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基于HPLC-QAMS多指标成分定量控制联合多元统计分析及加权TOPSIS法的食凉茶综合质量评价

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中国药师 2023年第12期26卷 499-509页

作者：周丹徐俊燕张乐怡张晓芹丽水市中医院药剂科浙江丽水323000 丽水市中医院药学研究中心浙江丽水323000

目的高效液相一测多评(HPLC-QAMS)法测定食凉茶中10种成分,并联合多元统计分析和加权优劣解距离(E-TOPSIS)法评价其综合质量。方法色谱柱为COSMOSIL5 C_(18)-MS-Ⅱ柱(250 mm×4.6 mm,5μm),流动相为乙腈-0.1%磷酸溶液,梯度洗脱,流速为1.... 详细信息

目的高效液相一测多评(HPLC-QAMS)法测定食凉茶中10种成分,并联合多元统计分析和加权优劣解距离(E-TOPSIS)法评价其综合质量。方法色谱柱为COSMOSIL5 C_(18)-MS-Ⅱ柱(250 mm×4.6 mm,5μm),流动相为乙腈-0.1%磷酸溶液,梯度洗脱,流速为1.0 mL·min^(-1),检测波长为360 nm和222 nm。以芦丁为参照,结合QAMS法,对18批食凉茶中东莨菪苷、东莨菪内酯、异嗪皮啶、芦丁、山柰酚-3-O-芸香糖苷、紫云英苷、滨蒿内酯、槲皮素、山柰酚和夏蜡梅碱的含量进行测定。运用统计软件对18批食凉茶的含量数据进行化学计量分析;用E-TOPSIS法对食凉茶质量进行综合评价。结果10个成分均实现良好分离,并在各自的范围内与峰面积呈良好的线性关系(r>0.9990);平均加样回收率为96.98%~100.12%,RSD<2.0%(n=9)。芦丁与其他9个成分的平均相对校正因子分别为2.1157、2.5924、0.5531、0.8976、0.7807、1.1593、0.6936、1.4583和0.6017,RSD<2.0%(n=6),QAMS法和常规外标法的定量结果显示两者无显著差异。多元统计分析结果显示,2个主成分的累计方差贡献率为83.886%,变量重要性投影值大于1的为山柰酚-3-O-芸香糖苷、芦丁和紫云英苷。E-TOPSIS分析结果显示,最优解的欧氏贴近度在0.1804~0.7394之间。结论建立的方法简便、准确且经济实用,可全面反映食凉茶的质量差异性,能较好地控制该品种质量。

关键词：食凉茶高效液相一测多评法多元统计分析加权优劣解距离法

Mineralization of the Lianhuashan Sn-polymetallic deposits associated with dynamic metamorphism:Constraints from cassiterite geochemistry and U-Pb geochronology

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Science China Earth Sciences 2023年第7期66卷 1664-1677页

作者： jun WANG Liming WANG Shuang yan Yong MA Diankui xu CAS Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Geology Bureau for Nonferrous Metal of Guangdong Province Guangzhou 510080China Nonferrous Geological Exploration Institute of Guangdong Province Guangzhou 510080China Nonferrous Metal Geological Bureau of Guangdong Province 931 Battalion Shantou 515041China

