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Metachronous contralateral testicular and bilateral adrenal metastasis of chromophobe renal cell carcinoma:a case report and review of the literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 386-389页

作者： Hai-yang WU Li-wei XU You-yun ZHANG yan-lan yu Xin-de LI Gong-hui LI Department of Urology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Chromophobe renal cell carcinoma(ChRCC) metastatic to the testis has not,to the best of our knowledge,been reported in the *** have there been reports of delayed bilateral adrenal metastasis of *** we report a case of metachronous contralateral testicular and bilateral adrenal metastasis of ChRCC in a 70-year-old man who underwent right radical nephrectomy for RCC six years *** was admitted to the hospital because of left intrascrotal enlargement of two-month *** revealed a mass in the upper pole of the left *** tomography(CT) showed irregular masses in the bilateral adrenal *** radical orchiectomy and laparoscopic bilateral adrenalectomy were *** pathologic examination showed metastatic ChRCC in the left testis and bilateral adrenal *** follow-up showed that the patient had survived for at least 56 months without *** case highlights the unique behavior of RCC with an unusual site of metastasis and favorable survival after multiple metastasectomy.

关键词： Renal cell carcinoma(RCC) Testicular metastasis Adrenal metastasis Metastasectomy

A new plastic surgical technique for adult congenital webbed penis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 757-760页

作者： yue-bing CHEN Xian-fan DING Chong LUO Shi-cheng yu yan-lan yu Bi-de CHEN Zhi-gen ZHANG Gong-hui LI Department of Urology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China

yue-bing CHEN, Xian-fan DING, Chong LUO, Shi-cheng yu, yan-lan yu, Bi-de CHEN, Zhi-gen ZHANGt;, Gong-hui LIt; （Department of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China） ~＇E-mail： Zhigenzhangsrrsh@***; ligonghui1970@*** Received Apr. 14, 2012; Revision accepted July 29, 2012 Crosschecked Aug. 21,2012 doi： 10.1631/jzus.B 1200117 Document code： A CLC number： R697＋.11

关键词： Webbed penis Plastic surgery Inconspicuous penis Penile anomalies

Antitumor effects of human interferon-alpha 2b secreted by recombinant bacillus Calmette-Guérin vaccine on bladder cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 335-341页

作者： Guo-qing DING yan-lan yu Zhou-jun SHEN Xie-lai ZHOU Shan-wen CHEN Guo-dong LIAO yue ZHANG Department of Urology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Urology Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Children's Hospital of Los Angeles Los AngelesCA 90027USA

Objective:Our objective was to construct a recombinant bacillus Calmette-Guérin vaccine(rBCG) that secretes human interferon-alpha 2b(IFNα-2b) and to study its immunogenicity and in vitro antitumor activity against human bladder cancer cell lines T24 and ***:The signal sequence BCG Ag85B and the gene IFNα-2b were amplified from the genome of BCG and human peripheral blood,respectively,by polymerase chain reaction(PCR).The two genes were cloned in Escherichia coli-BCG shuttle-vector pMV261 to obtain a new recombinant plasmid pMV261-Ag85B-IFNα-*** was transformed with the recombinant plasmid by electroporation and designated rBCG-IFNα-*** cells were isolated from human peripheral blood(PBMCs) and stimulated with rBCG-IFNα-2b or wild type BCG for 3 d,and then cultured with human bladder cancer cell lines T24 and *** cytotoxicities were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) ***:BCG was successfully transformed with the recombinant plasmid pMV261-Ag85B-IFNα-2b by electroporation and the recombinant BCG(rBCG-IFNα-2b) was capable of synthesizing and secreting cytokine IFNα-*** proliferation was enhanced significantly by rBCG-IFNα-2b,and the cytotoxicity of PBMCs stimulated by rBCG-IFNα-2b to T24 and T5627 was significantly stronger in comparison to wild type ***:A recombinant BCG,secreting human IFNα-2b(rBCG-IFNα-2b),was constructed successfully and was superior to control wild type BCG in inducing immune responses and enhancing cytotoxicity to human bladder cancer cell lines T24 and *** suggests that rBCG-IFNα-2b could be a promising agent for bladder cancer patients in terms of possible reductions in both clinical dosage and side effects of BCG immunotherapy.

