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A novel phosphate ligand used for the Rh-catalyzed hydroformylation of cyclohexene in a thermoregulated PEG biphase system

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Chinese Chemical Letters 2007年第8期18卷 933-935页

作者： Wei Wei yan Hua Wang jing yang Jiang Zi Lin Jin State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China

A novel phosphate ligand, tri-（methoxyl polyethylene glycol）-phosphate （TMPGPA）, has been synthesized and used in the Rhcatalyzed hydroformylation of cyclohexene in a thermoregulated PEG biphase system. Under the optimized conditions, pressure = 5 MPa （H2：CO = 1：1）, P/Rh = 10 （molar ratio）, reaction time = 4 h and temperature = 120 ℃, the conversion of cyclohexene and the yield of aldehyde are 99%. The catalyst retained in PEG phase can be easily separated from the organic phase containing product by simple phase separation and reused ten times without obvious loss in activity.

关键词： Thermoregulated PEG biphase system Hydroformylation Phosphate ligand Rhodium Cyclohexene

PEG-stabilized palladium nanoparticles:An efficient and recyclable catalyst for the selective hydrogenation of 1,5-cyclooctadiene in thermoregulated PEG biphase system

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Chinese Chemical Letters 2008年第1期19卷 102-104页

作者： Tian Song Huang yan Hua Wang jing yang Jiang Zi Lin Jin State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China

Polyethylene glycol （PEG）-stabilized palladium nanoparticles were prepared and applied to the selective hydrogenation of 1,5- cyclooctadiene （1,5-COD） in thermoregulated PEG biphase system, which allows a reaction in a single-phase at a higher temperature followed by a phase split at a lower temperature. Under the optimized reaction conditions, the conversion of 1,5-COD and the selectivity of cyclooctene （COE） were 100 and 98%, respectively. The catalyst could be easily separated from the product by phase separation and reused for 6 times without evident loss in activity and selectivity. 2007 yan Hua Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Palladium Nanoparticle Selective hydrogenation 1,5-Cyclooctadiene Thermoregulated PEG biphase system

Retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal miners in northern China:a community-based observational study

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 135-140页

作者： jing-yan yang Wen-Jia Zhou Qian Wang yang Li yan-Ni yan Ya-Xing Wang Shou-Ling Wu Wen-Bin Wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Cardiology Department Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To evaluate retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal mine ***:The community-based observational crosssectional study included 4004 participants of a subpopulation of the Kailuan *** the study participants underwent structured interviews with a standardized questionnaire,fundus photography and spectral-domain optical coherence tomography(OCT)examinations performed by trained ***:The retinal nerve fiber layer thickness was significantly higher(P=0.006)and the central macular thickness was lower in coal miners(n=659,51.0±7.8 y)as compared to the control(working above the ground;n=477,51.8±7.5 y;P=0.032).Additionally,the downhole workers showed a significantly thicker retinal artery(P=0.012)and vein diameters(P<0.001).In multivariable regression,a thicker retinal nerve fiber layer was associated with a higher cumulative silica dust exposure(P=0.005)after adjusting for younger age and larger spherical *** a reverse pattern,a higher cumulative silica dust exposure(P=0.004)was significantly associated with a thicker retinal nerve fiber layer after adjusting for age,high-density lipoproteins and uric *** retinal vein diameters were associated with higher cumulative silica dust exposure(P=0.036)after adjusting for younger age and larger spherical ***:The retinal vessels diameters and retinal nerve fiber layer thickness are significantly thicker in long term of coal *** results of our study indicate that underground working environment may lead to retinal vessel dilation and ***,ocular examination might be needed within coal miners in order to monitor the occupational eye health as well as the incidence and progression of eye diseases.