The Lianhuashan metallogenic belt in Eastern Guangdong Province(South China)is the most important Sn polymetallic district in the region,hosting many medium-sized deposits such as the Tashan,Xianshuili,and ***,the metallogenic mechanism of these deposits remains hotly *** this paper,two types of cassiterites(Cst1 and Cst2)have been identified in the Xianshuili and Jiangxikeng Sn deposits,which are hosted in the biotite-mylonite and garnetcordierite-muscovite blastomylonite,*** euhedral Cst1(0.50–1.8 mm)coexists with biotite,feldspar,and *** is platy and zoned with a mosaic *** subhedral to anhedral Cst2(0.02–0.35 mm)coexists with metamorphic minerals such as garnet and cordierite,and it is characterized by well-developed porosity and has no ***-situ U-Pb dating of the Cst1 and Cst2 yielded ages of 149.5±1.0 Ma(MSWD=1.6,n=45)and 125.1±2.3 Ma(MSWD=4.5,n=43),***1 is most likely to be related to the intermediate-felsic magmatism that formed Gaojiping Group,whereas Cst2 has relatively high Ta,Nb,Fe,and W contents with obvious rare earth tetragroup effect,and may have formed by the late Early Cretaceous dynamic *** presented here,when combined with regional geology and geochemistry,led us to suggest that the Mesozoic intermediate-felsic volcanic rocks in the LMB are significantly enriched in Sn and F,with high Sn-polymetallic mineralization potential which likely have contributed to the volcanic-related *** the late Early Cretaceous period,due to the NW-dipping subduction of the paleo-Pacific plate,the intermediate-felsic volcanic rocks underwent dynamic metamorphism that led to Sn mobilization,migration,and precipitation in the regional ductile shear zones,and eventually generating Sn *** propose that areas beneath Xianshuili and Jiangxikeng have great potential for discovery of new Sn *** findings likely offer practical importance to regional geological

关键词： Lianhuashan metallogenic belt(LMB) Sn-polymetallic deposit Cassiterite U-Pb geohronology Dynamic metamorphism

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自主可控平台AGV设计及视觉循线算法研究

计算机科学与探索 2025年第1期19卷 264-276页

作者：徐诗高军孙秋君上海海事大学信息工程学院中国电信股份有限公司嘉兴分公司

设计并实现了一种基于自主可控平台的自动导引车（AGV）。AGV满足核心硬件国产化、软件开源可控的要求，并可兼容多种自主导航算法。对传统纯追踪算法在跟踪精度和安全性上进行了改进：一是载具在直线路段偏离参考轨迹较远的情况下使用D... 详细信息

设计并实现了一种基于自主可控平台的自动导引车（AGV）。AGV满足核心硬件国产化、软件开源可控的要求，并可兼容多种自主导航算法。对传统纯追踪算法在跟踪精度和安全性上进行了改进：一是载具在直线路段偏离参考轨迹较远的情况下使用Dubins路径进行快速回归；二是在大曲率参考轨迹处使用预瞄点偏移算法纠正跟踪轨迹，减小跟踪误差；三是应用动态预瞄距离和动态速度进一步减小大曲率路段的跟踪误差和安全风险。改进的算法在设计的AGV上进行了实现。在完成AGV设计和改进算法实现后，在实际环境中进行了视觉循线实验。改进的算法在0.1 m/s的速度下在曲率较小路段的平均偏差相较改进前的两种纯追踪算法变体分别减少了3.3%、7.3%，在大曲率路段减少了8.34%、23.06%；在0.5 m/s的速度下在曲率较小路段的平均偏差相较改进前的两种纯追踪算法变体分别减少了9.08%、11.33%，在大曲率路段减少了2.97%、24.67%。改进算法实验的整体结果优于使用改进前两种算法变体的结果，且设计并实现的AGV能够满足一般环境下的视觉循线导航需求，可应用于多种实际场合。

关键词：自主可控自动导引车(AGV) 跟踪控制纯追踪算法

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Wormhole Solution in Lovelock Gravity Theory

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Chinese Physics Letters 1999年第2期16卷 85-87页

作者： SHANG yan-wen xu Jian-jun Department of Physics Fudan UniversityShanghai 200433

In this work,we confirm the existence of wormhole solution in general form of Lovelock gravity theory,and present some diagrams from the numerical calculation with special coupling constants as support to our ***,we also find out that whether the cosmology constant is actually zero is also critical to the behavior of the solution as it is in general relativity.

关键词： conclusion constants coupling

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Electron Momentum Spectroscopy of Ethanethiol Complete Valence Shell

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Chinese Journal of Chemical Physics 2008年第6期21卷 515-520页

作者： Xin-xia xue Mi yan Fang Wu xu Shan Ke-zun xu Xiang-jun Chen Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China Hefei 230025 China

The binding energy spectra and electron momentum distributions for the complete valence orbitals of ethanethiol were measured for the first time by binary （e, 2e） electron momentum spectroscopy employing non-coplanar symmetric kinematics at an impact energy of 1200 eV plus binding energy. The experimental results are generally consistent with the theoretical calculations using density functional theory and Hartree-Fock methods with various basis sets. A possible satellite line at 17.8 eV in binding energy spectrum was observed and studied by electron momentum spectroscopy.

