷流行音乐、古典音乐、对民族音乐不感兴趣。长此以往,将会造成民族音乐的后继乏人,同时会导致好的民族音乐就此流失。本文将结合新课程标准下的教育... 详细信息

随着世界多元文化的发展,我国的民族音乐文化遇到了前所未有的挑战,当前许多大学生热衷流行音乐、古典音乐、对民族音乐不感兴趣。长此以往,将会造成民族音乐的后继乏人,同时会导致好的民族音乐就此流失。本文将结合新课程标准下的教育理念,围绕如何在高校更好的学习民族音乐这一命题,以铜陵学院为调研方向来进行考察和探究,综合分析调研材料和结果,探索在高校更好的学习民族音乐的方法,并提出自己的实施建议。

关键词：民族文化民族音乐高校学习

Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B

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World Journal of Gastroenterology 2001年第3期7卷 407-410页

作者： Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua yan Dan Peng yan mei Zhang lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China Lin Zhuang Department of Hepatology Kunming Third Municipal People's Hospital Kunming 650041 Yunnan Province China Jing You Bao-Zhang Tang Su-Ying Ding Kui-Hua Yan Dan Peng Yan-Mei Zhang Lu Zhang Department of Infectious Diseases The First Affiliated Hospital of Kunming Medical College Kunming 650032 Yunnan Province China

INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 a... 详细信息

关键词： hepatitis B hepatitis B surface antigens interferon-α thymosin-a1 hepatitis B E antigens serology

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin yan Xiangyu lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie yang Xinyi Li Jiaying lu Jingjie Ge Mingjia Chen Ruixin Yao mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2