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Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/m TOR Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 251-259页

作者： YAO Jun-peng FENG Xiu-mei WANG Lu li yan-qiu ZHU Zi-yue yan Xiang-yun yanG Yu-qing li Ying ZHANG Wei Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu611137China Department of Rehabilitation Medicine Guanghan People’s HospitalGuanghanSichuan Province618399China Academic Affairs Office Chengdu University of Traditional Chinese MedicineChengdu611137China

Objective:To explore the mechanism of electroacupuncture(EA) in promoting recovery of the facial function with the involvement of autophagy,glial cell line-derived neurotrophic factor(GDNF),and phosphatidylinositol-3-kinase(PI3K)/mammalian target of rapamycin(mTOR) signaling ***:Seventy-two male Sprague-Dawley rats were randomly allocated into the control,sham-operated,facial nerve injury(FNI),EA,EA+3-methyladenine(3-MA),and EA+GDNF antagonist groups using a random number table,with 12 rats in each *** FNI rat model was established with facial nerve crushing *** intervention was conducted at Dicang(ST 4),Jiache(ST 6),Yifeng(SJ 17),and Hegu(li 4) acupoints for 2 *** Simone’s 10-Point Scale was utilized to monitor the recovery of facial *** histopathological evaluation of facial nerves was performed using hematoxylin-eosin(HE) *** levels of Beclin-1,light chain 3(LC3),and P62 were detected by immunohistochemistry(IHC),immunofluorescence,and reverse transcriptionpolymerase chain reaction,***,IHC was also used to detect the levels of GDNF,Rai,PI3K,and ***:The facial functional scores were significantly increased in the EA group than the FNI group(Plin sheaths,which were destroyed immediately after the injury,were recovered with EA *** expressions of Beclin-1 and LC3 were significantly elevated and the expression of P62 was markedly reduced in FNI rats(P<0.01);however,EA treatment reversed these abnormal changes(P<0.01).Meanwhile,EA stimulation significantly increased the levels of GDNF,Rai,PI3K,and mTOR(P<0.01).After exogenous administration with autophagy inhibitor 3-MA or GDNF antagonist,the repair effect of EA on facial function was attenuated(P<0.05 or P<0.01).Conclusions:EA could promote the recovery of facial function and repair the facial nerve damages in a rat model of *** may exert this neuroreparative effect through

关键词： electroacupuncture facial nerve injury autophagy glial cell line-derived neurotrophic factor phosphatidylinositol-3-kinase/mammalian target of rapamycin Chinese medicine

Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute liver Injury

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Chinese Journal of Integrative Medicine 2022年第8期28卷 683-692页

作者： ZHENG Yao LEI Lei liANG Shuai AI Jiao DENG Xin li yan-qiu ZHANG Tian-pei PU Shi-biao REN Yong-shen School of Pharmaceutical Science South-Central University for NationalitiesWuhan430074China College of Chinese Materia Medica Yunnan University of Chinese MedicineKunming650500China

Objecitvie:To compare the liver protective activity of fresh/dried dandelion extracts against acetaminophen(APAP)-induced ***:Totally 90 Kunming mice were randomly divided into10 groups according to body weight(9 mice for each group).The mice in the normal control and model(vehicle control)groups were administered sodium carboxymethyl cellulose(CMC-Na,0.5%)*** groups were pretreated with high and low-dose dry dandelion extract(1,000 or 500 g fresh herb dried and then decocted into 120 mL solution,DDE-H and DDE-L);low-,medium-and high-dose dandelion juice(250,500,1,000 g/120 mL,DJ-L,DJ-M,and DJ-H);fresh dandelions evaporation juice water(120 mL,DEJW);dry dandelion extract dissolved by pure water(1 kg/120 mL,DDED-PW);dry dandelion extract dissolved by DEJW(120 g/120 mL,DDED-DEJW)by oral gavage for 7 days at the dosage of 0.5 mL solution/10 g body weight;after that,except normal control group,all other groups were intraperitonealy injected with 350 mg/kg APAP to induce liver *** hours after APAP administration,serum and liver tissue were collected and serum alanine aminotransferase(AST),aspartate transaminase(ALT),alkaline phosphatase(AKP),malondialdehyde(MDA),glutathione(GSH),superoxide dismutase(SOD)activities were quantified by biochemical kits;tumor necrosis factor(TNF-α),interleukin(IL)-2,and IL-1β contents in liver tissue were determined by enzyme linked immunosorbent assay *** changes in liver tissues were observed by hematoxylin and eosin staining;TUNEL Assay and Hoechst 33258 staining were applied for cell apoptosis *** expressions of heme oxygenase-1(HO-1),nuclear factor erythroid-2-related factor 2(Nrf-2),caspase-9,B-cell leukemia/lymphoma 2(Bcl-2),Bax and p-JNK were determined by Western blot ***:Pretreatment with fresh dandelion juice(FDJ,including DJ-L,DJ-M,DJ-H,DEJW and DDED-DEJW)significantly decreased the levels of serum ALT,AST,AKP,TNF-α and IL-1β compared with veh