关键词： retinal vessels diameter retinal nerve fiber layer thickness cumulative silica dust exposure

10-year fundus tessellation progression and retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1192-1197页

作者： yan-Ni yan Ya-Xing Wang yan yang Liang Xu Jie Xu Qian Wang jing-yan yang Wen-Jia Zhou Wen-Bin Wei Jost B.Jonas Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology & Visual Sciences Key Lab Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical UniversityBeijing Ophthalmology & Visual Science Key Lab Beijing 100730 China Beijing Aier-Intech Eye Hospital Beijing 100730 China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University Seegartenklinik Heidelberg 68167 Germany

AIM： To access the 10-year fundus tessellation progression in patients with retinal vein occlusion. METHODS： The Beijing Eye Study 2001/2011 is a populationbased longitudinal study. The study participants underwent a detailed physical and ophthalmic examination. Degree of fundus tessellation was graded by using fundus photographs of the macula and optic disc. Progression of fundus tessellation was calculated by fundus tessellation degree of 2011 minus degree of 2001. Fundus photographs were used for assessment of retinal vein occlusion. RESULTS： The Beijing Eye Study included 4403 subjects in 2001, 3468 subjects was repeated in 2011. Assessment of retinal vein obstruction and fundus tessellation progression were available for 2462 subjects（71.0%）, with 66 subjects fulfilled the diagnosis of retinal vein occlusion. Of the 66 participants, 59 participants with unilateral branch retinal vein occlusion, 5 participants with unilateral central retinal vein occlusion, 1 participant with bilateral branch retinal vein occlusion, and 1 participant with branch retinal vein occlusion in one eye and central retinal vein occlusion in the other eye. Mean degree of peripapillary fundus tessellation progression were significantly higher in the whole retinal vein occlusion group（0.33±0.39, P〈0.001）, central retinal vein occlusion group（0.71±0.8, P=0.025） and branch retinal vein occlusion group（0.29±0.34, P=0.006） than the control group（0.20±0.26）. After adjustment for age, prevalence of tilted disc, change of best corrected visual acuity, axial length, progression of peripapillary fundus tessellation was associated with the presence of retinal vein occlusion（P=0.004; regression coefficient B, 0.094; 95%CI, 0.029, 0.158; standardized coefficient B, 0.056）. As a corollary, after adjusting for smoking duration, systolic blood pressure, anterior corneal curvature, prevalence of RVO was associated with more peripapillary fundus tessellation progression（P〈0.001; regression coefficient B： 1

关键词： fundus tessellation retinal vein occlusion Beijing Eye Study

Influencing factors for peripheral and posterior lesions in mild non-proliferative diabetic retinopathy--the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1467-1476页

作者： Mo-Chi yang Xiao-Bo Zhu Ya-Xing Wang Shou-Ling Wu Qian Wang yan-Ni yan Xuan yang jing-yan yang Meng-Xi Chen Ya-Hui Lei Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Dongfang Hospital Beijing University of Chinese Medicine Beijing 100078China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To explore the influencing factors of diabetes type 2 patients with mild non-proliferative diabetic retinopathy(NPDR)in the Kailuan area of Tangshan,Hebei Province,***:In this non-interventional,retrospective study,683 patients with type 2 diabetes were included in the Kailuan Diabetic Retinopathy Study involving participants with diabetes in the community-based longitudinal Kailuan *** on the undilated ultrawide field(200°;UWF)images and partial dilated digital fundus images,the diabetic retinopathy(DR)of the surveyed population was *** agreement was estimated by using Cohen’s Kappa *** main outcome indicators included gender,age,weight,height,body mass index,blood pressure,circumferences of neck,waist and hip,current smoking,levels of fasting plasma glucose(FPG),hypersensitive C-reactive protein,creatinine,and cholesterol,*** to different lesions’locations of patients with mild NPDR,logistic regression models were used to estimate the odds ratios(ORs)and their 95%Cls of each risk ***:The study group of 683 patients included 570 males and 113 *** mean age of the patients was62.18±9.41 *** with dilated fundus examinations,there was fair agreement with the level of DR identified on UWF images in 63.91%of eyes(k=0.369,95%CI,0.00-0.00).Detected by UWF images,there were 98 patients with mild NPDR having peripheral retinal lesions,35 patients with mild NPDR having posterior lesions,44 patients with mild NPDR whose lesions were detected both in and out the standard two fields area,and 336 patients with non obvious *** that conferred a statistically significant increased risks for mild NPDR with having peripheral retinal lesions were neck circumstance(OR,1.124;95%CI,1.044-1.211),and with posterior lesions were FPG(OR,1.052;95%CI,1.007-1.099).CONCLUSION:UWF is an effectiveness means of DR ***,it is necessary to evaluate peripheral diabetic retinal lesions which can