关键词： Bacillus Calmette-Guérin(BCG) vaccine Bladder neoplasms Gene recombination Interferon-alpha 2b

Fluorescence in situ hybridization in uncultured amniocytes for detection of aneuploidy in 4210 prenatal cases

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Chinese Medical Journal 2011年第8期124卷 1164-1168页

作者： JIA Chan-wei WANG Shu-yu MA yan-min lan Yong-lian SI yan-mei yu lan ZHOU Li-ying Reproductive and Genetic Medical Centre Beijing Obstetrics andGynecology Hospital Affiliated of Capital Medical UniversityBeijing 100026 China

Background Almost all reported fluorescence in situ hybridization （FISH） kits for prenatal diagnosis use probes from foreign （non-Chinese） countries. The aim of this study was to analyze the reliability of domestic （Chinese） FISH probe sets to detect aneuploidies of chromosomes 13, 18, 21, X, and Y related to prenatal diagnosis in 4210 *** Cytogenetic karyotyping was carded out as a standard prenatal diagnostic test, and amniotic fluid cell interphase FISH analysis was performed using two sets of probes （centromeric probes for chromosomes 18, X, and Y,and locus-specific probes for chromosomes 13 and 21） provided by GP Medical Technologies, Beijing, China. Then we compared the two results and found the performance characteristics for informative FISH results of aneuploidies by the domestic kit *** In 4210 cases, 4126 cases generated karyotype results and 133 abnormal karyotypes （including 97 aneuploidies） were found. The FISH results of 98 cases （among them, 31 cases gave normal cytogenetic results） were uninformative. The rate of abnormal cases was 3.2% （133/4126）. For the abnormal karyotypes, the rate of aneuploidy was 72.9% （97/133）. Among the 97 aneuploidies, there were 58 cases of trisomy 21 （58/97, 59.8%）, four cases of trisomy 13, 23 cases of trisomy 18, and 12 cases of sex chromosomal aneuploidies. The total concordance of the two methods was 97.9% （95/97; two cases were mosaics that had a low percentage of abnormal cells）, and the concordance of trisomy 21, 13, and 18 by the two methods was 100%.Conclusions The two sets of the domestic FISH kit probes are reliable for prenatal diagnosis. The results demonstrate that FISH is a rapid and accurate clinical method for prenatal identification of chromosome aneuploidies.

关键词： aneuploidy in situ hybridization prenatal diagnosis

Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： yan-Heng yu Sai Wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

Simultaneous determination of human plasma protein binding of bioactive favonoids in Polygonum orientale by equilibrium dialysis combined with UPLC–MS/MS

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Journal of Pharmaceutical Analysis 2013年第5期3卷 376-381页

作者： Yong Huang Hui Chen Feng He Zhi-Rong Zhang Lin Zheng yue Liu yan-yu lan Shang-Gao Liao Yong-Jun Li Yong-Lin Wang Provincial Key Laboratory of Pharmaceutics in Guizhou Province School of Pharmacy Guiyang Medical University

A simple and selective ultra performance liquid chromatography--electrospray ionization tandem mass spectrometry （UPLC-ESI-MS/MS） assay was developed for the determination of the human plasma protein binding of four bioactive ftavonoids （such as orientin and vitexin） in Polygonum orientale. Protein precipitation was used for sample preparation. Equilibrium dialysis technique was applied to determine the plasma protein binding under physiological conditions. The separation was achieved through a Waters C i s column with a mobile phase composed of 0.1% formic acid in acetonitrile and 0.1% aqueous formic acid using step gradient elution at a flow rate of 0.35 mL/min. A Waters ACQUITYTM TQD system was operated under the multiple reaction monitoring （MRM） mode of positive electrospray ionization. All of the recovery, precision, accuracy and stability of the method met the requirements. Good correlations （r 〉 0.99） of the four compounds were found, which suggested that these compounds can be simultaneously determined with acceptable accuracy. Results showed that the plasma protein bindings of the four bioactive flavonoids were in the range of 74-89% over the six concentrations studied. The binding parameters containing protein binding affinity, protein binding dissociation constant, and protein binding site were studied. The maximum ability to bind with protein was also determined in the assay in order to understand the drug-protein binding of each compound better.