关键词： fresh dandelion juice acetaminophen-induced liver injury oxidative stress anti-inflammation anti-apoptosis

Promoting an ideal ecosystem through the arts

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中国周刊 2004年第1期 13-15页

作者： li yan qiu Qian

Each year, from May to August, the Tibetan antelopes will gather in herds, migrate and give birth to their offspring. As the original planner of the TV series "Blue Sky and Wild Land", the reporter and the TV crew together explored the Zhuoer Lake, the centre of Hoh Xil Wildlife Protection Reserve in Qinghai Province. With the support of the personnel working in the protection reserve, the team started the tough but exciting shooting experience of ecological scenes. The director and screenwriter of this TV series has expressed that in the

关键词： Lake Promoting an ideal ecosystem through the arts Wild

Aneurysmal Fibrous Histiocytoma:Clinicopathology Analysis of 30 Cases of a Rare Variant of Cutaneous Fibrohistiocytoma

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Current Medical Science 2019年第1期39卷 134-137页

作者： Amelia Nabatanzi Musa Male Xiao-ying QU yan-qiu li Xie MENG Wu-shi DI Chang-zheng HUANG Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Dermatology No.457 Airforce HospitaU Wuhan 430012China Department of Dermatology Zhongshan Hospital Wuhan 430030China

Aneurysmal fibrous histiocytoma is often clinically *** this study,we put forward an insight on how to help diagnose this disease clinically.A retrospective chart review was performed on all patients diagnosed with aneuiysmal fibrous histiocytoma from 2007 to 2017 in the Department of Dermatology,Union Hospital,China,and all clinical data were collected from the hospital *** a total of 418 patients diagnosed with cutaneous fibrous histiocytoma,only 30 patients were confirmed to have aneurysmal fibrous histiocytoma out of which only 2 patients were clinically diagnosed with aneurysmal fibrous *** remaining 28 patients were diagnosed with various types of vascular tumors although pathology classified them as having aneurysmal fibrous *** the 30 patients,9 were male and 21 were *** were following age groups:13-19(mean 16,n=4),20-29(mean 26.25,n=8),30-39(mean 33,n=7),40-49(mean 44,n=4),50-59(mean 56.75,n=4)5 60 and above(mean 61,n=3).Tumors were present on the head,neck,back,waist,hips and upper and lower *** complete excision,there was no recurrence and no ***,lesions showed the typical pseudoangiomatoid spaces without endothelial lining and infiltration of fibrohistiocytes in hemosiderotic *** was suggested that although the prognosis of aneurysmal fibrous histiocytoma is good,accurate diagnosis is paramount to avoid clinical misdiagnosis and subsequent complications.

关键词： aneurysmal fibrous histiocytoma cutaneous fibrous histiocytoma

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稀土元素催化活化制备中孔炭

新型炭材料 2010年第3期25卷 181-186页

作者：李艳秋李开喜中国科学院山西煤炭化学研究所中国科学院炭材料重点实验室山西太原030001 中国科学院研究生院北京100049

以线型酚醛树脂为前驱体,采用溶液混合法将Y(NO3)3或Ce(NO3)3掺杂在其中,通过水蒸气活化制备含有大量中孔的酚醛树脂基活性炭。利用红外光谱(IR)、热重(TG)分析、N2吸附、扫描电镜(SEM)等对酚醛树脂以及其相应的活性炭进行表征。结果表... 详细信息

以线型酚醛树脂为前驱体,采用溶液混合法将Y(NO3)3或Ce(NO3)3掺杂在其中,通过水蒸气活化制备含有大量中孔的酚醛树脂基活性炭。利用红外光谱(IR)、热重(TG)分析、N2吸附、扫描电镜(SEM)等对酚醛树脂以及其相应的活性炭进行表征。结果表明:掺杂Y(NO3)3或Ce(NO3)3可以提高水蒸气活化的速率,促进孔的发展。由于稀土金属盐与酚醛树脂前驱体相容性的限制,Y(NO3)3或Ce(NO3)3的催化效率随着其在树脂中含量的增加先增大后减小。其中,Y(NO3)3可以同时促进中孔和微孔的发展,且促进微孔发展的作用更强一些,而Ce(NO3)3则在促进中孔的发展中显示出较大的优势。

关键词：酚醛树脂中孔炭稀土催化活化孔径分布

X-ray activity from different types of stars

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Research in Astronomy and Astrophysics 2019年第7期19卷 87-102页

作者： lin He Song Wang Xiao-Jie Xu Roberto Soria Ji-Feng liu Xiang-Dong li Yu Bai Zhong-Rui Bai Jin-Cheng Guo yan-li qiu Yong Zhang Ruo-Chuan Xu Ke-Cheng Qian School of Astronomy and Space Science and Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 210093China United World College Changshu 215500China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China International Centre for Radio Astronomy Research Curtin UniversityGPO Box U1987PerthWA 6845Australia Sydney Institute for Astronomy School of Physics A2& The University of SydneySydneyNSW 2006Australia WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China Department of Astronomy Peking UniversityBeijing 100871China Nanjing Inst让ute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China International Department the Affiliated High School of SCNUGuangzhou 510630China