关键词： Ethanethiol Electron momentum spectroscopy Valence orbital Satellite line Binding energy spectrum

Influencing factors on elastic-plastic deformation of multi-layered surfaces under sliding contact

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中国有色金属学会会刊：英文版 2004年第z1期14卷 472-477页

作者： yan Li PAN Xin-xiang xu Jiu-jun CHENG Dong Institute of Materials and Technology Dalian Maritime University China Institute of Materials and Technology Dalian Maritime University China Institute of Materials and Technology Dalian Maritime University China Institute of Materials and Technology Dalian Maritime University China

Stress distribution in the gradient multi-layered surface under a sliding contact was investigated using finite element method(FEM). The main structure parameters of layered surface discussed are total layer thickness,layer number and elastic modulus ratio of layer to the substrate. A model of multi-layered surface contact with rough slider was studied. The effect of the surface structure parameters on the elastic-plastic deformation was analyzed.

关键词： gradient multi-layered surface elastic-plastic deformation surface structure parameter FEM

Preparation and electrochemical performance of carbon-coated LiFePO4/LiMnPO4-positive material for a Li-ion battery

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Particuology 2017年第1期15卷 144-150页

作者： Qiangqiang Tan Bo yan Yuxing xu Yunfa Chen jun yang State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Lithium iron phosphate （LiFePO4）/lithium manganese phosphate （LiMnPO4）-positive material was suc- cessfully prepared through ball milling and high-temperature sintering using manganese acetate, lithium hydroxide, ammonium dihydrogen phosphate, and ferrous oxalate as raw materials. The as-prepared samples were characterized by X-ray diffraction, transmission electron microscopy, scanning elec- tron microscopy, a constant current charge-discharge test, cyclic voltammetry, and electrochemical impedance spectroscopy. The effects of lithium iron phosphate coating were also discussed. Because of its special core-shell structure, the as-prepared ***0.3PO4-LiFeP04-C exhibits excellent electro- chemical performance. The discharge capacity reached 136.6 mAh/g and the specific discharge energy reached 506.9 Wh/kg at a rate of 0.1 C.

关键词： LiMn1-xFexPO4 Composite Core-shell structure Positive material Li-ion battery

Cellular signaling pathways of T cells in giant cell arteritis

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Journal of Geriatric Cardiology 2021年第9期18卷 768-778页

作者： Hai-yan LI jun-Nan xu Zong-Wen SHUAI Department of Rheumatology and Immunology the First Affiliated Hospital of Anhui Medical UniversityHefeiChina

Giant cell arteritis(GCA)is a commonly occurring large vacuities characterized by angiopathy of medium and large-sized *** granulomatous formation plays an important role in the pathogenesis of *** of T cell lineages and signaling pathways in GCA have revealed the essential role of T cells in the pathology of GCA.T cells are the dominant population present in GCA ***4+T cell subtypes that are present include Th1,Th2,Th9,Th17,follicular helper T(Tfh)cells,and regulatory T(Treg)***8 T cells can primarily differentiate into cytotoxic CD8+T lymphocytes and Treg *** instrumental part of GCA is the interplay between dendritic cells,macrophages and endothelial cells,which can result in the vascular injury and the characteristics granulomatous infiltrates *** the inflammatory loop of GCA,several signaling pathways have been reported to play an essential role in recruiting,activating and differentiating T cells,including T-cell receptor(TCR)signaling,vascular endothelial growth factor(VEGF)-Jagged-Notch signaling and the Janus kinase and signal transducer and activator of transcription(STAT)pathway(JAK-STAT)*** this review,we have focused on the role of T cells and their potential signaling mechanism(s)that are involved in the pathogenesis of GCA.A better understanding of the role of T cells mediated complicated orchestration during the homeostasis and the changes could possibly favor developments of novel treatment strategies against immunological disorders associated with GCA.

关键词： GCA Cellular signaling pathways of T cells in giant cell arteritis