关键词： diabetic retinopathy ultra-wide field image neck circumference peripheral lesions fasting plasma glucose posterior pole lesions

Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

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Traditional Medicine Research 2024年第6期9卷 42-54页

作者： jing-yan yang Xiao-Xing Li Juan Chen yan-Jun Liu Yue-Hong Wu Ning-Yu Luo Cai-Xia yang yang Li Si-jing Liu Jin-Lin Guo College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chengdu 611137China Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still ***,our study aimed to investigate the impact of Jianqu on functional dyspepsia in ***:The phytochemical profile of Jianqu was analyzed by ***,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit *** pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin *** occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical ***,the serum gastrointestinal hormones were detected by *** addition,the gut microbiota composition was determined using 16S rRNA gene *** cecal short chain fatty acids were assessed by gas ***:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(p<0.01),increased the body weight and food intake(p<0.0001)in HCHP mice as *** HCHP did not cause significant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(p<0.05)was ***,Jianqu attenuated this abnormal expression of CD45(p<0.05).The levels of serum gastrointestinal hormones were significantly normalized by Jianqu intervention(p<0.05).Moreover,Jianqu increased the relative abundance of Roseburia as well as short chain fatty acids levels in cecum(p<0.05).Conclusion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal *** effects may be partly related to the increasing cecal short ch

关键词： herbal formula dyspepsia gastrointestinal hormones gastric emptying intestinal transit

MicroRNA-145 suppresses uveal melanoma angiogenesis and growth by targeting neuroblastoma RAS viral oncogene homolog and vascular endothelial growth factor

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Chinese Medical Journal 2020年第16期133卷 1922-1929页

作者： jing-yan yang yang Li Qian Wang Wen-Jia Zhou yan-Ni yan Wen-Bin Wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentCapital Medical UniversityBeijing 100730China

Background:Uveal melanoma(UM)is the most common primary intraocular malignancy in *** has been demonstrated that microRNA-145(miR-145)is correlated with the progression of various cancers by regulating the expression of multiple target genes,especially a number of genes that regulate angiogenesis and ***,the underlying mechanisms of miR-145 in tumor angiogenesis of UM are still not well ***,we aimed to explore the potential target genes or pathways regulated by miR-145 in UM and the effect of miR-145 on invasion and ***:Totally,24 choroid samples were collected in our study,including 12 UM samples and 12 normal uveal *** expression of neuroblastoma RAS viral oncogene homolog(N-RAS),phosphorylated protein kinase B(p-AKT),and vascular endothelial growth factor(VEGF)in UM tissues and normal uveal tissues was analyzed using Western blotting *** expression system was used to construct MUM-2B and OCM-1 cell lines with stable overexpression of *** and endothelial cell tube formation assay were used to measure the effects of miR-145 on the invasion and angiogenesis of UM in *** downstream target genes of miR-145 were predicted by bioinformatics and confirmed using a luciferase ***/c nude mice models were established to investigate the mechanisms of miR-145 on tumor growth and angiogenesis in *** data comparisons were performed using analysis of Student’s t test.A two-tailed P<0.05 was considered as statistically ***:The results of Western blotting analysis indicated that the expressions of N-RAS(1.10±0.35 vs.0.41±0.36,t=3.997,P=0.012),p-AKT(1.16±0.22 vs.0.57±0.03,t=7.05,P=0.001),and VEGF(0.97±0.32 vs.0.45±0.21,t=3.314,P=0.008)inUMtumor tissues were significantly higher than those in normal uveal *** assay demonstrated N-RAS and VEGF as downstream targets of ***,tube formation assay revealed that miR-145-transfected human

关键词： Uveal melanoma Vascular endothelial growth factor A Neuroblastoma RAS viral oncogene homolog microRNA-145 Angiogenesis

Retinal vessel oxygen saturation in healthy subjects and early branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 267-270页

作者： jing-yan yang Bing You Qian Wang Szy yann Chan Jost B.Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabCapital Medical UniversityBeijing 100730China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-UniversityMannheim 69047Germany Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing 100730China