X-ray emission is an important indicator of stellar *** this paper,we study stellar Xray activity using the XMM-Newton and LAMOST data for different types of *** provide a sample including 1259 X-ray-emitting stars,of which 1090 have accurate stellar parameter *** sample size is much larger than those used in previous *** find a bimodal distribution of the X-ray to optical flux ratio(log(fX/fV)) for G and K *** interpret that this bimodality is due to two subpopulations with different coronal heating ***,using the full widths at half maxima calculated from Hα and Hβ lines,we show that these stars in the inactive peaks have smaller rotational *** is consistent with the magnetic dynamo theory that presumes stars with low rotational velocities have low levels of stellar *** also examine the correlation between log(fX/fV) and luminosity of the excess emission in the Hα line,and find a tight relation between the coronal and chromospheric activity indicators.

关键词： X-rays stars-stars activity-stars late-type

镝与二甘醇酸的配位聚合物的水热合成、晶体结构及荧光性质(英文)

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无机化学学报 2007年第12期23卷 2059-2064页

作者：张艳斌鞠艳玲李艳秋李夏首都师范大学化学系北京100037

DyCl3.6H2O与二甘醇酸(H2dga)在水热条件下反应得到配位聚合物{[Dy2(dga)3(H2O)4].2H2O}n,用X-射线衍射单晶结构分析方法确定了其晶体结构。该配合物的晶体属于正交晶系,C2221空间群。在配合物中,Dy3+离子存在两种类型的配位环境。九配... 详细信息

DyCl3.6H2O与二甘醇酸(H2dga)在水热条件下反应得到配位聚合物{[Dy2(dga)3(H2O)4].2H2O}n,用X-射线衍射单晶结构分析方法确定了其晶体结构。该配合物的晶体属于正交晶系,C2221空间群。在配合物中,Dy3+离子存在两种类型的配位环境。九配位的Dy1离子与3个二甘醇酸根的6个羧基氧原子和3个醚氧原子配位,其配位多面体可描述为一个扭曲的单帽四方反棱柱;八配位的Dy2离子周围的8个配位氧原子形成一个扭曲的四方反棱柱配位多面体,其中4个氧原子来自4个二甘醇酸根,另外4个氧原子由4个配位水分子提供。二甘醇酸配体的2个羧基和其醚氧原子同时与Dy3+离子配位而形成2D网状结构。该配合物在室温下的固体荧光光谱显示了中心Dy3+离子的特征荧光,位于483 nm和574 nm的发射峰分别对应于Dy3+离子的4F9/2→6H15/2和4F9/2→6H13/2跃迁。

关键词：二甘醇酸配位聚合物晶体结构荧光

Abnormality of chromosome 8 in desmoid-type fibromatosis

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Chinese Medical Journal 2007年第9期120卷 838-840页

作者： yanG Ji-long WANG Jian ZHOU Xiao-yan li Xiao-qiu ZHU Xiong-zeng Department of Pathology Cancer Hospital Fudan University Shanghai 200032 China

Desmoid-type fibromatoses are clonal fibroblastic proliferations that arise in deep soft tissues and are characterized by infiltrative growth and a tendency toward local recurrence. The molecular genetic studies show that there are chromosomal abnormalities relating to the pathogenesis of this lesion, such as trisomy 8. However, there are different results concerning this type of abnormality. Fluorescence in situ hybridization （FISH） is a sensitive and reproducible technique that combines molecular cytogenetics with morphologic information and brings them together in a single frame for evaluation. To explore the controversy of the aneuploid abnormality of chromosome 8, we collected specimens of desmoid-type fibromatosis to determine whether the existence of trisomy 8 chromosome abnormalities correlates with clinicopathologic features, as well as to investigate the feasibility of detecting trisomy 8 in FFPE tissue by FISH method.

关键词： desmoid-type fibromatosis fluorescence in situ hybridization trisomy 8

A New Particle Filter for Nonlinear Tracking Problems

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Chinese Journal of Aeronautics 2004年第3期17卷 170-175页

作者：李延秋沈毅刘志言 Dept. of Control Science and Engineering Harbin Institute of TechnologyHarbin 150001 China

A new particle filter is presented for nonlinear tracking problems. Inpractice, maneuvering target-tracking systems are usually nonlinear and incompletely observed, andthe main difficulty of maneuvering target-tracking problem lies in the fact that the maneuverabilityat every step is of high uncertainties. Here a new smoothing particle filter algorithm is proposed,which combines the particle filter to tackle the non-linear and non-Gaussian peculiarities of theproblem, together with smoothing of the PDF of system modes and thus settles the estimate problem ofthe target maneuverability. The simulation comparison with the auxiliary particle filters showsthat the approach has superiority and yields performance improvements in solving nonlinear trackingproblems.

关键词： particle filters nonlinear/non-Gaussian model maneuvering target tracking smoothing technique