关键词： Polygonum orientale Plasma protein binding Bioactive compounds Equilibrium dialysis UPLC–ESI-MS/MS

Effects of Compound Salviae Miltiorrhizae Injection on Metabolism of Phosphoinosititides in Myocardial Ischemia

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Chinese Journal of Integrative Medicine 1995年第4期1卷 288-290页

作者： Tao yue-yu (陶月玉) Guo Song-duo(郭松铎) Chen Hui-zheng (陈惠珍)and Hu Hua (胡华)(Nanjing 414 Hospital of Navy, Nanjing 210015)Lu Bu-feng (卢步峰) yan yu-lan(严玉兰) and Lu You-ming (鲁友明)(Nanjing Research Center of Neuro-biology of Navy) Nanjing 414 Hospital of Navy Nanjing Nanjing Research Center of Neuro-biology of Navy China

Using the model of acute myocardial ischemia in rats formed by ligation of the descending an-terior branch of the left coronary artery, this study showed some effects of compound Salviae miltiorrhizae in-jection ( CSMI) on metabolism of phosphoinositide in myocardial ischemia. The results of the experimentshowed that after 10 minutes of acute ischemia, the function of myocardial messangers ot phosphoinositide in-creased, and the levels of phosphatidylinositol-4, 5-biphosphate ( PIP2 ) and inositol-1, 4, 5-trisphosphate(IP3 ) were obviously higher than those of the non-ischemia control groups ( P < 0. 01 , n = 7) . CSMI (2 glkgbody weight) could markediy inhibit myocardial PIP2 and IP3, whose levels became lower than those of theischemia control groups ( P < 0 . 01 , n = 7 ) .

关键词： Myocardial ischemia phophoinositides compound Salviae miltiorrhizae injection

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang yuefeng yan Zhen Wang Guansheng Ma Dechang Jia Xiaoxiao Huang yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

GFRF R-CNN:Object Detection Algorithm for Transmission Lines

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Computers, Materials & Continua 2025年第1期82卷 1439-1458页

作者： Xunguang yan Wenrui Wang Fanglin Lu Hongyong Fan Bo Wu Jianfeng yu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Sciences Beijing100049China Jingwei Textile Machinery Co. Ltd.Beijing100176China

To maintain the reliability of power systems,routine inspections using drones equipped with advanced object detection algorithms are essential for preempting power-related *** increasing resolution of drone-captured images has posed a challenge for traditional target detection methods,especially in identifying small objects in high-resolution *** study presents an enhanced object detection algorithm based on the Faster Regionbased Convolutional Neural Network(Faster R-CNN)framework,specifically tailored for detecting small-scale electrical components like insulators,shock hammers,and screws in transmission *** algorithm features an improved backbone network for Faster R-CNN,which significantly boosts the feature extraction network’s ability to detect fine *** Region Proposal Network is optimized using a method of guided feature refinement(GFR),which achieves a balance between accuracy and *** incorporation of Generalized Intersection over Union(GIOU)and Region of Interest(ROI)Align further refines themodel’s *** results demonstrate a notable improvement in mean Average Precision,reaching 89.3%,an 11.1%increase compared to the standard Faster *** highlights the effectiveness of the proposed algorithm in identifying electrical components in high-resolution aerial images.

关键词： Faster R-CNN transmission line object detection GIOU GFR