AIM： To measure the retinal oxygen saturation in healthy subjects and early branch retinal vein occlusion（BRVO） in Chinese ***： The retinal vessel oxygen saturation of the healthy subjects and BRVO patients were measured by a noninvasive retinal oximeter（Oxymap ehf.,Reykjavik,Iceland）.RESULTS： The study included 22 patients with unilateral BRVO（mean age： 55.1±8.8y） in the study group and 91 healthy participants（mean age： 37.5±14.0y） in the control *** the healthy individuals,mean arterial and venous oxygen saturation were significantly（P〈0.001）higher in the superior nasal quadrant（98.5%±10.1%and 57.3%±8.7%,respectively） than in the inferior nasal quadrant（94.2%±9.0% and 54.1%±9.6%,respectively）,followed by the superior temporal quadrant（89.1%±10.1%and 51.9%±8.9%,respectively） and the inferior temporal quadrant（86.4%±9.4% and 46.6%±9.6%,respectively）.In patients with ischemic BRVO,arterial oxymetric values were significantly higher and venous measurements significantly lower for the affected vessel（107.5%±9.7% and46.4%±14.2%,respectively） than the unaffected vessel in the same eye（99.2%±12.2% and 55.5%±7.9%,respectively）and as compared to the vessel in the unaffected fellow eye（93.1%±6.9% and 55.7%±6.8%）（P=0.005 and P=0.02,respectively）.In the patients with non-ischemic BRVO,mean venous oxygen saturation was lower in the affected vein（39.8%±12.2%） than in the unaffected vessels of the same eye（50.8%±10.5%） and in the fellow eye（58.21%±5.7%）（P=0.03）.Mean arterial oxygen saturation did not differ significantly（P=0.42） between all three ***： In patients with BRVO,the venous oxygen saturation in the affected vessels is decreased potentially due to decreased blood velocity and ***,thearterial oxygen saturation in eyes with ischemic BRVO is increased in the affected arteries.

关键词： ischemia retinal oxygen saturation branchretinal vein occlusion retinal oximetry

Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 427-433页

作者： Ye-Nan Wang Ya-Xing Wang Jin-Qiong Zhou Qian-Qian Wan Li-Jian Fang Hai-Wei Wang jing-yan yang Li Dong Jin-Yuan Wang Xuan yang yan-Ni yan Qian Wang Shou-Ling Wu Shuo-Hua Chen jing-Yuan Zhu Wen-Bin Wei Jost B.Jonas Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230011Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102401China Department of Ophthalmology Fuxing HospitalCapital Medical UniversityBeijing 100045China Cardiology Department Kailuan General HospitalTangshan 063001Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 68167Germany

AIM:To investigate the risk and protective factors associated with the retinal nerve fiber layer defect(RNFLD)in a Chinese adult ***:This study was a cross-sectional populationbased investigation including employees and retirees of a coal mining company in Kailuan City,Hebei *** the study participants underwent a comprehensive systemic and ophthalmic *** was diagnosed on fundus *** logistic regression was used to investigate the risk and protective factors associated with the ***:The community-based study included 14440 *** were 10473 participants in our study,including 7120 males(68.0%)and 3353 females(32.0%).The age range was 45-108y,averaging 59.56±*** 568 participants had RNFLD and the prevalence rate was 5.42%.A higher prevalence of RNFLD was associated with older age[P<0.001,odds ratio(OR):1.032;95%confidence interval(CI):1.018-1.046],longer axial length(P=0.010,OR:1.190;95%CI:1.042-1.359),hypertension(P=0.007,OR:0.639;95%CI:0.460-0.887),and diabetes mellitus(P=0.019,OR:0.684;95%CI:0.499-0.939).The protective factors of RNFLD were visual acuity(P=0.038,OR:0.617;95%CI:0.391-0.975),and central anterior chamber depth(P=0.046,OR:0.595;95%CI:0.358-0.990).CONCLUSION:In our cross-sectional community-based study,with an age range of 45-108y,RNFLD is associated with older age,longer axial length,hypertension,and diabetes *** protective factors of RNFLD are visual acuity and central anterior chamber *** can help to predict and evaluate RNFLD related diseases and identify high-risk populations early.

关键词： retinal nerve fiber layer defect retinal nerve fiber layer age axial length hypertension diabetes mellitus visual acuity central anterior chamber depth